Searching for up to 100 curated homologs for WP_012976790.1 NCBI__GCF_000010725.1:WP_012976790.1 (303 a.a.)
Found high-coverage hits (≥70%) to 59 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PP_3599 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Pseudomonas putida KT2440
69% identity, 100% coverage of query (443 bits)
PS417_04195 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Pseudomonas simiae WCS417
69% identity, 100% coverage of query (441 bits)
HSERO_RS15785 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Herbaspirillum seropedicae SmR1
70% identity, 99% coverage of query (437 bits)
Pf1N1B4_1110 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Pseudomonas fluorescens FW300-N1B4
69% identity, 100% coverage of query (434 bits)
A1VMN2 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Polaromonas naphthalenivorans CJ2 (see paper)
69% identity, 100% coverage of query (432 bits)
BPHYT_RS24155 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Burkholderia phytofirmans PsJN
69% identity, 99% coverage of query (430 bits)
B7WZA5 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Comamonas testosteroni (see paper)
67% identity, 100% coverage of query (418 bits)
kdgD / Q6FFQ1 5-dehydro-4-deoxyglucarate dehydratase subunit (EC 4.2.1.41) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
KDGD_ACIAD / Q6FFQ1 Probable 5-dehydro-4-deoxyglucarate dehydratase; 5-keto-4-deoxy-glucarate dehydratase; KDGDH; EC 4.2.1.41 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
Q6FFQ1 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Acinetobacter baylyi (see 2 papers)
61% identity, 100% coverage of query (393 bits)
4ur8A Crystal structure of keto-deoxy-d-galactarate dehydratase complexed with 2-oxoadipic acid
56% identity, 98% coverage of query (332 bits)
5hwnB / Q8UB77 Crystal structure of keto-deoxy-d-galactarate dehydratase complexed with pyruvate (see paper)
56% identity, 98% coverage of query (331 bits)
Q8UB77 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) from Agrobacterium fabrum (see 2 papers)
56% identity, 98% coverage of query (331 bits)
4i7wA Agrobacterium tumefaciens dhdps with lysine and pyruvate
34% identity, 74% coverage of query (125 bits)
DAPA_AGRFC / Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see 2 papers)
34% identity, 77% coverage of query (125 bits)
7lvlA / A0A0F4VK59 Dihydrodipicolinate synthase bound with allosteric inhibitor (s)- lysine from candidatus liberibacter solanacearum
30% identity, 87% coverage of query (119 bits)
7mjfA Crystal structure of candidatus liberibacter solanacearum dihydrodipicolinate synthase with pyruvate and succinic semi-aldehyde bound in active site
30% identity, 87% coverage of query (119 bits)
DAPA_RHIML / Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
Q07607 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Sinorhizobium meliloti (see 2 papers)
30% identity, 93% coverage of query (112 bits)
Build an alignment for WP_012976790.1 and 16 homologs with ≥ 30% identity
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Q8RBI5 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
29% identity, 93% coverage of query (108 bits)
Q6G468 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bartonella henselae (see paper)
30% identity, 95% coverage of query (108 bits)
O67216 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Aquifex aeolicus (see paper)
28% identity, 86% coverage of query (102 bits)
dapA2 dihydrodipicolinate synthase; EC 4.2.1.52 from Bacillus anthracis (see paper)
27% identity, 93% coverage of query (97.1 bits)
Q7CU96 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
29% identity, 89% coverage of query (96.7 bits)
DAPA_NEIMB / Q9JZR4 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Neisseria meningitidis serogroup B (strain MC58) (see paper)
Q9JZR4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Neisseria meningitidis (see paper)
27% identity, 96% coverage of query (92.4 bits)
dapA / Q65JG7 dihydrodipicolinate synthase subunit (EC 4.3.3.7) from Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) (see paper)
27% identity, 93% coverage of query (91.3 bits)
DAPAL_RHIML / O69782 Uncharacterized DapA-like lyase; EC 4.-.-.- from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
28% identity, 92% coverage of query (90.9 bits)
5j5dA / P9WP25 Crystal structure of dihydrodipicolinate synthase from mycobacterium tuberculosis in complex with alpha-ketopimelic acid (see paper)
27% identity, 92% coverage of query (89.7 bits)
1xxxA Crystal structure of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis
27% identity, 92% coverage of query (89.7 bits)
DAPA_MYCTU / P9WP25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
27% identity, 92% coverage of query (89.4 bits)
3na8A / Q9I6R5 Crystal structure of a putative dihydrodipicolinate synthetase from pseudomonas aeruginosa
27% identity, 95% coverage of query (88.6 bits)
4pfmA / A9DKW4 Shewanella benthica dhdps with lysine and pyruvate
27% identity, 88% coverage of query (87.8 bits)
3l21B The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis - dhdps- a204r
27% identity, 92% coverage of query (87.8 bits)
1o5kA / Q9X1K9 Crystal structure of dihydrodipicolinate synthase (tm1521) from thermotoga maritima at 1.80 a resolution
25% identity, 91% coverage of query (85.9 bits)
DAPA_THEMA / Q9X1K9 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
25% identity, 91% coverage of query (85.9 bits)
dapA / Q04796 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bacillus subtilis (strain 168) (see paper)
26% identity, 93% coverage of query (84.7 bits)
DAPA_METJA / Q57695 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
26% identity, 89% coverage of query (84.0 bits)
A9CFV4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
26% identity, 95% coverage of query (83.2 bits)
5ud6C / M1V4H9 Crystal structure of dhdps from cyanidioschyzon merolae with lysine bound
28% identity, 86% coverage of query (80.9 bits)
dapA / P19808 dihydropicolinate synthase subunit (EC 4.3.3.7) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
P19808 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Corynebacterium glutamicum (see paper)
dapA / CAA79714.1 dihydrodipicolinate synthase from Corynebacterium glutamicum (see paper)
30% identity, 91% coverage of query (80.9 bits)
DapA / b2478 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli K-12 substr. MG1655 (see 24 papers)
dapA / P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli (strain K12) (see 23 papers)
DAPA_ECOLI / P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Escherichia coli (strain K12) (see 11 papers)
P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli (see 15 papers)
26% identity, 71% coverage of query (80.1 bits)
5t25A / B7M7I1 Kinetic, spectral and structural characterization of the slow binding inhibitor acetopyruvate with dihydrodipicolinate synthase from escherichia coli.
26% identity, 71% coverage of query (80.1 bits)
2atsA Dihydrodipicolinate synthase co-crystallised with (s)-lysine
26% identity, 71% coverage of query (80.1 bits)
YagE / b0268 CP4-6 prophage; putative 2-dehydro-3-deoxygluconate aldolase (EC 4.1.2.28; EC 4.1.2.51) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
yagE / P75682 CP4-6 prophage; putative 2-dehydro-3-deoxygluconate aldolase (EC 4.1.2.28; EC 4.1.2.51) from Escherichia coli (strain K12) (see 8 papers)
YAGE_ECOLI / P75682 Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE; KDG aldolase YagE; Putative 2-dehydro-3-deoxy-D-pentonate aldolase YagE; EC 4.1.2.51; EC 4.1.2.28 from Escherichia coli (strain K12) (see 4 papers)
P75682 2-dehydro-3-deoxyglucarate aldolase (EC 4.1.2.20) from Escherichia coli (see paper)
27% identity, 72% coverage of query (79.0 bits)
3nevA / P75682 Crystal structure of yage, a prophage protein from e. Coli k12 in complex with kdgal (see paper)
27% identity, 72% coverage of query (79.0 bits)
4ptnA Crystal structure of yage, a kdg aldolase protein in complex with magnesium cation coordinated l-glyceraldehyde
27% identity, 72% coverage of query (79.0 bits)
4onvA Crystal structure of yage, a kdg aldolase protein in complex with 2- keto-3-deoxy gluconate
27% identity, 72% coverage of query (79.0 bits)
4oe7D Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
27% identity, 72% coverage of query (79.0 bits)
4oe7B Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
27% identity, 72% coverage of query (79.0 bits)
4oe7A Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
27% identity, 72% coverage of query (79.0 bits)
4fhaA Structure of dihydrodipicolinate synthase from streptococcus pneumoniae,bound to pyruvate and lysine
27% identity, 93% coverage of query (75.5 bits)
dhdps / CAC50571.1 dihydrodipicolinate synthetase from Yersinia enterocolitica (see paper)
25% identity, 76% coverage of query (73.6 bits)
YjhH / b4298 KpLE2 phage-like element; putative 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
yjhH / P39359 KpLE2 phage-like element; putative 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) from Escherichia coli (strain K12) (see 7 papers)
YJHH_ECOLI / P39359 Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH; EC 4.1.2.28 from Escherichia coli (strain K12) (see paper)
25% identity, 92% coverage of query (68.6 bits)
Q3M723 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Trichormus variabilis (see paper)
26% identity, 92% coverage of query (68.2 bits)
5ktlA / Q3M723 Dihydrodipicolinate synthase from the industrial and evolutionarily important cyanobacteria anabaena variabilis. (see paper)
26% identity, 92% coverage of query (67.8 bits)
HOGA1 / Q86XE5 4-hydroxy-2-ketoglutarate aldolase subunit (EC 4.1.3.16) from Homo sapiens (see 6 papers)
HOGA1_HUMAN / Q86XE5 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; Protein 569272; EC 4.1.3.16 from Homo sapiens (Human) (see 2 papers)
Q86XE5 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) from Homo sapiens (see 5 papers)
27% identity, 91% coverage of query (67.0 bits)
HOGA1_BOVIN / Q0P5I5 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; EC 4.1.3.16 from Bos taurus (Bovine) (see 2 papers)
Q0P5I5 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) from Bos taurus (see paper)
26% identity, 91% coverage of query (67.0 bits)
2r94A / Q704D1 Crystal structure of kd(p)ga from t.Tenax (see paper)
27% identity, 90% coverage of query (61.2 bits)
KDGA_THETE / Q704D1 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase; KD(P)G aldolase; EC 4.1.2.14; EC 4.1.2.51 from Thermoproteus tenax (see 3 papers)
Q704D1 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) from Thermoproteus tenax (see paper)
kdgA / CAF18463.1 2-Keto-3-deoxy-(6-phospho-)gluconate aldolase from Thermoproteus tenax (see paper)
27% identity, 89% coverage of query (60.8 bits)
NANA_MEDG7 / A7B555 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Mediterraneibacter gnavus (strain ATCC 29149 / DSM 114966 / JCM 6515 / VPI C7-9) (Ruminococcus gnavus) (see paper)
21% identity, 92% coverage of query (45.8 bits)
6rb7A / A7B555 Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant (see paper)
21% identity, 92% coverage of query (43.5 bits)
6rd1A Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant in complex with sialic acid
21% identity, 92% coverage of query (43.5 bits)
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