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Searching for up to 100 curated homologs for WP_012674308.1 NCBI__GCF_000021545.1:WP_012674308.1 (249 a.a.)

Found high-coverage hits (≥70%) to 86 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pabC / P28821 4-amino-4-deoxychorismate pyruvate-lyase (EC 4.1.3.38) from Bacillus subtilis (strain 168) (see paper)
PABC_BACSU / P28821 Aminodeoxychorismate lyase; 4-amino-4-deoxychorismate lyase; ADC lyase; ADCL; EC 4.1.3.38 from Bacillus subtilis (strain 168) (see paper)
    30% identity, 90% coverage of query (104 bits)

E6TUA8 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Evansella cellulosilytica (see paper)
    30% identity, 90% coverage of query (95.5 bits)

Build an alignment

Build an alignment for WP_012674308.1 and 2 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

PabC / b1096 aminodeoxychorismate lyase (EC 4.1.3.38) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
pabC / P28305 aminodeoxychorismate lyase (EC 4.1.3.38) from Escherichia coli (strain K12) (see 5 papers)
PABC_ECOLI / P28305 Aminodeoxychorismate lyase; 4-amino-4-deoxychorismate lyase; ADC lyase; ADCL; EC 4.1.3.38 from Escherichia coli (strain K12) (see 4 papers)
P28305 aminodeoxychorismate lyase (EC 4.1.3.38) from Escherichia coli (see paper)
1i2kA / P28305 Aminodeoxychorismate lyase from escherichia coli
pabC / AAA24267.1 4-amino-4-deoxychorismate lyase from Escherichia coli (see paper)
    25% identity, 99% coverage of query (90.5 bits)

1i2lA Deoxychorismate lyase from escherichia coli with inhibitor
    25% identity, 99% coverage of query (90.5 bits)

GB|AAU18968.1 branched-chain amino acid aminotransferase 2; EC 2.6.1.42 from Bacillus cereus E33L (see paper)
    32% identity, 90% coverage of query (88.2 bits)

A0A1B1L2T7 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Bacillus thuringiensis (see paper)
    32% identity, 90% coverage of query (88.2 bits)

ilvE / A6UWA0 branched-chain amino acid aminotransferase subunit (EC 2.6.1.6; EC 2.6.1.42) from Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) (see 3 papers)
A6UWA0 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Methanococcus aeolicus (see paper)
    29% identity, 90% coverage of query (84.3 bits)

5mr0D / O29329 Thermophilic archaeal branched-chain amino acid transaminases from geoglobus acetivorans and archaeoglobus fulgidus: biochemical and structural characterisation (see paper)
    30% identity, 90% coverage of query (81.6 bits)

5e25A / A0A0A7GJ30 Crystal structure of branched-chain aminotransferase from thermophilic archaea geoglobus acetivorans complexed with alpha-ketoglutarate (see paper)
    32% identity, 90% coverage of query (80.1 bits)

F2L0W0 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermoproteus uzoniensis (see 3 papers)
    26% identity, 99% coverage of query (77.4 bits)

6thqB / F2L0W0 Crystal structure of branched-chain aminotransferase from thermophilic archaea thermoproteus uzoniensis with norvaline
    26% identity, 99% coverage of query (77.4 bits)

8yrvA Crystal structure of d-amino acid transaminase from haliscomenobacter hydrossis complexed with 3-aminooxypropionic acid
    25% identity, 95% coverage of query (74.7 bits)

A0A0A0LN48 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Cucumis sativus var. sativus (see paper)
    26% identity, 90% coverage of query (73.9 bits)

Q9HZN6 aminodeoxychorismate lyase (EC 4.1.3.38) from Pseudomonas aeruginosa (see paper)
    23% identity, 96% coverage of query (73.6 bits)

2y4rA / Q9HZN6 Crystal structure of 4-amino-4-deoxychorismate lyase from pseudomonas aeruginosa (see paper)
    23% identity, 96% coverage of query (73.6 bits)

8ahuA / F4KWH0 Crystal structure of d-amino acid aminotrensferase from haliscomenobacter hydrossis complexed with d-cycloserine (see paper)
    24% identity, 95% coverage of query (73.2 bits)

7p7xA Crystal structure of d-amino acid transaminase from haliscomenobacter hydrossis (holo form).
    24% identity, 95% coverage of query (73.2 bits)

8raiA Crystal structure of d-amino acid transaminase from haliscomenobacter hydrossis point mutant r90i complexed with phenylhydrazine
    24% identity, 95% coverage of query (72.4 bits)

7dbeB Structure of a novel transaminase
    27% identity, 81% coverage of query (72.0 bits)

8pnwA / H6RQF3 Crystal structure of d-amino acid aminotransferase from blastococcus saxobsidens in holo form with plp (see paper)
    20% identity, 93% coverage of query (69.7 bits)

8pnyA Crystal structure of d-amino acid aminotransferase from blastococcus saxobsidens complexed with phenylhydrazine and in its apo form
    20% identity, 93% coverage of query (69.7 bits)

8pnxA Crystal structure of d-amino acid aminotransferase from blastococcus saxobsidens in pmp form
    20% identity, 93% coverage of query (69.7 bits)

P54691 branched-chain-amino-acid transaminase (EC 2.6.1.42); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Synechocystis sp. (see paper)
    27% identity, 94% coverage of query (68.6 bits)

Q9FYA6 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana (see paper)
    27% identity, 94% coverage of query (68.2 bits)

B6RFK8 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Nicotiana benthamiana (see paper)
    26% identity, 90% coverage of query (67.8 bits)

Q70KX9 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Hordeum vulgare (see paper)
    25% identity, 90% coverage of query (67.4 bits)

BCAT2_HUMLU / K7QHS5 Branched-chain amino acid aminotransferase 2, chloroplastic; HlBCAT2; EC 2.6.1.42 from Humulus lupulus (European hop) (see paper)
    27% identity, 90% coverage of query (67.4 bits)

Q9LPM9 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana (see 2 papers)
    25% identity, 96% coverage of query (67.4 bits)

1i1lA / P0AB80 Crystal structure of eschelichia coli branched-chain amino acid aminotransferase. (see paper)
    25% identity, 92% coverage of query (67.0 bits)

IlvE / b3770 branched-chain-amino-acid aminotransferase (EC 2.6.1.1; EC 2.6.1.57; EC 2.6.1.27; EC 2.6.1.42; EC 2.6.1.6) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ilvE / P0AB80 branched-chain-amino-acid aminotransferase (EC 2.6.1.1; EC 2.6.1.42; EC 2.6.1.6) from Escherichia coli (strain K12) (see paper)
ilvE / RF|YP_026247 branched-chain-amino-acid aminotransferase; EC 2.6.1.42 from Escherichia coli K12 (see 11 papers)
    25% identity, 92% coverage of query (67.0 bits)

pabC-2 / B8Y8J0 4-amino-4-deoxychorismate lyase (EC 4.1.3.38) from Streptomyces sp. FR-008 (see 2 papers)
B8Y8J0 aminodeoxychorismate lyase (EC 4.1.3.38) from Streptomyces sp. (see paper)
    23% identity, 90% coverage of query (67.0 bits)

1iyeA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase
    25% identity, 92% coverage of query (67.0 bits)

1iydA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase
    25% identity, 92% coverage of query (67.0 bits)

1i1mA Crystal structure of escherichia coli branched-chain amino acid aminotransferase.
    25% identity, 92% coverage of query (67.0 bits)

BCAT3 / Q9M401 branched-chain aminotransferase from Arabidopsis thaliana (see paper)
BCAT3_ARATH / Q9M401 Branched-chain-amino-acid aminotransferase 3, chloroplastic; Atbcat-3; EC 2.6.1.42; EC 2.6.1.88 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9M401 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana (see paper)
    26% identity, 90% coverage of query (66.6 bits)

ilvE / O27481 branched-chain-amino-acid aminotransferase subunit (EC 2.6.1.42) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see 3 papers)
    24% identity, 97% coverage of query (66.2 bits)

3cswC / P74921 Crystal structure of a putative branched-chain amino acid aminotransferase (tm0831) from thermotoga maritima at 2.15 a resolution
    27% identity, 95% coverage of query (64.7 bits)

BCAT1_HUMLU / K7QKH1 Branched-chain amino acid aminotransferase 1, mitochondrial; HlBCAT1; EC 2.6.1.42 from Humulus lupulus (European hop) (see paper)
    24% identity, 90% coverage of query (63.9 bits)

BCAT2_ARATH / Q9M439 Branched-chain-amino-acid aminotransferase 2, chloroplastic; Atbcat-2; EC 2.6.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9M439 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana (see paper)
    25% identity, 90% coverage of query (63.5 bits)

A0A0A0KG15 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Cucumis sativus var. sativus (see paper)
    26% identity, 90% coverage of query (61.6 bits)

Q5SKM2 aminodeoxychorismate lyase (EC 4.1.3.38) from Thermus thermophilus (see paper)
2zgiD / Q5SKM2 Crystal structure of putative 4-amino-4-deoxychorismate lyase (see paper)
    26% identity, 92% coverage of query (61.6 bits)

ADCL / Q8L493 aminodeoxychorismate lyase (EC 4.1.3.38) from Arabidopsis thaliana (see 3 papers)
DAAA_ARATH / Q8L493 D-amino-acid transaminase, chloroplastic; Aminodeoxychorismate lyase; AtADCL; Branched-chain-amino-acid aminotransferase-like protein 3; EC 2.6.1.21; EC 4.1.3.38 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8L493 D-amino-acid transaminase (EC 2.6.1.21) from Arabidopsis thaliana (see paper)
    29% identity, 78% coverage of query (60.8 bits)

6snlD / A0A0D1XFW6 (R)-selective amine transaminase from exophiala sideris (see paper)
    24% identity, 82% coverage of query (60.1 bits)

6xwbA Crystal structure of an r-selective transaminase from thermomyces stellatus. (see paper)
    24% identity, 82% coverage of query (58.9 bits)

Psest_0450 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Pseudomonas stutzeri RCH2
    24% identity, 94% coverage of query (58.9 bits)

pabB para-aminobenzoate synthase, component I from Ralstonia solanacearum (see paper)
    22% identity, 87% coverage of query (58.5 bits)

7p3tB / B8KQT8 Transaminase of gamma-proteobacterium (see paper)
    25% identity, 90% coverage of query (57.8 bits)

7z79B / T1XIY1 Crystal structure of aminotransferase-like protein from variovorax paradoxus
    23% identity, 92% coverage of query (57.4 bits)

DAAA_BACYM / P19938 D-alanine aminotransferase; D-amino acid aminotransferase; D-amino acid transaminase; DAAT; D-aspartate aminotransferase; EC 2.6.1.21 from Bacillus sp. (strain YM-1) (see 3 papers)
dat D-alanine aminotransferase; EC 2.6.1.21 from Bacillus sp. YM-1 (see 6 papers)
    26% identity, 91% coverage of query (57.4 bits)

A0A2Z4MEX9 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Brevibacillus brevis (see paper)
    24% identity, 87% coverage of query (57.4 bits)

4whxA X-ray crystal structure of an amino acid aminotransferase from burkholderia pseudomallei bound to the co-factor pyridoxal phosphate
    23% identity, 92% coverage of query (57.4 bits)

D0LR31 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Haliangium ochraceum (see paper)
    24% identity, 96% coverage of query (57.4 bits)

3lqsA Complex structure of d-amino acid aminotransferase and 4-amino-4,5- dihydro-thiophenecarboxylic acid (adta)
    26% identity, 91% coverage of query (57.4 bits)

3daaA Crystallographic structure of d-amino acid aminotransferase inactivated by pyridoxyl-d-alanine
    26% identity, 91% coverage of query (57.4 bits)

2daaA Crystallographic structure of d-amino acid aminotransferase inactivated by d-cycloserine
    26% identity, 91% coverage of query (57.4 bits)

1daaA Crystallographic structure of d-amino acid aminotransferase complexed with pyridoxal-5'-phosphate
    26% identity, 91% coverage of query (57.4 bits)

6h65C / D0LR31 Crystal structure of the branched-chain-amino-acid aminotransferase from haliangium ochraceum
    24% identity, 96% coverage of query (57.0 bits)

BPHYT_RS16285 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Burkholderia phytofirmans PsJN
    22% identity, 92% coverage of query (57.0 bits)

1kt8A Human branched chain amino acid aminotransferase (mitochondrial): three dimensional structure of enzyme in its ketimine form with the substrate l-isoleucine
    26% identity, 86% coverage of query (55.8 bits)

BCAT4 / Q9LE06 methionine transaminase (EC 2.6.1.88) from Arabidopsis thaliana (see paper)
BCAT4_ARATH / Q9LE06 Methionine aminotransferase BCAT4; Branched-chain-amino-acid aminotransferase 4; Atbcat-4; Methionine-oxo-acid transaminase BCAT4; EC 2.6.1.88 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9LE06 branched-chain-amino-acid transaminase (EC 2.6.1.42); methionine transaminase (EC 2.6.1.88) from Arabidopsis thaliana (see 2 papers)
    25% identity, 94% coverage of query (55.5 bits)

A0A0A0LJI6 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Cucumis sativus var. sativus (see paper)
    26% identity, 89% coverage of query (55.5 bits)

1a0gB / P19938 L201a mutant of d-amino acid aminotransferase complexed with pyridoxamine-5'-phosphate (see paper)
    26% identity, 91% coverage of query (55.5 bits)

ilvE / O86428 branched-chain-amino-acid aminotransferase subunit (EC 2.6.1.6; EC 2.6.1.42) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
O86428 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Pseudomonas aeruginosa (see paper)
    23% identity, 92% coverage of query (55.1 bits)

2ej3A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with gabapentin
    26% identity, 92% coverage of query (55.1 bits)

2eiyA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with 4-methylvaleric acid
    26% identity, 92% coverage of query (55.1 bits)

1wrvA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase
    26% identity, 92% coverage of query (55.1 bits)

4cmdA / C7YVL8 The (r)-selective transaminase from nectria haematococca (see paper)
    22% identity, 83% coverage of query (54.7 bits)

4cmfA The (r)-selective transaminase from nectria haematococca with inhibitor bound
    22% identity, 83% coverage of query (54.7 bits)

2ej2A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with n-(5'-phosphopyridoxyl)-l-glutamate
    26% identity, 92% coverage of query (54.7 bits)

6fteB / A0A0D2C5V9 Crystal structure of an (r)-selective amine transaminase from exophiala xenobiotica
    25% identity, 83% coverage of query (53.1 bits)

ilvK / P39576 branched-chain amino acid aminotransferase (EC 2.6.1.42; EC 2.6.1.6) from Bacillus subtilis (strain 168) (see 2 papers)
ILVE2_BACSU / P39576 Branched-chain-amino-acid aminotransferase 2; BCAT 2; Vegetative protein 85; VEG85; EC 2.6.1.42 from Bacillus subtilis (strain 168) (see paper)
    25% identity, 87% coverage of query (52.4 bits)

A6UP94 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Methanococcus vannielii (see paper)
    26% identity, 93% coverage of query (51.2 bits)

2ej0B / Q5SM19 Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase with pyridoxamine 5'-phosphate
    24% identity, 92% coverage of query (51.2 bits)

ilvE / O31461 branched-chain amino acid aminotransferase (EC 2.6.1.6; EC 2.6.1.42) from Bacillus subtilis (strain 168) (see 4 papers)
ILVE1_BACSU / O31461 Branched-chain-amino-acid transaminase 1; BCAT 1; EC 2.6.1.42 from Bacillus subtilis (strain 168) (see paper)
    22% identity, 82% coverage of query (50.4 bits)

2coiA Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with gabapentin
    28% identity, 72% coverage of query (48.9 bits)

2cogA Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with 4-methylvalerate
    28% identity, 72% coverage of query (48.9 bits)

4chiA / Q4WH08 (R)-selective amine transaminase from aspergillus fumigatus at 1.27 a resolution (see paper)
    22% identity, 83% coverage of query (47.8 bits)

4ce5B First crystal structure of an (r)-selective omega-transaminase from aspergillus terreus
    23% identity, 82% coverage of query (47.8 bits)

4ce5A / Q0C8G1 First crystal structure of an (r)-selective omega-transaminase from aspergillus terreus (see paper)
    23% identity, 82% coverage of query (47.8 bits)

4uugA The (r)-selective amine transaminase from aspergillus fumigatus with inhibitor bound
    22% identity, 83% coverage of query (47.8 bits)

8onjA / D5EHC5 Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense point mutant r88l (see paper)
    24% identity, 94% coverage of query (44.7 bits)

8aieB Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense complexed with d-cycloserine
    24% identity, 94% coverage of query (43.1 bits)

8aykA Crystal structure of d-amino acid aminotrensferase from aminobacterium colombiense complexed with d-glutamate
    24% identity, 94% coverage of query (43.1 bits)

8ayjA Crystal structure of d-amino acid aminotransferase from aminobacterium colombiens complexed with 3-aminooxypropionic acid
    24% identity, 94% coverage of query (43.1 bits)

8aieA Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense complexed with d-cycloserine
    24% identity, 94% coverage of query (43.1 bits)

3wwhA / F7J696 Crystal structure of the first r-stereoselective -transaminase identified from arthrobacter sp. Knk168 (ferm-bp-5228) (see paper)
    21% identity, 82% coverage of query (42.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory