Searching for up to 100 curated homologs for WP_012676942.1 NCBI__GCF_000021565.1:WP_012676942.1 (356 a.a.)
Found high-coverage hits (≥70%) to 97 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
O66740 threonine synthase (EC 4.2.3.1) from Aquifex aeolicus (see paper)
76% identity, 99% coverage of query (530 bits)
2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
76% identity, 99% coverage of query (530 bits)
6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
61% identity, 98% coverage of query (417 bits)
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
61% identity, 98% coverage of query (417 bits)
P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
59% identity, 98% coverage of query (404 bits)
1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
59% identity, 98% coverage of query (404 bits)
3aeyA Apo form of threonine synthase from thermus thermophilus hb8
59% identity, 98% coverage of query (404 bits)
1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
59% identity, 98% coverage of query (404 bits)
A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
59% identity, 99% coverage of query (404 bits)
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
60% identity, 97% coverage of query (400 bits)
thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
60% identity, 98% coverage of query (399 bits)
THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
63% identity, 93% coverage of query (395 bits)
2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
63% identity, 93% coverage of query (394 bits)
THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
51% identity, 95% coverage of query (332 bits)
THRC2_ARATH / Q9SSP5 Threonine synthase 2, chloroplastic; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
34% identity, 94% coverage of query (203 bits)
THRC1_ARATH / Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
33% identity, 98% coverage of query (203 bits)
2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine
33% identity, 97% coverage of query (202 bits)
2c2gA / Q9S7B5 Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
32% identity, 98% coverage of query (187 bits)
DvMF_1945 threonine synthase (EC 4.2.3.1) from Desulfovibrio vulgaris Miyazaki F
35% identity, 90% coverage of query (158 bits)
Build an alignment for WP_012676942.1 and 19 homologs with ≥ 30% identity
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MA_3297 / Q8TKU7 cysteate synthase monomer (EC 2.5.1.76) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
CYAS_METAC / Q8TKU7 Cysteate synthase; CS; Cya synthase; EC 2.5.1.76 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
Q8TKU7 cysteate synthase (EC 2.5.1.76) from Methanosarcina acetivorans (see paper)
28% identity, 78% coverage of query (90.9 bits)
T1KF23 L-3-cyanoalanine synthase (EC 4.4.1.9) from Tetranychus urticae (see paper)
29% identity, 87% coverage of query (78.2 bits)
7mfjBBB / T1KF23 7mfjBBB (see paper)
29% identity, 86% coverage of query (75.9 bits)
8y1jA / Q9I6G0 Structure of the pyridoxal 5'-phosphate-dependent (plp) threonine deaminase ilva1 from pseudomonas aeruginosa pao1 (see paper)
29% identity, 82% coverage of query (70.5 bits)
Q93968 serine racemase (EC 5.1.1.18) from Caenorhabditis elegans (see paper)
25% identity, 82% coverage of query (69.7 bits)
B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica (see paper)
28% identity, 86% coverage of query (69.3 bits)
CysM / b2421 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1; EC 4.4.1.28) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
cysM / P16703 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1) from Escherichia coli (strain K12) (see 15 papers)
CYSM_ECOLI / P16703 Cysteine synthase B; CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B; EC 2.5.1.47 from Escherichia coli (strain K12) (see paper)
25% identity, 77% coverage of query (68.6 bits)
LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
26% identity, 80% coverage of query (67.4 bits)
ILV1 putative uncharacterized protein ILV1 from Candida albicans (see paper)
26% identity, 78% coverage of query (67.4 bits)
FSDH_RALPI / Q10725 Phenylserine dehydratase; EC 4.2.1.- from Ralstonia pickettii (Burkholderia pickettii) (see 2 papers)
26% identity, 79% coverage of query (67.0 bits)
A2GMG5 cysteine synthase (EC 2.5.1.47) from Trichomonas vaginalis (see paper)
28% identity, 76% coverage of query (66.6 bits)
CS1 / A2EI82 O-phosphoserine sulfhydrylase monomer (EC 2.5.1.47; EC 2.5.1.65) from Trichomonas vaginalis (strain ATCC PRA-98 / G3) (see paper)
28% identity, 76% coverage of query (66.6 bits)
P29848 S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) (EC 2.5.1.144); cysteine synthase (EC 2.5.1.47) from Salmonella enterica subsp. enterica serovar Typhimurium (see 9 papers)
25% identity, 78% coverage of query (66.2 bits)
A0A220K835 L-3-cyanoalanine synthase (EC 4.4.1.9) from Spodoptera littoralis (see paper)
28% identity, 84% coverage of query (66.2 bits)
A0A220K8F1 L-3-cyanoalanine synthase (EC 4.4.1.9) from Aporia crataegi (see paper)
27% identity, 86% coverage of query (65.5 bits)
A0A220K8J3 L-3-cyanoalanine synthase (EC 4.4.1.9) from Aporia crataegi (see paper)
27% identity, 78% coverage of query (65.5 bits)
2bhtA / P16703 Crystal structure of o-acetylserine sulfhydrylase b (see paper)
25% identity, 77% coverage of query (65.1 bits)
Q54HH2 D-Serine ammonia-lyase (EC 4.3.1.18) from Dictyostelium discoideum (see paper)
27% identity, 71% coverage of query (63.9 bits)
SDSL_MOUSE / Q8R238 Serine dehydratase-like; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; SDH; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse) (see paper)
25% identity, 76% coverage of query (63.2 bits)
L0N5C4 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. N99 (see paper)
25% identity, 82% coverage of query (63.2 bits)
A0A220K8D1 L-3-cyanoalanine synthase (EC 4.4.1.9) from Anthocharis cardamines (see paper)
26% identity, 84% coverage of query (63.2 bits)
6xo2A / T1KF23 Structural characterization of beta cyanoalanine synthase from tetranychus urticae (two-spotted spider mite) (see paper)
27% identity, 87% coverage of query (63.2 bits)
A0A220K8D8 L-3-cyanoalanine synthase (EC 4.4.1.9) from Anthocharis cardamines (see paper)
29% identity, 84% coverage of query (62.0 bits)
A0A0U3S5Y4 L-3-cyanoalanine synthase (EC 4.4.1.9) from Pieris rapae (see paper)
26% identity, 78% coverage of query (61.2 bits)
2zpuA / O59791 Crystal structure of modified serine racemase from s.Pombe. (see paper)
25% identity, 77% coverage of query (61.2 bits)
SRR_SCHPO / O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
O59791 serine racemase (EC 5.1.1.18) from Schizosaccharomyces pombe (see 2 papers)
25% identity, 77% coverage of query (61.2 bits)
2zr8A Crystal structure of modified serine racemase complexed with serine
25% identity, 77% coverage of query (61.2 bits)
1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp
25% identity, 77% coverage of query (60.8 bits)
1v71A Crystal structure of s.Pombe serine racemase
25% identity, 77% coverage of query (60.8 bits)
Q8VBT2 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse)
25% identity, 84% coverage of query (60.8 bits)
Q04513 threonine ammonia-lyase (EC 4.3.1.19) from Corynebacterium glutamicum (see paper)
25% identity, 82% coverage of query (60.5 bits)
A0A0U3QZ45 L-3-cyanoalanine synthase (EC 4.4.1.9) from Pieris rapae (see paper)
27% identity, 84% coverage of query (60.5 bits)
A0A0U3SCD8 L-3-cyanoalanine synthase (EC 4.4.1.9) from Pieris rapae (see paper)
28% identity, 84% coverage of query (60.1 bits)
CA265_RS15860 threonine deaminase (EC 4.3.1.19) from Pedobacter sp. GW460-11-11-14-LB5
26% identity, 81% coverage of query (59.7 bits)
SRR / Q9GZT4 Serine racemase (EC 5.1.1.10) from Homo sapiens (see 4 papers)
SRR_HUMAN / Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 8 papers)
26% identity, 81% coverage of query (59.3 bits)
A0A220K8E3 L-3-cyanoalanine synthase (EC 4.4.1.9) from Colias croceus (see paper)
26% identity, 84% coverage of query (58.9 bits)
K1QH67 aspartate racemase (EC 5.1.1.13) from Crassostrea gigas (see paper)
26% identity, 78% coverage of query (58.9 bits)
A0A220K813 L-3-cyanoalanine synthase (EC 4.4.1.9) from Spodoptera littoralis (see paper)
27% identity, 84% coverage of query (58.2 bits)
1pwhA / P09367 Rat liver l-serine dehydratase- complex with pyridoxyl-(o-methyl- serine)-5-monophosphate (see paper)
24% identity, 76% coverage of query (58.2 bits)
ilvA / AAA96639.1 threonine dehydratase from Bacillus subtilis (see 3 papers)
26% identity, 82% coverage of query (58.2 bits)
ILV / CAA10977.1 threonine deaminase from Blastobotrys adeninivorans (see paper)
28% identity, 77% coverage of query (57.8 bits)
sr / Q2PGG3 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Arabidopsis thaliana (see paper)
SRR_ARATH / Q2PGG3 Serine racemase; AtSR; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q2PGG3 serine racemase (EC 5.1.1.18) from Arabidopsis thaliana (see paper)
25% identity, 82% coverage of query (57.4 bits)
A0A220K819 L-3-cyanoalanine synthase (EC 4.4.1.9) from Colias croceus (see paper)
25% identity, 84% coverage of query (56.6 bits)
A0A220K8A8 L-3-cyanoalanine synthase (EC 4.4.1.9) from Zygaena filipendulae (see paper)
26% identity, 85% coverage of query (56.6 bits)
7nbcAAA / Q9GZT4 structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
25% identity, 76% coverage of query (56.6 bits)
7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
25% identity, 76% coverage of query (56.6 bits)
7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen
25% identity, 76% coverage of query (56.6 bits)
7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen
25% identity, 76% coverage of query (56.6 bits)
7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen
25% identity, 76% coverage of query (56.6 bits)
trpB1 / P50909 β subunit of tryptophan synthase (EC 4.2.1.122) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
P50909 tryptophan synthase (EC 4.2.1.20) from Thermotoga maritima (see paper)
26% identity, 85% coverage of query (56.2 bits)
7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen
25% identity, 76% coverage of query (56.2 bits)
6zspAAA serine racemase bound to atp and malonate.
25% identity, 76% coverage of query (56.2 bits)
7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
25% identity, 76% coverage of query (56.2 bits)
3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
25% identity, 76% coverage of query (55.5 bits)
6uapB Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
25% identity, 90% coverage of query (54.3 bits)
6usaB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk1-bound form
25% identity, 90% coverage of query (54.3 bits)
6dweB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and brd0059-bound form
25% identity, 90% coverage of query (54.3 bits)
5tciH / P9WFX9 Crystal structure of tryptophan synthase from m. Tuberculosis - brd4592-bound form (see paper)
25% identity, 90% coverage of query (53.9 bits)
5ocwB Structure of mycobacterium tuberculosis tryptophan synthase in space group f222
25% identity, 90% coverage of query (53.9 bits)
6u6cB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form
25% identity, 90% coverage of query (53.9 bits)
5ey5B Lbcats
25% identity, 85% coverage of query (53.1 bits)
SDS / P20132 L-serine dehydratase (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see 2 papers)
SDHL_HUMAN / P20132 L-serine dehydratase/L-threonine deaminase; SDH; Hepatic serine dehydratase; hSDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 5 papers)
P20132 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see 3 papers)
25% identity, 76% coverage of query (52.4 bits)
8vhhA / P50909 Engineered holo tryptophan synthase (tm9d8 ) Derived from t. Maritima trpb (see paper)
26% identity, 85% coverage of query (52.4 bits)
1p5jA / P20132 Crystal structure analysis of human serine dehydratase (see paper)
25% identity, 76% coverage of query (51.2 bits)
6cutA Engineered holo trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3s)- isopropylserine bound as the external aldimine
25% identity, 86% coverage of query (50.4 bits)
5vm5D Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9, with ser bound
24% identity, 86% coverage of query (48.9 bits)
cysK / P56067 cystathionine β-synthase (O-acetyl-L-serine) monomer (EC 4.2.1.22; EC 2.5.1.134; EC 2.5.1.47) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 2 papers)
6ahiB / P56067 Crystal structure of o-acetylserine dependent cystathionine beta- synthase from helicobacter pylori. (see paper)
25% identity, 78% coverage of query (48.1 bits)
6am8B Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9 with trp bound as e(aex2)
23% identity, 86% coverage of query (48.1 bits)
5ixjD / Q8U093 Tryptophan synthase beta-subunit from pyrococcus furiosus with l- threonine non-covalently bound in the active site (see paper)
23% identity, 87% coverage of query (47.4 bits)
5t6mA Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound
23% identity, 86% coverage of query (47.0 bits)
6cuzA Engineered trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3r)- ethylserine bound as the amino-acrylate
24% identity, 85% coverage of query (47.0 bits)
5xemA / Q8RE94 Crystal structure of a hydrogen sulfide-producing enzyme (fn1220) from fusobacterium nucleatum in complex with l-lanthionine-plp schiff base
24% identity, 82% coverage of query (47.0 bits)
5xenA Crystal structure of a hydrogen sulfide-producing enzyme (fn1220) from fusobacterium nucleatum in complex with l-serine-plp schiff base
24% identity, 82% coverage of query (47.0 bits)
7rnpA Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9_h275e with 4-cl-trp non-covalently bound
23% identity, 85% coverage of query (46.6 bits)
SRR_MOUSE / Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see 6 papers)
24% identity, 76% coverage of query (45.4 bits)
5dw3A Tryptophan synthase beta-subunit from pyrococcus furiosus with product l-tryptophan non-covalently bound in the active site
24% identity, 85% coverage of query (45.4 bits)
SDSL / Q96GA7 Serine dehydratase-like (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see paper)
SDSL_HUMAN / Q96GA7 Serine dehydratase-like; Cancerous serine dehydratase; cSDH; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; SDHL; L-threonine dehydratase; TDH; Serine dehydratase 2; SDH 2; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see 2 papers)
Q96GA7 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see paper)
24% identity, 78% coverage of query (43.9 bits)
2rkbA / Q96GA7 Serine dehydratase like-1 from human cancer cells (see paper)
24% identity, 78% coverage of query (43.9 bits)
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