Searching for up to 100 curated homologs for WP_012973991.1 NCBI__GCF_000010725.1:WP_012973991.1 (275 a.a.)
Found high-coverage hits (≥70%) to 55 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q9ZE84 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Rickettsia prowazekii (see paper)
59% identity, 98% coverage of query (343 bits)
3undB / Q3JP68 Substrate-bound crystal structure of 2-dehydro-3-deoxyphosphooctonate aldolase from burkholderia pseudomallei (see paper)
52% identity, 96% coverage of query (277 bits)
O68662 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Actinobacillus pleuropneumoniae (see paper)
48% identity, 99% coverage of query (277 bits)
P45251 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Haemophilus influenzae (see paper)
47% identity, 99% coverage of query (275 bits)
Q9ZFK4 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Pseudomonas aeruginosa (see paper)
47% identity, 99% coverage of query (274 bits)
P95514 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Mannheimia haemolytica (see paper)
48% identity, 99% coverage of query (273 bits)
Q8GLK7 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Aquifex pyrophilus (see paper)
52% identity, 93% coverage of query (272 bits)
O66496 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Aquifex aeolicus (see 5 papers)
52% identity, 89% coverage of query (271 bits)
2a21A / O66496 Aquifex aeolicus kdo8ps in complex with pep, po4, and zn2+ (see paper)
52% identity, 89% coverage of query (271 bits)
3e0iA Cu2+ substituted aquifex aeolicus kdo8ps in complex with pep
52% identity, 89% coverage of query (271 bits)
1jcyA Aquifex aeolicus kdo8p synthase in complex with r5p, pep and cadmium
52% identity, 89% coverage of query (271 bits)
1fwwA Aquifex aeolicus kdo8p synthase in complex with pep, a5p and cadmium
52% identity, 89% coverage of query (271 bits)
1fwtA Aquifex aeolicus kdo8p synthase in complex with pep, e4p and cadmium
52% identity, 89% coverage of query (271 bits)
Q9JZ55 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Neisseria meningitidis serogroup B (see paper)
48% identity, 98% coverage of query (270 bits)
2nx3D Structural and mechanistic changes along an engineered path from metallo to non-metallo kdo8p synthase
52% identity, 89% coverage of query (270 bits)
KdsA / b1215 3-deoxy-D-manno-octulosonate 8-phosphate synthase (EC 2.5.1.55) from Escherichia coli K-12 substr. MG1655 (see 24 papers)
kdsA / P0A715 3-deoxy-D-manno-octulosonate 8-phosphate synthase (EC 2.5.1.55) from Escherichia coli (strain K12) (see 25 papers)
KDSA_ECOLI / P0A715 2-dehydro-3-deoxyphosphooctonate aldolase; 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase; EC 2.5.1.55 from Escherichia coli (strain K12) (see paper)
P0A715 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Escherichia coli (see 5 papers)
kdsA / PDB|1PHQ 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; EC 2.5.1.55 from Escherichia coli K12 (see 11 papers)
48% identity, 99% coverage of query (269 bits)
1g7vA Crystal structures of kdo8p synthase in its binary complexes with the mechanism-based inhibitor
48% identity, 99% coverage of query (269 bits)
2nx1A Structural and mechanistic changes along an engineered path from metallo to non-metallo kdo8p synthase
52% identity, 89% coverage of query (268 bits)
1g7uA / P0A715 Crystal structures of kdo8p synthase in its binary complex with substrate phosphoenol pyruvate (see paper)
48% identity, 99% coverage of query (266 bits)
Q9Z7I4 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Chlamydia pneumoniae (see paper)
51% identity, 90% coverage of query (263 bits)
3e12A Cu2+ substituted aquifex aeolicus kdo8ps in complex with kdo8p
51% identity, 89% coverage of query (263 bits)
kdsA1 / Q9AV97 3-deoxy-8-phosphooctulonate synthase subunit (EC 2.5.1.55) from Arabidopsis thaliana (see 2 papers)
KDSA1_ARATH / Q9AV97 2-dehydro-3-deoxyphosphooctonate aldolase 1; 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase 1; AtkdsA1; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase; EC 2.5.1.55 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9AV97 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Arabidopsis thaliana (see 4 papers)
50% identity, 93% coverage of query (261 bits)
KDSA2_ARATH / Q6NQL4 2-dehydro-3-deoxyphosphooctonate aldolase 2; 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase 2; AtkdsA2; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase; EC 2.5.1.55 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q6NQL4 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Arabidopsis thaliana (see 2 papers)
52% identity, 87% coverage of query (261 bits)
kdsA / CAA74644.1 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase from Pisum sativum (see paper)
kdsA / CAA74645.1 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase from Pisum sativum (see paper)
50% identity, 93% coverage of query (260 bits)
1pe1A Aquifex aeolicus kdo8ps in complex with cadmium and 2-pga
51% identity, 89% coverage of query (260 bits)
1pcwA Aquifex aeolicus kdo8ps in complex with cadmium and app, a bisubstrate inhibitor
51% identity, 89% coverage of query (260 bits)
1pckA Aquifex aeolicus kdo8ps in complex with z-methyl-pep
51% identity, 89% coverage of query (260 bits)
kdsA / BAB41014.1 2-dehydro-3-deoxyphosphooctonate aldolase from Arabidopsis thaliana (see paper)
50% identity, 93% coverage of query (259 bits)
1x6uA Kdo8p synthase in it's binary complex with the product kdo8p
47% identity, 99% coverage of query (258 bits)
1phwA Crystal structure of kdo8p synthase in its binary complex with substrate analog 1-deoxy-a5p
47% identity, 99% coverage of query (258 bits)
1phqA Crystal structure of kdo8p synthase in its binary complex with substrate analog e-fpep
47% identity, 99% coverage of query (258 bits)
1gg0A Crystal structure analysis of kdop synthase at 3.0 a
47% identity, 99% coverage of query (256 bits)
1jcxA Aquifex aeolicus kdo8p synthase in complex with api and cadmium
50% identity, 89% coverage of query (255 bits)
Q46225 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Chlamydia psittaci (see paper)
52% identity, 88% coverage of query (254 bits)
P0CD74 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Chlamydia trachomatis (see paper)
48% identity, 92% coverage of query (253 bits)
3fyoD / Q9JZ55 Crystal structure of the triple mutant (n23c/d247e/p249a) of 3-deoxy- d-manno-octulosonate 8-phosphate synthase (kdo8ps) from neisseria meningitidis (see paper)
46% identity, 98% coverage of query (253 bits)
Q9ZN55 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Helicobacter pylori (see paper)
45% identity, 92% coverage of query (230 bits)
P56060 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Helicobacter pylori (see paper)
46% identity, 92% coverage of query (229 bits)
4z1dA / P56060 Structure of pep and zinc bound kdo8ps from h.Pylori (see paper)
45% identity, 92% coverage of query (214 bits)
Q9WYH8 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Thermotoga maritima (see paper)
3pg9A / Q9WYH8 Thermotoga maritima dah7p synthase in complex with inhibitor (see paper)
32% identity, 96% coverage of query (116 bits)
1rzmA Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahps) from thermotoga maritima complexed with cd2+, pep and e4p
32% identity, 96% coverage of query (116 bits)
4grsA / Q8U0A9,Q9WYH8 Crystal structure of a chimeric dah7ps (see paper)
30% identity, 96% coverage of query (110 bits)
4c1kA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
30% identity, 96% coverage of query (107 bits)
1zcoB Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
30% identity, 96% coverage of query (105 bits)
1zcoA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
30% identity, 96% coverage of query (105 bits)
5j6fA / L8A208 Crystal structure of dah7ps-cm complex from geobacillus sp. With prephenate (see paper)
30% identity, 95% coverage of query (100 bits)
3nvtA / Q8Y6T2 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e (see paper)
30% identity, 92% coverage of query (97.8 bits)
3tfcA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e in complex with phosphoenolpyruvate
30% identity, 92% coverage of query (97.4 bits)
Build an alignment for WP_012973991.1 and 48 homologs with ≥ 30% identity
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P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis (see paper)
29% identity, 89% coverage of query (91.7 bits)
P39912 Protein AroA(G); EC 2.5.1.54; EC 5.4.99.5 from Bacillus subtilis (strain 168)
29% identity, 89% coverage of query (91.7 bits)
ccmA / BAA05463.1 32.4kD protein from Synechocystis sp. PCC 6803 (see paper)
30% identity, 81% coverage of query (82.8 bits)
A0A482F152 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from uncultured bacterium (see paper)
29% identity, 95% coverage of query (82.0 bits)
1vs1D / Q9YEJ7 Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep
29% identity, 91% coverage of query (67.4 bits)
Q9YEJ7 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Aeropyrum pernix (see paper)
29% identity, 91% coverage of query (67.4 bits)
Echvi_0120 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase / chorismate mutase (EC 2.5.1.54; EC 5.4.99.5) from Echinicola vietnamensis KMM 6221, DSM 17526
25% identity, 90% coverage of query (57.0 bits)
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Lawrence Berkeley National Laboratory