Searching for up to 100 curated homologs for WP_012975006.1 NCBI__GCF_000010725.1:WP_012975006.1 (896 a.a.)
Found high-coverage hits (≥70%) to 49 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
HP15_3433 Aconitate hydratase (EC 4.2.1.3) from Marinobacter adhaerens HP15
63% identity, 99% coverage of query (1204 bits)
ACON_LEGPH / P37032 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; IP210; Iron-responsive protein-like; IRP-like; Major iron-containing protein; MICP; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) (see paper)
66% identity, 99% coverage of query (1201 bits)
ACNA_BRADU / P70920 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) (see paper)
63% identity, 100% coverage of query (1199 bits)
acnA / Q8ZP52 aconitate hydratase 1 (EC 4.2.1.99) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
ACNA_SALTY / Q8ZP52 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
66% identity, 99% coverage of query (1171 bits)
Acn / b1276 aconitate hydratase 1 from Escherichia coli K-12 substr. MG1655 (see 16 papers)
acnA / P25516 aconitate hydratase 1 from Escherichia coli (strain K12) (see 15 papers)
ACNA_ECOLI / P25516 Aconitate hydratase A; ACN; Aconitase; Iron-responsive protein-like; IRP-like; RNA-binding protein; Stationary phase enzyme; EC 4.2.1.3 from Escherichia coli (strain K12) (see 12 papers)
P25516 aconitate hydratase (EC 4.2.1.3) from Escherichia coli (see paper)
acnA aconitate hydratase 1; EC 4.2.1.3 from Escherichia coli K12 (see 6 papers)
66% identity, 99% coverage of query (1168 bits)
rpfa / CAA05170.1 aconitase from Xanthomonas campestris (see paper)
60% identity, 99% coverage of query (1085 bits)
ACNA_THET8 / Q5SMF6 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
61% identity, 99% coverage of query (1074 bits)
acn / O53166 aconitase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
ACNA_MYCTU / O53166 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
57% identity, 99% coverage of query (1056 bits)
A0QX20 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
56% identity, 100% coverage of query (1054 bits)
citB / P09339 aconitate hydratase (bifunctional aconitase) (EC 4.2.1.99; EC 4.2.1.3) from Bacillus subtilis (strain 168) (see 21 papers)
ACNA_BACSU / P09339 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 7 papers)
P09339 aconitate hydratase (EC 4.2.1.3) from Bacillus subtilis (see paper)
56% identity, 99% coverage of query (1043 bits)
Q9RIL1 aconitate hydratase (EC 4.2.1.3) from Streptomyces viridochromogenes (see paper)
58% identity, 99% coverage of query (1040 bits)
ACNA_STRVT / D9X0I3 Aconitate hydratase A; ACN; Aconitase; EC 4.2.1.3 from Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494) (see 5 papers)
58% identity, 99% coverage of query (1039 bits)
ACNA_CORGL / Q8NQ98 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see 5 papers)
54% identity, 99% coverage of query (1016 bits)
ACOHC_CAEEL / Q23500 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Gex-3-interacting protein 22; EC 4.2.1.3 from Caenorhabditis elegans (see 2 papers)
Q23500 aconitate hydratase (EC 4.2.1.3) from Caenorhabditis elegans (see paper)
55% identity, 99% coverage of query (963 bits)
A0A090AMG4 aconitate hydratase (EC 4.2.1.3) from Achromobacter denitrificans (see paper)
55% identity, 99% coverage of query (962 bits)
ACO1 / Q42560 aconitase from Arabidopsis thaliana (see paper)
ACO1_ARATH / Q42560 Aconitate hydratase 1; Aconitase 1; Citrate hydro-lyase 1; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q42560 aminocyclopropanecarboxylate oxidase (EC 1.14.17.4) from Arabidopsis thaliana (see paper)
54% identity, 98% coverage of query (962 bits)
D3GQL0 aconitate hydratase (EC 4.2.1.3) from Citrus clementina (see paper)
55% identity, 98% coverage of query (958 bits)
ACO3M_ARATH / Q9SIB9 Aconitate hydratase 3, mitochondrial; Aconitase 3; mACO1; Citrate hydro-lyase 3; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9SIB9 aconitate hydratase (EC 4.2.1.3) from Arabidopsis thaliana (see paper)
54% identity, 98% coverage of query (956 bits)
D3GQL1 aconitate hydratase (EC 4.2.1.3) from Citrus clementina (see paper)
54% identity, 98% coverage of query (949 bits)
D3GQL2 aconitate hydratase (EC 4.2.1.3) from Citrus clementina (see paper)
54% identity, 98% coverage of query (945 bits)
ACO2M_ARATH / Q94A28 Aconitate hydratase 2, mitochondrial; Aconitase 2; mACO2; Citrate hydro-lyase 2; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
53% identity, 98% coverage of query (941 bits)
ACO1 / P21399 cytoplasmic aconitate hydratase from Homo sapiens (see 6 papers)
ACOHC_HUMAN / P21399 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) (see 8 papers)
P21399 aconitate hydratase (EC 4.2.1.3) from Homo sapiens (see 3 papers)
53% identity, 97% coverage of query (935 bits)
2b3xA / P21399 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) (see paper)
53% identity, 97% coverage of query (935 bits)
Q9NFX2 aconitate hydratase (EC 4.2.1.3) from Drosophila melanogaster (see paper)
52% identity, 98% coverage of query (925 bits)
pmi / Q5IW57 phosphinomethylmalate isomerase (EC 4.2.1.166) from Streptomyces viridochromogenes (see paper)
PMI_STRVT / D9XF46 Phosphinomethylmalate isomerase; EC 4.2.1.166 from Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494) (see paper)
54% identity, 99% coverage of query (918 bits)
Ac3H11_1140 2-methylisocitrate dehydratase (EC 4.2.1.99) from Acidovorax sp. GW101-3H11
52% identity, 99% coverage of query (915 bits)
ACOHC_MOUSE / P28271 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Mus musculus (Mouse) (see paper)
P28271 aconitate hydratase (EC 4.2.1.3) from Mus musculus (see paper)
53% identity, 97% coverage of query (914 bits)
Q9NFX3 aconitate hydratase (EC 4.2.1.3) from Drosophila melanogaster (see paper)
52% identity, 98% coverage of query (914 bits)
ACOHC_BOVIN / Q0VCU1 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Bos taurus (Bovine) (see paper)
53% identity, 97% coverage of query (909 bits)
ACOHC_RABIT / Q01059 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Oryctolagus cuniculus (Rabbit) (see paper)
53% identity, 97% coverage of query (909 bits)
ACOHC_RAT / Q63270 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Rattus norvegicus (Rat) (see paper)
Q63270 aconitate hydratase (EC 4.2.1.3) from Rattus norvegicus (see paper)
52% identity, 97% coverage of query (907 bits)
pmi / A0A0M3N196 phosphinomethylmalate isomerase (EC 4.2.1.166) from Kitasatospora phosalacinea (see 2 papers)
56% identity, 98% coverage of query (907 bits)
Q4JFF1 phosphinomethylmalate isomerase (EC 4.2.1.166) from Streptomyces viridochromogenes (see paper)
54% identity, 99% coverage of query (898 bits)
3snpA / Q01059 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA (see paper)
51% identity, 97% coverage of query (838 bits)
acnD / Q8EJW3 2-methylcitrate dehydratase (EC 4.2.1.117) from Shewanella oneidensis (strain MR-1) (see paper)
ACND_SHEON / Q8EJW3 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming); Aconitate hydratase; ACN; Aconitase; EC 4.2.1.117; EC 4.2.1.3 from Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1) (see paper)
Q8EJW3 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) (EC 4.2.1.117) from Shewanella oneidensis (see paper)
45% identity, 97% coverage of query (734 bits)
IREB2_MOUSE / Q811J3 Iron-responsive element-binding protein 2; IRE-BP 2; Iron regulatory protein 2; IRP2 from Mus musculus (Mouse) (see paper)
48% identity, 83% coverage of query (733 bits)
ACNA_CUPNE / Q937N8 Aconitate hydratase A; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see paper)
46% identity, 97% coverage of query (730 bits)
IREB2_HUMAN / P48200 Iron-responsive element-binding protein 2; IRE-BP 2; Iron regulatory protein 2; IRP2 from Homo sapiens (Human) (see 6 papers)
47% identity, 83% coverage of query (728 bits)
Build an alignment for WP_012975006.1 and 38 homologs with ≥ 30% identity
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ACON_YEAST / P19414 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 8 papers)
P19414 aconitate hydratase (EC 4.2.1.3) from Saccharomyces cerevisiae (see 2 papers)
29% identity, 90% coverage of query (222 bits)
5acnA / P16276 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal (see paper)
30% identity, 90% coverage of query (211 bits)
ACON_PIG / P16276 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) (see 4 papers)
30% identity, 91% coverage of query (211 bits)
1b0kA S642a:fluorocitrate complex of aconitase
29% identity, 91% coverage of query (211 bits)
ACON_BOVIN / P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see paper)
30% identity, 91% coverage of query (211 bits)
8acnA Crystal structures of aconitase with isocitrate and nitroisocitrate bound
29% identity, 91% coverage of query (210 bits)
1fghA Complex with 4-hydroxy-trans-aconitate
29% identity, 91% coverage of query (210 bits)
1amjA Steric and conformational features of the aconitase mechanism
29% identity, 91% coverage of query (210 bits)
1amiA Steric and conformational features of the aconitase mechanism
29% identity, 91% coverage of query (210 bits)
1acoA Crystal structure of aconitase with transaconitate bound
29% identity, 91% coverage of query (210 bits)
1nisA Crystal structure of aconitase with trans-aconitate and nitrocitrate bound
29% identity, 90% coverage of query (209 bits)
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Lawrence Berkeley National Laboratory