Searching for up to 100 curated homologs for WP_012676652.1 NCBI__GCF_000021565.1:WP_012676652.1 (768 a.a.)
Found high-coverage hits (≥70%) to 37 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
METE_THEMA / Q9X112 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
Q9X112 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Thermotoga maritima (see paper)
53% identity, 99% coverage of query (784 bits)
1t7lA / Q9X112 Crystal structure of cobalamin-independent methionine synthase from t. Maritima (see paper)
53% identity, 99% coverage of query (783 bits)
1xpgA Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and methyltetrahydrofolate
53% identity, 99% coverage of query (783 bits)
1xdjA Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and homocysteine
53% identity, 99% coverage of query (780 bits)
3bq5A / Q9X112 Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and homocysteine (monoclinic) (see paper)
52% identity, 98% coverage of query (753 bits)
metE / P80877 cobalamin-independent methionine synthase (EC 2.1.1.14) from Bacillus subtilis (strain 168) (see paper)
50% identity, 99% coverage of query (736 bits)
P80877 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; Superoxide-inducible protein 9; SOI9; EC 2.1.1.14 from Bacillus subtilis (strain 168)
50% identity, 99% coverage of query (736 bits)
METE3_ARATH / Q0WNZ5 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 3, chloroplastic; Cobalamin-independent methionine synthase 3; AtMS3; EC 2.1.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
44% identity, 99% coverage of query (655 bits)
METE_STRMU / Q8CWX6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
Q8CWX6 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Streptococcus mutans (see paper)
47% identity, 99% coverage of query (655 bits)
METE1_ARATH / O50008 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1; Cobalamin-independent methionine synthase 1; AtMS1; Vitamin-B12-independent methionine synthase 1; EC 2.1.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O50008 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Arabidopsis thaliana (see 2 papers)
43% identity, 98% coverage of query (652 bits)
METE_SCHPO / Q9UT19 Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
met26 / RF|NP_593352.1 homocysteine methyltransferase Met26; EC 2.1.1.14 from Schizosaccharomyces pombe (see 2 papers)
44% identity, 99% coverage of query (648 bits)
metE / CAA58474.1 methionine synthase from Catharanthus roseus (see paper)
44% identity, 98% coverage of query (645 bits)
AtMS2 / Q9SRV5 cobalamin-independent methionine synthase MS2 (EC 2.1.1.14) from Arabidopsis thaliana (see paper)
METE2_ARATH / Q9SRV5 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 2; Cobalamin-independent methionine synthase 2; AtMS2; EC 2.1.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
43% identity, 98% coverage of query (644 bits)
METE_KALTU / C1KEU0 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Pollen allergen Sal k 3; SkMetE; Vitamin-B12-independent methionine synthase; Allergen Sal k 3.0101; EC 2.1.1.14 from Kali turgidum (Prickly saltwort) (Salsola kali) (see paper)
44% identity, 97% coverage of query (641 bits)
ms2 / CAJ01714.1 methionine synthase 2 enzyme from Hordeum vulgare (see paper)
43% identity, 98% coverage of query (637 bits)
1u1hA / O50008 A. Thaliana cobalamine independent methionine synthase (see paper)
43% identity, 98% coverage of query (635 bits)
1u22A A. Thaliana cobalamine independent methionine synthase
43% identity, 98% coverage of query (635 bits)
1u1jA A. Thaliana cobalamine independent methionine synthase
43% identity, 98% coverage of query (635 bits)
A0A1B2JIW1 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Komagataella pastoris (see paper)
43% identity, 99% coverage of query (634 bits)
4l61A Crystal structure of the candida albicans methionine synthase in complex with methionine
45% identity, 99% coverage of query (634 bits)
3t0cA / Q8CWX6 Crystal structure of streptococcus mutans mete complexed with zinc (see paper)
47% identity, 99% coverage of query (632 bits)
METE_CANAL / P82610 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
P82610 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Candida albicans (see paper)
MET6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC 2.1.1.14 from Candida albicans (see 10 papers)
44% identity, 99% coverage of query (631 bits)
4l6hA Crystal structure of the candida albicans methionine synthase in complex with methotrexate and homocysteine
44% identity, 99% coverage of query (631 bits)
ms1 / CAJ01713.1 methionine synthase 1 enzyme from Hordeum vulgare (see paper)
43% identity, 98% coverage of query (630 bits)
metH cobalamin-independent methionine synthase; EC 2.1.1.14 from Emericella nidulans (see 2 papers)
43% identity, 99% coverage of query (629 bits)
4qquA / P82610 Crystal structure of the cobalamin-independent methionine synthase enzyme in a closed conformation (see paper)
44% identity, 99% coverage of query (629 bits)
Q6GYJ7 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Komagataella pastoris (see paper)
42% identity, 99% coverage of query (624 bits)
Q8X1E4 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Neurospora crassa (see paper)
43% identity, 99% coverage of query (618 bits)
4ztxA / Q8X1E4 Neurospora crassa cobalamin-independent methionine synthase complexed with zn2+ (see paper)
43% identity, 99% coverage of query (618 bits)
MetE / b3829 cobalamin-independent homocysteine transmethylase (EC 2.1.1.14) from Escherichia coli K-12 substr. MG1655 (see 19 papers)
metE / P25665 cobalamin-independent homocysteine transmethylase (EC 2.1.1.14) from Escherichia coli (strain K12) (see 16 papers)
P25665 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Escherichia coli (see 2 papers)
metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC 2.1.1.14 from Escherichia coli K12 (see 9 papers)
43% identity, 99% coverage of query (617 bits)
P25665 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Escherichia coli (strain K12)
43% identity, 99% coverage of query (617 bits)
met6 / P05694 cobalamin-independent methionine synthase (EC 2.1.1.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
METE_YEAST / P05694 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Delta-P8 protein; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P05694 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Saccharomyces cerevisiae (see paper)
43% identity, 99% coverage of query (615 bits)
3ppcB / P82610 Crystal structure of the candida albicans methionine synthase by surface entropy reduction, tyrosine variant with zinc (see paper)
44% identity, 99% coverage of query (613 bits)
4l6oA Crystal structure of the candida albicans methionine synthase in complex with glutamine
44% identity, 99% coverage of query (612 bits)
4l64A Crystal structure of the candida albicans methionine synthase in complex with 5-methyl-tetrahydrofolate
42% identity, 99% coverage of query (578 bits)
metE / Q8NRB3 cobalamin-independent methionine synthase (EC 2.1.1.14) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
39% identity, 99% coverage of query (572 bits)
A0A077D1A3 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Fragilariopsis cylindrus (see paper)
42% identity, 98% coverage of query (572 bits)
Build an alignment for WP_012676652.1 and 37 homologs with ≥ 30% identity
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Lawrence Berkeley National Laboratory