Searching for up to 100 curated homologs for WP_012674346.1 NCBI__GCF_000021545.1:WP_012674346.1 (516 a.a.)
Found high-coverage hits (≥70%) to 58 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
54% identity, 97% coverage of query (535 bits)
LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
52% identity, 96% coverage of query (509 bits)
Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus (see 2 papers)
49% identity, 98% coverage of query (499 bits)
K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
50% identity, 98% coverage of query (497 bits)
Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis (see paper)
51% identity, 96% coverage of query (489 bits)
Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
50% identity, 97% coverage of query (486 bits)
LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 2 papers)
50% identity, 96% coverage of query (486 bits)
Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
50% identity, 97% coverage of query (484 bits)
LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
51% identity, 99% coverage of query (484 bits)
LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 3 papers)
50% identity, 96% coverage of query (482 bits)
LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
50% identity, 99% coverage of query (480 bits)
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus (see paper)
48% identity, 96% coverage of query (462 bits)
BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
50% identity, 97% coverage of query (461 bits)
LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii (see paper)
46% identity, 98% coverage of query (430 bits)
LEU1_SOYBN / Q39891 Probable 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; Late nodulin-56; N-56; EC 2.3.3.13 from Glycine max (Soybean) (Glycine hispida) (see paper)
44% identity, 97% coverage of query (422 bits)
K4CJ56 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
55% identity, 73% coverage of query (411 bits)
Echvi_3833 2-isopropylmalate synthase (EC 2.3.3.13) from Echinicola vietnamensis KMM 6221, DSM 17526
52% identity, 73% coverage of query (408 bits)
cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
45% identity, 96% coverage of query (392 bits)
CA265_RS15855 2-isopropylmalate synthase (EC 2.3.3.13) from Pedobacter sp. GW460-11-11-14-LB5
52% identity, 73% coverage of query (389 bits)
6e1jA / C5J4P1 Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
49% identity, 73% coverage of query (385 bits)
MAM1 / Q9FG67 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 2 papers)
MAM1_ARATH / Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9FG67 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 7 papers)
48% identity, 73% coverage of query (382 bits)
MAM2_ARATH / Q8VX04 Methylthioalkylmalate synthase 2, chloroplastic; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q8VX04 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see paper)
49% identity, 73% coverage of query (378 bits)
MAM3 / Q9FN52 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see paper)
MAM3_ARATH / Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9FN52 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 4 papers)
48% identity, 73% coverage of query (378 bits)
LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
48% identity, 74% coverage of query (329 bits)
HOSA_SULAC / Q4J989 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J989 homocitrate synthase (EC 2.3.3.14) from Sulfolobus acidocaldarius (see paper)
36% identity, 74% coverage of query (224 bits)
6ktqA / Q4J989 Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
36% identity, 74% coverage of query (223 bits)
B0K6M2 (R)-citramalate synthase (EC 2.3.3.21) from Thermoanaerobacter sp. (see paper)
31% identity, 96% coverage of query (202 bits)
BT1858 (R)-citramalate synthase (EC 2.3.1.182) from Bacteroides thetaiotaomicron VPI-5482
30% identity, 96% coverage of query (196 bits)
nifV / P05342 homocitrate synthase monomer (EC 2.3.3.14) from Azotobacter vinelandii (see paper)
NIFV_AZOVI / P05342 Homocitrate synthase; EC 2.3.3.14 from Azotobacter vinelandii (see paper)
36% identity, 72% coverage of query (194 bits)
Build an alignment for WP_012674346.1 and 29 homologs with ≥ 30% identity
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cimA / Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
CIMA_GEOSL / Q74C76 (R)-citramalate synthase; Citramalate synthase; EC 2.3.3.21 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (see paper)
28% identity, 96% coverage of query (186 bits)
cimA / Q8F3Q1 (R)-citramalate synthase subunit (EC 2.3.3.21) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
CIMA_LEPIN / Q8F3Q1 (R)-citramalate synthase CimA; LiCMS; EC 2.3.3.21 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 3 papers)
31% identity, 90% coverage of query (182 bits)
CIMA_SULAC / Q4J6H1 (R)-citramalate synthase; Citramalate synthase; CMS; EC 2.3.3.21 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
29% identity, 98% coverage of query (181 bits)
LEU12_LEPIN / Q8F8T4 2-isopropylmalate synthase 2; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 2 papers)
32% identity, 72% coverage of query (176 bits)
4ov4A Isopropylmalate synthase binding with ketoisovalerate
33% identity, 72% coverage of query (176 bits)
B0SN40 2-isopropylmalate synthase (EC 2.3.3.13) from Leptospira biflexa (see paper)
32% identity, 72% coverage of query (175 bits)
4ov9A / B0SN40 Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
32% identity, 72% coverage of query (173 bits)
A0A0S6UXF5 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. DOA9 (see paper)
34% identity, 71% coverage of query (173 bits)
A0A1Y6KBA1 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. ORS 285 (see 2 papers)
33% identity, 74% coverage of query (172 bits)
HOSM_SCHPO / Q9Y823 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
lys4 / RF|NP_596458.1 homocitrate synthase (predicted); EC 2.3.3.14 from Schizosaccharomyces pombe (see 2 papers)
30% identity, 73% coverage of query (153 bits)
3ivtB / Q9Y823 Homocitrate synthase lys4 bound to 2-og (see paper)
30% identity, 73% coverage of query (152 bits)
LYS21 / Q12122 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSM_YEAST / Q12122 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Q12122 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see paper)
31% identity, 73% coverage of query (152 bits)
LYS20 / P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSC_YEAST / P48570 Homocitrate synthase, cytosolic isozyme; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see 2 papers)
31% identity, 73% coverage of query (152 bits)
3mi3A Homocitrate synthase lys4 bound to lysine
31% identity, 72% coverage of query (149 bits)
M1U949 homocitrate synthase (EC 2.3.3.14) from Flammulina velutipes (see paper)
30% identity, 73% coverage of query (148 bits)
DVU1914 (R)-citramalate synthase (EC 2.3.3.21) from Desulfovibrio vulgaris Hildenborough JW710
26% identity, 96% coverage of query (145 bits)
hcs / O87198 homocitrate synthase (EC 2.3.3.14) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
HOSA_THET2 / O87198 Homocitrate synthase; HCS; EC 2.3.3.14 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
31% identity, 72% coverage of query (144 bits)
LEU9_YEAST / Q12166 2-isopropylmalate synthase 2, mitochondrial; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; Alpha-isopropylmalate synthase II; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
26% identity, 94% coverage of query (136 bits)
C7C437 homocitrate synthase (EC 2.3.3.14) from Aspergillus fumigatus (see paper)
30% identity, 72% coverage of query (135 bits)
LEU1_YEAST / P06208 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
27% identity, 94% coverage of query (135 bits)
3ivsA Homocitrate synthase lys4
30% identity, 72% coverage of query (135 bits)
CH_124190 2-isopropylmalate synthase 2 from Magnaporthe grisea 70-15 (see paper)
24% identity, 97% coverage of query (117 bits)
LEU4 putative 2-isopropylmalalate synthase from Candida albicans (see paper)
25% identity, 96% coverage of query (113 bits)
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
25% identity, 95% coverage of query (102 bits)
3figB / P9WQB3 Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
25% identity, 95% coverage of query (102 bits)
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
25% identity, 95% coverage of query (102 bits)
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
25% identity, 95% coverage of query (102 bits)
1sr9A Crystal structure of leua from mycobacterium tuberculosis
25% identity, 95% coverage of query (102 bits)
LEU1_MYCTO / P9WQB2 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see paper)
LEU1_MYCTU / P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WQB3 2-isopropylmalate synthase (EC 2.3.3.13) from Mycobacterium tuberculosis (see 6 papers)
24% identity, 87% coverage of query (91.3 bits)
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Lawrence Berkeley National Laboratory