Searching for up to 100 curated homologs for WP_012851086.1 NCBI__GCF_000024385.1:WP_012851086.1 (397 a.a.)
Found high-coverage hits (≥70%) to 19 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
SO1963 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Shewanella oneidensis MR-1
43% identity, 99% coverage of query (305 bits)
Psest_3513 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas stutzeri RCH2
34% identity, 97% coverage of query (187 bits)
Build an alignment for WP_012851086.1 and 2 homologs with ≥ 30% identity
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HGD_EMENI / Q00667 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
GI|2832726 homogentisate dioxygenase; EC 1.13.11.5; EC 1.13.11.15 from Emericella nidulans (see 2 papers)
hmgA / CAA05042.1 homogentisate dioxygenase from Aspergillus nidulans (see paper)
27% identity, 93% coverage of query (82.0 bits)
HMGA_ASPFU / Q4WHT9 Homogentisate 1,2-dioxygenase hmgA; Homogentisate oxygenase hmgA; Homogentisic acid oxidase hmgA; Homogentisicase hmgA; L-tyrosine degradation gene cluster protein hmgA; Pyomelanin biosynthesis cluster protein hmgA; EC 1.13.11.5 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
26% identity, 83% coverage of query (77.4 bits)
HGD_RHIME / Q9X4F5 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
25% identity, 71% coverage of query (69.7 bits)
HGD_CAEEL / Q9Y041 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Caenorhabditis elegans (see paper)
25% identity, 94% coverage of query (68.9 bits)
RR42_RS31275 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Cupriavidus basilensis FW507-4G11
27% identity, 71% coverage of query (68.6 bits)
HGD / Q93099 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Homo sapiens (see paper)
HGD_HUMAN / Q93099 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Homo sapiens (Human) (see 14 papers)
26% identity, 94% coverage of query (66.2 bits)
4aq6D / Q88E47 Substrate bound homogentisate 1,2-dioxygenase (see paper)
25% identity, 94% coverage of query (65.9 bits)
HGD_PSEPK / Q88E47 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
Q88E47 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas putida (see paper)
25% identity, 94% coverage of query (65.9 bits)
3zdsF Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
25% identity, 94% coverage of query (65.9 bits)
3zdsC Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
25% identity, 94% coverage of query (65.9 bits)
3zdsA Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
25% identity, 94% coverage of query (65.5 bits)
B8YB76 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Bos taurus (see 2 papers)
25% identity, 94% coverage of query (64.7 bits)
HGD_PSEPU / Q6EMI9 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
26% identity, 94% coverage of query (63.2 bits)
HGD_MOUSE / O09173 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Mus musculus (Mouse) (see paper)
25% identity, 94% coverage of query (61.6 bits)
Pf6N2E2_5290 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens FW300-N2E2
24% identity, 70% coverage of query (59.7 bits)
PfGW456L13_4962 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens GW456-L13
24% identity, 70% coverage of query (57.4 bits)
AO353_15550 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens FW300-N2E3
24% identity, 70% coverage of query (55.8 bits)
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Lawrence Berkeley National Laboratory