Searching for up to 100 curated homologs for WP_012707955.1 NCBI__GCF_000018545.1:WP_012707955.1 (440 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Ga0059261_2711 homoserine dehydrogenase (EC 1.1.1.3) from Sphingomonas koreensis DSMZ 15582
    47% identity, 99% coverage of query (360 bits)

hom / AAF21129.1 homoserine dehydrogenase from Methylobacillus flagellatus (see paper)
    41% identity, 98% coverage of query (319 bits)

DHOM_NEIG1 / Q5F8J4 Homoserine dehydrogenase; HDH; HSD; NAD(+)-dependent homoserine dehydrogenase; NAD(+)-dependent HSD; NgHSD; EC 1.1.1.3 from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) (see paper)
    43% identity, 95% coverage of query (317 bits)

DvMF_1412 homoserine dehydrogenase (EC 1.1.1.3) from Desulfovibrio vulgaris Miyazaki F
    40% identity, 98% coverage of query (300 bits)

D8WXQ1 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    41% identity, 92% coverage of query (286 bits)

DHOM_CORGL / P08499 Homoserine dehydrogenase; HDH; HSD; EC 1.1.1.3 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see 2 papers)
P08499 homoserine dehydrogenase (EC 1.1.1.3) from Corynebacterium glutamicum (see 2 papers)
    42% identity, 98% coverage of query (281 bits)

Q56R01 homoserine dehydrogenase (EC 1.1.1.3) from Streptomyces clavuligerus (see paper)
    39% identity, 98% coverage of query (268 bits)

DHOM_BACSU / P19582 Homoserine dehydrogenase; HDH; HSD; EC 1.1.1.3 from Bacillus subtilis (strain 168) (see 3 papers)
P19582 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus subtilis (see paper)
    39% identity, 93% coverage of query (264 bits)

6dzsA / K5BJC9 Mycobacterial homoserine dehydrogenase thra in complex with NADP
    40% identity, 98% coverage of query (257 bits)

DHOM_LACLC / P52985 Homoserine dehydrogenase; HDH; HSD; EC 1.1.1.3 from Lactococcus lactis subsp. cremoris (Streptococcus cremoris) (see paper)
    37% identity, 87% coverage of query (248 bits)

P46806 homoserine dehydrogenase (EC 1.1.1.3) from Mycobacterium leprae (see paper)
    39% identity, 99% coverage of query (247 bits)

A0A0H2WVX4 homoserine dehydrogenase (EC 1.1.1.3) from Staphylococcus aureus (see 2 papers)
    40% identity, 72% coverage of query (245 bits)

4pg7A / A0A0M3KKV6 Crystal structure of s. Aureus homoserine dehydrogenase at ph7.5 (see paper)
    39% identity, 72% coverage of query (225 bits)

D8WXQ2 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    35% identity, 78% coverage of query (221 bits)

Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima (see paper)
    41% identity, 73% coverage of query (204 bits)

DHOM_PSECO / P0DXC5 NAD(+)-dependent homoserine dehydrogenase; NAD(+)-dependent HSD; EC 1.1.1.3 from Pseudomonas canavaninivorans (see paper)
    35% identity, 72% coverage of query (183 bits)

Q5SL04 homoserine dehydrogenase (EC 1.1.1.3) from Thermus thermophilus (see paper)
6a0tB / Q5SL04 Homoserine dehydrogenase k99a mutant from thermus thermophilus hb8 complexed with hse and NADP+ (see paper)
    40% identity, 75% coverage of query (155 bits)

6a0sA Homoserine dehydrogenase from thermus thermophilus hb8 complexed with hse and NADPH
    40% identity, 75% coverage of query (155 bits)

2ejwA Homoserine dehydrogenase from thermus thermophilus hb8
    40% identity, 75% coverage of query (155 bits)

7f4cA The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon sulfurisphaera tokodaii.
    34% identity, 71% coverage of query (146 bits)

DHOM_SULTO / F9VNG5 Homoserine dehydrogenase; HDH; HSD; StHSD; EC 1.1.1.3 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see 3 papers)
F9VNG5 homoserine dehydrogenase (EC 1.1.1.3) from Sulfurisphaera tokodaii (see paper)
    33% identity, 71% coverage of query (145 bits)

5x9dA / F9VNG5 Crystal structure of homoserine dehydrogenase in complex with l- cysteine and NAD (see paper)
    33% identity, 71% coverage of query (141 bits)

DHOM_PYRHO / O58802 Homoserine dehydrogenase; HDH; HSD; HseDH; EC 1.1.1.3 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
O58802 homoserine dehydrogenase (EC 1.1.1.3) from Pyrococcus horikoshii (see paper)
4xb1A / O58802 Hyperthermophilic archaeal homoserine dehydrogenase in complex with NADPH (see paper)
    31% identity, 71% coverage of query (134 bits)

4xb2A Hyperthermophilic archaeal homoserine dehydrogenase mutant in complex with NADPH
    31% identity, 71% coverage of query (133 bits)

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Build an alignment for WP_012707955.1 and 24 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    28% identity, 72% coverage of query (95.1 bits)

O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
    27% identity, 72% coverage of query (94.4 bits)

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
    26% identity, 72% coverage of query (93.6 bits)

AAA16972.1 aspartokinase-homoserine dehydrogenase, partial from Daucus carota (see paper)
    26% identity, 72% coverage of query (85.9 bits)

Q5AIA2 homoserine dehydrogenase (EC 1.1.1.3) from Candida albicans (see 2 papers)
    27% identity, 73% coverage of query (84.7 bits)

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    25% identity, 71% coverage of query (82.8 bits)

MetM / b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
metL / P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 9 papers)
    24% identity, 72% coverage of query (75.1 bits)

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