Searching for up to 100 curated homologs for WP_012708366.1 NCBI__GCF_000018545.1:WP_012708366.1 (232 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PGA1_c13350 Methionine synthase component, B12 binding and B12-binding cap domains (EC:2.1.1.13) from Phaeobacter inhibens BS107
    82% identity, 98% coverage of query (390 bits)

Q8THX4 tetrahydromethanopterin S-methyltransferase (EC 2.1.1.86) from Methanosarcina acetivorans (see paper)
    40% identity, 89% coverage of query (161 bits)

mtbC / O93657 dimethylamine corrinoid protein from Methanosarcina barkeri (see paper)
MTBC_METBA / O93657 Dimethylamine corrinoid protein from Methanosarcina barkeri (see 2 papers)
mtbC / GB|AAD14629.1 dimethylamine corrinoid protein from Methanosarcina barkeri (see 2 papers)
    40% identity, 91% coverage of query (160 bits)

mtgC / Q24SP8 glycine betaine-specific corrinoid protein from Desulfitobacterium hafniense (strain Y51) (see paper)
    44% identity, 76% coverage of query (154 bits)

7xcnP / O93659 Crystal structure of the mttb-mttc complex at 2.7 a resolution (see paper)
    36% identity, 90% coverage of query (137 bits)

mttC / O93659 trimethylamine-specific corrinoid protein from Methanosarcina barkeri (see paper)
MTTC_METBA / O93659 Trimethylamine corrinoid protein; TCP from Methanosarcina barkeri (see paper)
    36% identity, 90% coverage of query (137 bits)

4jgiB / Q8RPG0 1.5 angstrom crystal structure of a novel cobalamin-binding protein from desulfitobacterium hafniense dcb-2 (see paper)
    34% identity, 88% coverage of query (125 bits)

DvMF_0476 vitamin B12-dependent methionine synthase without a reactivation domain (EC 2.1.1.13) from Desulfovibrio vulgaris Miyazaki F
    38% identity, 82% coverage of query (123 bits)

DVU1585 Methionine synthase (cobalamin-dependent) (EC 2.1.1.13) from Desulfovibrio vulgaris Hildenborough JW710
    38% identity, 82% coverage of query (123 bits)

Q9WYA5 methionine synthase (EC 2.1.1.13) from Thermotoga maritima (see paper)
    38% identity, 77% coverage of query (121 bits)

metH / Q8NQD1 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    37% identity, 85% coverage of query (119 bits)

cmuA / CAB39403.1 CmuA protein from Methylorubrum extorquens (see paper)
    34% identity, 91% coverage of query (115 bits)

mtaC / Q46EH4 Co(I) methanol-specific corrinoid protein from Methanosarcina barkeri (strain Fusaro / DSM 804) (see 6 papers)
MTAC_METBF / Q46EH4 Methanol--corrinoid protein; Methanol:corrinoid methyltransferase 1 subunit of 27 kDa; MT1 subunit 27 kDa from Methanosarcina barkeri (strain Fusaro / DSM 804) (see 2 papers)
Q46EH4 methanol-corrinoid protein Co-methyltransferase (subunit 1/3) (EC 2.1.1.90) from Methanosarcina barkeri (see paper)
2i2xB / Q46EH4 Crystal structure of methanol:cobalamin methyltransferase complex mtabc from methanosarcina barkeri (see paper)
    33% identity, 88% coverage of query (114 bits)

MTQC_EUBLI / P0DX07 Quaternary-amine-specific corrinoid protein; Corrinoid protein MtqC from Eubacterium limosum (see 2 papers)
    35% identity, 72% coverage of query (111 bits)

3bulA / P13009 E. Coli i690c/g743c meth c-terminal fragment (649-1227) (see paper)
    34% identity, 77% coverage of query (110 bits)

MetH / b4019 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Escherichia coli K-12 substr. MG1655 (see 60 papers)
metH / P13009 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Escherichia coli (strain K12) (see 58 papers)
METH_ECOLI / P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 4 papers)
metH methionine synthase; EC 2.1.1.13 from Escherichia coli K12 (see 15 papers)
    34% identity, 77% coverage of query (110 bits)

3ivaA Structure of the b12-dependent methionine synthase (meth) c-teminal half with adohcy bound
    34% identity, 77% coverage of query (110 bits)

8sseA / Q5SKM5 Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8 (see paper)
    36% identity, 79% coverage of query (109 bits)

1bmtA How a protein binds b12: a 3.O angstrom x-ray structure of the b12- binding domains of methionine synthase
    35% identity, 77% coverage of query (109 bits)

8g3hA / A0A0A2XCD7 Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
    34% identity, 85% coverage of query (103 bits)

3ezxA / O30641 Structure of methanosarcina barkeri monomethylamine corrinoid protein
    35% identity, 80% coverage of query (103 bits)

mtmC / O30641 monomethylamine corrinoid protein from Methanosarcina barkeri (see 2 papers)
MTMC1_METBA / O30641 Monomethylamine corrinoid protein 1; MMCP 1 from Methanosarcina barkeri (see paper)
    34% identity, 80% coverage of query (101 bits)

mtsB / Q48925 methanethiol corrinoid protein from Methanosarcina barkeri (see 3 papers)
MTSB_METBA / Q48925 Methylated-thiol--corrinoid protein MtsB; Methylthiol:coenzyme M methyltransferase 30 kDa subunit from Methanosarcina barkeri (see paper)
    30% identity, 89% coverage of query (94.7 bits)

Build an alignment

Build an alignment for WP_012708366.1 and 23 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

5c8eA Crystal structure of thermus thermophilus carh bound to adenosylcobalamin and a 26-bp DNA segment
    26% identity, 82% coverage of query (42.4 bits)

5c8dE / Q746J7 Crystal structure of full-length thermus thermophilus carh bound to adenosylcobalamin (dark state) (see paper)
    26% identity, 82% coverage of query (42.0 bits)

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