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Searching for up to 100 curated homologs for WP_012850512.1 NCBI__GCF_000024385.1:WP_012850512.1 (305 a.a.)

Found high-coverage hits (≥70%) to 37 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3mwbA / A1R118 The crystal structure of prephenate dehydratase in complex with l-phe from arthrobacter aurescens to 2.0a
    51% identity, 99% coverage of query (292 bits)

3mwbB The crystal structure of prephenate dehydratase in complex with l-phe from arthrobacter aurescens to 2.0a
    50% identity, 99% coverage of query (286 bits)

pdt / AAA88840.1 prephenate dehydratase from Amycolatopsis methanolica (see paper)
    52% identity, 99% coverage of query (273 bits)

PHEA_MYCTU / P9WIC3 Prephenate dehydratase; PDT; EC 4.2.1.51 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
PHEA_MYCBO / Q7TVJ6 Prephenate dehydratase; PDT; EC 4.2.1.51 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
P9WIC3 prephenate dehydratase (EC 4.2.1.51) from Mycobacterium tuberculosis (see paper)
    49% identity, 100% coverage of query (261 bits)

CMPDT_STUST / P27603 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Stutzerimonas stutzeri (Pseudomonas stutzeri) (see paper)
    40% identity, 90% coverage of query (169 bits)

PHEA_METJA / Q58054 Prephenate dehydratase; PDT; MjPDT; EC 4.2.1.51 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
    35% identity, 88% coverage of query (156 bits)

Q8DUV6 prephenate dehydratase (EC 4.2.1.51) from Streptococcus mutans (see paper)
    38% identity, 89% coverage of query (153 bits)

AROD1_ARATH / Q9SA96 Arogenate dehydratase/prephenate dehydratase 1, chloroplastic; AtADT1; AtPDT1; EC 4.2.1.51; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9SA96 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana (see 5 papers)
    39% identity, 89% coverage of query (145 bits)

O30012 prephenate dehydrogenase (EC 1.3.1.12); prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Archaeoglobus fulgidus (see paper)
    34% identity, 90% coverage of query (145 bits)

A0A1I9WKA6 prephenate dehydratase (EC 4.2.1.51) from Pinus pinaster (see paper)
    38% identity, 89% coverage of query (137 bits)

AROD2_ARATH / Q9SSE7 Arogenate dehydratase/prephenate dehydratase 2, chloroplastic; AtADT2; AtPDT2; EC 4.2.1.51; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9SSE7 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana (see 4 papers)
    38% identity, 89% coverage of query (137 bits)

AROD2_PETHY / D3U716 Arogenate dehydratase 2; PhADT2; Prephenate dehydratase ADT3; EC 4.2.1.91; EC 4.2.1.51 from Petunia hybrida (Petunia) (see paper)
D3U716 arogenate dehydratase (EC 4.2.1.91) from Petunia x hybrida (see paper)
    39% identity, 89% coverage of query (134 bits)

A0A1I9WKA2 prephenate dehydratase (EC 4.2.1.51) from Pinus pinaster (see paper)
    36% identity, 89% coverage of query (132 bits)

6vh5D / Q2YPM5 Crystal structure of prephenate dehydratase from brucella melitensis biovar abortus 2308 in complex with phenylalanine
    35% identity, 90% coverage of query (130 bits)

Q6Z3Y3 prephenate dehydratase (EC 4.2.1.51) from Oryza sativa (see paper)
    34% identity, 89% coverage of query (128 bits)

AROD3_PETHY / D3U717 Arogenate dehydratase 3; PhADT3; Prephenate dehydratase ADT3; EC 4.2.1.91; EC 4.2.1.51 from Petunia hybrida (Petunia) (see paper)
D3U717 arogenate dehydratase (EC 4.2.1.91) from Petunia x hybrida (see paper)
    35% identity, 89% coverage of query (126 bits)

A0A1I9WKA1 prephenate dehydratase (EC 4.2.1.51) from Pinus pinaster (see paper)
    38% identity, 89% coverage of query (125 bits)

AROD4_ARATH / O22241 Arogenate dehydratase 4, chloroplastic; AtADT4; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O22241 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana (see 4 papers)
    37% identity, 89% coverage of query (124 bits)

2qmxA / Q8KBW6 The crystal structure of l-phe inhibited prephenate dehydratase from chlorobium tepidum tls (see paper)
    33% identity, 88% coverage of query (123 bits)

Q74NC4 prephenate dehydratase (EC 4.2.1.51) from Nanoarchaeum equitans (see paper)
    31% identity, 89% coverage of query (122 bits)

Build an alignment

Build an alignment for WP_012850512.1 and 20 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

phenA prephenate dehydratase from Emericella nidulans (see 2 papers)
    29% identity, 89% coverage of query (119 bits)

AROD3_ARATH / Q9ZUY3 Arogenate dehydratase 3, chloroplastic; AtADT3; Prephenate dehydratase 1; AtPDT1; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9ZUY3 prephenate dehydratase (EC 4.2.1.51); arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana (see 7 papers)
    34% identity, 89% coverage of query (118 bits)

AROD1_PETHY / D3U715 Arogenate dehydratase 1; PhADT1; EC 4.2.1.91 from Petunia hybrida (Petunia) (see 4 papers)
D3U715 arogenate dehydratase (EC 4.2.1.91) from Petunia x hybrida (see paper)
    36% identity, 89% coverage of query (118 bits)

AROD6_ARATH / Q9SGD6 Arogenate dehydratase/prephenate dehydratase 6, chloroplastic; AtADT6; AtPDT6; EC 4.2.1.51; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9SGD6 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana (see 5 papers)
    34% identity, 89% coverage of query (118 bits)

AROD5_ARATH / Q9FNJ8 Arogenate dehydratase 5, chloroplastic; AtADT5; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9FNJ8 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana (see 5 papers)
    36% identity, 89% coverage of query (117 bits)

CA265_RS11630 prephenate and/or arogenate dehydratase (EC 4.2.1.51) from Pedobacter sp. GW460-11-11-14-LB5
    29% identity, 90% coverage of query (115 bits)

PHA2_SCHPO / O14361 Putative prephenate dehydratase; PDT; EC 4.2.1.51 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
    29% identity, 89% coverage of query (113 bits)

Echvi_0123 prephenate and/or arogenate dehydratase (EC 4.2.1.51) from Echinicola vietnamensis KMM 6221, DSM 17526
    29% identity, 89% coverage of query (112 bits)

pha2 / RF|NP_596269.1 phrenate dehydratase; EC 4.2.1.51 from Schizosaccharomyces pombe (see 3 papers)
    27% identity, 89% coverage of query (107 bits)

3luyA / A1A2B5 Putative chorismate mutase from bifidobacterium adolescentis
    32% identity, 91% coverage of query (103 bits)

BT3936 prephenate and/or arogenate dehydratase (EC 4.2.1.51) from Bacteroides thetaiotaomicron VPI-5482
    27% identity, 89% coverage of query (101 bits)

PheA / b2599 fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheA / P0A9J8 fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51) from Escherichia coli (strain K12) (see 16 papers)
CMPDT_ECOLI / P0A9J8 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Escherichia coli (strain K12) (see paper)
CH_024084 P-protein; EC 4.2.1.51; EC 5.4.99.5 from Escherichia coli K12 (see paper)
    29% identity, 89% coverage of query (97.8 bits)

CMPDT_BUCAI / P57472 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) (see paper)
P57472 prephenate dehydratase (EC 4.2.1.51) from Buchnera aphidicola (see paper)
    23% identity, 91% coverage of query (96.3 bits)

C7EXK8 prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Escherichia coli (see 2 papers)
    29% identity, 89% coverage of query (95.9 bits)

Q5NLV8 prephenate dehydratase (EC 4.2.1.51) from Zymomonas mobilis (see paper)
    34% identity, 82% coverage of query (92.4 bits)

7am0B / A0A0M0ELU2 Gqqa- a novel type of quorum quenching acylases (see paper)
    32% identity, 80% coverage of query (90.9 bits)

PHA2_YEAST / P32452 Probable prephenate dehydratase; PDT; Phenylalanine-requiring protein 2; EC 4.2.1.51 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    25% identity, 75% coverage of query (80.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory