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Searching for up to 100 curated homologs for WP_012975779.1 NCBI__GCF_000010725.1:WP_012975779.1 (587 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A4YXN1 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Bradyrhizobium japonicum (see paper)
    78% identity, 98% coverage of query (921 bits)

7b2eA / C5AX46 Quadruple mutant of oxalyl-coa decarboxylase from methylorubrum extorquens with bound tpp and adp (see paper)
    81% identity, 93% coverage of query (876 bits)

B2T9D2 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Paraburkholderia phytofirmans (see paper)
    69% identity, 97% coverage of query (826 bits)

D4C4C5 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Providencia rettgeri (see paper)
    63% identity, 95% coverage of query (728 bits)

oxc / P40149 oxalyl-CoA decarboxylase monomer (EC 4.1.1.8) from Oxalobacter formigenes (see 5 papers)
OXC_OXAFO / P40149 Oxalyl-CoA decarboxylase; EC 4.1.1.8 from Oxalobacter formigenes (see 2 papers)
C3XBB9 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Oxalobacter formigenes (see paper)
    61% identity, 96% coverage of query (687 bits)

2ji6A / P40149 X-ray structure of oxalyl-coa decarboxylase in complex with 3-deaza- thdp and oxalyl-coa (see paper)
    61% identity, 95% coverage of query (685 bits)

2jibA X-ray structure of oxalyl-coa decarboxylase in complex with coenzyme- a
    61% identity, 95% coverage of query (685 bits)

2ji8A X-ray structure of oxalyl-coa decarboxylase in complex with formyl- coa
    61% identity, 95% coverage of query (685 bits)

2ji7A X-ray structure of oxalyl-coa decarboxylase with covalent reaction intermediate
    61% identity, 95% coverage of query (685 bits)

2c31A Crystal structure of oxalyl-coa decarboxylase in complex with the cofactor derivative thiamin-2-thiazolone diphosphate and adenosine diphosphate
    61% identity, 93% coverage of query (671 bits)

YfdU / b2373 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
oxc / P0AFI0 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Escherichia coli (strain K12) (see 2 papers)
OXC_ECOLI / P0AFI0 Oxalyl-CoA decarboxylase; EC 4.1.1.8 from Escherichia coli (strain K12) (see 2 papers)
P0AFI0 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Escherichia coli (see paper)
    60% identity, 95% coverage of query (670 bits)

Q31Y98 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Shigella boydii (see paper)
    60% identity, 95% coverage of query (668 bits)

2q28A / P0AFI0 Crystal structure of oxalyl-coa decarboxylase from escherichia coli in complex with adenosine-5`-diphosphate (see paper)
    61% identity, 94% coverage of query (663 bits)

2q29A Crystal structure of oxalyl-coa decarboxylase from escherichia coli in complex with acetyl coenzyme a
    61% identity, 93% coverage of query (658 bits)

C2E3B5 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Lactobacillus johnsonii (see paper)
    53% identity, 97% coverage of query (602 bits)

D1NS77 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Bifidobacterium gallicum (see paper)
    51% identity, 96% coverage of query (573 bits)

B9X297 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Bifidobacterium animalis subsp. lactis (see paper)
Q75PZ0 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Bifidobacterium animalis subsp. lactis (see paper)
    49% identity, 95% coverage of query (536 bits)

AT5G17380 / Q9LF46 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Arabidopsis thaliana (see 5 papers)
    43% identity, 95% coverage of query (444 bits)

Hacl1 / Q8CHM7 2-hydroxyacyl-CoA lyase 1 subunit (EC 4.1.2.63) from Rattus norvegicus (see 3 papers)
HACL1_RAT / Q8CHM7 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2; EC 4.1.2.63 from Rattus norvegicus (Rat) (see paper)
Q8CHM7 2-hydroxyacyl-CoA lyase (EC 4.1.2.63) from Rattus norvegicus (see 5 papers)
    40% identity, 94% coverage of query (414 bits)

HACL1 / Q9UJ83 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) from Homo sapiens (see 7 papers)
HACL1_HUMAN / Q9UJ83 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2; EC 4.1.2.63 from Homo sapiens (Human) (see 3 papers)
Q9UJ83 2-hydroxyacyl-CoA lyase (EC 4.1.2.63) from Homo sapiens (see 3 papers)
    38% identity, 96% coverage of query (412 bits)

HACL1_MOUSE / Q9QXE0 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2; EC 4.1.2.63 from Mus musculus (Mouse) (see 2 papers)
Q9QXE0 2-hydroxyacyl-CoA lyase (EC 4.1.2.63) from Mus musculus (see 2 papers)
    39% identity, 94% coverage of query (404 bits)

6xn8A / A0A1H8YFL8 Crystal structure of 2-hydroxyacyl coa lyase (hacl) from rhodospirillales bacterium urhd0017
    41% identity, 91% coverage of query (374 bits)

Q6NYI5 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) from Danio rerio (see paper)
    38% identity, 92% coverage of query (360 bits)

PXP1_SCHPO / Q9Y7M1 2-hydroxyacyl-CoA lyase; EC 4.1.2.63 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    36% identity, 92% coverage of query (310 bits)

PXP1_YEAST / P39994 2-hydroxyacyl-CoA lyase; Peroxisomal protein 1; EC 4.1.2.63 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    33% identity, 89% coverage of query (257 bits)

ILVG_MYCTU / P9WG39 Acetolactate synthase large subunit IlvG; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG39 acetolactate synthase (EC 2.2.1.6) from Mycobacterium tuberculosis (see 2 papers)
    32% identity, 93% coverage of query (221 bits)

Build an alignment

Build an alignment for WP_012975779.1 and 26 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ILVB1_MYCTU / P9WG41 Acetolactate synthase large subunit IlvB1; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WG41 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
    27% identity, 89% coverage of query (180 bits)

HACL2_HUMAN / A1L0T0 2-hydroxyacyl-CoA lyase 2; Acetolactate synthase-like protein; IlvB-like protein; EC 4.1.2.- from Homo sapiens (Human) (see 2 papers)
    28% identity, 92% coverage of query (179 bits)

Q5M4L0 acetolactate synthase (EC 2.2.1.6) from Streptococcus thermophilus (see paper)
    27% identity, 91% coverage of query (178 bits)

Q8U2A4 acetolactate synthase (EC 2.2.1.6) from Pyrococcus furiosus (see paper)
    27% identity, 91% coverage of query (177 bits)

HACL_ACTC0 / P0DUV9 2-hydroxyacyl-CoA lyase; AcHACL; HACL; 2-hydroxyisobutyryl-CoA lyase; EC 4.1.-.- from Actinomycetospora chiangmaiensis (strain DSM 45062 / JCM 15998 / CCTCC AA 205017 / NBRC 104400 / YIM 0006) (see 2 papers)
    27% identity, 92% coverage of query (173 bits)

Q5SJ01 acetolactate synthase (EC 2.2.1.6); pyruvate decarboxylase (EC 4.1.1.1) from Thermus thermophilus (see paper)
    27% identity, 90% coverage of query (173 bits)

7pt4B / P0DUV9 Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone (see paper)
    27% identity, 92% coverage of query (173 bits)

7pt4A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone
    27% identity, 92% coverage of query (173 bits)

7pt1A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with substrate 2-hib-coa and inactive cofactor 3-deaza-thdp
    27% identity, 92% coverage of query (173 bits)

ilvB / AAB38426.1 acetolactate synthase from Mycobacterium avium (see paper)
    27% identity, 92% coverage of query (172 bits)

P42463 acetolactate synthase (EC 2.2.1.6) from Corynebacterium glutamicum (see paper)
    27% identity, 92% coverage of query (172 bits)

ilvB / O08353 acetohydroxy-acid synthase large subunit (EC 2.2.1.6) from Methanococcus aeolicus (see 2 papers)
    26% identity, 92% coverage of query (171 bits)

4qq8C / Q9F4L3 Crystal structure of the formolase fls in space group p 43 21 2 (see paper)
    29% identity, 92% coverage of query (171 bits)

Q5S3P7 acetolactate synthase (EC 2.2.1.6) from Streptomyces cinnamonensis (see 2 papers)
ilvB / AAV52901.1 acetohydroxy acid synthase large subunit from Streptomyces cinnamonensis (see paper)
    27% identity, 91% coverage of query (171 bits)

IlvI / b0077 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ilvI / P00893 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli (strain K12) (see 7 papers)
P00893 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
    25% identity, 92% coverage of query (169 bits)

3d7kA Crystal structure of benzaldehyde lyase in complex with the inhibitor mbp
    29% identity, 92% coverage of query (169 bits)

IlvB / b3671 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
ilvB / P08142 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli (strain K12) (see 4 papers)
P08142 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
    28% identity, 80% coverage of query (162 bits)

6lpiB / P08142 Crystal structure of ahas holo-enzyme (see paper)
    27% identity, 80% coverage of query (160 bits)

xsc / Q93PS3 sulfoacetaldehyde acetyltransferase subunit (EC 2.3.3.15) from Desulfonispora thiosulfatigenes (see 2 papers)
    26% identity, 87% coverage of query (160 bits)

P45261 acetolactate synthase (EC 2.2.1.6) from Haemophilus influenzae (see paper)
    25% identity, 89% coverage of query (159 bits)

ilvB / Q0KCU4 acetohydroxyacid synthase subunit B (EC 2.2.1.6) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
    25% identity, 91% coverage of query (159 bits)

als / Q7DAV2 α-acetolactate synthase subunit (EC 2.2.1.6) from Lactococcus lactis subsp. lactis (strain IL1403) (see 2 papers)
Q7DAV2 acetolactate synthase (EC 2.2.1.6) from Lactococcus lactis (see paper)
    26% identity, 91% coverage of query (158 bits)

A0A1X9M8K4 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Alkalihalobacillus krulwichiae (see paper)
    26% identity, 91% coverage of query (158 bits)

Q04789 acetolactate synthase (EC 2.2.1.6); branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) from Bacillus subtilis (see 2 papers)
    25% identity, 95% coverage of query (157 bits)

4rjiC Acetolactate synthase from bacillus subtilis bound to thdp - crystal form i (see paper)
    25% identity, 91% coverage of query (157 bits)

4rjkF Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
    25% identity, 91% coverage of query (157 bits)

4rjkG Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
    25% identity, 91% coverage of query (157 bits)

thzk0150 / BAO66169.1 2-hydroxy-4-methyl-2-(2-phenylacetyl)pentanoic acid synthase from Thermosporothrix hazakensis (see paper)
    25% identity, 91% coverage of query (155 bits)

ilvB / AAA93098.1 acetolactate synthase from Streptomyces avermitilis (see paper)
    27% identity, 91% coverage of query (155 bits)

P37251 acetolactate synthase (EC 2.2.1.6) from Bacillus subtilis (see paper)
    24% identity, 80% coverage of query (151 bits)

ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12) (see 2 papers)
ilvG / GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12 (see 8 papers)
    25% identity, 91% coverage of query (149 bits)

P51853 benzoin aldolase (EC 4.1.2.38) from Pseudomonas fluorescens (see 4 papers)
bznB / AAA50176.1 benzaldehyde lyase from Pseudomonas fluorescens (see paper)
    30% identity, 78% coverage of query (147 bits)

SYNPCC7002_A2770 / B1XMM5 2-oxoglutarate decarboxylase monomer (EC 4.1.1.71) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see 2 papers)
B1XMM5 oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) from Synechococcus sp. PCC 7002 (see paper)
    26% identity, 91% coverage of query (146 bits)

G0ZSE6 acetolactate synthase (EC 2.2.1.6) from Pseudomonas sp. (see paper)
    26% identity, 92% coverage of query (143 bits)

P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
    25% identity, 95% coverage of query (140 bits)

P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
    25% identity, 95% coverage of query (140 bits)

6wo1A / Q96VZ6 Hybrid acetohydroxyacid synthase complex structure with cryptococcus neoformans ahas catalytic subunit and saccharomyces cerevisiae ahas regulatory subunit (see paper)
    23% identity, 91% coverage of query (139 bits)

1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
    26% identity, 91% coverage of query (134 bits)

5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
    26% identity, 91% coverage of query (134 bits)

5dx6B / P27696 Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
    25% identity, 91% coverage of query (133 bits)

1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors
    26% identity, 91% coverage of query (132 bits)

5wdgA Acetolactate synthase from klebsiella pneumoniae in complex with a reaction intermediate
    26% identity, 91% coverage of query (132 bits)

5dx6A Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
    26% identity, 91% coverage of query (132 bits)

6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl
    22% identity, 88% coverage of query (128 bits)

6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone
    22% identity, 88% coverage of query (127 bits)

6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl
    22% identity, 88% coverage of query (127 bits)

6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam
    22% identity, 88% coverage of query (127 bits)

6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl
    22% identity, 88% coverage of query (127 bits)

6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl
    22% identity, 88% coverage of query (127 bits)

6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl
    22% identity, 88% coverage of query (126 bits)

6deqA / A0A1D8PJF9 Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
    22% identity, 88% coverage of query (125 bits)

1jscA Crystal structure of the catalytic subunit of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors
    23% identity, 91% coverage of query (124 bits)

6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
    23% identity, 91% coverage of query (124 bits)

6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
    22% identity, 91% coverage of query (123 bits)

6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit
    22% identity, 88% coverage of query (123 bits)

5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam
    22% identity, 91% coverage of query (122 bits)

1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl
    22% identity, 91% coverage of query (122 bits)

5imsA Saccharomyces cerevisiae acetohydroxyacid synthase
    23% identity, 91% coverage of query (122 bits)

1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
    22% identity, 91% coverage of query (122 bits)

1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
    22% identity, 91% coverage of query (121 bits)

7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium
    24% identity, 80% coverage of query (120 bits)

8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron
    24% identity, 80% coverage of query (120 bits)

5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam
    24% identity, 80% coverage of query (120 bits)

5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium
    24% identity, 80% coverage of query (120 bits)

5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl
    24% identity, 80% coverage of query (120 bits)

1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin
    24% identity, 80% coverage of query (120 bits)

1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
    24% identity, 80% coverage of query (120 bits)

1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
    24% identity, 80% coverage of query (120 bits)

1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
    24% identity, 80% coverage of query (120 bits)

1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
    24% identity, 80% coverage of query (120 bits)

1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl
    24% identity, 80% coverage of query (120 bits)

5k2oA / P17597 Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
    24% identity, 80% coverage of query (120 bits)

ILVB_ARATH / P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 16 papers)
P17597 acetolactate synthase (EC 2.2.1.6) from Arabidopsis thaliana (see 8 papers)
    24% identity, 80% coverage of query (120 bits)

5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium
    24% identity, 80% coverage of query (120 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory