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Searching for up to 100 curated homologs for WP_012502227.1 NCBI__GCF_000020505.1:WP_012502227.1 (401 a.a.)

Found high-coverage hits (≥70%) to 30 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ASSY_THET8 / P59846 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
    49% identity, 97% coverage of query (392 bits)

ASSY_SYNY3 / P77973 Argininosuccinate synthase; Argininosuccinate synthetase; Citrulline--aspartate ligase; SyArgG; EC 6.3.4.5 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    49% identity, 98% coverage of query (391 bits)

7k5zA / Q5ZY78 Crystal structure of argininosuccinate synthase from legionella pneumophila philadelphia 1 in complex with anppnp and a substrate analogue arginine
    48% identity, 99% coverage of query (390 bits)

1j1zA / P59846 Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with substrate (see paper)
    48% identity, 97% coverage of query (374 bits)

4xfjB / G7CBN9 Crystal structure of argininosuccinate synthase from mycobacterium thermoresistibile in complex with amppnp and arginine
    48% identity, 96% coverage of query (374 bits)

1j20A Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with product
    48% identity, 97% coverage of query (374 bits)

1kh3A Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with inhibitor
    48% identity, 97% coverage of query (368 bits)

ASSY_THEMA / Q9X2A1 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
    47% identity, 99% coverage of query (363 bits)

A4I066 argininosuccinate synthase (EC 6.3.4.5) from Leishmania infantum (see paper)
    46% identity, 98% coverage of query (356 bits)

H9BG20 argininosuccinate synthase (EC 6.3.4.5) from Leishmania donovani (see 2 papers)
    46% identity, 98% coverage of query (355 bits)

argG / CAA88926.1 argininosuccinate synthetase from Streptomyces clavuligerus (see 3 papers)
    44% identity, 99% coverage of query (352 bits)

ARG1 argininosuccinate synthase; EC 6.3.4.5 from Candida albicans (see paper)
    44% identity, 99% coverage of query (339 bits)

Q2Z0F6 argininosuccinate synthase (EC 6.3.4.5) from Agaricus bisporus (see paper)
    42% identity, 100% coverage of query (337 bits)

S4V5K7 argininosuccinate synthase (EC 6.3.4.5) from Protopterus annectens (see paper)
    41% identity, 99% coverage of query (337 bits)

argG / CAB95023.1 argininosuccinate synthetase from Moritella abyssi (see paper)
    43% identity, 96% coverage of query (334 bits)

ASSY_YEAST / P22768 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    43% identity, 99% coverage of query (334 bits)

ASSY_RAT / P09034 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Rattus norvegicus (Rat) (see paper)
    44% identity, 99% coverage of query (331 bits)

ASSY_BOVIN / P14568 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Bos taurus (Bovine) (see paper)
    43% identity, 99% coverage of query (327 bits)

ASSY_MOUSE / P16460 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Mus musculus (Mouse) (see 3 papers)
P16460 argininosuccinate synthase (EC 6.3.4.5) from Mus musculus (see 4 papers)
    43% identity, 99% coverage of query (327 bits)

2nz2A / P00966 Crystal structure of human argininosuccinate synthase in complex with aspartate and citrulline (see paper)
    43% identity, 99% coverage of query (325 bits)

ASS1 / P00966 Argininosuccinate synthase (EC 6.3.4.5) from Homo sapiens (see 7 papers)
ASSY_HUMAN / P00966 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Homo sapiens (Human) (see 21 papers)
P00966 argininosuccinate synthase (EC 6.3.4.5) from Homo sapiens (see 9 papers)
    43% identity, 99% coverage of query (325 bits)

ASSY_SCHPO / O94354 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
arg12 / RF|NP_595183.1 argininosuccinate synthase (predicted); EC 6.3.4.5 from Schizosaccharomyces pombe (see 2 papers)
    42% identity, 98% coverage of query (318 bits)

ABZR86_RS08715 arginosuccinate synthetase (EC 6.3.4.5) from Dyella japonica UNC79MFTsu3.2
    33% identity, 99% coverage of query (194 bits)

Build an alignment

Build an alignment for WP_012502227.1 and 23 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

BT3760 arginosuccinate synthetase (EC 6.3.4.5) from Bacteroides thetaiotaomicron VPI-5482
    29% identity, 98% coverage of query (158 bits)

argG / BAC65286.1 argininosuccinate synthase from Burkholderia multivorans (see paper)
    30% identity, 99% coverage of query (158 bits)

5us8A / Q7VTJ9 2.15 angstrom resolution crystal structure of argininosuccinate synthase from bordetella pertussis
    32% identity, 90% coverage of query (150 bits)

6e5yA 1.50 angstrom resolution crystal structure of argininosuccinate synthase from bordetella pertussis in complex with amp.
    32% identity, 90% coverage of query (150 bits)

ArgG / b3172 argininosuccinate synthetase (EC 6.3.4.5) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ASSY_ECOLI / P0A6E4 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Escherichia coli (strain K12) (see 2 papers)
argG / RF|NP_417640 argininosuccinate synthase from Escherichia coli K12 (see paper)
    30% identity, 93% coverage of query (145 bits)

1kp3A / P0A6E4 Crystal structure of e. Coli argininosuccinate synthetase in complex with atp and citrulline (see paper)
    29% identity, 92% coverage of query (145 bits)

1k97A Crystal structure of e. Coli argininosuccinate synthetase in complex with aspartate and citrulline
    30% identity, 90% coverage of query (143 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory