Searching for up to 100 curated homologs for WP_012756106.1 NCBI__GCF_000023185.1:WP_012756106.1 (429 a.a.)

Found high-coverage hits (≥70%) to 36 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

7rbxC / Q2YQA0 Crystal structure of isocitrate lyase and phosphorylmutase:isocitrate lyase from brucella melitensis biovar abortus 2308 bound to itaconic acid (see paper)
    88% identity, 99% coverage of query (793 bits)

6lrtA / A9WDE7 Crystal structure of isocitrate lyase (caur_3889) from chloroflexus aurantiacus in complex with isocitrate and manganese ion
    75% identity, 96% coverage of query (629 bits)

GCP_CAEEL / Q10663 Bifunctional glyoxylate cycle protein; Gex-3-interacting protein 7; EC 4.1.3.1; EC 2.3.3.9 from Caenorhabditis elegans (see 2 papers)
    69% identity, 99% coverage of query (621 bits)

7cmyC / Q81GQ9 Isocitrate lyase from bacillus cereus atcc 14579 in complex with magnessium ion, glyoxylate, and succinate
    69% identity, 96% coverage of query (593 bits)

7rb1A Isocitrate lyase-1 from mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-d-isocitric acid
    68% identity, 96% coverage of query (563 bits)

6wsiA Intact cis-2,3-epoxysuccinic acid bound to isocitrate lyase-1 from mycobacterium tuberculosis
    68% identity, 96% coverage of query (563 bits)

6vb9A Covalent adduct of cis-2,3-epoxysuccinic acid with isocitrate lyase-1 from mycobacterium tuberculosis
    68% identity, 96% coverage of query (563 bits)

5dqlA Crystal structure of 2-vinyl glyoxylate modified isocitrate lyase from mycobacterium tuberculosis
    68% identity, 96% coverage of query (563 bits)

6c4aA / P9WKK7 Crystal structure of 3-nitropropionate modified isocitrate lyase from mycobacterium tuberculosis with pyruvate (see paper)
    68% identity, 96% coverage of query (562 bits)

icl / P9WKK7 isocitrate lyase subunit (EC 4.1.3.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
ACEA1_MYCTE / H8EVV4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) (see paper)
ACEA1_MYCBO / P0A5H4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
ACEA1_MYCTO / P9WKK6 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see 3 papers)
ACEA_MYCTU / P9WKK7 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 7 papers)
P9WKK7 isocitrate lyase (EC 4.1.3.1) from Mycobacterium tuberculosis (see 4 papers)
    68% identity, 96% coverage of query (562 bits)

6xppA Crystal structure of itaconate modified mycobaterium tuberculosis isocitrate lyase
    68% identity, 96% coverage of query (562 bits)

1f8iA Crystal structure of isocitrate lyase:nitropropionate:glyoxylate complex from mycobacterium tuberculosis
    67% identity, 96% coverage of query (558 bits)

Q8RPZ0 isocitrate lyase (EC 4.1.3.1) from Streptomyces clavuligerus (see paper)
    67% identity, 96% coverage of query (556 bits)

A0A3S5YB92 isocitrate lyase (EC 4.1.3.1) from Rhodococcus hoagii (see paper)
    64% identity, 96% coverage of query (540 bits)

Pf1N1B4_4042 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas fluorescens FW300-N1B4
    62% identity, 96% coverage of query (532 bits)

icl / CAA82555.1 isocitrate lyase from Rhodococcus fascians (see paper)
    63% identity, 96% coverage of query (528 bits)

ACEA_CORGL / P42449 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see 3 papers)
    62% identity, 96% coverage of query (524 bits)

BWI76_RS01665 Isocitrate lyase (EC 4.1.3.1) from Klebsiella michiganensis M5al
    62% identity, 96% coverage of query (520 bits)

Icl / b4015 isocitrate lyase (EC 4.1.3.1) from Escherichia coli K-12 substr. MG1655 (see paper)
aceA / P0A9G6 isocitrate lyase (EC 4.1.3.1) from Escherichia coli (strain K12) (see 25 papers)
ACEA_ECOLI / P0A9G6 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Escherichia coli (strain K12) (see 7 papers)
    62% identity, 96% coverage of query (518 bits)

Shew_1276 Isocitrate lyase (EC 4.1.3.1) from Shewanella loihica PV-4
    62% identity, 96% coverage of query (517 bits)

Q97YI8 isocitrate lyase (EC 4.1.3.1) from Saccharolobus solfataricus (see paper)
    60% identity, 97% coverage of query (511 bits)

SO1484 Isocitrate lyase (EC 4.1.3.1) from Shewanella oneidensis MR-1
    61% identity, 96% coverage of query (507 bits)

Sama_2380 Isocitrate lyase (EC 4.1.3.1) from Shewanella amazonensis SB2B
    61% identity, 96% coverage of query (505 bits)

1igwC / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
    61% identity, 92% coverage of query (494 bits)

Ac3H11_2831 Isocitrate lyase (EC 4.1.3.1) from Acidovorax sp. GW101-3H11
    57% identity, 96% coverage of query (476 bits)

1igwA / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
    58% identity, 92% coverage of query (441 bits)

5e9fD / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    35% identity, 91% coverage of query (249 bits)

5e9gD / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    34% identity, 92% coverage of query (237 bits)

Build an alignment

Build an alignment for WP_012756106.1 and 28 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

ACEA_HYPME / O50078 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Hyphomicrobium methylovorum (see paper)
    28% identity, 82% coverage of query (142 bits)

Psest_2014 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas stutzeri RCH2
    28% identity, 78% coverage of query (125 bits)

A8C781 isocitrate lyase (EC 4.1.3.1) from Azotobacter vinelandii (see paper)
    27% identity, 81% coverage of query (123 bits)

Q9I0K4 isocitrate lyase (EC 4.1.3.1) from Pseudomonas aeruginosa (see 2 papers)
    27% identity, 78% coverage of query (121 bits)

ACEA_HALVD / D4GTL3 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
    29% identity, 77% coverage of query (118 bits)

prpB / Q0KAG5 2-methylcitrate lyase (EC 4.1.3.30) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
    26% identity, 77% coverage of query (72.0 bits)

PRPB_CUPNE / Q937P0 2-methylisocitrate lyase; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see paper)
    26% identity, 79% coverage of query (70.9 bits)

dml / Q0QLE4 2,3-dimethylmalate lyase subunit (EC 4.1.3.32) from Eubacterium barkeri (see 2 papers)
DML_EUBBA / Q0QLE4 2,3-dimethylmalate lyase; EC 4.1.3.32 from Eubacterium barkeri (Clostridium barkeri) (see 3 papers)
    24% identity, 82% coverage of query (70.9 bits)

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