Searching for up to 100 curated homologs for WP_012759263.1 NCBI__GCF_000023185.1:WP_012759263.1 (310 a.a.)
Found high-coverage hits (≥70%) to 48 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Ac3H11_603 L-2-keto-3-deoxyarabonate dehydratase (EC 4.2.1.43) from Acidovorax sp. GW101-3H11
33% identity, 86% coverage of query (119 bits)
BPHYT_RS22715 L-2-keto-3-deoxyarabonate dehydratase (EC 4.2.1.43) from Burkholderia phytofirmans PsJN
33% identity, 88% coverage of query (119 bits)
Q7D313 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
32% identity, 93% coverage of query (117 bits)
HSERO_RS06870 L-2-keto-3-deoxyarabonate dehydratase (EC 4.2.1.43) from Herbaspirillum seropedicae SmR1
34% identity, 90% coverage of query (116 bits)
KDADA_AZOBR / Q1JUQ0 L-2-keto-3-deoxyarabonate dehydratase; L-KDA dehydratase; 2-dehydro-3-deoxy-L-arabinonate dehydratase; L-2-keto-3-deoxyarabinonate dehydratase; EC 4.2.1.43 from Azospirillum brasilense (see 2 papers)
Q1JUQ0 2-dehydro-3-deoxy-L-arabinonate dehydratase (EC 4.2.1.43) from Azospirillum brasilense (see 2 papers)
31% identity, 91% coverage of query (100 bits)
Build an alignment for WP_012759263.1 and 5 homologs with ≥ 30% identity
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1o5kA / Q9X1K9 Crystal structure of dihydrodipicolinate synthase (tm1521) from thermotoga maritima at 1.80 a resolution
29% identity, 79% coverage of query (89.7 bits)
DAPA_THEMA / Q9X1K9 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
29% identity, 79% coverage of query (89.7 bits)
DAPA_METJA / Q57695 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
28% identity, 79% coverage of query (88.2 bits)
A5F699 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Vibrio cholerae (see paper)
28% identity, 90% coverage of query (86.7 bits)
3na8A / Q9I6R5 Crystal structure of a putative dihydrodipicolinate synthetase from pseudomonas aeruginosa
30% identity, 81% coverage of query (85.1 bits)
YjhH / b4298 KpLE2 phage-like element; putative 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
yjhH / P39359 KpLE2 phage-like element; putative 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) from Escherichia coli (strain K12) (see 7 papers)
YJHH_ECOLI / P39359 Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH; EC 4.1.2.28 from Escherichia coli (strain K12) (see paper)
26% identity, 81% coverage of query (84.0 bits)
3nevA / P75682 Crystal structure of yage, a prophage protein from e. Coli k12 in complex with kdgal (see paper)
26% identity, 77% coverage of query (82.4 bits)
4ptnA Crystal structure of yage, a kdg aldolase protein in complex with magnesium cation coordinated l-glyceraldehyde
26% identity, 77% coverage of query (82.4 bits)
4onvA Crystal structure of yage, a kdg aldolase protein in complex with 2- keto-3-deoxy gluconate
26% identity, 77% coverage of query (82.4 bits)
4oe7D Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
26% identity, 77% coverage of query (82.4 bits)
4oe7B Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
26% identity, 77% coverage of query (82.4 bits)
4oe7A Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
26% identity, 77% coverage of query (82.4 bits)
YagE / b0268 CP4-6 prophage; putative 2-dehydro-3-deoxygluconate aldolase (EC 4.1.2.28; EC 4.1.2.51) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
yagE / P75682 CP4-6 prophage; putative 2-dehydro-3-deoxygluconate aldolase (EC 4.1.2.28; EC 4.1.2.51) from Escherichia coli (strain K12) (see 8 papers)
YAGE_ECOLI / P75682 Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE; KDG aldolase YagE; Putative 2-dehydro-3-deoxy-D-pentonate aldolase YagE; EC 4.1.2.51; EC 4.1.2.28 from Escherichia coli (strain K12) (see 4 papers)
P75682 2-dehydro-3-deoxyglucarate aldolase (EC 4.1.2.20) from Escherichia coli (see paper)
26% identity, 77% coverage of query (82.0 bits)
dapA / Q65JG7 dihydrodipicolinate synthase subunit (EC 4.3.3.7) from Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) (see paper)
26% identity, 76% coverage of query (79.0 bits)
dapA / Q04796 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bacillus subtilis (strain 168) (see paper)
25% identity, 76% coverage of query (79.0 bits)
4pfmA / A9DKW4 Shewanella benthica dhdps with lysine and pyruvate
26% identity, 90% coverage of query (78.2 bits)
dhdps / CAC50571.1 dihydrodipicolinate synthetase from Yersinia enterocolitica (see paper)
25% identity, 90% coverage of query (77.8 bits)
4i7wA Agrobacterium tumefaciens dhdps with lysine and pyruvate
28% identity, 88% coverage of query (77.0 bits)
DAPA_AGRFC / Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see 2 papers)
28% identity, 85% coverage of query (76.6 bits)
Q8NMD2 N-acetylneuraminate lyase (EC 4.1.3.3) from Corynebacterium glutamicum (see paper)
25% identity, 93% coverage of query (74.3 bits)
5c55A / Q8NMD2 Crystal structure of the y138f mutant of c.Glutamicum n- acetylneuraminic acid lyase in complex with pyruvate
25% identity, 93% coverage of query (73.6 bits)
DAPA_STAAR / Q6GH13 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Staphylococcus aureus (strain MRSA252) (see paper)
Q6GH13 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Staphylococcus aureus (see 2 papers)
24% identity, 84% coverage of query (71.6 bits)
DAPA_RHIML / Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
Q07607 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Sinorhizobium meliloti (see 2 papers)
26% identity, 90% coverage of query (71.2 bits)
dapA2 dihydrodipicolinate synthase; EC 4.2.1.52 from Bacillus anthracis (see paper)
26% identity, 74% coverage of query (70.9 bits)
1xxxA Crystal structure of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis
27% identity, 90% coverage of query (70.1 bits)
5j5dA / P9WP25 Crystal structure of dihydrodipicolinate synthase from mycobacterium tuberculosis in complex with alpha-ketopimelic acid (see paper)
27% identity, 90% coverage of query (69.7 bits)
DAPA_MYCTU / P9WP25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
27% identity, 90% coverage of query (69.7 bits)
DAPA_STAAC / Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Staphylococcus aureus (strain COL) (see paper)
Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Staphylococcus aureus (see paper)
23% identity, 84% coverage of query (68.9 bits)
3di1B / Q5HG25 Crystal structure of the staphylococcus aureus dihydrodipicolinate synthase-pyruvate complex (see paper)
23% identity, 84% coverage of query (68.9 bits)
3l21B The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis - dhdps- a204r
27% identity, 90% coverage of query (68.9 bits)
Q8RBI5 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
23% identity, 79% coverage of query (68.6 bits)
Q8A3Z0 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bacteroides thetaiotaomicron (see paper)
27% identity, 89% coverage of query (67.0 bits)
A9CL97 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
27% identity, 95% coverage of query (64.3 bits)
4fhaA Structure of dihydrodipicolinate synthase from streptococcus pneumoniae,bound to pyruvate and lysine
23% identity, 78% coverage of query (63.5 bits)
NANA_MEDG7 / A7B555 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Mediterraneibacter gnavus (strain ATCC 29149 / DSM 114966 / JCM 6515 / VPI C7-9) (Ruminococcus gnavus) (see paper)
26% identity, 78% coverage of query (63.2 bits)
6rb7A / A7B555 Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant (see paper)
26% identity, 78% coverage of query (60.8 bits)
6rd1A Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant in complex with sialic acid
26% identity, 78% coverage of query (60.5 bits)
3qfeA Crystal structures of a putative dihydrodipicolinate synthase family protein from coccidioides immitis
28% identity, 75% coverage of query (59.3 bits)
A9CFV4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
26% identity, 79% coverage of query (58.9 bits)
5ktlA / Q3M723 Dihydrodipicolinate synthase from the industrial and evolutionarily important cyanobacteria anabaena variabilis. (see paper)
23% identity, 79% coverage of query (57.8 bits)
Q3M723 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Trichormus variabilis (see paper)
23% identity, 79% coverage of query (57.8 bits)
5ud6C / M1V4H9 Crystal structure of dhdps from cyanidioschyzon merolae with lysine bound
24% identity, 76% coverage of query (47.4 bits)
8u8wA / A0A0H3FJT8 Crystal structure of n-acetylneuraminate lyase (nana) from klebsiella aerogenes (pyruvate and halides bound)
24% identity, 78% coverage of query (46.6 bits)
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Lawrence Berkeley National Laboratory