Searching for up to 100 curated homologs for WP_012977207.1 NCBI__GCF_000010725.1:WP_012977207.1 (552 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q8U2A4 acetolactate synthase (EC 2.2.1.6) from Pyrococcus furiosus (see paper)
33% identity, 96% coverage of query (275 bits)
ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12) (see 2 papers)
ilvG / GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12 (see 8 papers)
33% identity, 96% coverage of query (256 bits)
P42463 acetolactate synthase (EC 2.2.1.6) from Corynebacterium glutamicum (see paper)
33% identity, 94% coverage of query (255 bits)
ILVB1_MYCTU / P9WG41 Acetolactate synthase large subunit IlvB1; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WG41 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
33% identity, 95% coverage of query (238 bits)
Q8RL88 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Geobacillus stearothermophilus (see paper)
ilvB / AAL99356.1 acetohydroxy acid synthase large subunit from Geobacillus stearothermophilus (see paper)
30% identity, 98% coverage of query (237 bits)
SYNPCC7002_A2770 / B1XMM5 2-oxoglutarate decarboxylase monomer (EC 4.1.1.71) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see 2 papers)
B1XMM5 oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) from Synechococcus sp. PCC 7002 (see paper)
30% identity, 95% coverage of query (232 bits)
Q5SJ01 acetolactate synthase (EC 2.2.1.6); pyruvate decarboxylase (EC 4.1.1.1) from Thermus thermophilus (see paper)
33% identity, 96% coverage of query (224 bits)
6lpiB / P08142 Crystal structure of ahas holo-enzyme (see paper)
31% identity, 96% coverage of query (223 bits)
G0ZSE6 acetolactate synthase (EC 2.2.1.6) from Pseudomonas sp. (see paper)
30% identity, 94% coverage of query (222 bits)
IlvB / b3671 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
ilvB / P08142 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli (strain K12) (see 4 papers)
P08142 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
32% identity, 96% coverage of query (220 bits)
Build an alignment for WP_012977207.1 and 10 homologs with ≥ 30% identity
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P37251 acetolactate synthase (EC 2.2.1.6) from Bacillus subtilis (see paper)
28% identity, 96% coverage of query (218 bits)
Q04789 acetolactate synthase (EC 2.2.1.6); branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) from Bacillus subtilis (see 2 papers)
28% identity, 96% coverage of query (217 bits)
4rjiC Acetolactate synthase from bacillus subtilis bound to thdp - crystal form i (see paper)
28% identity, 96% coverage of query (217 bits)
4rjkG Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
28% identity, 96% coverage of query (217 bits)
4rjkF Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
28% identity, 96% coverage of query (217 bits)
P45261 acetolactate synthase (EC 2.2.1.6) from Haemophilus influenzae (see paper)
29% identity, 93% coverage of query (216 bits)
ilvB / AAB38426.1 acetolactate synthase from Mycobacterium avium (see paper)
31% identity, 94% coverage of query (215 bits)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam
29% identity, 96% coverage of query (215 bits)
ilvB / O08353 acetohydroxy-acid synthase large subunit (EC 2.2.1.6) from Methanococcus aeolicus (see 2 papers)
29% identity, 97% coverage of query (214 bits)
ilv1 / RF|NP_595382.1 acetolactate synthase catalytic subunit; EC 2.2.1.6 from Schizosaccharomyces pombe (see 2 papers)
29% identity, 96% coverage of query (214 bits)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
29% identity, 96% coverage of query (214 bits)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
29% identity, 96% coverage of query (214 bits)
1t9bA / P07342 Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
29% identity, 96% coverage of query (213 bits)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
29% identity, 96% coverage of query (213 bits)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
29% identity, 96% coverage of query (213 bits)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl
29% identity, 96% coverage of query (213 bits)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
29% identity, 96% coverage of query (213 bits)
Q5S3P7 acetolactate synthase (EC 2.2.1.6) from Streptomyces cinnamonensis (see 2 papers)
ilvB / AAV52901.1 acetohydroxy acid synthase large subunit from Streptomyces cinnamonensis (see paper)
31% identity, 90% coverage of query (212 bits)
AN4956 acetolactate synthase; EC 2.2.1.6 from Emericella nidulans (see paper)
30% identity, 96% coverage of query (211 bits)
6u9dB / P07342 Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
28% identity, 96% coverage of query (210 bits)
ILVB_YEAST / P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P07342 acetolactate synthase (EC 2.2.1.6) from Saccharomyces cerevisiae (see 5 papers)
28% identity, 96% coverage of query (210 bits)
G4MMK2 acetolactate synthase (subunit 1/2) (EC 2.2.1.6) from Pyricularia oryzae (see paper)
29% identity, 97% coverage of query (209 bits)
IlvI / b0077 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ilvI / P00893 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli (strain K12) (see 7 papers)
P00893 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
30% identity, 95% coverage of query (209 bits)
5dx6B / P27696 Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
30% identity, 96% coverage of query (208 bits)
als / CAA66718.1 acetolactate synthase from Synechocystis sp (see paper)
30% identity, 95% coverage of query (208 bits)
budB / P27696 catabolic acetolactate synthase (EC 2.2.1.6) from Klebsiella pneumoniae (see 2 papers)
30% identity, 96% coverage of query (208 bits)
1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
30% identity, 96% coverage of query (208 bits)
5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
30% identity, 96% coverage of query (206 bits)
7egvA Acetolactate synthase from trichoderma harzianum with inhibitor harzianic acid (see paper)
29% identity, 97% coverage of query (205 bits)
1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors
30% identity, 96% coverage of query (204 bits)
CFOL_ASPCN / A0A2I2F2I5 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; Chlorflavonin biosynthesis cluster protein L; EC 2.2.1.6 from Aspergillus candidus (see paper)
28% identity, 97% coverage of query (201 bits)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl
28% identity, 95% coverage of query (201 bits)
6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
28% identity, 96% coverage of query (201 bits)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl
28% identity, 95% coverage of query (200 bits)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl
28% identity, 95% coverage of query (200 bits)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone
28% identity, 95% coverage of query (200 bits)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam
28% identity, 95% coverage of query (200 bits)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl
28% identity, 95% coverage of query (200 bits)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl
28% identity, 95% coverage of query (200 bits)
5wdgA Acetolactate synthase from klebsiella pneumoniae in complex with a reaction intermediate
30% identity, 96% coverage of query (200 bits)
6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
28% identity, 96% coverage of query (200 bits)
A0A1X9M8K4 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Alkalihalobacillus krulwichiae (see paper)
28% identity, 97% coverage of query (199 bits)
6deqA / A0A1D8PJF9 Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
27% identity, 95% coverage of query (199 bits)
1jscA Crystal structure of the catalytic subunit of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors
28% identity, 96% coverage of query (199 bits)
ilvB / Q0KCU4 acetohydroxyacid synthase subunit B (EC 2.2.1.6) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
29% identity, 99% coverage of query (198 bits)
5imsA Saccharomyces cerevisiae acetohydroxyacid synthase
28% identity, 96% coverage of query (198 bits)
ilvB / AAA93098.1 acetolactate synthase from Streptomyces avermitilis (see paper)
31% identity, 88% coverage of query (197 bits)
6wo1A / Q96VZ6 Hybrid acetohydroxyacid synthase complex structure with cryptococcus neoformans ahas catalytic subunit and saccharomyces cerevisiae ahas regulatory subunit (see paper)
28% identity, 91% coverage of query (197 bits)
5dx6A Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
30% identity, 96% coverage of query (197 bits)
ILV2 acetolactate synthase; EC 2.2.1.6 from Candida albicans (see paper)
29% identity, 92% coverage of query (195 bits)
thzk0150 / BAO66169.1 2-hydroxy-4-methyl-2-(2-phenylacetyl)pentanoic acid synthase from Thermosporothrix hazakensis (see paper)
29% identity, 95% coverage of query (194 bits)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
29% identity, 96% coverage of query (190 bits)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit
27% identity, 95% coverage of query (188 bits)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
28% identity, 96% coverage of query (187 bits)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium
30% identity, 88% coverage of query (187 bits)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester
30% identity, 88% coverage of query (187 bits)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron
30% identity, 88% coverage of query (187 bits)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron
30% identity, 88% coverage of query (187 bits)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam
30% identity, 88% coverage of query (187 bits)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium
30% identity, 88% coverage of query (187 bits)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl
30% identity, 88% coverage of query (187 bits)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin
30% identity, 88% coverage of query (187 bits)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
30% identity, 88% coverage of query (187 bits)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
30% identity, 88% coverage of query (187 bits)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
30% identity, 88% coverage of query (187 bits)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
30% identity, 88% coverage of query (187 bits)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl
30% identity, 88% coverage of query (187 bits)
ILVB_ARATH / P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 16 papers)
P17597 acetolactate synthase (EC 2.2.1.6) from Arabidopsis thaliana (see 8 papers)
30% identity, 88% coverage of query (187 bits)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium
30% identity, 88% coverage of query (187 bits)
5k2oA / P17597 Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
30% identity, 88% coverage of query (186 bits)
6vz8D / P17597 Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound (see paper)
29% identity, 88% coverage of query (179 bits)
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
27% identity, 94% coverage of query (164 bits)
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
27% identity, 94% coverage of query (164 bits)
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
27% identity, 94% coverage of query (163 bits)
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
27% identity, 94% coverage of query (163 bits)
8rphD 8rphD (see paper)
25% identity, 96% coverage of query (163 bits)
8rpjA Janthe from janthinobacterium sp. Hh01
25% identity, 96% coverage of query (162 bits)
8rpiA Janthe from janthinobacterium sp. Hh01, lactyl-thdp
25% identity, 96% coverage of query (162 bits)
8i01A / P0AEP7 Crystal structure of escherichia coli glyoxylate carboligase (see paper)
27% identity, 94% coverage of query (162 bits)
1powA The refined structures of a stabilized mutant and of wild-type pyruvate oxidase from lactobacillus plantarum
27% identity, 94% coverage of query (156 bits)
2ezuA Pyruvate oxidase variant f479w in complex with reaction intermediate 2-acetyl-thiamin diphosphate
27% identity, 94% coverage of query (156 bits)
2ez9A Pyruvate oxidase variant f479w in complex with reaction intermediate analogue 2-phosphonolactyl-thiamin diphosphate
27% identity, 94% coverage of query (156 bits)
2ez8A Pyruvate oxidase variant f479w in complex with reaction intermediate 2-lactyl-thiamin diphosphate
27% identity, 94% coverage of query (156 bits)
2ez4B Pyruvate oxidase variant f479w
27% identity, 94% coverage of query (156 bits)
4feeA High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal b (see paper)
27% identity, 94% coverage of query (155 bits)
7pt4B / P0DUV9 Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone (see paper)
29% identity, 96% coverage of query (154 bits)
HACL_ACTC0 / P0DUV9 2-hydroxyacyl-CoA lyase; AcHACL; HACL; 2-hydroxyisobutyryl-CoA lyase; EC 4.1.-.- from Actinomycetospora chiangmaiensis (strain DSM 45062 / JCM 15998 / CCTCC AA 205017 / NBRC 104400 / YIM 0006) (see 2 papers)
29% identity, 96% coverage of query (154 bits)
7pt1A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with substrate 2-hib-coa and inactive cofactor 3-deaza-thdp
29% identity, 96% coverage of query (154 bits)
7pt4A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone
29% identity, 97% coverage of query (154 bits)
7orxCCC / Q0SCE8 jostii RHA1 thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase
26% identity, 96% coverage of query (150 bits)
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