Searching for up to 100 curated homologs for WP_012536422.1 NCBI__GCF_000021485.1:WP_012536422.1 (338 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q9WYH8 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Thermotoga maritima (see paper)
3pg9A / Q9WYH8 Thermotoga maritima dah7p synthase in complex with inhibitor (see paper)
    49% identity, 99% coverage of query (342 bits)

4grsA / Q8U0A9,Q9WYH8 Crystal structure of a chimeric dah7ps (see paper)
    51% identity, 99% coverage of query (342 bits)

1rzmA Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahps) from thermotoga maritima complexed with cd2+, pep and e4p
    49% identity, 99% coverage of query (342 bits)

3nvtA / Q8Y6T2 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e (see paper)
    53% identity, 72% coverage of query (270 bits)

3tfcA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e in complex with phosphoenolpyruvate
    53% identity, 73% coverage of query (270 bits)

4c1kA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
    51% identity, 78% coverage of query (267 bits)

1zcoB Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
    51% identity, 78% coverage of query (266 bits)

1zcoA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
    51% identity, 78% coverage of query (266 bits)

Q9YEJ7 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Aeropyrum pernix (see paper)
    57% identity, 79% coverage of query (261 bits)

5j6fA / L8A208 Crystal structure of dah7ps-cm complex from geobacillus sp. With prephenate (see paper)
    49% identity, 76% coverage of query (260 bits)

1vs1D / Q9YEJ7 Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep
    57% identity, 78% coverage of query (260 bits)

ccmA / BAA05463.1 32.4kD protein from Synechocystis sp. PCC 6803 (see paper)
    45% identity, 86% coverage of query (249 bits)

P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis (see paper)
    49% identity, 76% coverage of query (248 bits)

P39912 Protein AroA(G); EC 2.5.1.54; EC 5.4.99.5 from Bacillus subtilis (strain 168)
    49% identity, 76% coverage of query (248 bits)

A0A482F152 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from uncultured bacterium (see paper)
    51% identity, 79% coverage of query (239 bits)

CA265_RS11635 chorismate mutase (EC 5.4.99.5); 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Pedobacter sp. GW460-11-11-14-LB5
    34% identity, 75% coverage of query (145 bits)

1jcxA Aquifex aeolicus kdo8p synthase in complex with api and cadmium
    30% identity, 71% coverage of query (82.0 bits)

1pe1A Aquifex aeolicus kdo8ps in complex with cadmium and 2-pga
    30% identity, 71% coverage of query (82.0 bits)

1pcwA Aquifex aeolicus kdo8ps in complex with cadmium and app, a bisubstrate inhibitor
    30% identity, 71% coverage of query (81.6 bits)

3e12A Cu2+ substituted aquifex aeolicus kdo8ps in complex with kdo8p
    30% identity, 71% coverage of query (81.3 bits)

1pckA Aquifex aeolicus kdo8ps in complex with z-methyl-pep
    30% identity, 71% coverage of query (80.5 bits)

Build an alignment

Build an alignment for WP_012536422.1 and 21 homologs with ≥ 30% identity

Or download the sequences

Additional hits (identity < 30%)

Q8GLK7 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Aquifex pyrophilus (see paper)
    29% identity, 70% coverage of query (80.1 bits)

O66496 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Aquifex aeolicus (see 5 papers)
    29% identity, 71% coverage of query (79.7 bits)

2a21A / O66496 Aquifex aeolicus kdo8ps in complex with pep, po4, and zn2+ (see paper)
    29% identity, 71% coverage of query (79.3 bits)

3e0iA Cu2+ substituted aquifex aeolicus kdo8ps in complex with pep
    29% identity, 71% coverage of query (79.3 bits)

1jcyA Aquifex aeolicus kdo8p synthase in complex with r5p, pep and cadmium
    29% identity, 71% coverage of query (79.3 bits)

1fwwA Aquifex aeolicus kdo8p synthase in complex with pep, a5p and cadmium
    29% identity, 71% coverage of query (79.3 bits)

1fwtA Aquifex aeolicus kdo8p synthase in complex with pep, e4p and cadmium
    29% identity, 71% coverage of query (79.3 bits)

2nx3D Structural and mechanistic changes along an engineered path from metallo to non-metallo kdo8p synthase
    29% identity, 71% coverage of query (75.9 bits)

2nx1A Structural and mechanistic changes along an engineered path from metallo to non-metallo kdo8p synthase
    29% identity, 71% coverage of query (74.7 bits)

Q9ZE84 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Rickettsia prowazekii (see paper)
    28% identity, 73% coverage of query (67.0 bits)

Or start over