Searching for up to 100 curated homologs for WP_012974023.1 NCBI__GCF_000010725.1:WP_012974023.1 (353 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HIBCH_HUMAN / Q6NVY1 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase; HIB-CoA hydrolase; HIBYL-CoA-H; EC 3.1.2.4 from Homo sapiens (Human) (see 2 papers)
    48% identity, 98% coverage of query (333 bits)

Hibch / Q5XIE6 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Rattus norvegicus (see 5 papers)
HIBCH_RAT / Q5XIE6 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase; HIB-CoA hydrolase; HIBYL-CoA-H; EC 3.1.2.4 from Rattus norvegicus (Rat) (see 2 papers)
    48% identity, 99% coverage of query (332 bits)

3bptA / Q6NVY1 Crystal structure of human beta-hydroxyisobutyryl-coa hydrolase in complex with quercetin
    48% identity, 98% coverage of query (329 bits)

HIBC1_ARATH / Q9LKJ1 3-hydroxyisobutyryl-CoA hydrolase 1; CoA-thioester hydrolase CHY1; EC 3.1.2.-; EC 3.1.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9LKJ1 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Arabidopsis thaliana (see paper)
    42% identity, 97% coverage of query (267 bits)

PS417_13835 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Pseudomonas simiae WCS417
    43% identity, 95% coverage of query (263 bits)

AO353_25665 3-hydroxy-isobutyryl-CoA hydrolase (EC 3.1.2.4) from Pseudomonas fluorescens FW300-N2E3
    42% identity, 95% coverage of query (263 bits)

C3KM96 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Sinorhizobium fredii (see paper)
    47% identity, 95% coverage of query (263 bits)

echA9 / O53419 steroid enoyl-CoA hydratase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    45% identity, 98% coverage of query (260 bits)

PfGW456L13_2986 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Pseudomonas fluorescens GW456-L13
    43% identity, 96% coverage of query (255 bits)

Pf1N1B4_4790 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Pseudomonas fluorescens FW300-N1B4
    42% identity, 95% coverage of query (255 bits)

Psest_2439 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Pseudomonas stutzeri RCH2
    44% identity, 95% coverage of query (249 bits)

HIBCH_NEUCR / Q1K7A4 Small ribosomal subunit protein mS47; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase; HIB-CoA hydrolase; HIBYL-CoA-H; EC 3.1.2.4 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see paper)
    39% identity, 93% coverage of query (245 bits)

bch / Q81DR3 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) (see paper)
Q81DR3 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Bacillus cereus (see paper)
    38% identity, 95% coverage of query (244 bits)

4hdtA / G7CC99 Crystal structure of a carnitinyl-coa dehydratase from mycobacterium thermoresistibile (see paper)
    43% identity, 99% coverage of query (233 bits)

RR42_RS28545 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Cupriavidus basilensis FW507-4G11
    42% identity, 97% coverage of query (226 bits)

Q9SE41 enoyl-CoA hydratase (EC 4.2.1.17) from Avicennia marina (see paper)
    37% identity, 88% coverage of query (216 bits)

PGA1_c17350 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) from Phaeobacter inhibens DSM 17395
    39% identity, 97% coverage of query (195 bits)

EHD3 / Q5AI24 3-hydroxypropanonyl-CoA hydrolase (EC 3.1.2.4) from Candida albicans (strain SC5314 / ATCC MYA-2876) (see paper)
    33% identity, 92% coverage of query (179 bits)

HIBCH_YEAST / P28817 Small ribosomal subunit protein mS47; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase; HIB-CoA hydrolase; HIBYL-CoA-H; EC 3.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
    31% identity, 91% coverage of query (152 bits)

crt1 / A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) (see paper)
    30% identity, 90% coverage of query (101 bits)

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Build an alignment for WP_012974023.1 and 20 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

CRCH_SYNWW / Q0AVM1 Crotonyl-CoA hydratase; EC 4.2.1.150 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) (see paper)
    29% identity, 74% coverage of query (97.1 bits)

SIDH_ASPFU / Q4WF54 Mevalonyl-coenzyme A hydratase sidH; Siderophore biosynthesis protein H; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 6 papers)
    24% identity, 89% coverage of query (57.4 bits)

3pe8A / A0QVP0 Crystal structure of enoyl-coa hydratase from mycobacterium smegmatis (see paper)
    26% identity, 73% coverage of query (52.0 bits)

7xwtB / Q8RR28 Crystal structure of feruoyl-coa hydratase/lyase complexed with coa from sphingomonas paucimobilis (see paper)
    22% identity, 71% coverage of query (49.3 bits)

7xwvA Feruloyl-coa hydratase/lyase complexed with vanillin and coenzyme a
    22% identity, 72% coverage of query (49.3 bits)

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