Searching for up to 100 curated homologs for WP_012674117.1 NCBI__GCF_000021545.1:WP_012674117.1 (198 a.a.)
Found high-coverage hits (≥70%) to 61 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
trpG / BAC65123.1 anthranilate synthase component II from Burkholderia multivorans (see paper)
61% identity, 94% coverage of query (250 bits)
para-aminobenzoate synthase glutamine amidotransferase component II / b3360 aminodeoxychorismate synthase subunit 2 (EC 2.6.1.85) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pabA / P00903 aminodeoxychorismate synthase subunit 2 (EC 2.6.1.85) from Escherichia coli (strain K12) (see 9 papers)
PABA_ECOLI / P00903 Aminodeoxychorismate synthase component 2; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component; EC 2.6.1.85 from Escherichia coli (strain K12) (see 3 papers)
P00903 aminodeoxychorismate synthase (EC 2.6.1.85); 2-amino-4-deoxychorismate synthase (EC 2.6.1.86) from Escherichia coli (see paper)
60% identity, 94% coverage of query (242 bits)
pabA / P28819 4-amino-4-deoxychorismate synthase; anthranilate synthase (subunit II) (EC 2.6.1.123) from Bacillus subtilis (strain 168) (see paper)
PABA_BACSU / P28819 Aminodeoxychorismate/anthranilate synthase component 2; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component; EC 2.6.1.85; EC 4.1.3.27 from Bacillus subtilis (strain 168) (see paper)
59% identity, 96% coverage of query (241 bits)
trpG / P20576 anthranilate synthase β subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
TRPG_PSEAE / P20576 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
P20576 anthranilate synthase (subunit 2/2) (EC 4.1.3.27) from Pseudomonas aeruginosa (see paper)
59% identity, 94% coverage of query (234 bits)
TRPG_PSEPU / P00901 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
57% identity, 94% coverage of query (229 bits)
TRPG_AZOBR / P26922 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Azospirillum brasilense (see paper)
49% identity, 99% coverage of query (221 bits)
trpG / AAD09117.1 anthranilate synthase component II from Rhodobacter sphaeroides (see paper)
52% identity, 98% coverage of query (216 bits)
ASB1_ORYSJ / Q7XUS2 Anthranilate synthase beta subunit 1, chloroplastic; OsASB1; Anthranilate synthase, glutamine amidotransferase component 2-1; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
54% identity, 96% coverage of query (206 bits)
ASB1_ARATH / Q42565 Anthranilate synthase beta subunit 1, chloroplastic; Anthranilate synthase component 2-1; Anthranilate synthase, glutamine amidotransferase component 2-1; Protein TRYPTOPHAN BIOSYNTHESIS 4; Protein WEAK ETHYLENE INSENSITIVE 7; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
51% identity, 97% coverage of query (201 bits)
ASB2_ORYSJ / Q764B9 Anthranilate synthase beta subunit 2, chloroplastic; OsASB2; Anthranilate synthase, glutamine amidotransferase component 2-2; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
52% identity, 95% coverage of query (197 bits)
trpG / Q06129 anthranilate synthase β subunit (EC 4.1.3.27) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
TRPG_SACS2 / Q06129 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q06129 anthranilate synthase (subunit 1/2) (EC 4.1.3.27) from Saccharolobus solfataricus (see paper)
52% identity, 94% coverage of query (187 bits)
TRPG_YEAST / P00937 Multifunctional tryptophan biosynthesis protein; EC 4.1.3.27; EC 4.1.1.48 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
45% identity, 95% coverage of query (178 bits)
pabAB / P32483 4-amino-4-deoxychorismate synthase (EC 2.6.1.85) from Streptomyces griseus (see 5 papers)
ADCS_STRGR / P32483 Aminodeoxychorismate synthase; ADC synthase; 4-amino-4-deoxychorismate synthase; p-aminobenzoic acid synthase; PABA synthase; EC 2.6.1.85 from Streptomyces griseus (see paper)
46% identity, 97% coverage of query (176 bits)
papA / BAD21140.1 4-amino-4-deoxychorismate synthase from Streptomyces venezuelae (see paper)
47% identity, 94% coverage of query (172 bits)
8hx8A / F2RB79 Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae co-crystallized with chorismate (see paper)
47% identity, 94% coverage of query (172 bits)
cmlB / F2RB79 4-amino-4-deoxychorismate synthase (EC 2.6.1.85) from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see 2 papers)
ADCS_STRVP / F2RB79 Aminodeoxychorismate synthase; ADC synthase; 4-amino-4-deoxychorismate synthase; p-aminobenzoate synthase; EC 2.6.1.85 from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see paper)
47% identity, 94% coverage of query (172 bits)
trpC anthranilate synthase component 2; EC 4.1.3.27 from Emericella nidulans (see 4 papers)
44% identity, 94% coverage of query (169 bits)
ADCS_STRPR / P72539 Aminodeoxychorismate synthase; ADC synthase; 4-amino-4-deoxychorismate synthase; EC 2.6.1.85 from Streptomyces pristinaespiralis (see paper)
46% identity, 96% coverage of query (169 bits)
TRPG_SERMA / P00900 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Serratia marcescens (see paper)
42% identity, 95% coverage of query (167 bits)
trpG anthranilate synthase component II; EC 4.1.3.27 from Leptospira biflexa serovar Patoc (see paper)
46% identity, 94% coverage of query (166 bits)
1i7qB / P00900 Anthranilate synthase from s. Marcescens (see paper)
41% identity, 95% coverage of query (164 bits)
TrpD / b1263 anthranilate synthase subunit TrpD (EC 2.4.2.18; EC 4.1.3.27) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
trpD / P00904 anthranilate synthase subunit TrpD (EC 2.4.2.18) from Escherichia coli (strain K12) (see 2 papers)
TRPGD_ECOLI / P00904 Bifunctional protein TrpGD; EC 4.1.3.27; EC 2.4.2.18 from Escherichia coli (strain K12) (see 3 papers)
40% identity, 96% coverage of query (154 bits)
TRPGD_SALTY / P00905 Bifunctional protein TrpGD; EC 4.1.3.27; EC 2.4.2.18 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
39% identity, 96% coverage of query (150 bits)
phnB / P09786 PhnB anthranilate synthase subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
PHNB_PSEAE / P09786 Anthranilate synthase component 2, pyocyanine specific; AS; ASII; Anthranilate synthase beta subunit, pyocyanine specific; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
P09786 anthranilate synthase (subunit 1/2) (EC 4.1.3.27) from Pseudomonas aeruginosa (see paper)
43% identity, 93% coverage of query (144 bits)
ADCS / Q6TAS3 aminodeoxychorismate synthase (EC 2.6.1.85) from Solanum lycopersicum (see 2 papers)
ADCS_SOLLC / Q6TAS3 Aminodeoxychorismate synthase, chloroplastic; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; EC 2.6.1.85 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
37% identity, 95% coverage of query (130 bits)
ADCS / Q8LPN3 aminodeoxychorismate synthase (EC 2.6.1.85) from Arabidopsis thaliana (see 2 papers)
ADCS_ARATH / Q8LPN3 Aminodeoxychorismate synthase, chloroplastic; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; Protein EMBRYO DEFFECTIVE 1997; EC 2.6.1.85 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
34% identity, 98% coverage of query (127 bits)
8hx9A / F2RB79 Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae with chorismate (see paper)
38% identity, 94% coverage of query (125 bits)
A0A060IGN1 aminodeoxychorismate synthase (EC 2.6.1.85) from Agaricus bisporus (see paper)
37% identity, 99% coverage of query (120 bits)
ADCS_SCHPO / O94277 Putative aminodeoxychorismate synthase; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; EC 2.6.1.85 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 95% coverage of query (110 bits)
7yc6A / Q58970 Crystal structure of d110p mutant of gatase subunit of methanocaldococcus jannaschii gmp synthetase
36% identity, 93% coverage of query (100 bits)
ADCS_YEAST / P37254 Aminodeoxychorismate synthase; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; EC 2.6.1.85 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
34% identity, 95% coverage of query (96.7 bits)
O59071 GMP synthase (glutamine-hydrolysing) (EC 6.3.5.2) from Pyrococcus horikoshii (see paper)
34% identity, 95% coverage of query (92.8 bits)
pabaA / GI|4885032 para aminobenzoic acid synthetase from Aspergillus fumigatus (see paper)
32% identity, 95% coverage of query (91.3 bits)
pabaA para-aminobenzoic acid synthase from Emericella nidulans (see 2 papers)
33% identity, 86% coverage of query (90.1 bits)
Build an alignment for WP_012674117.1 and 34 homologs with ≥ 30% identity
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CARA_ARATH / Q9LVW7 Carbamoyl phosphate synthase small chain, chloroplastic; Carbamoyl phosphate synthetase glutamine chain; Protein VENOSA 6; EC 6.3.5.5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
27% identity, 96% coverage of query (86.7 bits)
CarA / b0032 carbamoyl phosphate synthetase subunit α (EC 6.3.5.5) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
carA / P0A6F1 carbamoyl-phosphate synthetase small subunit (EC 6.3.5.5) from Escherichia coli (strain K12) (see 10 papers)
CARA_ECOLI / P0A6F1 Carbamoyl phosphate synthase small chain; Carbamoyl phosphate synthetase glutamine chain; EC 6.3.5.5 from Escherichia coli (strain K12) (see 4 papers)
30% identity, 95% coverage of query (85.1 bits)
1ce8B Carbamoyl phosphate synthetase from escherichis coli with complexed with the allosteric ligand imp
30% identity, 94% coverage of query (82.4 bits)
1c3oB / P0A6F1 Crystal structure of the carbamoyl phosphate synthetase: small subunit mutant c269s with bound glutamine (see paper)
29% identity, 94% coverage of query (78.6 bits)
carA / CAB89872.1 carbamoyl phosphate synthetase small subunit from Lactococcus lactis (see paper)
29% identity, 75% coverage of query (74.7 bits)
2ywcA / Q5SI28 Crystal structure of gmp synthetase from thermus thermophilus in complex with xmp
28% identity, 95% coverage of query (74.3 bits)
B9V284 carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) from Medicago truncatula (see paper)
28% identity, 81% coverage of query (73.2 bits)
PYR1_SCHPO / Q09794 Multifunctional protein ura1; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
ura1 / RF|NP_593055.1 carbamoyl-phosphate synthase (glutamine hydrolyzing), aspartate carbamoyltransferase Ura1; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5 from Schizosaccharomyces pombe (see 3 papers)
30% identity, 86% coverage of query (63.5 bits)
CAD / P27708 CAD protein (EC 3.5.2.3; EC 6.3.5.5; EC 2.1.3.2) from Homo sapiens (see 6 papers)
PYR1_HUMAN / P27708 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Homo sapiens (Human) (see 11 papers)
P27708 aspartate carbamoyltransferase (EC 2.1.3.2); dihydroorotase (EC 3.5.2.3); carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) from Homo sapiens (see 7 papers)
28% identity, 73% coverage of query (60.8 bits)
PYR1_MESAU / P08955 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Mesocricetus auratus (Golden hamster) (see 2 papers)
P08955 dihydroorotase (EC 3.5.2.3) from Mesocricetus auratus (see 2 papers)
28% identity, 80% coverage of query (60.5 bits)
3uowA Crystal structure of pf10_0123, a gmp synthetase from plasmodium falciparum
28% identity, 81% coverage of query (59.3 bits)
CPA1 / P07258 carbamoyl phosphate synthetase (EC 6.3.5.5) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 4 papers)
CARA_YEAST / P07258 Carbamoyl phosphate synthase arginine-specific small chain; CPS; CPSase; CPSase-arg; Arginine-specific carbamoyl phosphate synthetase, glutamine chain; Carbamoyl phosphate synthase A; CPS-A; Glutamine-dependent carbamoyl phosphate synthetase; EC 6.3.5.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 9 papers)
31% identity, 74% coverage of query (58.2 bits)
GUAA_PLAF7 / Q8IJR9 GMP synthase [glutamine-hydrolyzing]; PfGMPS; Glutamine amidotransferase; Guanosine monophosphate synthetase; EC 6.3.5.2 from Plasmodium falciparum (isolate 3D7) (see 6 papers)
28% identity, 81% coverage of query (57.8 bits)
1gpmA / P04079 Escherichia coli gmp synthetase complexed with amp and pyrophosphate (see paper)
26% identity, 94% coverage of query (56.2 bits)
4wioA / Q8IJR9 Crystal structure of the c89a gmp synthetase inactive mutant from plasmodium falciparum in complex with glutamine (see paper)
28% identity, 81% coverage of query (55.5 bits)
P20054 Multifunctional protein pyr1-3; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Dictyostelium discoideum (Social amoeba)
27% identity, 73% coverage of query (55.1 bits)
URA2 / P07259 carbamoyl phosphate synthase/aspartate carbamoyltransferase (EC 2.1.3.2; EC 6.3.5.5) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 8 papers)
PYR1_YEAST / P07259 Multifunctional protein URA2; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 15 papers)
30% identity, 86% coverage of query (54.7 bits)
3uowB / Q8IJR9 Crystal structure of pf10_0123, a gmp synthetase from plasmodium falciparum
29% identity, 89% coverage of query (52.4 bits)
6w2jA Cps1 bound to allosteric inhibitor h3b-374
29% identity, 86% coverage of query (50.8 bits)
6w2jB / P31327 Cps1 bound to allosteric inhibitor h3b-374 (see paper)
29% identity, 86% coverage of query (50.8 bits)
CPS1 / P31327 ammonia-dependent carbamoyl-phosphate synthase (EC 6.3.4.16) from Homo sapiens (see 4 papers)
CPSM_HUMAN / P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial; Carbamoyl-phosphate synthetase I; CPSase I; EC 6.3.4.16 from Homo sapiens (Human) (see 19 papers)
P31327 carbamoyl-phosphate synthase (ammonia) (EC 6.3.4.16) from Homo sapiens (see 10 papers)
29% identity, 86% coverage of query (50.8 bits)
6uelA / P31327 Cps1 bound to allosteric inhibitor h3b-193 (see paper)
29% identity, 86% coverage of query (50.8 bits)
5tw7F / B4RJH7 Crystal structure of a gmp synthase (glutamine-hydrolyzing) from neisseria gonorrhoeae
25% identity, 78% coverage of query (50.8 bits)
5douD / P31327 Crystal structure of human carbamoyl phosphate synthetase i (cps1), ligand-bound form (see paper)
29% identity, 86% coverage of query (50.8 bits)
3r75B / Q396C7 Crystal structure of 2-amino-2-desoxyisochorismate synthase (adic) synthase phze from burkholderia lata 383 in complex with benzoate, pyruvate, glutamine and contaminating zn2+ (see paper)
28% identity, 96% coverage of query (48.5 bits)
CPSM_RAT / P07756 Carbamoyl-phosphate synthase [ammonia], mitochondrial; Carbamoyl-phosphate synthetase I; CPSase I; EC 6.3.4.16 from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 86% coverage of query (48.5 bits)
CPSM_MOUSE / Q8C196 Carbamoyl-phosphate synthase [ammonia], mitochondrial; Carbamoyl-phosphate synthetase I; CPSase I; EC 6.3.4.16 from Mus musculus (Mouse) (see 4 papers)
Q8C196 carbamoyl-phosphate synthase (ammonia) (EC 6.3.4.16) from Mus musculus (see 2 papers)
28% identity, 86% coverage of query (46.6 bits)
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