Searching for up to 100 curated homologs for WP_012709948.1 NCBI__GCF_000018545.1:WP_012709948.1 (319 a.a.)
Found high-coverage hits (≥70%) to 87 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q92T34 hydroxypyruvate reductase (EC 1.1.1.81) from Sinorhizobium meliloti (see paper)
91% identity, 100% coverage of query (594 bits)
4weqA / Q92T34 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADP and sulfate (see paper)
91% identity, 99% coverage of query (588 bits)
4z0pA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADPH and oxalate
91% identity, 99% coverage of query (588 bits)
5bqfA / Q2KDT2 Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADP, hepes and l(+)-tartaric acid
60% identity, 99% coverage of query (405 bits)
4xcvA Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH
60% identity, 99% coverage of query (405 bits)
5tsdA Crystal structure of NADPH-dependent 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH and oxalate
60% identity, 99% coverage of query (405 bits)
5vg6B / A7IIH0 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from xanthobacter autotrophicus py2 in complex with NADPH and mes.
38% identity, 96% coverage of query (174 bits)
3kboA / Q8ZQ30 2.14 angstrom crystal structure of putative oxidoreductase (ycdw) from salmonella typhimurium in complex with NADP
39% identity, 87% coverage of query (173 bits)
7jqiA Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with alpha-ketoglutarate and NADP+
38% identity, 88% coverage of query (171 bits)
6p35A 2.5 angstrom structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with 2-keto arginine and NADP
38% identity, 88% coverage of query (171 bits)
7jqhA / A0A140NAE3 Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with phosphate and NADP+
38% identity, 88% coverage of query (170 bits)
GhrA / b1033 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ghrA / P75913 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli (strain K12) (see 4 papers)
GHRA_ECOLI / P75913 Glyoxylate/hydroxypyruvate reductase A; 2-ketoacid reductase; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli (strain K12) (see paper)
38% identity, 88% coverage of query (170 bits)
4zqbB / Q3IWN8 Crystal structure of NADP-dependent dehydrogenase from rhodobactersphaeroides in complex with NADP and sulfate
35% identity, 86% coverage of query (135 bits)
Sama_3039 Phosphoglycerate dehydrogenase (EC 1.1.1.95) from Shewanella amazonensis SB2B
31% identity, 86% coverage of query (94.7 bits)
Build an alignment for WP_012709948.1 and 14 homologs with ≥ 30% identity
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hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
29% identity, 82% coverage of query (92.4 bits)
serA / GB|AAC83943.1 phosphoglycerate dehydrogenase; EC 1.1.1.95 from Bacillus subtilis (see paper)
serA / AAC83943.1 phosphoglycerate dehydrogenase from Bacillus subtilis (see 3 papers)
31% identity, 80% coverage of query (91.7 bits)
3dc2A / P9WNX3 Crystal structure of serine bound d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis (see paper)
31% identity, 72% coverage of query (89.4 bits)
P9WNX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mycobacterium tuberculosis (see 5 papers)
31% identity, 72% coverage of query (89.4 bits)
3ddnB Crystal structure of hydroxypyruvic acid phosphate bound d-3- phosphoglycerate dehydrogenase in mycobacterium tuberculosis
31% identity, 72% coverage of query (89.4 bits)
O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pyrococcus horikoshii (see paper)
29% identity, 75% coverage of query (89.0 bits)
kguD / Q5TM04 2-dehydro-6-phosphogluconate reductase (EC 1.1.1.43) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see 2 papers)
30% identity, 72% coverage of query (86.7 bits)
PS417_12555 phosphogluconate 2-dehydrogenase KguD (EC 1.1.1.43) from Pseudomonas simiae WCS417
32% identity, 72% coverage of query (83.6 bits)
AO353_26885 phosphogluconate 2-dehydrogenase KguD (EC 1.1.1.43) from Pseudomonas fluorescens FW300-N2E3
31% identity, 72% coverage of query (83.6 bits)
5v6qB / Q92LZ4 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and malonate (see paper)
31% identity, 86% coverage of query (83.2 bits)
5j23A Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with 2'-phospho-adp-ribose
31% identity, 86% coverage of query (83.2 bits)
5v7gA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADPH and oxalate
31% identity, 86% coverage of query (83.2 bits)
5v7nA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and 2-keto-d-gluconic acid
31% identity, 86% coverage of query (83.2 bits)
Q92LZ4 hydroxypyruvate reductase (EC 1.1.1.81) from Sinorhizobium meliloti (see paper)
31% identity, 86% coverage of query (82.8 bits)
HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
28% identity, 73% coverage of query (82.0 bits)
6plfB Crystal structure of human phgdh complexed with compound 1
29% identity, 74% coverage of query (81.6 bits)
A0A178WMD4 hydroxyphenylpyruvate reductase (EC 1.1.1.237); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 2 papers)
27% identity, 72% coverage of query (81.3 bits)
PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
29% identity, 77% coverage of query (80.5 bits)
6rj5A Crystal structure of phgdh in complex with compound 39
29% identity, 77% coverage of query (80.5 bits)
7ewhA Crystal structure of human phgdh in complex with homoharringtonine
29% identity, 77% coverage of query (80.5 bits)
6rihA Crystal structure of phgdh in complex with compound 9
29% identity, 77% coverage of query (80.5 bits)
6rj2A Crystal structure of phgdh in complex with compound 40
29% identity, 77% coverage of query (80.5 bits)
6plgA Crystal structure of human phgdh complexed with compound 15
29% identity, 77% coverage of query (80.5 bits)
Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Streptomyces coelicolor (see paper)
28% identity, 90% coverage of query (80.1 bits)
7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
29% identity, 77% coverage of query (80.1 bits)
Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
28% identity, 77% coverage of query (80.1 bits)
SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
28% identity, 77% coverage of query (80.1 bits)
6plfA Crystal structure of human phgdh complexed with compound 1
29% identity, 77% coverage of query (80.1 bits)
6rj3A Crystal structure of phgdh in complex with compound 15
29% identity, 77% coverage of query (80.1 bits)
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
29% identity, 77% coverage of query (80.1 bits)
hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
26% identity, 83% coverage of query (79.7 bits)
HPR3 / Q9LE33 glyoxylate reductase (NADP+) (EC 1.1.1.79; EC 1.1.1.81) from Arabidopsis thaliana (see 8 papers)
HPR3_ARATH / Q9LE33 Glyoxylate/hydroxypyruvate reductase HPR3; NAD(P)H-dependent hydroxypyruvate reductase 3; AtHPR3; HPR 3; EC 1.1.1.79; EC 1.1.1.81 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LE33 hydroxyphenylpyruvate reductase (EC 1.1.1.237); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 3 papers)
27% identity, 72% coverage of query (79.3 bits)
Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
25% identity, 72% coverage of query (77.0 bits)
5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
25% identity, 72% coverage of query (76.6 bits)
7arzA / A9SQZ2 Ternary complex of NAD-dependent formate dehydrogenase from physcomitrium patens
26% identity, 76% coverage of query (76.6 bits)
A0A0A7RFJ3 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Salvia miltiorrhiza (see paper)
29% identity, 72% coverage of query (76.6 bits)
HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
28% identity, 72% coverage of query (75.5 bits)
3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
28% identity, 72% coverage of query (75.5 bits)
H9JRZ9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Bombyx mori (see paper)
30% identity, 75% coverage of query (74.7 bits)
GYAR_THELN / Q9C4M5 Glyoxylate reductase; EC 1.1.1.26 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
Q9C4M5 glyoxylate reductase (EC 1.1.1.26) from Thermococcus litoralis (see paper)
26% identity, 78% coverage of query (73.2 bits)
ptxD / O69054 phosphonate dehydrogenase monomer (EC 1.20.1.1) from Stutzerimonas stutzeri (see paper)
PTXD_STUST / O69054 Phosphonate dehydrogenase; NAD-dependent phosphite dehydrogenase; EC 1.20.1.1 from Stutzerimonas stutzeri (Pseudomonas stutzeri) (see paper)
O69054 phosphonate dehydrogenase (EC 1.20.1.1) from Pseudomonas stutzeri (see 5 papers)
30% identity, 82% coverage of query (73.2 bits)
HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
26% identity, 81% coverage of query (72.4 bits)
4e5pA / O69054 Thermostable phosphite dehydrogenase a176r variant in complex with nad (see paper)
30% identity, 82% coverage of query (72.0 bits)
4e5mA Thermostable phosphite dehydrogenase e175a/a176r in complex with NADP
30% identity, 82% coverage of query (72.0 bits)
HPR2 / Q9CA90 glyoxylate reductase (NADP+) (EC 1.1.1.79; EC 1.1.1.81) from Arabidopsis thaliana (see 11 papers)
HPR2_ARATH / Q9CA90 Glyoxylate/hydroxypyruvate reductase A HPR2; NAD(P)H-dependent hydroxypyruvate reductase 2; AtHPR2; HPR 2; EC 1.1.1.79; EC 1.1.1.81 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9CA90 hydroxyphenylpyruvate reductase (EC 1.1.1.237); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 4 papers)
27% identity, 72% coverage of query (70.9 bits)
F2YGD2 phosphonate dehydrogenase (EC 1.20.1.1) from Pseudomonas sp. (see paper)
29% identity, 82% coverage of query (70.9 bits)
4e5kA Thermostable phosphite dehydrogenase in complex with NAD and sulfite
29% identity, 82% coverage of query (70.5 bits)
EFUE_HORCR / A0A2Z4HPZ6 Dehydrogenase efuE; Enfumafungin biosynthesis cluster protein E; EC 1.-.-.- from Hormonema carpetanum (see paper)
28% identity, 79% coverage of query (68.2 bits)
slcC / Q1QWN6 S-sulfolactate dehydrogenase subunit (EC 1.1.1.310) from Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) (see paper)
SLCC_CHRSD / Q1QWN6 (S)-sulfolactate dehydrogenase; (2S)-3-sulfolactate dehydrogenase; (S)-sulfolactate oxidoreductase; EC 1.1.1.310 from Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) (see paper)
27% identity, 71% coverage of query (67.8 bits)
6biiA / F8AEA4 Crystal structure of pyrococcus yayanosii glyoxylate hydroxypyruvate reductase in complex with NADP and malonate (re-refinement of 5aow) (see paper)
24% identity, 78% coverage of query (67.4 bits)
F8AEA4 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus yayanosii (see paper)
24% identity, 78% coverage of query (67.0 bits)
5z20F / Q9I530 The ternary structure of d-lactate dehydrogenase from pseudomonas aeruginosa with nadh and oxamate (see paper)
29% identity, 74% coverage of query (66.2 bits)
FDH1 / O13437 formate dehydrogenase (EC 1.17.1.9) from Candida boidinii (see 3 papers)
FDH_CANBO / O13437 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Candida boidinii (Yeast) (see 6 papers)
O13437 formate dehydrogenase (EC 1.17.1.9) from [Candida] boidinii (see 12 papers)
fdh3 / CAB54834.1 formate dehydrogenase from [Candida] boidinii (see paper)
25% identity, 77% coverage of query (65.1 bits)
6ttbA / A0A0H3JSR9 Crystal structure of NAD-dependent formate dehydrogenase from staphylococcus aureus in complex with NAD
25% identity, 87% coverage of query (64.7 bits)
6d4bA / A0A0A1EQY0 Crystal structure of candida boidinii formate dehydrogenase v123a mutant complexed with NAD+ and azide
24% identity, 77% coverage of query (61.6 bits)
CTBP2_HUMAN / P56545 C-terminal-binding protein 2; CtBP2 from Homo sapiens (Human) (see 5 papers)
27% identity, 71% coverage of query (61.6 bits)
8atiA / P56545 Human ctbp2(31-364) in complex with rai2 peptide(315-322)
28% identity, 71% coverage of query (60.8 bits)
4lcjA Ctbp2 in complex with substrate mtob
28% identity, 71% coverage of query (60.8 bits)
FDH1_YEASC / N1P3Y5 Formate dehydrogenase 1; FDH 1; NAD-dependent formate dehydrogenase 1; EC 1.17.1.9 from Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) (see paper)
FDH1_YEAST / Q08911 Formate dehydrogenase 1; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
23% identity, 74% coverage of query (60.1 bits)
6t9wB / G8NTI5 Crystal structure of formate dehydrogenase fdh2 d222a/q223r enzyme from granulicella mallensis mp5actx8 in complex with NADP and azide.
25% identity, 73% coverage of query (57.4 bits)
2gsdA / O08375 NAD-dependent formate dehydrogenase from bacterium moraxella sp.C2 in complex with NAD and azide (see paper)
25% identity, 71% coverage of query (56.6 bits)
O66939 D-lactate dehydrogenase (EC 1.1.1.28) from Aquifex aeolicus (see paper)
3kb6B / O66939 Crystal structure of d-lactate dehydrogenase from aquifex aeolicus complexed with NAD and lactic acid (see paper)
25% identity, 74% coverage of query (56.2 bits)
8bxxAA Formate dehydrogenase
24% identity, 73% coverage of query (56.2 bits)
8oq2A Binding of NADP to a formate dehydrogenase from starkeya novella.
24% identity, 73% coverage of query (55.5 bits)
6jujA Crystal structure of formate dehydrogenase mutant v198i/c256i/p260s/e261p/s381n/s383f from pseudomonas sp. 101in complex with non-natural cofactor nicotinamide cytosine dinucleotide
24% identity, 73% coverage of query (55.1 bits)
4prlA Crystal structure of d-lactate dehydrogenase with NAD+ from lactobacillus jensenii (see paper)
24% identity, 76% coverage of query (54.7 bits)
1qp8A / Q8ZXP5 Crystal structure of a putative formate dehydrogenase from pyrobaculum aerophilum
25% identity, 77% coverage of query (54.7 bits)
FDH_PSESR / P33160 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Pseudomonas sp. (strain 101) (Achromobacter parvulus T1) (see 2 papers)
P33160 formate dehydrogenase (EC 1.17.1.9) from Pseudomonas sp. 101 (see paper)
23% identity, 73% coverage of query (53.9 bits)
2nadA High resolution structures of holo and apo formate dehydrogenase
23% identity, 73% coverage of query (53.9 bits)
3wr5A / Q76EB7 Structural basis on the efficient co2 reduction of acidophilic formate dehydrogenase
24% identity, 73% coverage of query (51.6 bits)
6t8zAAA Formate dehydrogenase
26% identity, 77% coverage of query (46.2 bits)
6t8yBBB / G0SGU4 6t8yBBB (see paper)
26% identity, 77% coverage of query (46.2 bits)
2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
22% identity, 73% coverage of query (44.7 bits)
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