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Searching for up to 100 curated homologs for WP_012965630.1 NCBI__GCF_000025505.1:WP_012965630.1 (342 a.a.)

Found high-coverage hits (≥70%) to 53 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

asd / Q57658 aspartate-semialdehyde dehydrogenase monomer (EC 1.2.1.11) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
DHAS_METJA / Q57658 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
    60% identity, 100% coverage of query (425 bits)

1ys4A / Q57658 Structure of aspartate-semialdehyde dehydrogenase from methanococcus jannaschii (see paper)
    60% identity, 100% coverage of query (424 bits)

P78780 Probable aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    50% identity, 99% coverage of query (318 bits)

4zicC / A0A140UHG6 Crystal structure of aspartate semialdehyde dehydrogenase with NADP from trichophyton rubrum (see paper)
    48% identity, 97% coverage of query (308 bits)

C5GC63 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Blastomyces dermatitidis (see paper)
    46% identity, 97% coverage of query (295 bits)

6c8wA Crystal structure of aspartate semialdehyde dehydrogenase with NADP from blastomyces dermatitidis (see paper)
    46% identity, 97% coverage of query (287 bits)

Msed_0709 / A4YEN2 succinyl-CoA reductase (NADPH) subunit (EC 1.2.1.75; EC 1.2.1.76) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 3 papers)
MCR_METS5 / A4YEN2 Malonyl CoA reductase (NADP); NADP-dependent malonyl CoA reductase; EC 1.2.1.75 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
    45% identity, 99% coverage of query (285 bits)

Q5KPK7 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Cryptococcus neoformans var. neoformans (see paper)
    45% identity, 100% coverage of query (285 bits)

6c85A Crystal structure of aspartate semialdehyde dehydrogenase from blastomyces dermatitidis with p-benzoquinone
    46% identity, 97% coverage of query (283 bits)

Q4WWR8 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Aspergillus fumigatus (see paper)
    45% identity, 98% coverage of query (278 bits)

3hskA / Q5ALM0 Crystal structure of aspartate semialdehyde dehydrogenase with NADP from candida albicans (see paper)
    43% identity, 99% coverage of query (270 bits)

4dpkA / Q96YK1 Structure of malonyl-coenzyme a reductase from crenarchaeota (see paper)
    45% identity, 99% coverage of query (270 bits)

mcr / Q96YK1 malonyl-CoA reductase subunit (EC 1.2.1.75) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see paper)
MCR_SULTO / Q96YK1 Malonyl-CoA reductase; EC 1.2.1.75 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
Q96YK1 malonyl-CoA reductase (malonate semialdehyde-forming) (EC 1.2.1.75) from Sulfurisphaera tokodaii (see 3 papers)
    45% identity, 99% coverage of query (270 bits)

4dpmA Structure of malonyl-coenzyme a reductase from crenarchaeota in complex with coa
    45% identity, 99% coverage of query (270 bits)

4dplA Structure of malonyl-coenzyme a reductase from crenarchaeota in complex with NADP
    45% identity, 99% coverage of query (270 bits)

DHAS_YEAST / P13663 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    43% identity, 99% coverage of query (266 bits)

8jusA / A0AAF0BGE9 Crystal structure of aspartate semialdehyde dehydrogenase from porphyromonas gingivalis complexed with 2',5'adenosine diphosphate
    31% identity, 98% coverage of query (142 bits)

DHAS2_VIBCH / P23247 Aspartate-semialdehyde dehydrogenase 2; ASA dehydrogenase 2; ASADH 2; Aspartate-beta-semialdehyde dehydrogenase 2; EC 1.2.1.11 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see 2 papers)
    33% identity, 99% coverage of query (134 bits)

2r00C / P23247 Crystal structure of aspartate semialdehyde dehydrogenase ii complexed with asa from vibrio cholerae (see paper)
    33% identity, 99% coverage of query (134 bits)

Q8KQ27 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Streptomyces clavuligerus (see paper)
    31% identity, 99% coverage of query (124 bits)

Build an alignment

Build an alignment for WP_012965630.1 and 20 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

asd / Q04797 aspartate semialdehyde dehydrogenase subunit (EC 1.2.1.11) from Bacillus subtilis (strain 168) (see paper)
    28% identity, 99% coverage of query (123 bits)

Q04797 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Bacillus subtilis (strain 168)
    28% identity, 99% coverage of query (123 bits)

DHAS_MYCTU / P9WNX5 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WNX5 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Mycobacterium tuberculosis (see 5 papers)
    30% identity, 99% coverage of query (116 bits)

3tz6A / P9WNX5 Crystal structure of aspartate semialdehyde dehydrogenase complexed with inhibitor smcs (cys) and phosphate from mycobacterium tuberculosis h37rv (see paper)
    30% identity, 98% coverage of query (113 bits)

3pylC Crystal structure of aspartate beta-semialdehide dehydrogenase from streptococcus pneumoniae with d-2,3-diaminopropionate (see paper)
    29% identity, 97% coverage of query (102 bits)

4r54A Complex crystal structure of sp-aspartate-semialdehyde-dehydrogenase with 3-carboxy-ethyl-phthalic acid
    29% identity, 97% coverage of query (102 bits)

4r41A Complex crystal structure of 4-nitro-2-phosphono-benzoic acid with sp- aspartate-semialdehyde dehydrogenase and nicotinamide-dinucleotide
    29% identity, 97% coverage of query (102 bits)

4r3nA Crystal structure of the ternary complex of sp-asadh with NADP and 1, 2,3-benzenetricarboxylic acid
    29% identity, 97% coverage of query (102 bits)

3q1lA Crystals structure of aspartate beta-semialdehyde dehydrogenase from streptococcus pneumoniae with cysteamine bound covalently to cys 128
    29% identity, 97% coverage of query (102 bits)

3pwsA Crystal structure of aspartate beta-semialdehide dehydrogenase from streptococcus pneumoniae with 2',5'-adenosine diphosphate and d-2- aminoadipate
    29% identity, 97% coverage of query (102 bits)

3pwkA Crystal structure of aspartate beta-semialdehide dehydrogenase from streptococcus pneumoniae with 2',5'-adenosine diphosphate and d-2- aminoadipate
    29% identity, 97% coverage of query (102 bits)

2gz3A Structure of aspartate semialdehyde dehydrogenase (asadh) from streptococcus pneumoniae complexed with NADP and aspartate- semialdehyde
    29% identity, 97% coverage of query (102 bits)

2gz2A Structure of aspartate semialdehyde dehydrogenase (asadh) from streptococcus pneumoniae complexed with 2',5'-adp
    29% identity, 97% coverage of query (102 bits)

2gz1A Structure of aspartate semialdehyde dehydrogenase (asadh) from streptococcus pneumoniae complexed with NADP
    29% identity, 97% coverage of query (102 bits)

3q11A Crystals structure of aspartate beta-semialdehyde dehydrogenase from streptococcus pneumoniae with NADP and aspartyl beta- difluorophosphonate
    29% identity, 97% coverage of query (102 bits)

4r5hA Crystal structure of sp-aspartate-semialdehyde-dehydrogenase with nicotinamide-adenine-dinucleotide-phosphate and 3-carboxy-propenyl- phthalic acid
    29% identity, 97% coverage of query (102 bits)

4r4jA Crystal structure of complex sp_asadh with 3-carboxypropyl-phthalic acid and nicotinamide adenine dinucleotide phosphate
    29% identity, 97% coverage of query (102 bits)

3pyxB Crystals structure of aspartate beta-semialdehyde dehydrogenase complex with NADP and 2-aminoterephthalate
    29% identity, 97% coverage of query (102 bits)

4r51A Crystal complex structure of sp-aspartate-semialdehyde-dehydrogenase with nicotinamide adenine dinucleotide phosphate and phthalic acid
    29% identity, 97% coverage of query (102 bits)

AT1G14810 / Q8VYI4 aspartate semialdehyde dehydrogenase (EC 1.2.1.11) from Arabidopsis thaliana (see paper)
    29% identity, 97% coverage of query (96.3 bits)

Usg / b2319 putative semialdehyde dehydrogenase Usg from Escherichia coli K-12 substr. MG1655 (see 6 papers)
usg / RF|NP_416822 USG-1 protein from Escherichia coli K12 (see 2 papers)
    26% identity, 99% coverage of query (76.6 bits)

Q5JFW1 [amino-group carrier protein]-5-phospho-L-glutamate reductase (EC 1.2.1.106) from Thermococcus kodakarensis (see paper)
    24% identity, 72% coverage of query (64.3 bits)

DHAS_PSEAE / Q51344 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    24% identity, 94% coverage of query (57.8 bits)

5bntC / Q51344 X-ray crystal structure of a aspartate-semialdehyde dehydrogenase bound to NADP from pseudomonas aeruginosa
    24% identity, 94% coverage of query (57.8 bits)

Q5NHM4 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Francisella tularensis subsp. tularensis (see paper)
    22% identity, 95% coverage of query (57.4 bits)

asd / AAB51626.1 aspartate semialdehyde dehydrogenase from Pseudomonas aeruginosa (see paper)
    24% identity, 94% coverage of query (56.2 bits)

ARGC_ARATH / Q93Z70 Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Arabidopsis thaliana (Mouse-ear cress)
    22% identity, 98% coverage of query (55.5 bits)

DHAS_SALTY / P0A1F8 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    24% identity, 94% coverage of query (53.9 bits)

DHAS_HAEIN / P44801 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
P44801 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Haemophilus influenzae (see 4 papers)
    24% identity, 94% coverage of query (53.5 bits)

Dap / b3433 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
asd / P0A9Q9 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) from Escherichia coli (strain K12) (see 12 papers)
DHAS_ECOLI / P0A9Q9 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Escherichia coli (strain K12) (see 5 papers)
1gl3A / P0A9Q9 Aspartate beta-semialdehyde dehydrogenase in complex with NADP and substrate analogue s-methyl cysteine sulfoxide (see paper)
asd / RF|NP_417891 aspartate-semialdehyde dehydrogenase from Escherichia coli K12 (see 2 papers)
    24% identity, 94% coverage of query (52.0 bits)

ABZR86_RS08700 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Dyella japonica UNC79MFTsu3.2
    24% identity, 97% coverage of query (51.2 bits)

1pquA / P44801 Crystal structure of the h277n mutant of aspartate semialdehyde dehydrogenase from haemophilus influenzae bound with NADP, s-methyl cysteine sulfoxide and cacodylate (see paper)
    24% identity, 94% coverage of query (50.4 bits)

ARG5,6 arginine biosynthetic enzyme activities from Candida albicans (see 3 papers)
    22% identity, 97% coverage of query (45.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory