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Searching for up to 100 curated homologs for WP_012675835.1 NCBI__GCF_000021565.1:WP_012675835.1 (338 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

O66939 D-lactate dehydrogenase (EC 1.1.1.28) from Aquifex aeolicus (see paper)
3kb6B / O66939 Crystal structure of d-lactate dehydrogenase from aquifex aeolicus complexed with NAD and lactic acid (see paper)
    44% identity, 84% coverage of query (236 bits)

5z20F / Q9I530 The ternary structure of d-lactate dehydrogenase from pseudomonas aeruginosa with nadh and oxamate (see paper)
    37% identity, 99% coverage of query (206 bits)

Q9I530 D-lactate dehydrogenase (EC 1.1.1.28) from Pseudomonas aeruginosa (see 2 papers)
    37% identity, 99% coverage of query (206 bits)

KK1H_CURCL / A0A348AXY0 D-lactate dehydrogenase kk1H; KK-1 biosynthesis cluster protein H; EC 1.1.1.- from Curvularia clavata (see 2 papers)
    38% identity, 91% coverage of query (196 bits)

Q8RG11 D-lactate dehydrogenase (EC 1.1.1.28) from Fusobacterium nucleatum subsp. nucleatum (see 2 papers)
    36% identity, 99% coverage of query (192 bits)

5z21B / Q8RG11 The ternary structure of d-lactate dehydrogenase from fusobacterium nucleatum with nadh and oxamate (see paper)
    36% identity, 99% coverage of query (192 bits)

4zgsA / B0LUZ5 Identification of the pyruvate reductase of chlamydomonas reinhardtii (see paper)
    35% identity, 89% coverage of query (186 bits)

HADHA_ASPOR / Q2UH56 2-hydroxyacid dehydrogenase A; 2-HadhA; EC 1.1.1.272 from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (see paper)
    36% identity, 97% coverage of query (186 bits)

F8A9V0 D-lactate dehydrogenase (EC 1.1.1.28) from Thermodesulfatator indicus (see paper)
    35% identity, 96% coverage of query (185 bits)

Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
    37% identity, 84% coverage of query (181 bits)

5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
    37% identity, 84% coverage of query (181 bits)

1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
    43% identity, 88% coverage of query (178 bits)

Q8EI78 D-lactate dehydrogenase (EC 1.1.1.28) from Shewanella oneidensis (see paper)
    32% identity, 97% coverage of query (177 bits)

GYAR_THELN / Q9C4M5 Glyoxylate reductase; EC 1.1.1.26 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
Q9C4M5 glyoxylate reductase (EC 1.1.1.26) from Thermococcus litoralis (see paper)
    36% identity, 96% coverage of query (177 bits)

A0A0R1RJ30 D-lactate dehydrogenase (EC 1.1.1.28) from Furfurilactobacillus rossiae (see 2 papers)
    33% identity, 99% coverage of query (172 bits)

fldH / G9EZR6 aromatic 2-oxoacid reductase (EC 1.1.1.110) from Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) (see 6 papers)
FLDH_CLOS3 / G9EZR6 Aromatic 2-oxoacid reductase; Phenyllactate dehydrogenase; EC 1.1.1.110 from Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) (see paper)
    34% identity, 87% coverage of query (167 bits)

FLDH_CLOS1 / J7SHB8 Aromatic 2-oxoacid reductase; Indolelactate dehydrogenase; EC 1.1.1.110 from Clostridium sporogenes (strain ATCC 15579) (see 2 papers)
    34% identity, 87% coverage of query (167 bits)

Build an alignment

Build an alignment for WP_012675835.1 and 17 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

HtpH / b1380 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ldhA / P52643 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli (strain K12) (see 22 papers)
ldhA D-lactate dehydrogenase; EC 1.1.1.28 from Escherichia coli K12 (see 7 papers)
    29% identity, 97% coverage of query (166 bits)

A0A140N893 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli (see 2 papers)
    29% identity, 97% coverage of query (166 bits)

HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    35% identity, 86% coverage of query (164 bits)

4cukA / Q8Z780 Structure of salmonella d-lactate dehydrogenase in complex with nadh
    30% identity, 92% coverage of query (164 bits)

ldhD / Q88VJ2 D-lactate dehydrogenase subunit (EC 1.1.1.28) from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (see paper)
C0LJH4 D-lactate dehydrogenase (EC 1.1.1.28) from Lactiplantibacillus plantarum subsp. plantarum (see paper)
    30% identity, 98% coverage of query (162 bits)

A0A0M3KL04 D-lactate dehydrogenase (EC 1.1.1.28) from Sporolactobacillus inulinus (see paper)
    35% identity, 98% coverage of query (160 bits)

4xkjA / A0A0M3KL04 A novel d-lactate dehydrogenase from sporolactobacillus sp
    35% identity, 98% coverage of query (160 bits)

HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
    33% identity, 87% coverage of query (160 bits)

CH_091795 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus pentosus (see 2 papers)
    30% identity, 98% coverage of query (159 bits)

8grvA / Q54UF7 Dictyostelium discoideum lactate dehydrogenase (dicldha)with NAD
    31% identity, 89% coverage of query (157 bits)

vanH / Q7B609 D-lactate dehydrogenase (EC 1.1.1.28) from Enterococcus faecium (see paper)
VANH_ENTFC / Q05709 D-specific alpha-keto acid dehydrogenase; Vancomycin resistance protein VanH; EC 1.1.1.- from Enterococcus faecium (Streptococcus faecium) (see paper)
    40% identity, 72% coverage of query (157 bits)

6biiA / F8AEA4 Crystal structure of pyrococcus yayanosii glyoxylate hydroxypyruvate reductase in complex with NADP and malonate (re-refinement of 5aow) (see paper)
    36% identity, 84% coverage of query (155 bits)

F8AEA4 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus yayanosii (see paper)
    36% identity, 84% coverage of query (155 bits)

O83080 D-lactate dehydrogenase (EC 1.1.1.28) from Treponema pallidum (see paper)
    31% identity, 99% coverage of query (154 bits)

2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
    32% identity, 93% coverage of query (153 bits)

Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Sulfurisphaera tokodaii (see paper)
    32% identity, 93% coverage of query (153 bits)

E0NDE9 D-lactate dehydrogenase (EC 1.1.1.28) from Pediococcus acidilactici (see paper)
    29% identity, 99% coverage of query (150 bits)

HGDH_ACIFV / D2RJU7 (R)-2-hydroxyglutarate dehydrogenase; HGDH; EC 1.1.1.399 from Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4) (see paper)
    32% identity, 99% coverage of query (150 bits)

SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
    34% identity, 80% coverage of query (149 bits)

7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
    34% identity, 80% coverage of query (149 bits)

LDHD_PEDAC / Q59642 D-lactate/D-glycerate dehydrogenase; D-LDH/GDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28; EC 1.1.1.29 from Pediococcus acidilactici (see paper)
ldhD / GI|897794 D-lactate dehydrogenase; EC 1.1.1.28; EC 1.1.1.81 from Pediococcus acidilactici (see paper)
    29% identity, 99% coverage of query (149 bits)

PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
    34% identity, 80% coverage of query (149 bits)

6plfA Crystal structure of human phgdh complexed with compound 1
    34% identity, 80% coverage of query (149 bits)

6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
    34% identity, 80% coverage of query (149 bits)

6rj2A Crystal structure of phgdh in complex with compound 40
    34% identity, 80% coverage of query (149 bits)

6plgA Crystal structure of human phgdh complexed with compound 15
    34% identity, 80% coverage of query (149 bits)

7ewhA Crystal structure of human phgdh in complex with homoharringtonine
    34% identity, 80% coverage of query (149 bits)

6rihA Crystal structure of phgdh in complex with compound 9
    34% identity, 80% coverage of query (149 bits)

6rj3A Crystal structure of phgdh in complex with compound 15
    34% identity, 80% coverage of query (149 bits)

6rj5A Crystal structure of phgdh in complex with compound 39
    34% identity, 80% coverage of query (149 bits)

hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
    33% identity, 82% coverage of query (148 bits)

Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
    33% identity, 80% coverage of query (148 bits)

1dxyA / P17584 Structure of d-2-hydroxyisocaproate dehydrogenase (see paper)
    30% identity, 98% coverage of query (144 bits)

DHD2_LACPA / P17584 D-2-hydroxyisocaproate dehydrogenase; D-HICDH; EC 1.1.1.- from Lacticaseibacillus paracasei (Lactobacillus paracasei) (see paper)
P17584 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lacticaseibacillus paracasei (see 2 papers)
CH_091798 D-2-hydroxyisocaproate dehydrogenase; EC 1.1.1.- from Lactobacillus paracasei (see 2 papers)
    30% identity, 98% coverage of query (144 bits)

BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) from Burkholderia phytofirmans PsJN
    35% identity, 80% coverage of query (143 bits)

LDHD_LACDA / P26297 D-lactate dehydrogenase; D-LDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28 from Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) (see paper)
ldhA / OMNI|NTL01LD0096 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 (see 3 papers)
    29% identity, 98% coverage of query (142 bits)

hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    32% identity, 83% coverage of query (141 bits)

kguD / Q5TM04 2-dehydro-6-phosphogluconate reductase (EC 1.1.1.43) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see 2 papers)
    31% identity, 83% coverage of query (141 bits)

serA / GB|AAC83943.1 phosphoglycerate dehydrogenase; EC 1.1.1.95 from Bacillus subtilis (see paper)
serA / AAC83943.1 phosphoglycerate dehydrogenase from Bacillus subtilis (see 3 papers)
    32% identity, 85% coverage of query (141 bits)

AO353_26885 phosphogluconate 2-dehydrogenase KguD (EC 1.1.1.43) from Pseudomonas fluorescens FW300-N2E3
    32% identity, 83% coverage of query (141 bits)

6plfB Crystal structure of human phgdh complexed with compound 1
    34% identity, 76% coverage of query (141 bits)

CTBP_DROME / O46036 C-terminal-binding protein; CtBP protein; dCtBP from Drosophila melanogaster (Fruit fly) (see 2 papers)
    34% identity, 79% coverage of query (140 bits)

Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Streptomyces coelicolor (see paper)
    33% identity, 80% coverage of query (140 bits)

D-ldh / P51011 D-lactate dehydrogenase subunit (EC 1.1.1.28) from Leuconostoc mesenteroides subsp. cremoris (see 3 papers)
CH_091801 D-lactate dehydrogenase; EC 1.1.1.28 from Leuconostoc mesenteroides subsp. cremoris (see paper)
    28% identity, 99% coverage of query (140 bits)

6cdfA / Q13363 Human ctbp1 (28-378) (see paper)
    33% identity, 82% coverage of query (139 bits)

CTBP1_RAT / Q9Z2F5 C-terminal-binding protein 1; CtBP1; 50 kDa BFA-dependent ADP-ribosylation substrate; BARS-50; C-terminal-binding protein 3; CtBP3; EC 1.1.1.- from Rattus norvegicus (Rat) (see 6 papers)
    34% identity, 80% coverage of query (139 bits)

1hl3A Ctbp/bars in ternary complex with NAD(h) and pidlskk peptide
    34% identity, 82% coverage of query (139 bits)

1hkuA Ctbp/bars: a dual-function protein involved in transcription corepression and golgi membrane fission
    34% identity, 82% coverage of query (139 bits)

6v89A Human ctbp1 (28-375) in complex with amp
    33% identity, 82% coverage of query (139 bits)

4lceA Ctbp1 in complex with substrate mtob
    33% identity, 82% coverage of query (139 bits)

4u6sA Ctbp1 in complex with substrate phenylpyruvate
    33% identity, 82% coverage of query (139 bits)

4u6qA Ctbp1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid
    33% identity, 82% coverage of query (139 bits)

CTBP1_MOUSE / O88712 C-terminal-binding protein 1; CtBP1; EC 1.1.1.- from Mus musculus (Mouse) (see 11 papers)
    34% identity, 80% coverage of query (138 bits)

1j49A / P26297 Insights into domain closure, substrate specificity and catalysis of d-lactate dehydrogenase from lactobacillus bulgaricus (see paper)
    28% identity, 98% coverage of query (138 bits)

8atiA / P56545 Human ctbp2(31-364) in complex with rai2 peptide(315-322)
    34% identity, 82% coverage of query (138 bits)

CTBP1 / Q13363 C-terminal-binding protein 1 (EC 1.1.1.428) from Homo sapiens (see 22 papers)
CTBP1_HUMAN / Q13363 C-terminal-binding protein 1; CtBP1; EC 1.1.1.- from Homo sapiens (Human) (see 24 papers)
    34% identity, 80% coverage of query (138 bits)

4lcjA Ctbp2 in complex with substrate mtob
    34% identity, 82% coverage of query (138 bits)

CTBP2_HUMAN / P56545 C-terminal-binding protein 2; CtBP2 from Homo sapiens (Human) (see 5 papers)
    34% identity, 80% coverage of query (137 bits)

2dbqA / O58320 Crystal structure of glyoxylate reductase (ph0597) from pyrococcus horikoshii ot3, complexed with NADP (i41) (see paper)
    35% identity, 93% coverage of query (137 bits)

CTBP2_MOUSE / P56546 C-terminal-binding protein 2; CtBP2 from Mus musculus (Mouse) (see 4 papers)
    34% identity, 80% coverage of query (137 bits)

CTBP2_RAT / Q9EQH5 C-terminal-binding protein 2; CtBP2 from Rattus norvegicus (Rat) (see paper)
    34% identity, 80% coverage of query (137 bits)

CTBP2_BOVIN / Q0VCQ1 C-terminal-binding protein 2; CtBP2 from Bos taurus (Bovine) (see paper)
    34% identity, 80% coverage of query (137 bits)

O58320 Glyoxylate reductase; EC 1.1.1.26 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    35% identity, 93% coverage of query (137 bits)

PS417_12555 phosphogluconate 2-dehydrogenase KguD (EC 1.1.1.43) from Pseudomonas simiae WCS417
    31% identity, 83% coverage of query (136 bits)

ind5 / A0A0D4BSA6 Ind5 from Streptomyces griseus subsp. griseus (see 2 papers)
    33% identity, 80% coverage of query (136 bits)

CTBP2_XENLA / Q9W758 C-terminal-binding protein 2; CtBP2; C-terminal-binding protein B; TCF-3 corepressor CtBP; XCtBP from Xenopus laevis (African clawed frog) (see paper)
    33% identity, 83% coverage of query (135 bits)

P30901 D-lactate dehydrogenase (EC 1.1.1.28) from Lactobacillus helveticus (see paper)
2dldA / P30901 D-lactate dehydrogenase complexed with nadh and oxamate
GB|CAA47255.1 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus helveticus (see 2 papers)
    28% identity, 98% coverage of query (134 bits)

P30901 D-lactate dehydrogenase; D-LDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28 from Lactobacillus helveticus (Lactobacillus suntoryeus)
    28% identity, 98% coverage of query (134 bits)

A0A1Z4EAX4 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
    29% identity, 92% coverage of query (133 bits)

SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 3 papers)
    30% identity, 90% coverage of query (132 bits)

H9JRZ9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Bombyx mori (see paper)
    31% identity, 85% coverage of query (131 bits)

4prlA Crystal structure of d-lactate dehydrogenase with NAD+ from lactobacillus jensenii (see paper)
    32% identity, 95% coverage of query (130 bits)

6p2iA Acyclic imino acid reductase (bsp5) in complex with NADPH and d-arg (see paper)
    31% identity, 85% coverage of query (126 bits)

7cvpA / O43175 The crystal structure of human phgdh from biortus.
    32% identity, 78% coverage of query (126 bits)

7arzA / A9SQZ2 Ternary complex of NAD-dependent formate dehydrogenase from physcomitrium patens
    32% identity, 83% coverage of query (125 bits)

2yq5C / Q1GAA2 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from lactobacillus delbrueckii ssp. Bulgaricus: NAD complexed form (see paper)
    29% identity, 99% coverage of query (125 bits)

1psdA The allosteric ligand site in the vmax-type cooperative enzyme phosphoglycerate dehydrogenase
    31% identity, 96% coverage of query (125 bits)

1ybaA The active form of phosphoglycerate dehydrogenase
    31% identity, 96% coverage of query (125 bits)

SerA / b2913 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli K-12 substr. MG1655 (see 36 papers)
serA / P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli (strain K12) (see 36 papers)
SERA_ECOLI / P0A9T0 D-3-phosphoglycerate dehydrogenase; PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Escherichia coli (strain K12) (see paper)
C3SVM7 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see paper)
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see 7 papers)
serA / RF|NP_417388 D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95 from Escherichia coli K12 (see 5 papers)
    31% identity, 96% coverage of query (124 bits)

2p9eA / P0A9T0 Crystal structure of g336v mutant of e.Coli phosphoglycerate dehydrogenase (see paper)
    31% identity, 96% coverage of query (124 bits)

P87228 Putative D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    28% identity, 93% coverage of query (120 bits)

3ddnB Crystal structure of hydroxypyruvic acid phosphate bound d-3- phosphoglycerate dehydrogenase in mycobacterium tuberculosis
    31% identity, 80% coverage of query (116 bits)

3dc2A / P9WNX3 Crystal structure of serine bound d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis (see paper)
    31% identity, 80% coverage of query (116 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory