Searching for up to 100 curated homologs for WP_012966712.1 NCBI__GCF_000025505.1:WP_012966712.1 (204 a.a.)

Found high-coverage hits (≥70%) to 42 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AROD_ARCFU / O30011 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
O30011 3-dehydroquinate dehydratase (EC 4.2.1.10) from Archaeoglobus fulgidus (see paper)
    53% identity, 98% coverage of query (194 bits)

aroD / Q6LXF7 3-dehydroquinate dehydratase (EC 4.2.1.10) from Methanococcus maripaludis (strain S2 / LL) (see paper)
AROD_METMP / Q6LXF7 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL) (see paper)
    37% identity, 90% coverage of query (94.7 bits)

A0A0A0LQ48 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Cucumis sativus (see paper)
    33% identity, 82% coverage of query (76.6 bits)

A0A5H2WZU5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis (see paper)
    31% identity, 83% coverage of query (75.9 bits)

A0A5H2X4C4 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis (see paper)
    32% identity, 82% coverage of query (73.6 bits)

A0A168S2G5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera (see paper)
    31% identity, 82% coverage of query (72.8 bits)

Q6PUF9 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum (see paper)
    33% identity, 82% coverage of query (72.0 bits)

2o7qA / Q9SQT8 Crystal structure of the a. Thaliana dhq-dehydroshikimate-sdh- shikimate-NADP(h)
    32% identity, 82% coverage of query (71.6 bits)

2o7sA Crystal structure of the a. Thaliana dhq-dehydroshikimate-sdh- shikimate-NADP(h)
    32% identity, 82% coverage of query (71.6 bits)

AT3G06350 / Q9SQT8 shikimate dehydrogenase (EC 1.1.1.25; EC 4.2.1.10) from Arabidopsis thaliana (see 3 papers)
DHQSD_ARATH / Q9SQT8 Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic; DHQ-SDH protein; DHQase-SORase; Protein EMBRYO DEFECTIVE 3004; EC 4.2.1.10; EC 1.1.1.25 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SQT8 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Arabidopsis thaliana (see 4 papers)
    32% identity, 82% coverage of query (71.2 bits)

6bmqA Crystal structure of arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase (t381g mutant) in complex with tartrate and shikimate
    32% identity, 82% coverage of query (71.2 bits)

2gptA Crystal structure of arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase in complex with tartrate and shikimate
    32% identity, 82% coverage of query (71.2 bits)

AROD_AQUAE / O66440 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Aquifex aeolicus (strain VF5) (see paper)
    31% identity, 87% coverage of query (69.7 bits)

A0A168S2H6 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera (see paper)
    30% identity, 83% coverage of query (68.9 bits)

A0A168S2B8 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera (see paper)
    34% identity, 82% coverage of query (68.2 bits)

A0A5H2WVH6 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Eucalyptus camaldulensis (see paper)
    30% identity, 82% coverage of query (67.8 bits)

Build an alignment

Build an alignment for WP_012966712.1 and 16 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

quiB / AAC37158.1 catabolic dehydroquinate dehydratase from Acinetobacter baylyi (see 11 papers)
    28% identity, 87% coverage of query (66.2 bits)

quiB / Q59087 catabolic 3-dehydroquinate dehydratase (EC 4.2.1.10) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see 2 papers)
3DHQ_ACIAD / Q59087 Catabolic 3-dehydroquinate dehydratase; 3-dehydroquinase; EC 4.2.1.10 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    28% identity, 87% coverage of query (65.9 bits)

A0A5H2X0F8 quinate/shikimate dehydrogenase (NAD+) (EC 1.1.1.24) from Eucalyptus camaldulensis (see paper)
    29% identity, 81% coverage of query (60.8 bits)

A0A5H2WXM2 quinate/shikimate dehydrogenase (NAD+) (EC 1.1.1.24) from Eucalyptus camaldulensis (see paper)
    29% identity, 81% coverage of query (59.7 bits)

1l9wA Crystal structure of 3-dehydroquinase from salmonella typhi complexed with reaction product
    24% identity, 83% coverage of query (53.5 bits)

4uioA Structure of the salmonella typhi type i dehydroquinase covalently inhibited by a 3-dehydroquinic acid derivative
    25% identity, 83% coverage of query (53.1 bits)

8b2cAAA 3-dehydroquinate dehydratase
    25% identity, 83% coverage of query (52.8 bits)

AROD_SALTI / P24670 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Salmonella typhi (see 3 papers)
P24670 3-dehydroquinate dehydratase (EC 4.2.1.10) from Salmonella enterica subsp. enterica serovar Typhi (see 2 papers)
8b2bAAA / P24670 8b2bAAA (see paper)
    25% identity, 83% coverage of query (52.8 bits)

6sfeA Crystal structure of dhq1 from salmonella typhi covalently modified by compound 7
    25% identity, 83% coverage of query (52.8 bits)

6h5jA Crystal structure of dhq1 from salmonella typhi covalently modified by ligand 4
    25% identity, 83% coverage of query (52.8 bits)

6h5gA Crystal structure of dhq1 from salmonella typhi covalently modified by ligand 3
    25% identity, 83% coverage of query (52.8 bits)

6h5cA Crystal structure of dhq1 from salmonella typhi covalently modified by ligand 1
    25% identity, 83% coverage of query (52.8 bits)

4cnpA Structure of the salmonella typhi type i dehydroquinase inhibited by a 3-epiquinic acid derivative
    25% identity, 83% coverage of query (52.8 bits)

4clmB Structure of salmonella typhi type i dehydroquinase irreversibly inhibited with a 1,3,4-trihydroxyciclohexane-1-carboxylic acid derivative
    25% identity, 83% coverage of query (52.8 bits)

1sfjA 2.4a crystal structure of staphylococcus aureus type i 3- dehydroquinase, with 3-dehydroquinate bound
    24% identity, 92% coverage of query (52.0 bits)

AROD_ENTFA / P36923 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Enterococcus faecalis (strain ATCC 700802 / V583) (see paper)
P36923 3-dehydroquinate dehydratase (EC 4.2.1.10) from Enterococcus faecalis (see paper)
    25% identity, 83% coverage of query (50.8 bits)

A0A3G3BK08 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Camellia sinensis (see paper)
    24% identity, 81% coverage of query (50.8 bits)

AroD / b1693 3-dehydroquinate dehydratase (EC 4.2.1.10) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
aroD / P05194 3-dehydroquinate dehydratase (EC 4.2.1.10) from Escherichia coli (strain K12) (see 6 papers)
AROD_ECOLI / P05194 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Escherichia coli (strain K12) (see 4 papers)
P05194 3-dehydroquinate dehydratase (EC 4.2.1.10) from Escherichia coli (see paper)
aroD / RF|NP_416208.1 3-dehydroquinate dehydratase; EC 4.2.1.10 from Escherichia coli K12 (see paper)
    24% identity, 83% coverage of query (49.7 bits)

AROD_STAAR / Q6GII7 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Staphylococcus aureus (strain MRSA252) (see paper)
    23% identity, 83% coverage of query (48.5 bits)

8b2aBBB / A0A6A9GSC0 8b2aBBB (see paper)
    24% identity, 71% coverage of query (46.2 bits)

D7TUX1 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera (see paper)
    25% identity, 80% coverage of query (46.2 bits)

6sfhA Crystal structure of dhq1 from staphylococcus aureus covalently modified by ligand 7
    24% identity, 71% coverage of query (46.2 bits)

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum (see paper)
    23% identity, 81% coverage of query (44.7 bits)

3js3A Crystal structure of type i 3-dehydroquinate dehydratase (arod) from clostridium difficile with covalent reaction intermediate
    25% identity, 81% coverage of query (43.1 bits)

AROD_CLOD6 / Q186A6 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Clostridioides difficile (strain 630) (Peptoclostridium difficile) (see paper)
    25% identity, 81% coverage of query (43.1 bits)

4h3dB / Q186A6 1.95 angstrom crystal structure of of type i 3-dehydroquinate dehydratase (arod) from clostridium difficile with covalent modified comenic acid.
    25% identity, 81% coverage of query (43.1 bits)

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