Searching for up to 100 curated homologs for WP_012991310.1 NCBI__GCF_000025605.1:WP_012991310.1 (653 a.a.)
Found high-coverage hits (≥70%) to 47 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
2OCL_HYDTT / D3DJ41 2-oxoglutarate carboxylase large subunit; 2-oxoglutarate carboxylase alpha subunit; EC 6.4.1.7 from Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) (see 2 papers)
90% identity, 99% coverage of query (1206 bits)
Q1H157 pyruvate carboxylase (EC 6.4.1.1) from Methylobacillus flagellatus (see paper)
45% identity, 95% coverage of query (563 bits)
5ks8C / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
45% identity, 95% coverage of query (555 bits)
5ks8D / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
44% identity, 95% coverage of query (531 bits)
PYCB_METJA / Q58628 Pyruvate carboxylase subunit B; Pyruvic carboxylase B; EC 6.4.1.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
45% identity, 94% coverage of query (511 bits)
pycB / Q6M0D1 pyruvate carboxylase subunit B (EC 6.4.1.1) from Methanococcus maripaludis (strain S2 / LL) (see paper)
43% identity, 94% coverage of query (491 bits)
pycB / O27179 pyruvate carboxylase subunit B (EC 6.4.1.1) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see paper)
43% identity, 95% coverage of query (476 bits)
Q9KUH1 oxaloacetate decarboxylase (EC 4.1.1.112) from Vibrio cholerae (see paper)
41% identity, 94% coverage of query (465 bits)
Q6A1F6 oxaloacetate decarboxylase (EC 4.1.1.112) from Vibrio cholerae (see paper)
TC 3.B.1.1.6 / Q6A1F6 Oxaloacetate decarboxylase, component of Na+-exporting oxaloacetate decarboxylase with three subunits, OadA (α), OadB (β) and OadG (γ) of 599 aas and 0 TMSs, 433 aas and 11 TMSs, and 90 aas and 1 TMS, respectively from Vibrio cholerae
40% identity, 94% coverage of query (465 bits)
TC 3.B.1.1.1 / Q03030 DCOA aka OADA1 aka OADA aka STM0055 aka OADA2 aka STM3352, component of Na+-transporting oxalo-acetate decarboxylase. Subunit stoichiometries have been described (Balsera et al., 2011). The crystal structure of the carboxyltransferase at 1.7 A resolution shows a dimer of alpha(8)beta(8) barrels with an active site metal ion, identified spectroscopically as Zn2+ from Salmonella typhimurium (see 2 papers)
40% identity, 94% coverage of query (443 bits)
PFREUD_18870 / Q70AC7 methylmalonyl-CoA carboxyltransferase 5S subunit (EC 2.1.3.1) from Propionibacterium freudenreichii subsp. shermanii (see 3 papers)
5S_PROFR / Q70AC7 Methylmalonyl-CoA carboxyltransferase 5S subunit; Transcarboxylase 5S subunit; EC 2.1.3.1 from Propionibacterium freudenreichii subsp. shermanii (see paper)
43% identity, 76% coverage of query (398 bits)
A5G5L1 biotin carboxylase (EC 6.3.4.14) from Geotalea uraniireducens (see paper)
33% identity, 95% coverage of query (304 bits)
Q2K340 pyruvate carboxylase (EC 6.4.1.1) from Rhizobium etli (see 8 papers)
31% identity, 94% coverage of query (293 bits)
PYC_STAAM / A0A0H3JRU9 Pyruvate carboxylase; EC 6.4.1.1 from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see 3 papers)
A0A0H3JRU9 pyruvate carboxylase (EC 6.4.1.1) from Staphylococcus aureus (see 4 papers)
31% identity, 95% coverage of query (292 bits)
3bg5A / A0A0H3JRU9 Crystal structure of staphylococcus aureus pyruvate carboxylase (see paper)
31% identity, 95% coverage of query (292 bits)
3bg5B / A0A0H3JRU9 Crystal structure of staphylococcus aureus pyruvate carboxylase (see paper)
31% identity, 95% coverage of query (291 bits)
4hnvB / A0A0H3JRU9 Crystal structure of r54e mutant of s. Aureus pyruvate carboxylase (see paper)
31% identity, 95% coverage of query (291 bits)
3hb9A Crystal structure of s. Aureus pyruvate carboxylase a610t mutant
31% identity, 95% coverage of query (290 bits)
PYC2_YEAST / P32327 Pyruvate carboxylase 2; Pyruvic carboxylase 2; PCB 2; EC 6.4.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P32327 pyruvate carboxylase (EC 6.4.1.1) from Saccharomyces cerevisiae (see paper)
30% identity, 94% coverage of query (288 bits)
PYC1_YEAST / P11154 Pyruvate carboxylase 1; Pyruvic carboxylase 1; PCB 1; EC 6.4.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P11154 pyruvate carboxylase (EC 6.4.1.1) from Saccharomyces cerevisiae (see 2 papers)
31% identity, 94% coverage of query (287 bits)
PYC_BACSU / Q9KWU4 Pyruvate carboxylase; Pyruvic carboxylase; PYC; EC 6.4.1.1 from Bacillus subtilis (strain 168) (see 2 papers)
30% identity, 95% coverage of query (286 bits)
A1ANN6 biotin carboxylase (EC 6.3.4.14) from Pelobacter propionicus (see paper)
31% identity, 95% coverage of query (286 bits)
pycA / Q9F843 pyruvate carboxylase subunit (EC 6.4.1.1) from Mycolicibacterium smegmatis (see paper)
33% identity, 93% coverage of query (285 bits)
A0QV14 pyruvate carboxylase (EC 6.4.1.1) from Mycolicibacterium smegmatis (see paper)
33% identity, 93% coverage of query (284 bits)
5vyzA Crystal structure of lactococcus lactis pyruvate carboxylase in complex with cyclic-di-amp (see paper)
30% identity, 95% coverage of query (284 bits)
5vyzC Crystal structure of lactococcus lactis pyruvate carboxylase in complex with cyclic-di-amp (see paper)
30% identity, 95% coverage of query (284 bits)
7zz3A Cryo-em structure of "bc react" conformation of lactococcus lactis pyruvate carboxylase with acetyl-coa
30% identity, 95% coverage of query (284 bits)
PYC1_CAEEL / O17732 Pyruvate carboxylase 1; Pyruvic carboxylase 1; PCB 1; EC 6.4.1.1 from Caenorhabditis elegans (see paper)
O17732 pyruvate carboxylase (EC 6.4.1.1) from Caenorhabditis elegans (see paper)
31% identity, 95% coverage of query (282 bits)
B9X0T8 pyruvate carboxylase (EC 6.4.1.1) from Emiliania huxleyi (see paper)
31% identity, 95% coverage of query (281 bits)
4qshC Crystal structure of l. Monocytogenes pyruvate carboxylase in complex with cyclic-di-amp (see paper)
30% identity, 95% coverage of query (276 bits)
2qf7A / Q2K340 Crystal structure of a complete multifunctional pyruvate carboxylase from rhizobium etli (see paper)
30% identity, 94% coverage of query (276 bits)
pycA putative pyruvate carboxylase or glutathione synthase from Emericella nidulans (see paper)
31% identity, 95% coverage of query (273 bits)
pyr1 / RF|NP_595900.1 pyruvate carboxylase Pyr1; EC 6.4.1.1 from Schizosaccharomyces pombe (see paper)
31% identity, 95% coverage of query (271 bits)
3tw6B / Q2K340 Structure of rhizobium etli pyruvate carboxylase t882a with the allosteric activator, acetyl coenzyme-a (see paper)
31% identity, 94% coverage of query (269 bits)
Q29RK2 pyruvate carboxylase (EC 6.4.1.1) from Bos taurus (see paper)
31% identity, 95% coverage of query (264 bits)
PYC / O93918 pyruvate carboxylase monomer (EC 6.4.1.1) from Aspergillus terreus (see paper)
30% identity, 95% coverage of query (260 bits)
8hwlA / P11498 Human pyruvate carboxylase
31% identity, 95% coverage of query (258 bits)
PC / P11498 pyruvate carboxylase, mitochondrial (EC 6.4.1.1) from Homo sapiens (see 5 papers)
PYC_HUMAN / P11498 Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase; PCB; EC 6.4.1.1 from Homo sapiens (Human) (see 5 papers)
P11498 pyruvate carboxylase (EC 6.4.1.1) from Homo sapiens (see 5 papers)
31% identity, 95% coverage of query (258 bits)
7wtbB / P11498 Cryo-em structure of human pyruvate carboxylase with acetyl-coa (see paper)
31% identity, 95% coverage of query (258 bits)
PYC_MOUSE / Q05920 Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase; PCB; EC 6.4.1.1 from Mus musculus (Mouse) (see paper)
30% identity, 95% coverage of query (258 bits)
7wtdC Cryo-em structure of human pyruvate carboxylase with acetyl-coa in the intermediate state 1
31% identity, 95% coverage of query (258 bits)
3bg3A Crystal structure of human pyruvate carboxylase (missing the biotin carboxylase domain at the n-terminus)
30% identity, 95% coverage of query (256 bits)
8gk8A R21a staphylococcus aureus pyruvate carboxylase
32% identity, 78% coverage of query (250 bits)
8gk8D R21a staphylococcus aureus pyruvate carboxylase
32% identity, 78% coverage of query (248 bits)
3ho8A Crystal structure of s. Aureus pyruvate carboxylase in complex with coenzyme a
32% identity, 78% coverage of query (248 bits)
8gk8C R21a staphylococcus aureus pyruvate carboxylase
32% identity, 78% coverage of query (248 bits)
3ho8D / A0A0H3JRU9 Crystal structure of s. Aureus pyruvate carboxylase in complex with coenzyme a (see paper)
30% identity, 78% coverage of query (226 bits)
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Lawrence Berkeley National Laboratory