Searching for up to 100 curated homologs for WP_012676449.1 NCBI__GCF_000021565.1:WP_012676449.1 (415 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
39% identity, 97% coverage of query (275 bits)
thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
41% identity, 78% coverage of query (204 bits)
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
41% identity, 78% coverage of query (204 bits)
6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
40% identity, 78% coverage of query (202 bits)
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
40% identity, 78% coverage of query (201 bits)
O66740 threonine synthase (EC 4.2.3.1) from Aquifex aeolicus (see paper)
39% identity, 84% coverage of query (194 bits)
2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
39% identity, 84% coverage of query (194 bits)
P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
40% identity, 79% coverage of query (191 bits)
1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
40% identity, 79% coverage of query (191 bits)
1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
40% identity, 79% coverage of query (191 bits)
3aeyA Apo form of threonine synthase from thermus thermophilus hb8
40% identity, 79% coverage of query (191 bits)
A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
38% identity, 83% coverage of query (184 bits)
2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
38% identity, 79% coverage of query (183 bits)
THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
38% identity, 79% coverage of query (183 bits)
Build an alignment for WP_012676449.1 and 14 homologs with ≥ 30% identity
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THRC1_ARATH / Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
29% identity, 85% coverage of query (137 bits)
2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine
29% identity, 85% coverage of query (137 bits)
THRC2_ARATH / Q9SSP5 Threonine synthase 2, chloroplastic; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 76% coverage of query (130 bits)
2c2gA / Q9S7B5 Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
28% identity, 85% coverage of query (124 bits)
DvMF_1945 threonine synthase (EC 4.2.3.1) from Desulfovibrio vulgaris Miyazaki F
26% identity, 89% coverage of query (94.0 bits)
MA_3297 / Q8TKU7 cysteate synthase monomer (EC 2.5.1.76) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
CYAS_METAC / Q8TKU7 Cysteate synthase; CS; Cya synthase; EC 2.5.1.76 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
Q8TKU7 cysteate synthase (EC 2.5.1.76) from Methanosarcina acetivorans (see paper)
26% identity, 91% coverage of query (91.7 bits)
1pwhA / P09367 Rat liver l-serine dehydratase- complex with pyridoxyl-(o-methyl- serine)-5-monophosphate (see paper)
27% identity, 75% coverage of query (62.0 bits)
trpB / RF|YP_045379.1 tryptophan synthase, beta subunit; EC 4.2.1.20 from Acinetobacter calcoaceticus (see paper)
23% identity, 73% coverage of query (60.1 bits)
Q8VBT2 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse)
26% identity, 74% coverage of query (58.9 bits)
5ey5B Lbcats
24% identity, 73% coverage of query (57.0 bits)
B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica (see paper)
25% identity, 73% coverage of query (55.8 bits)
K1QH67 aspartate racemase (EC 5.1.1.13) from Crassostrea gigas (see paper)
25% identity, 73% coverage of query (54.7 bits)
SDS / P20132 L-serine dehydratase (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see 2 papers)
SDHL_HUMAN / P20132 L-serine dehydratase/L-threonine deaminase; SDH; Hepatic serine dehydratase; hSDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 5 papers)
P20132 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see 3 papers)
27% identity, 75% coverage of query (53.5 bits)
BHCB_PARDP / A1B8Z2 beta-hydroxyaspartate dehydratase; EC 4.2.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
25% identity, 72% coverage of query (53.1 bits)
SDSL_RAT / A0A6N3IN21 Serine dehydratase-like; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Rattus norvegicus (Rat) (see paper)
22% identity, 74% coverage of query (50.4 bits)
trpB / Q9YGB0 tryptophan synthase β subunit (EC 4.2.1.122) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
Q9YGB0 tryptophan synthase (indole-salvaging) (EC 4.2.1.122); tryptophan synthase (subunit 2/2) (EC 4.2.1.20) from Thermococcus kodakarensis (see paper)
23% identity, 74% coverage of query (50.1 bits)
5dw3A Tryptophan synthase beta-subunit from pyrococcus furiosus with product l-tryptophan non-covalently bound in the active site
23% identity, 74% coverage of query (50.1 bits)
SDSL_MOUSE / Q8R238 Serine dehydratase-like; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; SDH; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse) (see paper)
24% identity, 75% coverage of query (49.7 bits)
TRP5 likely tryptophan synthetase alpha chain from Candida albicans (see paper)
25% identity, 74% coverage of query (49.7 bits)
1p5jA / P20132 Crystal structure analysis of human serine dehydratase (see paper)
26% identity, 74% coverage of query (48.9 bits)
O28672 tryptophan synthase (EC 4.2.1.20) from Archaeoglobus fulgidus (see paper)
22% identity, 75% coverage of query (48.1 bits)
6am8B Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9 with trp bound as e(aex2)
23% identity, 74% coverage of query (48.1 bits)
Q8U093 tryptophan synthase (subunit 2/2) (EC 4.2.1.20) from Pyrococcus furiosus (see paper)
23% identity, 74% coverage of query (47.8 bits)
5ixjD / Q8U093 Tryptophan synthase beta-subunit from pyrococcus furiosus with l- threonine non-covalently bound in the active site (see paper)
23% identity, 74% coverage of query (47.8 bits)
7rnpA Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9_h275e with 4-cl-trp non-covalently bound
23% identity, 74% coverage of query (47.8 bits)
5dw0A Trpb from pyrococcus furiosus with l-serine bound as the external aldimine
23% identity, 74% coverage of query (47.8 bits)
5t6mB Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound
23% identity, 74% coverage of query (47.8 bits)
1v8zA X-ray crystal structure of the tryptophan synthase b2 subunit from hyperthermophile, pyrococcus furiosus
23% identity, 74% coverage of query (47.8 bits)
5t6mA Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound
23% identity, 74% coverage of query (47.8 bits)
5vm5D Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9, with ser bound
24% identity, 74% coverage of query (47.8 bits)
LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
23% identity, 72% coverage of query (47.0 bits)
6cuzA Engineered trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3r)- ethylserine bound as the amino-acrylate
23% identity, 74% coverage of query (47.0 bits)
6cutA Engineered holo trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3s)- isopropylserine bound as the external aldimine
23% identity, 74% coverage of query (46.6 bits)
TrpB / b1261 tryptophan synthase subunit β (EC 4.2.1.122) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
trpB / P0A879 tryptophan synthase subunit β (EC 4.2.1.122) from Escherichia coli (strain K12) (see 7 papers)
23% identity, 72% coverage of query (46.2 bits)
P0A879 Tryptophan synthase beta chain; EC 4.2.1.20 from Escherichia coli (strain K12)
23% identity, 72% coverage of query (46.2 bits)
7mfjBBB / T1KF23 7mfjBBB (see paper)
26% identity, 73% coverage of query (43.9 bits)
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Lawrence Berkeley National Laboratory