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Searching for up to 100 curated homologs for WP_012976506.1 NCBI__GCF_000010725.1:WP_012976506.1 (278 a.a.)

Found high-coverage hits (≥70%) to 47 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

F9VNL6 glyceraldehyde dehydrogenase (FAD-containing) (subunit 2/3) (EC 1.2.99.8) from Sulfurisphaera tokodaii (see paper)
    35% identity, 99% coverage of query (168 bits)

kdhA / O87681 ketone dehydrogenase medium subunit (EC 1.5.99.14) from Paenarthrobacter nicotinovorans (see paper)
KDHA_PAENI / O87681 6-hydroxypseudooxynicotine dehydrogenase complex subunit alpha; Ketone dehydrogenase medium FAD subunit; EC 1.5.99.14 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see paper)
AAK64248.1 kdhM from Paenarthrobacter nicotinovorans (see paper)
kdhM / CAC37486.2 ketone dehydrogenase medium subunit from Paenarthrobacter nicotinovorans (see paper)
    36% identity, 99% coverage of query (162 bits)

7dqxE / O87681 Crystal structure of xanthine dehydrogenase family protein
    36% identity, 99% coverage of query (162 bits)

atcB / A0A127F985 1-testosterone hydratase/dehydrogenase β subunit (EC 1.17.99.11) from Steroidobacter denitrificans (see 2 papers)
A0A127F985 3-oxo-DELTA1-steroid hydratase/dehydrogenase (subunit 2/3) (EC 1.17.99.11) from Steroidobacter denitrificans (see paper)
    35% identity, 99% coverage of query (159 bits)

CDHB_PSEU3 / D7REY4 Caffeine dehydrogenase subunit beta; Caffeine dehydrogenase medium subunit; EC 1.17.5.2 from Pseudomonas sp. (strain CBB1) (see paper)
    40% identity, 73% coverage of query (155 bits)

ndhA / Q59127 NdhA (EC 1.5.99.4) from Paenarthrobacter nicotinovorans (see 2 papers)
NDHM_PAENI / Q59127 Nicotine 6-hydroxylase medium subunit; Nicotine dehydrogenase medium subunit; Nicotine dehydrogenase subunit A; NDH A; EC 1.5.99.4 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see 2 papers)
Q59127 nicotine dehydrogenase (EC 1.5.99.4) from Paenarthrobacter nicotinovorans (see 2 papers)
AAK64243.1 ndhM from Paenarthrobacter nicotinovorans (see paper)
    38% identity, 98% coverage of query (154 bits)

1ffuC / P19914 Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
    36% identity, 76% coverage of query (149 bits)

cutB / Q4J6M6 aldehyde dehydrogenase β subunit (EC 1.2.99.8) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
CUTB_SULAC / Q4J6M6 Glyceraldehyde dehydrogenase medium chain; Glyceraldehyde dehydrogenase subunit B; Glyceraldehyde dehydrogenase subunit beta; EC 1.2.99.8 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J6M6 glyceraldehyde dehydrogenase (FAD-containing) (subunit 2/3) (EC 1.2.99.8) from Sulfolobus acidocaldarius (see paper)
    30% identity, 98% coverage of query (148 bits)

DCMM_HYDPS / P19914 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
P19914 aerobic carbon monoxide dehydrogenase (subunit 2/3) (EC 1.2.5.3) from Hydrogenophaga pseudoflava (see 2 papers)
    37% identity, 73% coverage of query (146 bits)

SSO2636 / Q97VI7 glycolaldehyde oxidoreductase medium subunit from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
    33% identity, 98% coverage of query (141 bits)

1t3qC / P72222 Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
    40% identity, 78% coverage of query (138 bits)

P72222 quinoline 2-oxidoreductase (subunit 3/3) (EC 1.3.99.17) from Pseudomonas putida (see paper)
    40% identity, 78% coverage of query (138 bits)

picA2 / A0A1X9WE64 picolinate 6-hydroxylase β subunit from Alcaligenes faecalis (see paper)
    36% identity, 72% coverage of query (112 bits)

4zohB / Q974U9 Crystal structure of glyceraldehyde oxidoreductase (see paper)
    33% identity, 72% coverage of query (105 bits)

Q974U9 glyceraldehyde dehydrogenase (FAD-containing) (subunit 2/3) (EC 1.2.99.8) from Sulfurisphaera tokodaii (see paper)
    33% identity, 72% coverage of query (105 bits)

D5G1Y0 anaerobic carbon-monoxide dehydrogenase (subunit 2/3) (EC 1.2.7.4) from Mycobacterium sp. (see paper)
    33% identity, 72% coverage of query (101 bits)

AO356_02560 Xanthine dehydrogenase (EC 1.17.1.4) from Pseudomonas fluorescens FW300-N2C3
    30% identity, 92% coverage of query (81.3 bits)

H281DRAFT_03961 xanthine dehydrogenase, small subunit (EC 1.17.1.4) from Paraburkholderia bryophila 376MFSha3.1
    31% identity, 93% coverage of query (77.0 bits)

PS417_20885 Xanthine dehydrogenase (EC 1.17.1.4) from Pseudomonas simiae WCS417
    32% identity, 76% coverage of query (77.0 bits)

Dshi_2958 Xanthine dehydrogenase (EC 1.17.1.4) from Dinoroseobacter shibae DFL-12
    31% identity, 73% coverage of query (75.9 bits)

Build an alignment

Build an alignment for WP_012976506.1 and 20 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

XdhB / b2867 putative xanthine dehydrogenase FAD-binding subunit XdhB (EC 1.17.1.4) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
xdhB / Q46800 putative xanthine dehydrogenase FAD-binding subunit XdhB (EC 1.17.1.4) from Escherichia coli (strain K12) (see 2 papers)
Q46800 xanthine dehydrogenase (subunit 1/2) (EC 1.17.1.4) from Escherichia coli (see paper)
    27% identity, 96% coverage of query (75.1 bits)

XDH_CHICK / P47990 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Gallus gallus (Chicken) (see 2 papers)
    27% identity, 77% coverage of query (66.2 bits)

XDH1 / Q8GUQ8 xanthine dehydrogenase monomer (EC 1.17.1.4) from Arabidopsis thaliana (see paper)
XDH1_ARATH / Q8GUQ8 Xanthine dehydrogenase 1; AtXDH1; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
    28% identity, 75% coverage of query (65.1 bits)

XDH_EMENI / Q12553 Xanthine dehydrogenase; Purine hydroxylase I; EC 1.17.1.4 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
hxA xanthine dehydrogenase (purine hydroxylase I); EC 1.17.1.4 from Emericella nidulans (see 2 papers)
    24% identity, 88% coverage of query (63.2 bits)

XDH2_ARATH / F4JLI5 Xanthine dehydrogenase 2; AtXDH2; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    27% identity, 75% coverage of query (61.6 bits)

1jroA / O54050 Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
    27% identity, 89% coverage of query (56.2 bits)

O54050 xanthine dehydrogenase (subunit 2/2) (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Rhodobacter capsulatus (see 2 papers)
xdhA / CAA04469.1 xanthine dehydrogenase from Rhodobacter capsulatus (see paper)
    27% identity, 89% coverage of query (56.2 bits)

2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde
    27% identity, 89% coverage of query (56.2 bits)

6a7xA Rat xanthine oxidoreductase, d428a variant, NAD bound form
    24% identity, 75% coverage of query (52.4 bits)

6a7xB Rat xanthine oxidoreductase, d428a variant, NAD bound form
    24% identity, 75% coverage of query (52.4 bits)

Xdh / P22985 xanthine oxidoreductase subunit (EC 1.17.1.4; EC 1.17.3.2) from Rattus norvegicus (see paper)
XDH_RAT / P22985 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Rattus norvegicus (Rat) (see 4 papers)
P22985 xanthine dehydrogenase (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Rattus norvegicus (see 4 papers)
    24% identity, 75% coverage of query (52.0 bits)

4yswA Structure of rat xanthine oxidoreductase, c-terminal deletion protein variant, nadh bound form
    24% identity, 75% coverage of query (51.6 bits)

XDH / P47989 xanthine dehydrogenase monomer (EC 1.17.1.4) from Homo sapiens (see 14 papers)
XDH_HUMAN / P47989 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Homo sapiens (Human) (see 6 papers)
P47989 xanthine oxidase (EC 1.17.3.2) from Homo sapiens (see paper)
    26% identity, 75% coverage of query (48.5 bits)

AOXA_BOVIN / P48034 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Bos taurus (Bovine) (see paper)
P48034 aldehyde oxidase (EC 1.2.3.1) from Bos taurus (see 3 papers)
    28% identity, 77% coverage of query (48.5 bits)

2e1qA / P47989 Crystal structure of human xanthine oxidoreductase mutant, glu803val (see paper)
    23% identity, 75% coverage of query (48.1 bits)

XDH_BOVIN / P80457 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Bos taurus (Bovine) (see 6 papers)
P80457 xanthine dehydrogenase (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Bos taurus (see 15 papers)
    25% identity, 75% coverage of query (47.8 bits)

3ax7A / P80457 Bovine xanthine oxidase, protease cleaved form (see paper)
    25% identity, 75% coverage of query (47.8 bits)

3am9A Complex of bovine xanthine dehydrogenase and trihydroxy fyx-051
    25% identity, 75% coverage of query (47.8 bits)

1n5xA Xanthine dehydrogenase from bovine milk with inhibitor tei-6720 bound
    25% identity, 75% coverage of query (47.8 bits)

3amzA Bovine xanthine oxidoreductase urate bound form
    25% identity, 75% coverage of query (47.8 bits)

1fo4A / P80457 Crystal structure of xanthine dehydrogenase isolated from bovine milk (see paper)
    25% identity, 75% coverage of query (47.4 bits)

3bdjA Crystal structure of bovine milk xanthine dehydrogenase with a covalently bound oxipurinol inhibitor
    25% identity, 75% coverage of query (47.4 bits)

3unaA Crystal structure of bovine milk xanthine dehydrogenase with NAD bound
    25% identity, 75% coverage of query (47.4 bits)

1vdvA Bovine milk xanthine dehydrogenase y-700 bound form
    25% identity, 75% coverage of query (47.4 bits)

1v97A Crystal structure of bovine milk xanthine dehydrogenase fyx-051 bound form
    25% identity, 75% coverage of query (47.4 bits)

2e3tA Crystal structure of rat xanthine oxidoreductase mutant (w335a and f336l)
    24% identity, 75% coverage of query (47.0 bits)

Xdh / Q00519 xanthine oxidase monomer (EC 1.17.1.4; EC 1.17.3.2) from Mus musculus (see 4 papers)
XDH_MOUSE / Q00519 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Mus musculus (Mouse) (see paper)
    24% identity, 75% coverage of query (46.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory