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Searching for up to 100 curated homologs for WP_012567802.1 NCBI__GCF_000016185.1:WP_012567802.1 (411 a.a.)

Found high-coverage hits (≥70%) to 48 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AKLYS_STUS1 / A4VJB4 Aspartate kinase Ask_LysC; Aspartokinase; EC 2.7.2.4 from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see paper)
    58% identity, 100% coverage of query (466 bits)

AK_PSEFS / C3JXY0 Aspartate kinase; Aspartokinase; EC 2.7.2.4 from Pseudomonas fluorescens (strain SBW25) (see 2 papers)
    57% identity, 100% coverage of query (456 bits)

AK_PSEPK / Q88EI9 Aspartate kinase; Aspartokinase; EC 2.7.2.4 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    57% identity, 100% coverage of query (453 bits)

O69077 aspartate kinase (EC 2.7.2.4) from Pseudomonas aeruginosa (see paper)
    57% identity, 100% coverage of query (449 bits)

5yeiC / O69077 Mechanistic insight into the regulation of pseudomonas aeruginosa aspartate kinase (see paper)
    56% identity, 99% coverage of query (435 bits)

AK_CORFL / P41398 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Corynebacterium flavescens (see paper)
lysC / GB|AAA23293.1 aspartate kinase; EC 2.7.2.4 from Corynebacterium flavescens (see paper)
    46% identity, 99% coverage of query (339 bits)

lysCα / P26512 aspartokinase α subunit (EC 2.7.2.4) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
lysCβ / P26512 aspartokinase β subunit (EC 2.7.2.4) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
AK_CORGL / P26512 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see 2 papers)
P26512 aspartate kinase (EC 2.7.2.4) from Corynebacterium glutamicum (see 2 papers)
lysC aspartate kinase 2; EC 2.7.2.4 from Corynebacterium glutamicum (see 3 papers)
    46% identity, 99% coverage of query (338 bits)

AK_MYCTU / P9WPX3 Aspartokinase; Aspartate kinase; ASK; EC 2.7.2.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WPX3 aspartate kinase (EC 2.7.2.4) from Mycobacterium tuberculosis (see paper)
    46% identity, 99% coverage of query (333 bits)

lysCα / P08495 aspartate kinase II α subunit (EC 2.7.2.4) from Bacillus subtilis (strain 168) (see 4 papers)
lysCβ / P08495 aspartate kinase II β subunit (EC 2.7.2.4) from Bacillus subtilis (strain 168) (see 4 papers)
AK2_BACSU / P08495 Aspartokinase 2; Aspartate kinase 2; Aspartokinase II; EC 2.7.2.4 from Bacillus subtilis (strain 168) (see 2 papers)
P08495 aspartate kinase (EC 2.7.2.4) from Bacillus subtilis (see paper)
lysC / GB|CAA99580.1 aspartate kinase 2; EC 2.7.2.4 from Bacillus subtilis (see paper)
    46% identity, 100% coverage of query (321 bits)

3aawC / P26512 Crystal structure of aspartate kinase from corynebacterium glutamicum in complex with lysine and threonine (see paper)
    45% identity, 99% coverage of query (320 bits)

AK_THET2 / P61488 Aspartokinase; Aspartate kinase; ASK; EC 2.7.2.4 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
    44% identity, 100% coverage of query (319 bits)

AK_THETH / P61489 Aspartokinase; Aspartate kinase; AK; ASK; Threonine-sensitive AK; ThrA; EC 2.7.2.4 from Thermus thermophilus (see 4 papers)
P61489 aspartate kinase (EC 2.7.2.4) from Thermus thermophilus (see 3 papers)
    44% identity, 100% coverage of query (318 bits)

P74569 aspartate kinase (EC 2.7.2.4) from Synechocystis sp. (see paper)
    44% identity, 99% coverage of query (303 bits)

3ab4A / P26512 Crystal structure of feedback inhibition resistant mutant of aspartate kinase from corynebacterium glutamicum in complex with lysine and threonine (see paper)
    41% identity, 99% coverage of query (286 bits)

3l76A / P74569 Crystal structure of aspartate kinase from synechocystis (see paper)
    43% identity, 99% coverage of query (285 bits)

Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima (see paper)
    39% identity, 99% coverage of query (283 bits)

3c1nA Crystal structure of allosteric inhibition threonine-sensitive aspartokinase from methanococcus jannaschii with l-threonine
    34% identity, 98% coverage of query (221 bits)

2hmfA Structure of a threonine sensitive aspartokinase from methanococcus jannaschii complexed with mg-adp and aspartate
    33% identity, 98% coverage of query (221 bits)

3c1mC / Q57991 Cyrstal structure of threonine-sensitive aspartokinase from methanococcus jannaschii with mgamp-pnp and l-aspartate (see paper)
    34% identity, 98% coverage of query (219 bits)

Q57991 aspartate kinase (EC 2.7.2.4) from Methanocaldococcus jannaschii (see 2 papers)
    33% identity, 98% coverage of query (219 bits)

dapG / Q04795 aspartokinase I (alpha and beta subunits) (EC 2.7.2.4) from Bacillus subtilis (strain 168) (see 6 papers)
    33% identity, 100% coverage of query (188 bits)

dapG aspartate kinase 1; EC 2.7.2.4 from Bacillus subtilis (see paper)
    33% identity, 100% coverage of query (185 bits)

Build an alignment

Build an alignment for WP_012567802.1 and 22 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    28% identity, 98% coverage of query (162 bits)

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
    27% identity, 99% coverage of query (153 bits)

Q9RUL9 aspartate kinase (EC 2.7.2.4) from Deinococcus radiodurans (see paper)
    31% identity, 99% coverage of query (150 bits)

ThrD / b0002 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
thrA / P00561 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 33 papers)
P00561 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
    34% identity, 72% coverage of query (141 bits)

O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
    27% identity, 99% coverage of query (137 bits)

AKH1_ARATH / Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    29% identity, 99% coverage of query (137 bits)

AK3 / Q9S702 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see paper)
AK3_ARATH / Q9S702 Aspartokinase 3, chloroplastic; Aspartate kinase 3; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9S702 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    28% identity, 97% coverage of query (136 bits)

AK2_ARATH / O23653 Aspartokinase 2, chloroplastic; Aspartate kinase 2; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O23653 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    27% identity, 98% coverage of query (136 bits)

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
    28% identity, 99% coverage of query (134 bits)

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    27% identity, 99% coverage of query (134 bits)

AK1_ARATH / Q9LYU8 Aspartokinase 1, chloroplastic; Aspartate kinase 1; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9LYU8 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    25% identity, 98% coverage of query (129 bits)

2cdqA / Q9LYU8 Crystal structure of arabidopsis thaliana aspartate kinase complexed with lysine and s- adenosylmethionine (see paper)
    25% identity, 98% coverage of query (129 bits)

Q5JK18 aspartate kinase (EC 2.7.2.4) from Oryza sativa Japonica Group (see paper)
    27% identity, 91% coverage of query (127 bits)

ABZR86_RS19560 aspartate kinase / diaminopimelate decarboxylase (EC 4.1.1.20; EC 2.7.2.4) from Dyella japonica UNC79MFTsu3.2
    29% identity, 98% coverage of query (120 bits)

Apk / b4024 aspartate kinase III (EC 2.7.2.4) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lysC / P08660 aspartate kinase III (EC 2.7.2.4) from Escherichia coli (strain K12) (see 27 papers)
AK3_ECOLI / P08660 Lysine-sensitive aspartokinase 3; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III; EC 2.7.2.4 from Escherichia coli (strain K12) (see 2 papers)
P08660 aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
    28% identity, 97% coverage of query (112 bits)

2j0wA / P08660 Crystal structure of e. Coli aspartokinase iii in complex with aspartate and adp (r-state) (see paper)
    28% identity, 97% coverage of query (112 bits)

2j0xA Crystal structure of e. Coli aspartokinase iii in complex with lysine and aspartate (t-state)
    28% identity, 97% coverage of query (112 bits)

FUB3_FUSO4 / A0A0D2YG09 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato) (see 8 papers)
    25% identity, 97% coverage of query (105 bits)

FUB3_GIBM7 / W7MS01 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) (see 10 papers)
    26% identity, 87% coverage of query (103 bits)

Q97MC0 aspartate kinase (EC 2.7.2.4) from Clostridium acetobutylicum (see paper)
    24% identity, 72% coverage of query (100 bits)

3tviE / Q97MC0 Crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production (see paper)
    24% identity, 72% coverage of query (100 bits)

FUB3_GIBF5 / S0DVT6 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi) (see 9 papers)
    24% identity, 94% coverage of query (98.6 bits)

yclM / P94417 aspartate kinase III (EC 2.7.2.4) from Bacillus subtilis (strain 168) (see 4 papers)
AK3_BACSU / P94417 Aspartokinase 3; Aspartate kinase 3; Aspartokinase III; EC 2.7.2.4 from Bacillus subtilis (strain 168) (see paper)
    26% identity, 83% coverage of query (98.6 bits)

3tviA Crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production
    23% identity, 72% coverage of query (90.1 bits)

O60163 Probable aspartokinase; Aspartate kinase; EC 2.7.2.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    23% identity, 86% coverage of query (87.4 bits)

AKECT_STUS1 / A4VFY3 Aspartate kinase Ask_Ect; Aspartokinase; EC 2.7.2.4 from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see paper)
ask / CBM40643.1 aspartokinase from Pseudomonas stutzeri (see paper)
    23% identity, 78% coverage of query (51.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory