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Searching for up to 100 curated homologs for WP_012973905.1 NCBI__GCF_000010725.1:WP_012973905.1 (144 a.a.)

Found high-coverage hits (≥70%) to 8 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hisI / CAX46381.1 phosphoribosyl AMP-cyclohydrolase, partial from Chromohalobacter salexigens (see paper)
    68% identity, 74% coverage of query (149 bits)

HIS3_METTH / O26347 Phosphoribosyl-AMP cyclohydrolase; PRA-CH; EC 3.5.4.19 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see paper)
    52% identity, 85% coverage of query (129 bits)

HSERO_RS20310 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) from Herbaspirillum seropedicae SmR1
    47% identity, 83% coverage of query (120 bits)

Q8YH95 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) from Brucella melitensis bv. 1 (see paper)
    54% identity, 77% coverage of query (108 bits)

7bgmA / A0A072U2X9 Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
    41% identity, 72% coverage of query (93.2 bits)

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway
    41% identity, 72% coverage of query (93.2 bits)

At-IE / O82768 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19; EC 3.6.1.31) from Arabidopsis thaliana (see paper)
HIS2_ARATH / O82768 Histidine biosynthesis bifunctional protein hisIE, chloroplastic; Protein HISTIDINE BIOSYNTHESIS 2; EC 3.5.4.19; EC 3.6.1.31 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    41% identity, 73% coverage of query (91.3 bits)

HIS2_YEAST / P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    39% identity, 70% coverage of query (71.2 bits)

Build an alignment

Build an alignment for WP_012973905.1 and 8 homologs with ≥ 30% identity

Select sequences

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory