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Searching for up to 100 curated homologs for WP_012991556.1 NCBI__GCF_000025605.1:WP_012991556.1 (385 a.a.)

Found high-coverage hits (≥70%) to 14 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

7e1qA / A0A0B2E3F3 Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori (see paper)
    55% identity, 93% coverage of query (397 bits)

7e1sC Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp
    55% identity, 93% coverage of query (397 bits)

7e1sA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp
    55% identity, 93% coverage of query (397 bits)

7e1rA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with holo-acp
    55% identity, 93% coverage of query (397 bits)

fabX / O25465 decanoate oxidase (EC 1.3.3.6; EC 5.3.3.14) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 2 papers)
    55% identity, 93% coverage of query (396 bits)

Build an alignment

Build an alignment for WP_012991556.1 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

7l00C / A0A031WIF2 Crystal structure of c. Difficile enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor
    27% identity, 93% coverage of query (95.5 bits)

5gvhA / Q9WZQ7 Structure of fabk from thermotoga maritima (see paper)
    28% identity, 73% coverage of query (90.1 bits)

fabK / D4YGY7 enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.9) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
    25% identity, 73% coverage of query (87.4 bits)

5lsmA / Q8EJJ2 Crystal structure of nitronate monooxygenase (so_0471) from shewanella oneidensis mr-1
    25% identity, 72% coverage of query (59.7 bits)

fabK / Q7MAW0 enoyl-[acyl-carrier-protein] reductase II (NADPH) monomer (EC 1.3.1.10) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83) (see 3 papers)
Q7MAW0 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) (EC 1.3.1.10); enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) (EC 1.3.1.39) from Porphyromonas gingivalis (see 2 papers)
4iqlA / Q7MAW0 Crystal structure of porphyromonas gingivalis enoyl-acp reductase ii (fabk) with cofactors NADPH and fmn (see paper)
    25% identity, 72% coverage of query (57.8 bits)

ipdC / P71847 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA dehydrogenase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
IPDC_MYCTU / P71847 (3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA dehydrogenase; 5OH-HIC-CoA dehydrogenase; EC 1.3.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    25% identity, 73% coverage of query (55.8 bits)

3bw2A / Q9FDD4 Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from streptomyces ansochromogenes (see paper)
    23% identity, 91% coverage of query (51.2 bits)

Q9FDD4 nitronate monooxygenase (EC 1.13.12.16); nitroalkane oxidase (EC 1.7.3.1) from Streptomyces ansochromogenes (see 2 papers)
    24% identity, 91% coverage of query (48.5 bits)

3bw3A Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from streptomyces ansochromogenes
    23% identity, 91% coverage of query (47.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory