Searching for up to 100 curated homologs for WP_012536144.1 NCBI__GCF_000021485.1:WP_012536144.1 (418 a.a.)

Found high-coverage hits (≥70%) to 18 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A7Y114 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Halobacillus halophilus (see paper)
    46% identity, 97% coverage of query (365 bits)

ProA / b0243 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
proA / P07004 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Escherichia coli (strain K12) (see 27 papers)
PROA_ECOLI / P07004 Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase; EC 1.2.1.41 from Escherichia coli (strain K12) (see 3 papers)
    42% identity, 99% coverage of query (334 bits)

PROA_YEAST / P54885 Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; GSA dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; EC 1.2.1.41 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    36% identity, 99% coverage of query (275 bits)

7wxgA / Q9VNW6 Gpr domain closed form of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
    38% identity, 98% coverage of query (273 bits)

7wxiA Gpr domain of drosophila p5cs filament with glutamate and atpgammas
    38% identity, 98% coverage of query (273 bits)

P5CS1 / P54887 δ1-pyrroline-5-carboxylate synthetase (EC 1.2.1.41; EC 2.7.2.11) from Arabidopsis thaliana (see 4 papers)
    36% identity, 96% coverage of query (266 bits)

P5CS1_ORYSJ / O04226 Delta-1-pyrroline-5-carboxylate synthase 1; OsP5CS1; EC 2.7.2.11; EC 1.2.1.41 from Oryza sativa subsp. japonica (Rice) (see paper)
    36% identity, 96% coverage of query (264 bits)

ALDH18A1 / P54886 δ-1-pyrroline-5-carboxylate synthase (EC 1.2.1.41; EC 2.7.2.11) from Homo sapiens (see 4 papers)
P5CS_HUMAN / P54886 Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; EC 2.7.2.11; EC 1.2.1.41 from Homo sapiens (Human) (see 8 papers)
    38% identity, 99% coverage of query (260 bits)

P5CS_MOUSE / Q9Z110 Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; EC 2.7.2.11; EC 1.2.1.41 from Mus musculus (Mouse) (see paper)
Q9Z110 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Mus musculus (see paper)
    37% identity, 99% coverage of query (256 bits)

P5CS2_ORYSJ / Q941T1 Delta-1-pyrroline-5-carboxylate synthase 2; OsP5CS2; EC 2.7.2.11; EC 1.2.1.41 from Oryza sativa subsp. japonica (Rice)
Q941T1 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Oryza sativa (see paper)
    35% identity, 96% coverage of query (254 bits)

Echvi_2633 gamma-glutamylphosphate reductase (EC 1.2.1.41) from Echinicola vietnamensis KMM 6221, DSM 17526
    35% identity, 93% coverage of query (244 bits)

p5cs / CAB40834.1 pyrroline-5-carboxylate synthetase from Vitis vinifera (see paper)
    34% identity, 98% coverage of query (244 bits)

4jbeB / C7MW73 1.95 angstrom crystal structure of gamma-glutamyl phosphate reductase from saccharomonospora viridis.
    32% identity, 97% coverage of query (156 bits)

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Build an alignment for WP_012536144.1 and 13 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

5j7iC Crystal structure of a geobacillus thermoglucosidasius acetylating aldehyde dehydrogenase in complex with adp
    23% identity, 93% coverage of query (58.9 bits)

5j7iB Crystal structure of a geobacillus thermoglucosidasius acetylating aldehyde dehydrogenase in complex with adp (see paper)
    23% identity, 93% coverage of query (58.5 bits)

Q0PH30 alcohol dehydrogenase (EC 1.1.1.1) from Thermoanaerobacter ethanolicus (see paper)
    21% identity, 88% coverage of query (54.7 bits)

SQWD_ACHSX / A0A3A6N9T6 Sulfoacetaldehyde dehydrogenase; CoA-acylating sulfoacetaldehyde dehydrogenase; NAD(+)-dependent acylating sulfoacetaldehyde dehydrogenase; EC 1.2.1.- from Acholeplasma sp. (see paper)
    22% identity, 72% coverage of query (53.1 bits)

xacF / D4GP41 α-ketoglutarate semialdehyde dehydrogenase subunit (EC 1.2.1.26) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see paper)
KGSDH_HALVD / D4GP41 Alpha-ketoglutarate semialdehyde dehydrogenase; KGSADH; EC 1.2.1.26 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
    25% identity, 70% coverage of query (50.1 bits)

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