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Searching for up to 100 curated homologs for WP_012674805.1 NCBI__GCF_000021545.1:WP_012674805.1 (303 a.a.)

Found high-coverage hits (≥70%) to 15 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

KHSE_YEAST / P17423 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
THR1 / AAA35154.1 homoserine kinase from Saccharomyces cerevisiae (see paper)
    33% identity, 98% coverage of query (186 bits)

P07128 homoserine kinase (EC 2.7.1.39) from Corynebacterium glutamicum (see paper)
    39% identity, 96% coverage of query (146 bits)

6cyzA / B1MLU6 Mycobacterial homoserine kinase thrb in complex with amppnp
    38% identity, 85% coverage of query (118 bits)

ThrB / b0003 homoserine kinase (EC 2.7.1.39) from Escherichia coli K-12 substr. MG1655 (see paper)
thrB / P00547 homoserine kinase (EC 2.7.1.39) from Escherichia coli (strain K12) (see 9 papers)
KHSE_ECOLI / P00547 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Escherichia coli (strain K12) (see paper)
thrB / GB|BAB96580.2 homoserine kinase; EC 2.7.1.39 from Escherichia coli (see 2 papers)
    30% identity, 85% coverage of query (116 bits)

Build an alignment

Build an alignment for WP_012674805.1 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

thrB / CAA43213.1 homoserine kinase from Serratia marcescens (see paper)
    28% identity, 86% coverage of query (110 bits)

Q4Q6Y2 homoserine kinase (EC 2.7.1.39) from Leishmania major (see paper)
    31% identity, 97% coverage of query (110 bits)

CA265_RS23470 homoserine kinase (EC 2.7.1.39) from Pedobacter sp. GW460-11-11-14-LB5
    30% identity, 98% coverage of query (101 bits)

Echvi_2001 homoserine kinase (EC 2.7.1.39) from Echinicola vietnamensis KMM 6221, DSM 17526
    30% identity, 97% coverage of query (94.4 bits)

KHSE_METMP / Q6M0H5 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL) (see paper)
    32% identity, 85% coverage of query (93.6 bits)

thrB / Q58504 homoserine kinase monomer (EC 2.7.1.39) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
1fwkA / Q58504 Crystal structure of homoserine kinase complexed with adp (see paper)
    30% identity, 86% coverage of query (92.4 bits)

1h74B Crystal structure of homoserine kinase complexed with ile
    30% identity, 86% coverage of query (92.4 bits)

1h74A Crystal structure of homoserine kinase complexed with ile
    30% identity, 86% coverage of query (92.4 bits)

1h73A Crystal structure of homoserine kinase complexed with threonine
    30% identity, 86% coverage of query (92.4 bits)

1h72C Crystal structure of homoserine kinase complexed with hse
    30% identity, 86% coverage of query (92.4 bits)

hsk / Q8L7R2 homoserine kinase (EC 2.7.1.39) from Arabidopsis thaliana (see paper)
KHSE_ARATH / Q8L7R2 Homoserine kinase; Protein DOWNY MILDEW RESISTANT 1; EC 2.7.1.39 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q8L7R2 homoserine kinase (EC 2.7.1.39) from Arabidopsis thaliana (see 4 papers)
    31% identity, 96% coverage of query (85.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory