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Searching for up to 100 curated homologs for WP_012757074.1 NCBI__GCF_000023185.1:WP_012757074.1 (263 a.a.)

Found high-coverage hits (≥70%) to 88 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AO353_18585 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Pseudomonas fluorescens FW300-N2E3
    46% identity, 98% coverage of query (257 bits)

SO1666 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Shewanella oneidensis MR-1
    48% identity, 98% coverage of query (256 bits)

Pf6N2E2_2630 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Pseudomonas fluorescens FW300-N2E2
    45% identity, 99% coverage of query (256 bits)

PfGW456L13_4394 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Pseudomonas fluorescens GW456-L13
    45% identity, 99% coverage of query (255 bits)

AO356_03975 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Pseudomonas fluorescens FW300-N2C3
    45% identity, 99% coverage of query (254 bits)

Q47XN7 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Colwellia psychrerythraea (see paper)
    44% identity, 100% coverage of query (254 bits)

2v27B / Q47XN7 Structure of the cold active phenylalanine hydroxylase from colwellia psychrerythraea 34h (see paper)
    44% identity, 98% coverage of query (251 bits)

phhA / P30967 phenylalanine hydroxylase (EC 1.14.16.1) from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) (see 4 papers)
P30967 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Chromobacterium violaceum (see 9 papers)
    39% identity, 92% coverage of query (186 bits)

4etlA / P30967 Crystallographic structure of phenylalanine hydroxylase from chromobacterium violaceum f258a mutation (see paper)
    39% identity, 92% coverage of query (186 bits)

3tcyA Crystallographic structure of phenylalanine hydroxylase from chromobacterium violaceum (cpah) bound to phenylalanine in a site distal to the active site
    39% identity, 92% coverage of query (186 bits)

1ltvA Crystal structure of chromobacterium violaceum phenylalanine hydroxylase, structure with bound oxidized fe(iii)
    39% identity, 92% coverage of query (185 bits)

1ltzA Crystal structure of chromobacterium violaceum phenylalanine hydroxylase, structure has bound iron (iii) and oxidized cofactor 7, 8-dihydrobiopterin
    40% identity, 84% coverage of query (185 bits)

Ac3H11_1847 Phenylalanine 4-monooxygenase (EC 1.14.16.1) from Acidovorax sp. GW101-3H11
    35% identity, 95% coverage of query (163 bits)

PH4H_PINTA / E5KBU3 Phenylalanine 4-monooxygenase, chloroplastic; Aromatic amino acid hydroxylase; Phenylalanine 4-hydroxylase; EC 1.14.16.1 from Pinus taeda (Loblolly pine) (see paper)
    32% identity, 81% coverage of query (130 bits)

PAH / A8HQD7 phenylalanine hydroxylase (EC 1.14.16.1) from Chlamydomonas reinhardtii (see 2 papers)
PH4H_CHLRE / A8HQD7 Phenylalanine 4-monooxygenase, chloroplastic; Aromatic amino acid hydroxylase; Phenylalanine 4-hydroxylase; EC 1.14.16.1 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
    32% identity, 87% coverage of query (128 bits)

PAH / E5KBU4 phenylalanine hydroxylase (EC 1.14.16.1) from Physcomitrium patens (see 2 papers)
PH4H_PHYPA / E5KBU4 Phenylalanine 4-monooxygenase, chloroplastic; Aromatic amino acid hydroxylase; Phenylalanine 4-hydroxylase; EC 1.14.16.1 from Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens) (see paper)
    31% identity, 86% coverage of query (127 bits)

TY3H_RAT / P04177 Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; EC 1.14.16.2 from Rattus norvegicus (Rat) (see 7 papers)
    33% identity, 81% coverage of query (126 bits)

1mlwA Crystal structure of human tryptophan hydroxylase with bound 7,8- dihydro-l-biopterin cofactor and fe(iii)
    34% identity, 81% coverage of query (125 bits)

3hf6A Crystal structure of human tryptophan hydroxylase type 1 with bound lp-521834 and fe
    34% identity, 81% coverage of query (125 bits)

3hfbA Crystal structure of human tryoptophan hydroxylase type 1 with lp- 534193
    34% identity, 81% coverage of query (125 bits)

3hf8A Crystal structure of human tryoptophan hydroxylase type 1 with bound lp-533401 and fe
    34% identity, 81% coverage of query (125 bits)

2tohA Tyrosine hydroxylase catalytic and tetramerization domains from rat
    32% identity, 88% coverage of query (125 bits)

3e2tA / P70080 The catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan (see paper)
    33% identity, 81% coverage of query (124 bits)

TPH1_MOUSE / P17532 Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; EC 1.14.16.4 from Mus musculus (Mouse) (see paper)
P17532 tryptophan 5-monooxygenase (EC 1.14.16.4) from Mus musculus (see paper)
    34% identity, 81% coverage of query (124 bits)

TPH1_CHICK / P70080 Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; EC 1.14.16.4 from Gallus gallus (Chicken) (see paper)
P70080 tryptophan 5-monooxygenase (EC 1.14.16.4) from Gallus gallus (see 2 papers)
    33% identity, 81% coverage of query (124 bits)

5tpgA / P17752 Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors (see paper)
    33% identity, 81% coverage of query (124 bits)

Build an alignment

Build an alignment for WP_012757074.1 and 26 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

7vgmA / Q818B4 Crystal structure of phenylalanine hydroxylase from bacillus cereus atcc 14579 (see paper)
    28% identity, 84% coverage of query (124 bits)

TPH1_RAT / P09810 Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; EC 1.14.16.4 from Rattus norvegicus (Rat) (see paper)
    34% identity, 81% coverage of query (124 bits)

TPH1 / P17752 Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) from Homo sapiens (see 4 papers)
TPH1_HUMAN / P17752 Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; EC 1.14.16.4 from Homo sapiens (Human) (see 2 papers)
P17752 tryptophan 5-monooxygenase (EC 1.14.16.4) from Homo sapiens (see 11 papers)
    33% identity, 81% coverage of query (124 bits)

TY3H_MOUSE / P24529 Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; EC 1.14.16.2 from Mus musculus (Mouse) (see 4 papers)
P24529 tyrosine 3-monooxygenase (EC 1.14.16.2) from Mus musculus (see 3 papers)
    31% identity, 88% coverage of query (124 bits)

8cjnA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-06-070
    33% identity, 81% coverage of query (124 bits)

8cjkA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-06-098
    33% identity, 81% coverage of query (124 bits)

7zifA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-480
    33% identity, 81% coverage of query (124 bits)

5j6dA Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors
    33% identity, 81% coverage of query (124 bits)

7zikA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor lp533401
    33% identity, 81% coverage of query (124 bits)

8cjjA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-06-057
    33% identity, 81% coverage of query (124 bits)

8cjlA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor tpt-004
    33% identity, 81% coverage of query (124 bits)

8cjiA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-07-052
    33% identity, 81% coverage of query (124 bits)

7ziiA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-05-193
    33% identity, 81% coverage of query (124 bits)

7zihA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor ag-01-128
    33% identity, 81% coverage of query (124 bits)

5l01A Tryptophan 5-hydroxylase in complex with inhibitor (3~{s})-8-[2- azanyl-6-[(1~{r})-1-(4-chloranyl-2-phenyl-phenyl)-2,2,2- tris(fluoranyl)ethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3- carboxylic acid
    33% identity, 81% coverage of query (124 bits)

8cjmA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-07-047
    33% identity, 81% coverage of query (124 bits)

7zijA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-05-080
    33% identity, 81% coverage of query (124 bits)

7zigA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-05-060
    33% identity, 81% coverage of query (124 bits)

P17289 Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; EC 1.14.16.2 from Bos taurus (Bovine)
    31% identity, 88% coverage of query (124 bits)

8cjoA Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor km-06-004
    33% identity, 81% coverage of query (124 bits)

TPH1_RABIT / P17290 Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; EC 1.14.16.4 from Oryctolagus cuniculus (Rabbit) (see paper)
    33% identity, 81% coverage of query (122 bits)

B3VBU9 tryptophan 5-monooxygenase (EC 1.14.16.4) from Micropogonias undulatus (see paper)
    34% identity, 81% coverage of query (122 bits)

5jk5A / Q54XS1 Phenylalanine hydroxylase from dictyostelium - bh2 complex
    32% identity, 84% coverage of query (121 bits)

PH4H_DICDI / Q54XS1 Phenylalanine-4-hydroxylase; PAH; Phe-4-monooxygenase; Tryptophan 5-hydroxylase; TRH; Tryptophan 5-monooxygenase; EC 1.14.16.1; EC 1.14.16.4 from Dictyostelium discoideum (Social amoeba) (see paper)
    32% identity, 84% coverage of query (120 bits)

Q9PU40 tyrosine 3-monooxygenase (EC 1.14.16.2) from Gallus gallus (see paper)
    32% identity, 81% coverage of query (120 bits)

A5YVV2 tyrosine 3-monooxygenase (EC 1.14.16.2) from Tribolium castaneum (see paper)
    31% identity, 88% coverage of query (120 bits)

TPH2_MOUSE / Q8CGV2 Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2; EC 1.14.16.4 from Mus musculus (Mouse) (see paper)
Q8CGV2 tryptophan 5-monooxygenase (EC 1.14.16.4) from Mus musculus (see 3 papers)
    33% identity, 81% coverage of query (120 bits)

5jk8A Phenylalanine hydroxylase from dictyostelium - bh2, norleucine complex
    32% identity, 84% coverage of query (120 bits)

5fgjA / P04176 Structure of tetrameric rat phenylalanine hydroxylase, residues 1-453 (see paper)
    31% identity, 88% coverage of query (119 bits)

PH4H_RAT / P04176 Phenylalanine-4-hydroxylase; PAH; Phe-4-monooxygenase; EC 1.14.16.1 from Rattus norvegicus (Rat) (see 2 papers)
P04176 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Rattus norvegicus (see 7 papers)
    31% identity, 88% coverage of query (119 bits)

6zn2A Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic domain and an alpha-helix from the regulatory domain involved in dopamine binding.
    32% identity, 81% coverage of query (119 bits)

2xsnA Crystal structure of human tyrosine hydroxylase catalytic domain
    32% identity, 81% coverage of query (119 bits)

6zvpD / P07101 Atomic model of the em-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms (see paper)
    32% identity, 81% coverage of query (118 bits)

TY3H_HUMAN / P07101 Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; EC 1.14.16.2 from Homo sapiens (Human) (see 31 papers)
P07101 tyrosine 3-monooxygenase (EC 1.14.16.2) from Homo sapiens (see 8 papers)
    32% identity, 81% coverage of query (118 bits)

TPH2 / Q8IWU9 Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) from Homo sapiens (see 6 papers)
TPH2_HUMAN / Q8IWU9 Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2; EC 1.14.16.4 from Homo sapiens (Human) (see 5 papers)
Q8IWU9 tryptophan 5-monooxygenase (EC 1.14.16.4) from Homo sapiens (see 21 papers)
    33% identity, 81% coverage of query (118 bits)

Q2HZ26 tryptophan 5-monooxygenase (EC 1.14.16.4) from Macaca mulatta (see paper)
    33% identity, 81% coverage of query (118 bits)

4v06A / Q8IWU9 Crystal structure of human tryptophan hydroxylase 2 (tph2), catalytic domain
    33% identity, 81% coverage of query (117 bits)

Q8CGU9 tryptophan 5-monooxygenase (EC 1.14.16.4) from Rattus norvegicus (see 5 papers)
    33% identity, 81% coverage of query (117 bits)

pacX / F5BFC8 phenylalanine 3-hydroxylase (EC 1.14.16.7) from Streptomyces coeruleorubidus (see 3 papers)
PH3H_STRC4 / F5BFC8 Phenylalanine 3-hydroxylase; Phe3H; Fe-dependent phenylalanine hydroxylase; Phenylalanine 3-monooxygenase; EC 1.14.16.7 from Streptomyces coeruleorubidus (see paper)
F5BFC8 phenylalanine 3-monooxygenase (EC 1.14.16.7) from Streptomyces coeruleorubidus (see paper)
    32% identity, 85% coverage of query (117 bits)

M4GVG2 tyrosine 3-monooxygenase (EC 1.14.16.2) from Spodoptera exigua (see paper)
    32% identity, 81% coverage of query (117 bits)

P16331 Phenylalanine-4-hydroxylase; PAH; Phe-4-monooxygenase; EC 1.14.16.1 from Mus musculus (Mouse)
    31% identity, 88% coverage of query (117 bits)

PAH / P00439 phenylalanine hydroxylase subunit (EC 1.14.16.1) from Homo sapiens (see 6 papers)
PH4H_HUMAN / P00439 Phenylalanine-4-hydroxylase; PAH; Phe-4-monooxygenase; EC 1.14.16.1 from Homo sapiens (Human) (see 51 papers)
P00439 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Homo sapiens (see 36 papers)
    30% identity, 91% coverage of query (116 bits)

1kw0A Catalytic domain of human phenylalanine hydroxylase (fe(ii)) in complex with tetrahydrobiopterin and thienylalanine
    31% identity, 86% coverage of query (116 bits)

1j8uA Catalytic domain of human phenylalanine hydroxylase fe(ii) in complex with tetrahydrobiopterin
    31% identity, 86% coverage of query (116 bits)

1j8tA Catalytic domain of human phenylalanine hydroxylase fe(ii)
    31% identity, 86% coverage of query (116 bits)

1dmwA Crystal structure of double truncated human phenylalanine hydroxylase with bound 7,8-dihydro-l-biopterin
    31% identity, 86% coverage of query (116 bits)

4anpA Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone
    31% identity, 86% coverage of query (116 bits)

6pahA Human phenylalanine hydroxylase catalytic domain dimer with bound l- dopa (3,4-dihydroxyphenylalanine) inhibitor
    31% identity, 86% coverage of query (116 bits)

5pahA Human phenylalanine hydroxylase catalytic domain dimer with bound dopamine inhibitor
    31% identity, 86% coverage of query (116 bits)

4pahA Human phenylalanine hydroxylase catalytic domain dimer with bound nor- adrenaline inhibitor
    31% identity, 86% coverage of query (116 bits)

3pahA Human phenylalanine hydroxylase catalytic domain dimer with bound adrenaline inhibitor
    31% identity, 86% coverage of query (116 bits)

1mmtA Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase (fe(ii)) complexed with tetrahydrobiopterin and norleucine
    31% identity, 86% coverage of query (116 bits)

1tg2A Crystal structure of phenylalanine hydroxylase a313t mutant with 7,8- dihydrobiopterin bound
    31% identity, 86% coverage of query (116 bits)

TY3H_ONCMY / A0A060X6Z0 Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; Tyrosine hydroxylase; EC 1.14.16.2 from Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) (see paper)
    32% identity, 81% coverage of query (115 bits)

Q8TEY0 phenylalanine 4-monooxygenase (EC 1.14.16.1) from Homo sapiens (see paper)
    30% identity, 91% coverage of query (115 bits)

A7VKD9 tryptophan 5-monooxygenase (EC 1.14.16.4) from Dugesia japonica (see paper)
    30% identity, 93% coverage of query (114 bits)

A0A084W0Q1 tyrosine 3-monooxygenase (EC 1.14.16.2) from Anopheles sinensis (see paper)
    32% identity, 81% coverage of query (114 bits)

A1Y9J6 tryptophan 5-monooxygenase (EC 1.14.16.4) from Ciona intestinalis (see paper)
    30% identity, 81% coverage of query (113 bits)

B3VBV0 tryptophan 5-monooxygenase (EC 1.14.16.4) from Micropogonias undulatus (see paper)
    30% identity, 87% coverage of query (112 bits)

TY3H_CAEEL / P90986 Tyrosine 3-monooxygenase; Abnormal catecholamine distribution protein 2; Tyrosine 3-hydroxylase; TH; EC 1.14.16.2 from Caenorhabditis elegans (see 11 papers)
    31% identity, 83% coverage of query (111 bits)

PH4H_CAEEL / P90925 Phenylalanine-4-hydroxylase; PAH; Biogenic amine synthesis protein 2; Phe-4-monooxygenase; Tryptophan 5-monooxygenase; EC 1.14.16.1; EC 1.14.16.4 from Caenorhabditis elegans (see 3 papers)
    31% identity, 81% coverage of query (110 bits)

5j6dB / P17752 Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors (see paper)
    31% identity, 77% coverage of query (95.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory