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Searching for up to 100 curated homologs for WP_012851206.1 NCBI__GCF_000024385.1:WP_012851206.1 (370 a.a.)

Found high-coverage hits (≥70%) to 49 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2fyfA / P9WQ73 Structure of a putative phosphoserine aminotransferase from mycobacterium tuberculosis (see paper)
    67% identity, 99% coverage of query (514 bits)

SERC_MYCTU / P9WQ73 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WQ73 phosphoserine transaminase (EC 2.6.1.52) from Mycobacterium tuberculosis (see paper)
    67% identity, 99% coverage of query (511 bits)

Build an alignment

Build an alignment for WP_012851206.1 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

3ffrA Crystal structure of a phosphoserine aminotransferase serc (chu_0995) from cytophaga hutchinsonii atcc 33406 at 1.75 a resolution
    25% identity, 94% coverage of query (99.8 bits)

5yb0B / Q60I38 Crystal structure of wild type phosphoserine aminotransferase (psat) from e. Histolytica (see paper)
    23% identity, 94% coverage of query (82.8 bits)

PSAT1 / Q9Y617 Phosphoserine aminotransferase (EC 2.6.1.52) from Homo sapiens (see 2 papers)
SERC_HUMAN / Q9Y617 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Homo sapiens (Human) (see 7 papers)
Q9Y617 glycine transaminase (EC 2.6.1.4); phosphoserine transaminase (EC 2.6.1.52) from Homo sapiens (see 5 papers)
    25% identity, 95% coverage of query (76.6 bits)

8a5vE / Q9Y617 Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
    25% identity, 95% coverage of query (76.3 bits)

8a5wC Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine
    25% identity, 95% coverage of query (76.3 bits)

8a5wA Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine
    25% identity, 95% coverage of query (76.3 bits)

8a5vA Crystal structure of the human phosposerine aminotransferase (psat)
    25% identity, 95% coverage of query (76.3 bits)

serC / Q58369 phosphoserine aminotransferase monomer (EC 2.6.1.1; EC 2.6.1.52) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
    27% identity, 95% coverage of query (75.9 bits)

8a5wE Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine
    24% identity, 95% coverage of query (73.6 bits)

3e77A Human phosphoserine aminotransferase in complex with plp
    25% identity, 90% coverage of query (73.6 bits)

V9NC98 phosphoserine transaminase (EC 2.6.1.52) from Acanthamoeba castellanii (see paper)
    22% identity, 87% coverage of query (69.7 bits)

SERC_DROME / Q9VAN0 Probable phosphoserine aminotransferase; PSAT; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Drosophila melanogaster (Fruit fly) (see paper)
    23% identity, 93% coverage of query (69.3 bits)

serC / Q8TNI1 phosphoserine aminotransferase monomer (EC 2.6.1.52; EC 2.6.1.1) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see 2 papers)
    24% identity, 96% coverage of query (68.9 bits)

3qboB Crystal structure of phosphoserine aminotransferase from yersinia pestis co92
    23% identity, 93% coverage of query (67.4 bits)

SERC_NIACI / Q59196 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Niallia circulans (Bacillus circulans) (see 2 papers)
Q59196 phosphoserine transaminase (EC 2.6.1.52) from Niallia circulans (see paper)
serC / CAA86558.2 phosphoserine aminotransferase from Bacillus circulans subsp. alkalophilus (see paper)
    24% identity, 95% coverage of query (67.4 bits)

1bt4A / Q59196 Phosphoserine aminotransferase from bacillus circulans subsp. Alkalophilus
    24% identity, 95% coverage of query (67.0 bits)

SERC_METBF / P52878 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Methanosarcina barkeri (strain Fusaro / DSM 804) (see paper)
P52878 phosphoserine transaminase (EC 2.6.1.52) from Methanosarcina barkeri (see paper)
    23% identity, 96% coverage of query (66.6 bits)

6czyA / Q96255 Crystal structure of arabidopsis thaliana phosphoserine aminotransferase isoform 1 (atpsat1) in complex with pyridoxamine-5'- phosphate (pmp) (see paper)
    24% identity, 94% coverage of query (65.5 bits)

6czzA Crystal structure of arabidopsis thaliana phosphoserine aminotransferase isoform 1 (atpsat1) in complex with plp- phosphoserine geminal diamine intermediate
    24% identity, 94% coverage of query (65.5 bits)

PSAT / Q96255 phosphoserine aminotransferase (EC 2.6.1.52) from Arabidopsis thaliana (see paper)
SERB1_ARATH / Q96255 Phosphoserine aminotransferase 1, chloroplastic; AtPSAT1; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q96255 phosphoserine transaminase (EC 2.6.1.52) from Arabidopsis thaliana (see 3 papers)
    24% identity, 94% coverage of query (65.1 bits)

SERB2_ARATH / Q9SHP0 Phosphoserine aminotransferase 2, chloroplastic; AtPSAT2; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SHP0 phosphoserine transaminase (EC 2.6.1.52) from Arabidopsis thaliana (see paper)
    23% identity, 94% coverage of query (62.4 bits)

SerC / b0907 phosphoserine/phosphohydroxythreonine aminotransferase (EC 2.6.1.52; EC 2.6.1.17) from Escherichia coli K-12 substr. MG1655 (see 21 papers)
serC / P23721 phosphoserine/phosphohydroxythreonine aminotransferase (EC 2.6.1.52; EC 2.6.1.17) from Escherichia coli (strain K12) (see 21 papers)
SERC_ECOLI / P23721 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Escherichia coli (strain K12) (see 3 papers)
P23721 phosphoserine transaminase (EC 2.6.1.52) from Escherichia coli (see paper)
serC phosphoserine aminotransferase; EC 2.6.1.52 from Escherichia coli K12 (see 9 papers)
    23% identity, 95% coverage of query (62.0 bits)

2dr1A / O59033 Crystal structure of the ph1308 protein from pyrococcus horikoshii ot3
    21% identity, 98% coverage of query (61.6 bits)

Q2F5M8 phosphoserine transaminase (EC 2.6.1.52) from Bombyx mori (see paper)
    23% identity, 94% coverage of query (60.1 bits)

1bjoA / P23721 The structure of phosphoserine aminotransferase from e. Coli in complex with alpha-methyl-l-glutamate (see paper)
    23% identity, 95% coverage of query (60.1 bits)

rhiJ / D4HRI8 L-α-amino acid transaminase from Bacillus subtilis subsp. spizizenii ATCC 6633 (see paper)
    25% identity, 95% coverage of query (59.3 bits)

AGT1_RABIT / P31030 Alanine--glyoxylate aminotransferase; AGT; Serine--pyruvate aminotransferase; SPT; EC 2.6.1.44; EC 2.6.1.51 from Oryctolagus cuniculus (Rabbit) (see paper)
    25% identity, 79% coverage of query (58.2 bits)

SERC_SPIOL / P52877 Phosphoserine aminotransferase, chloroplastic; PSAT; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Spinacia oleracea (Spinach) (see paper)
    24% identity, 94% coverage of query (55.1 bits)

7t7jB / A6T700 Crystal structure of phosphoserine aminotransferase from klebsiella pneumoniae subsp. Pneumoniae in complex with pyridoxal phosphate
    22% identity, 93% coverage of query (53.9 bits)

3kgwB / O35423 Crystal structure of putative aminotransferase (aah25799.1) from mus musculus at 1.65 a resolution
    23% identity, 81% coverage of query (53.5 bits)

3kgxA Crystal structure of putative aminotransferase (aah25799.1) from mus musculus at 1.80 a resolution
    23% identity, 81% coverage of query (53.5 bits)

Agxt / P09139 serine-pyruvate aminotransferase, mitochondrial subunit (EC 2.6.1.51) from Rattus norvegicus (see 5 papers)
AGT1_RAT / P09139 Alanine--glyoxylate aminotransferase; AGT; Serine--pyruvate aminotransferase, mitochondrial; SPT; EC 2.6.1.44; EC 2.6.1.51 from Rattus norvegicus (Rat) (see 3 papers)
    24% identity, 79% coverage of query (52.4 bits)

SGAA_METEA / P55819 Serine--glyoxylate aminotransferase; SGAT; EC 2.6.1.45 from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (Methylobacterium extorquens) (see paper)
    26% identity, 83% coverage of query (52.0 bits)

6xdkD / B2FKF0 Crystal structure of phosphoserine aminotransferase (serc) from stenotrophomonas maltophilia k279a
    26% identity, 94% coverage of query (52.0 bits)

2yriA / Q5SLX0 Crystal structure of alanine-pyruvate aminotransferase with 2- methylserine
    24% identity, 78% coverage of query (49.3 bits)

2yrrA Hypothetical alanine aminotransferase (tth0173) from thermus thermophilus hb8
    24% identity, 78% coverage of query (49.3 bits)

A2V838 alanine-glyoxylate transaminase (EC 2.6.1.44) from Homo sapiens (see 2 papers)
    23% identity, 79% coverage of query (48.5 bits)

1h0cA The crystal structure of human alanine:glyoxylate aminotransferase
    22% identity, 79% coverage of query (48.5 bits)

5hhyA Structure of human alanine:glyoxylate aminotransferase major allele (agt-ma) showing x-ray induced reduction of plp internal aldimine to 4'-deoxy-piridoxine-phosphate (plr)
    22% identity, 79% coverage of query (47.8 bits)

AGXT1 / P21549 Serine--pyruvate aminotransferase (EC 2.6.1.44; EC 2.6.1.51) from Homo sapiens (see 6 papers)
AGT1_HUMAN / P21549 Alanine--glyoxylate aminotransferase; AGT; Serine--pyruvate aminotransferase; SPT; EC 2.6.1.44; EC 2.6.1.51 from Homo sapiens (Human) (see 26 papers)
    22% identity, 79% coverage of query (47.4 bits)

6rv0A Human alanine:glyoxylate aminotransferase major allele (agt-ma); with pmp in the active site
    22% identity, 79% coverage of query (47.4 bits)

4azjA / Q9RME2 Structural basis of l-phosphoserine binding to bacillus alcalophilus phosphoserine aminotransferase (see paper)
    20% identity, 94% coverage of query (47.0 bits)

SERC_ALKAL / Q9RME2 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Alkalihalobacillus alcalophilus (Bacillus alcalophilus) (see 3 papers)
Q9RME2 phosphoserine transaminase (EC 2.6.1.52) from Alkalihalobacillus alcalophilus (see paper)
    20% identity, 94% coverage of query (47.0 bits)

1j04A / P21549 Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro (see paper)
    22% identity, 79% coverage of query (46.2 bits)

1w23B Crystal structure of phosphoserine aminotransferase from bacillus alcalophilus
    20% identity, 94% coverage of query (45.8 bits)

6xdkB Crystal structure of phosphoserine aminotransferase (serc) from stenotrophomonas maltophilia k279a
    26% identity, 94% coverage of query (45.1 bits)

3qm2B / P55900 2.25 angstrom crystal structure of phosphoserine aminotransferase (serc) from salmonella enterica subsp. Enterica serovar typhimurium
    23% identity, 83% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory