Searching for up to 100 curated homologs for WP_012568196.1 NCBI__GCF_000016185.1:WP_012568196.1 (276 a.a.)
Found high-coverage hits (≥70%) to 38 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ptmS4 / A0A2R3ZBG9 [sulfur-carrier protein]--sulfur ligase from Streptomyces platensis (see 3 papers)
51% identity, 96% coverage of query (273 bits)
moeZ / P9WMN7 [sulfur-carrier protein CysO]--sulfur ligase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
MOEZ_MYCTU / P9WMN7 Probable adenylyltransferase/sulfurtransferase MoeZ; EC 2.7.7.-; EC 2.8.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
51% identity, 91% coverage of query (248 bits)
ttuC / B6ZH72 [sulfur carrier protein TtuB] adenylyltransferase from Thermus thermophilus (see paper)
53% identity, 94% coverage of query (242 bits)
TTUC_THET2 / Q72J02 Sulfur carrier protein adenylyltransferase; E1-like protein TtuC; Sulfur carrier protein MoaD adenylyltransferase; Sulfur carrier protein ThiS adenylyltransferase; Sulfur carrier protein TtuB adenylyltransferase; tRNA two-thiouridine-synthesizing protein C; EC 2.7.7.80; EC 2.7.7.73; EC 2.7.7.- from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
53% identity, 94% coverage of query (241 bits)
MOCS3_DROME / Q9VLJ8 Adenylyltransferase and sulfurtransferase MOCS3; Molybdenum cofactor synthesis protein 3; Ubiquitin activating enzyme 4; EC 2.7.7.80; EC 2.8.1.11 from Drosophila melanogaster (Fruit fly) (see paper)
43% identity, 95% coverage of query (232 bits)
MOCS3 / O95396 MOCS3 adenylyltransferase/sulfurtransferase (EC 2.8.1.11; EC 2.7.7.80) from Homo sapiens (see 6 papers)
MOCS3_HUMAN / O95396 Adenylyltransferase and sulfurtransferase MOCS3; Molybdenum cofactor synthesis protein 3; Molybdopterin synthase sulfurylase; MPT synthase sulfurylase; EC 2.7.7.80; EC 2.8.1.11 from Homo sapiens (Human) (see 6 papers)
O95396 molybdopterin-synthase adenylyltransferase (EC 2.7.7.80); molybdopterin synthase sulfurtransferase (EC 2.8.1.11) from Homo sapiens (see 6 papers)
51% identity, 95% coverage of query (223 bits)
ubaA / D4GSF3 E1 SAMP-activating enzyme monomer (EC 2.7.7.100) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
UBAA_HALVD / D4GSF3 SAMP-activating enzyme E1; Ubiquitin-like activating enzyme of archaea; Ubl-activating enzyme; EC 2.7.7.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 4 papers)
D4GSF3 SAMP-activating enzyme (EC 2.7.7.100); E1 SAMP-activating enzyme (EC 6.2.1.55) from Haloferax volcanii (see 8 papers)
53% identity, 89% coverage of query (223 bits)
UBA4_EMENI / O59954 Adenylyltransferase and sulfurtransferase uba4; Common component for nitrate reductase and xanthine dehydrogenase protein F; Ubiquitin-like protein activator 4; EC 2.7.7.80; EC 2.8.1.11 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
cnxF adenylyltransferase and sulfurtransferase uba4; EC 2.7.7.-; EC 2.8.1.- from Emericella nidulans (see 2 papers)
43% identity, 91% coverage of query (204 bits)
UBA4_YEAST / P38820 Adenylyltransferase and sulfurtransferase UBA4; Needs CLA4 to survive protein 3; Ubiquitin-like protein activator 4; EC 2.7.7.-; EC 2.8.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 8 papers)
42% identity, 91% coverage of query (199 bits)
ChlN / b0826 molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
moeB / P12282 molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) from Escherichia coli (strain K12) (see 10 papers)
MOEB_ECOLI / P12282 Molybdopterin-synthase adenylyltransferase; MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase; Sulfur carrier protein MoaD adenylyltransferase; EC 2.7.7.80 from Escherichia coli (strain K12) (see 2 papers)
P12282 molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) from Escherichia coli (see 2 papers)
moeB / GB|BAA35514.1 molybdopterin biosynthesis protein moeB from Escherichia coli K12 (see 4 papers)
43% identity, 91% coverage of query (196 bits)
1jw9B / P12282 Structure of the native moeb-moad protein complex (see paper)
42% identity, 91% coverage of query (191 bits)
1jwbB Structure of the covalent acyl-adenylate form of the moeb-moad protein complex
42% identity, 91% coverage of query (191 bits)
ThiA / b3992 sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
thiF / P30138 sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73) from Escherichia coli (strain K12) (see 11 papers)
THIF_ECOLI / P30138 Sulfur carrier protein ThiS adenylyltransferase; EC 2.7.7.73 from Escherichia coli (strain K12) (see 4 papers)
P30138 sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73) from Escherichia coli (see 3 papers)
41% identity, 92% coverage of query (171 bits)
1zfnA / P30138 Structural analysis of escherichia coli thif (see paper)
40% identity, 90% coverage of query (167 bits)
1zud3 Structure of this-thif protein complex
40% identity, 91% coverage of query (165 bits)
1jwaB Structure of the atp-bound moeb-moad protein complex
38% identity, 88% coverage of query (157 bits)
6yubA / G0SC54 Crystal structure of uba4 from chaetomium thermophilum (see paper)
40% identity, 78% coverage of query (156 bits)
6yubB Crystal structure of uba4 from chaetomium thermophilum
40% identity, 78% coverage of query (153 bits)
Build an alignment for WP_012568196.1 and 18 homologs with ≥ 30% identity
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TC 3.A.25.2.1 / Q8ID54 UBA/THIF-type NAD/FAD binding protein, putative, component of The SELMA system in the apicoplast of the malaria paraiste, Plasmodium falciparum from Plasmodium falciparum (isolate 3D7)
29% identity, 88% coverage of query (117 bits)
thiF / O31619 [sulfur-carrier protein ThiS] adenylyltransferase (EC 2.7.7.73) from Bacillus subtilis (strain 168) (see 4 papers)
O31619 sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73) from Bacillus subtilis (see paper)
28% identity, 88% coverage of query (98.2 bits)
3h9jA Crystal structure of e. Coli mccb + ampcpp + semet mcca
23% identity, 93% coverage of query (72.4 bits)
3h5nA Crystal structure of e. Coli mccb + atp
23% identity, 92% coverage of query (72.0 bits)
3h5rA Crystal structure of e. Coli mccb + succinimide
23% identity, 93% coverage of query (68.6 bits)
mccB / Q47506 MccB protein monomer from Escherichia coli (see paper)
22% identity, 93% coverage of query (66.6 bits)
3h5aC / Q47506 Crystal structure of e. Coli mccb (see paper)
22% identity, 93% coverage of query (66.2 bits)
UBA6_HUMAN / A0AVT1 Ubiquitin-like modifier-activating enzyme 6; Ubiquitin-activating enzyme 6; Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2; EC 6.2.1.45 from Homo sapiens (Human) (see 4 papers)
A0AVT1 E1 ubiquitin-activating enzyme (EC 6.2.1.45) from Homo sapiens (see 4 papers)
24% identity, 73% coverage of query (64.7 bits)
6om4A The structure of microcin c7 biosynthetic enzyme mccb in complex with n-formylated mcca
23% identity, 83% coverage of query (62.0 bits)
6om4B The structure of microcin c7 biosynthetic enzyme mccb in complex with n-formylated mcca
23% identity, 82% coverage of query (62.0 bits)
7pvnB / A0AVT1 Crystal structure of human uba6 in complex with atp (see paper)
23% identity, 73% coverage of query (60.8 bits)
7solA / A0AVT1 Crystal structures of the bispecific ubiquitin/fat10 activating enzyme, uba6 (see paper)
23% identity, 73% coverage of query (60.8 bits)
7solC Crystal structures of the bispecific ubiquitin/fat10 activating enzyme, uba6
23% identity, 73% coverage of query (60.8 bits)
7pvnA Crystal structure of human uba6 in complex with atp
23% identity, 73% coverage of query (60.8 bits)
6h77B / Q9GZZ9 E1 enzyme for ubiquitin like protein activation in complex with ubl (see paper)
27% identity, 86% coverage of query (58.5 bits)
UBA5_HUMAN / Q9GZZ9 Ubiquitin-like modifier-activating enzyme 5; Ubiquitin-activating enzyme 5; ThiFP1; UFM1-activating enzyme; Ubiquitin-activating enzyme E1 domain-containing protein 1 from Homo sapiens (Human) (see 21 papers)
Q9GZZ9 E1 ubiquitin-activating enzyme (EC 6.2.1.45) from Homo sapiens (see 3 papers)
27% identity, 86% coverage of query (58.5 bits)
UBA5_MOUSE / Q8VE47 Ubiquitin-like modifier-activating enzyme 5; Ubiquitin-activating enzyme 5; UFM1-activating enzyme from Mus musculus (Mouse) (see 3 papers)
26% identity, 91% coverage of query (55.8 bits)
3gucA Human ubiquitin-activating enzyme 5 in complex with amppnp
25% identity, 72% coverage of query (51.2 bits)
5l95A Crystal structure of human uba5 in complex with ufm1 and amp
24% identity, 72% coverage of query (50.1 bits)
5iaaB / Q9GZZ9 Crystal structure of human uba5 in complex with ufm1 (see paper)
24% identity, 72% coverage of query (43.5 bits)
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Lawrence Berkeley National Laboratory