Searching for up to 100 curated homologs for WP_012851176.1 NCBI__GCF_000024385.1:WP_012851176.1 (413 a.a.)

Found high-coverage hits (≥70%) to 34 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
    36% identity, 96% coverage of query (250 bits)

thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
    36% identity, 79% coverage of query (169 bits)

2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
    34% identity, 84% coverage of query (158 bits)

O66740 threonine synthase (EC 4.2.3.1) from Aquifex aeolicus (see paper)
    34% identity, 84% coverage of query (157 bits)

P83823 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see paper)
Q5SL02 threonine synthase (EC 4.2.3.1) from Thermus thermophilus (see 2 papers)
3aexA / Q5SL02 Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
    37% identity, 80% coverage of query (156 bits)

1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
    37% identity, 80% coverage of query (156 bits)

1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form
    37% identity, 80% coverage of query (156 bits)

3aeyA Apo form of threonine synthase from thermus thermophilus hb8
    37% identity, 80% coverage of query (156 bits)

6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    33% identity, 84% coverage of query (155 bits)

6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
    32% identity, 84% coverage of query (154 bits)

6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    32% identity, 84% coverage of query (154 bits)

THRC_MYCTU / P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG59 threonine synthase (EC 4.2.3.1) from Mycobacterium tuberculosis (see 2 papers)
    33% identity, 81% coverage of query (142 bits)

2d1fA / P9WG59 Structure of mycobacterium tuberculosis threonine synthase (see paper)
    33% identity, 81% coverage of query (142 bits)

A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    33% identity, 81% coverage of query (141 bits)

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Build an alignment for WP_012851176.1 and 14 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

THRC1_ARATH / Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    29% identity, 74% coverage of query (122 bits)

THRC2_ARATH / Q9SSP5 Threonine synthase 2, chloroplastic; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    29% identity, 71% coverage of query (122 bits)

2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine
    29% identity, 74% coverage of query (122 bits)

2c2gA / Q9S7B5 Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
    28% identity, 74% coverage of query (114 bits)

DvMF_1945 threonine synthase (EC 4.2.3.1) from Desulfovibrio vulgaris Miyazaki F
    26% identity, 90% coverage of query (86.7 bits)

TSAL_GEOSL / Q74FW6 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine/serine ammonia-lyase; EC 4.3.1.19; EC 4.3.1.17 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74FW6 threonine ammonia-lyase (EC 4.3.1.19) from Geobacter sulfurreducens (see paper)
    27% identity, 75% coverage of query (62.0 bits)

T1KF23 L-3-cyanoalanine synthase (EC 4.4.1.9) from Tetranychus urticae (see paper)
    25% identity, 74% coverage of query (55.5 bits)

B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica (see paper)
    27% identity, 73% coverage of query (55.1 bits)

7mfjBBB / T1KF23 7mfjBBB (see paper)
    25% identity, 74% coverage of query (54.7 bits)

CysM / b2421 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1; EC 4.4.1.28) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
cysM / P16703 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1) from Escherichia coli (strain K12) (see 15 papers)
CYSM_ECOLI / P16703 Cysteine synthase B; CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B; EC 2.5.1.47 from Escherichia coli (strain K12) (see paper)
    25% identity, 75% coverage of query (52.8 bits)

2bhtA / P16703 Crystal structure of o-acetylserine sulfhydrylase b (see paper)
    25% identity, 75% coverage of query (52.8 bits)

THDH_SCHPO / O94634 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    24% identity, 73% coverage of query (51.2 bits)

2ecoA / Q5SLE6 Crystal structure of t.Th. Hb8 o-acetylserine sulfhydrylase complexed with 4-methylvalerate
    25% identity, 74% coverage of query (48.9 bits)

2efyA Crystal structure of t.Th. Hb8 o-acetylserine sulfhydrylase complexed with 4-acetylbutyric acid
    25% identity, 74% coverage of query (48.9 bits)

2ecqA Crystal structure of t.Th. Hb8 o-acetylserine sulfhydrylase complexed with 3-hydroxylactate
    25% identity, 74% coverage of query (48.9 bits)

MA_3297 / Q8TKU7 cysteate synthase monomer (EC 2.5.1.76) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
CYAS_METAC / Q8TKU7 Cysteate synthase; CS; Cya synthase; EC 2.5.1.76 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
Q8TKU7 cysteate synthase (EC 2.5.1.76) from Methanosarcina acetivorans (see paper)
    25% identity, 91% coverage of query (48.5 bits)

A0A220K8B9 L-3-cyanoalanine synthase (EC 4.4.1.9) from Plutella xylostella (see paper)
    27% identity, 74% coverage of query (47.8 bits)

SDHL_RAT / P09367 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Rattus norvegicus (Rat) (see 7 papers)
P09367 L-serine ammonia-lyase (EC 4.3.1.17) from Rattus norvegicus (see 3 papers)
    25% identity, 70% coverage of query (46.6 bits)

LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    23% identity, 73% coverage of query (46.2 bits)

SDSL_RAT / A0A6N3IN21 Serine dehydratase-like; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; EC 5.1.1.3; EC 4.3.1.17; EC 4.3.1.19 from Rattus norvegicus (Rat) (see paper)
    23% identity, 72% coverage of query (46.2 bits)

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