Searching for up to 100 curated homologs for WP_012566957.1 NCBI__GCF_000016185.1:WP_012566957.1 (517 a.a.)

Found high-coverage hits (≥70%) to 45 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ILVX_MYCTU / O53554 Putative acetolactate synthase large subunit IlvX; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
O53554 acetolactate synthase (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
    49% identity, 100% coverage of query (393 bits)

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Build an alignment for WP_012566957.1 and 1 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

6a50A Structure of benzoylformate decarboxylases in complex with cofactor tpp
    28% identity, 98% coverage of query (155 bits)

mdlC / P20906 MdlC (EC 4.1.1.7) from Pseudomonas putida (see 2 papers)
P20906 benzoylformate decarboxylase (EC 4.1.1.7) from Pseudomonas putida (see 16 papers)
    28% identity, 98% coverage of query (154 bits)

5deiA Benzoylformate decarboxylase from pseudomonas putida
    28% identity, 98% coverage of query (154 bits)

3fsjX Crystal structure of benzoylformate decarboxylase in complex with the inhibitor mbp
    28% identity, 98% coverage of query (154 bits)

1mczA Benzoylformate decarboxylase from pseudomonas putida complexed with an inhibitor, r-mandelate
    28% identity, 98% coverage of query (154 bits)

3fznA Intermediate analogue in benzoylformate decarboxylase
    28% identity, 98% coverage of query (154 bits)

1bfdA Benzoylformate decarboxylase from pseudomonas putida
    28% identity, 98% coverage of query (154 bits)

3f6bX Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor paa
    28% identity, 98% coverage of query (154 bits)

1pi3A E28q mutant benzoylformate decarboxylase from pseudomonas putida
    27% identity, 98% coverage of query (153 bits)

dpgB / A3RJV5 benzoylformate decarboxylase monomer (EC 4.1.1.7) from Stutzerimonas stutzeri (see paper)
    27% identity, 98% coverage of query (152 bits)

bfd / CAK95977.1 benzoylformate decarboxylase from Pseudomonas putida (see paper)
    31% identity, 98% coverage of query (149 bits)

6qsiA / Q4KB02 Pseudomonas fluorescens pf-5 thiamine diphosphate-dependent 4- hydroxybenzoylformate decarboxylase (see paper)
    31% identity, 98% coverage of query (149 bits)

bfd / CAK95976.1 benzoylformate decarboxylase from Pseudomonas putida (see paper)
    31% identity, 97% coverage of query (147 bits)

C5ARG4 indolepyruvate decarboxylase (EC 4.1.1.74) from Methylorubrum extorquens (see paper)
    27% identity, 100% coverage of query (137 bits)

7orxCCC / Q0SCE8 jostii RHA1 thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase
    30% identity, 99% coverage of query (136 bits)

4q9dB / A0QSU7 X-ray structure of a putative thiamin diphosphate-dependent enzyme isolated from mycobacterium smegmatis (see paper)
    27% identity, 97% coverage of query (125 bits)

4k9qA / A4SXU0 The crystal structure of benzoylformate decarboxylase from polynucleobacter necessarius
    26% identity, 97% coverage of query (115 bits)

SYNPCC7002_A2770 / B1XMM5 2-oxoglutarate decarboxylase monomer (EC 4.1.1.71) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see 2 papers)
B1XMM5 oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) from Synechococcus sp. PCC 7002 (see paper)
    23% identity, 100% coverage of query (101 bits)

ILVB1_MYCTU / P9WG41 Acetolactate synthase large subunit IlvB1; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WG41 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
    24% identity, 100% coverage of query (90.9 bits)

Q5VB49 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
    26% identity, 100% coverage of query (83.2 bits)

Q5VB44 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
    26% identity, 100% coverage of query (81.6 bits)

6lpiB / P08142 Crystal structure of ahas holo-enzyme (see paper)
    25% identity, 100% coverage of query (79.7 bits)

Q836A5 acetolactate synthase (EC 2.2.1.6) from Enterococcus faecalis (see 2 papers)
    23% identity, 99% coverage of query (78.2 bits)

Q8RL88 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Geobacillus stearothermophilus (see paper)
ilvB / AAL99356.1 acetohydroxy acid synthase large subunit from Geobacillus stearothermophilus (see paper)
    24% identity, 99% coverage of query (77.0 bits)

Q5S3P7 acetolactate synthase (EC 2.2.1.6) from Streptomyces cinnamonensis (see 2 papers)
ilvB / AAV52901.1 acetohydroxy acid synthase large subunit from Streptomyces cinnamonensis (see paper)
    24% identity, 100% coverage of query (75.5 bits)

Q5VB42 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
    24% identity, 100% coverage of query (75.1 bits)

Q6TA05 N2-(2-carboxyethyl)arginine synthase (EC 2.5.1.66) from Streptomyces clavuligerus (see 2 papers)
    25% identity, 99% coverage of query (72.8 bits)

ilvB / AAA93098.1 acetolactate synthase from Streptomyces avermitilis (see paper)
    25% identity, 88% coverage of query (65.5 bits)

4feeA High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal b (see paper)
    23% identity, 99% coverage of query (64.3 bits)

1powA The refined structures of a stabilized mutant and of wild-type pyruvate oxidase from lactobacillus plantarum
    23% identity, 99% coverage of query (64.3 bits)

P37063 pyruvate oxidase (EC 1.2.3.3) from Lactiplantibacillus plantarum (see 2 papers)
    23% identity, 99% coverage of query (63.9 bits)

1v5gA Crystal structure of the reaction intermediate between pyruvate oxidase containing fad and tpp, and substrate pyruvate
    23% identity, 97% coverage of query (63.9 bits)

1v5fA Crystal structure of pyruvate oxidase complexed with fad and tpp, from aerococcus viridans
    23% identity, 97% coverage of query (63.9 bits)

2djiA / A9X9K8 Crystal structure of pyruvate oxidase from aerococcus viridans containing fad (see paper)
    23% identity, 97% coverage of query (63.5 bits)

2ezuA Pyruvate oxidase variant f479w in complex with reaction intermediate 2-acetyl-thiamin diphosphate
    23% identity, 99% coverage of query (63.2 bits)

2ez9A Pyruvate oxidase variant f479w in complex with reaction intermediate analogue 2-phosphonolactyl-thiamin diphosphate
    23% identity, 99% coverage of query (63.2 bits)

2ez8A Pyruvate oxidase variant f479w in complex with reaction intermediate 2-lactyl-thiamin diphosphate
    23% identity, 99% coverage of query (63.2 bits)

2ez4B Pyruvate oxidase variant f479w
    23% identity, 99% coverage of query (63.2 bits)

PoxB / b0871 pyruvate oxidase (EC 1.2.5.1) from Escherichia coli K-12 substr. MG1655 (see 70 papers)
poxB / P07003 pyruvate oxidase (EC 1.2.5.1) from Escherichia coli (strain K12) (see 69 papers)
POXB_ECOLI / P07003 Pyruvate dehydrogenase [ubiquinone]; Pyruvate oxidase; POX; Pyruvate:ubiquinone-8 oxidoreductase; EC 1.2.5.1 from Escherichia coli (strain K12) (see 13 papers)
P07003 pyruvate dehydrogenase (quinone) (EC 1.2.5.1) from Escherichia coli (see paper)
    24% identity, 99% coverage of query (61.6 bits)

1ovmA / P23234 Crystal structure of indolepyruvate decarboxylase from enterobacter cloacae (see paper)
    24% identity, 86% coverage of query (61.2 bits)

ipdC / P23234 indole-3-pyruvate decarboxylase subunit (EC 4.1.1.74) from Enterobacter cloacae (see 2 papers)
DCIP_ENTCL / P23234 Indole-3-pyruvate decarboxylase; Indolepyruvate decarboxylase; EC 4.1.1.74 from Enterobacter cloacae (see paper)
P23234 indolepyruvate decarboxylase (EC 4.1.1.74) from Enterobacter cloacae (see paper)
    24% identity, 86% coverage of query (61.2 bits)

3ey9A / P07003 Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from escherichia coli (see paper)
    24% identity, 99% coverage of query (61.2 bits)

PXP1_YEAST / P39994 2-hydroxyacyl-CoA lyase; Peroxisomal protein 1; EC 4.1.2.63 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    22% identity, 85% coverage of query (48.1 bits)

6xn8A / A0A1H8YFL8 Crystal structure of 2-hydroxyacyl coa lyase (hacl) from rhodospirillales bacterium urhd0017
    24% identity, 100% coverage of query (45.4 bits)

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