Searching for up to 100 curated homologs for WP_012978535.1 NCBI__GCF_000010725.1:WP_012978535.1 (280 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
SM_b21112 L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase from Sinorhizobium meliloti 1021
76% identity, 99% coverage of query (434 bits)
BMULJ_04921 / A0A0H3KT28 2,4-didehydro-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Burkholderia multivorans (strain ATCC 17616 / 249) (see 2 papers)
68% identity, 100% coverage of query (407 bits)
BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
69% identity, 98% coverage of query (402 bits)
C785_RS20550 / A0A2E7P912 5-hydroxy-2,4-dioxopentanoate hydrolase (EC 3.7.1.26) from Herbaspirillum sp. (see paper)
65% identity, 99% coverage of query (399 bits)
HSERO_RS06355 2,4-diketo-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Herbaspirillum seropedicae SmR1
64% identity, 99% coverage of query (398 bits)
lra6 / Q1NEI7 2,4-didehydro-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Sphingomonas sp. (strain SKA58) (see paper)
56% identity, 100% coverage of query (316 bits)
8gsrA / Q1NEI7 Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
56% identity, 99% coverage of query (313 bits)
8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form)
56% identity, 99% coverage of query (313 bits)
FAH2B_BOVIN / Q2KIB0 Oxaloacetate tautomerase FAHD2B, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2B; Oxaloacetate tautomerase 1-B; OAT1-B; EC 5.3.2.2 from Bos taurus (Bovine) (see paper)
52% identity, 74% coverage of query (219 bits)
FAH2A_BOVIN / F1MLX0 Oxaloacetate tautomerase FAHD2A, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2A; Oxaloacetate tautomerase 1-A; OAT1-A; EC 5.3.2.2 from Bos taurus (Bovine) (see paper)
52% identity, 74% coverage of query (219 bits)
FAH2A_HUMAN / Q96GK7 Oxaloacetate tautomerase FAHD2A, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2A; EC 5.3.2.2 from Homo sapiens (Human) (see paper)
50% identity, 74% coverage of query (216 bits)
FAH2B_HUMAN / Q6P2I3 Oxaloacetate tautomerase FAHD2B, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2B; EC 5.3.2.2 from Homo sapiens (Human) (see paper)
50% identity, 74% coverage of query (211 bits)
dntG / Q8VUC7 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate isomerase from Burkholderia cepacia (see 2 papers)
37% identity, 100% coverage of query (178 bits)
6v77B / A0QTY3 Crystal structure of a putative hpce protein from mycobacterium smegmatis
42% identity, 74% coverage of query (171 bits)
Y2993_MYCTU / I6Y276 Protein Rv2993c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
43% identity, 74% coverage of query (170 bits)
6iymA Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
37% identity, 99% coverage of query (166 bits)
K0A9N9 fumarylacetoacetase (EC 3.7.1.2) from Exiguobacterium antarcticum (see paper)
36% identity, 99% coverage of query (164 bits)
YISK_BACSU / O06724 Oxaloacetate tautomerase YisK; Oxaloacetate decarboxylase YisK; EC 5.3.2.2; EC 4.1.1.112 from Bacillus subtilis (strain 168) (see 3 papers)
41% identity, 72% coverage of query (163 bits)
8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid
41% identity, 72% coverage of query (163 bits)
8skyB / O06724 Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
41% identity, 72% coverage of query (162 bits)
3qdfA / B2HIH3 Crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from mycobacterium marinum (see paper)
42% identity, 74% coverage of query (157 bits)
6j5xA / Q8NLC0 Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
36% identity, 74% coverage of query (149 bits)
FAHD1_ARATH / Q93ZE5 Oxaloacetate tautomerase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; EC 5.3.2.2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
40% identity, 71% coverage of query (149 bits)
A0A1R4GQY2 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Corynebacterium glutamicum (see paper)
36% identity, 74% coverage of query (149 bits)
6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate
36% identity, 74% coverage of query (149 bits)
FAHD1_MOUSE / Q8R0F8 Oxaloacetate tautomerase FAHD1, mitochondrial; Acylpyruvase FAHD1; Acylpyruvate hydrolase; ApH; Fumarylacetoacetate hydrolase domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; ODx; EC 5.3.2.2; EC 3.7.1.5; EC 4.1.1.112 from Mus musculus (Mouse) (see 3 papers)
36% identity, 73% coverage of query (146 bits)
6sbiA / Q8R0F8 X-ray structure of murine fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate (see paper)
36% identity, 73% coverage of query (146 bits)
Q6P587 acylpyruvate hydrolase (EC 3.7.1.5); oxaloacetate decarboxylase (EC 4.1.1.112) from Homo sapiens (see 3 papers)
38% identity, 71% coverage of query (145 bits)
6fogA / Q6P587 X-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate at 1.94a resolution. (see paper)
38% identity, 71% coverage of query (145 bits)
FAHD1_HUMAN / Q6P587 Oxaloacetate tautomerase FAHD1, mitochondrial; Acylpyruvase FAHD1; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; ODx; YisK-like protein; EC 5.3.2.2; EC 3.7.1.5; EC 4.1.1.112 from Homo sapiens (Human) (see 5 papers)
38% identity, 71% coverage of query (145 bits)
3r6oA / B1MJ53 Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
34% identity, 86% coverage of query (141 bits)
A0A076VF18 fumarylacetoacetase (EC 3.7.1.2) from Rhodotorula diobovata (see paper)
41% identity, 72% coverage of query (140 bits)
hbzF / Q0QFQ3 maleylpyruvate hydrolase monomer (EC 3.7.1.23) from Pseudomonas alcaligenes (see 2 papers)
HBZF_PSEAC / Q0QFQ3 Maleylpyruvate hydrolase; MPH11; EC 3.7.1.23 from Pseudomonas alcaligenes (see 3 papers)
Q0QFQ3 maleylpyruvate hydrolase (EC 3.7.1.23) from Pseudomonas alcaligenes (see 2 papers)
37% identity, 75% coverage of query (136 bits)
FAHD1_CAEEL / P34673 Oxaloacetate tautomerase fahd-1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; EC 5.3.2.2 from Caenorhabditis elegans (see 2 papers)
35% identity, 70% coverage of query (135 bits)
FAHD2_ARATH / Q9LUR3 Oxaloacetate tautomerase FAHD2, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2; FAH domain-containing protein 2; EC 5.3.2.2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
37% identity, 71% coverage of query (134 bits)
YcgM / b1180 putative isomerase/hydrolase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
YCGM_ECOLI / P76004 Oxaloacetate tautomerase YcgM; EC 5.3.2.2 from Escherichia coli (strain K12) (see paper)
35% identity, 71% coverage of query (133 bits)
4dbhA / Q8NQY2 Crystal structure of cg1458 with inhibitor (see paper)
35% identity, 75% coverage of query (129 bits)
CPH_NEONM / A0A3G9JYJ6 Caffeoylpyruvate hydrolase; CPH; Fungal bioluminescence cycle protein cph; EC 3.7.-.- from Neonothopanus nambi (Agaricus nambi) (see 2 papers)
37% identity, 75% coverage of query (125 bits)
1nr9D / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
34% identity, 71% coverage of query (119 bits)
1nr9B / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
34% identity, 71% coverage of query (119 bits)
1nr9A / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
33% identity, 71% coverage of query (117 bits)
1nr9C / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
33% identity, 71% coverage of query (116 bits)
A0A0M3SVN7 fumarylacetoacetase (EC 3.7.1.2) from Cupriavidus gilardii (see paper)
32% identity, 75% coverage of query (107 bits)
G2IPX5 maleylpyruvate hydrolase (EC 3.7.1.23) from Sphingobium sp. SYK-6 (see paper)
35% identity, 75% coverage of query (106 bits)
6jvwB / G2IPX5 Crystal structure of maleylpyruvate hydrolase from sphingobium sp. Syk-6 in complex with manganese (ii) ion and pyruvate (see paper)
34% identity, 75% coverage of query (106 bits)
6j5yA / Q9I111 Crystal structure of fumarylpyruvate hydrolase from pseudomonas aeruginosa in complex with mn2+ and pyruvate (see paper)
33% identity, 75% coverage of query (103 bits)
A0A080VH08 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Pseudomonas aeruginosa (see paper)
33% identity, 75% coverage of query (102 bits)
naaD / F8QQ75 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Bradyrhizobium sp. JS329 (see paper)
31% identity, 74% coverage of query (97.4 bits)
A0A1B0ZSC0 fumarylacetoacetase (EC 3.7.1.2) from Phaeobacter gallaeciensis (see paper)
32% identity, 71% coverage of query (95.9 bits)
Build an alignment for WP_012978535.1 and 49 homologs with ≥ 30% identity
Or download the sequences
A0A0D5YDA5 fumarylacetoacetase (EC 3.7.1.2) from Acinetobacter baumannii (see paper)
28% identity, 71% coverage of query (91.7 bits)
Or start over
Lawrence Berkeley National Laboratory