Searching for up to 100 curated homologs for WP_012991819.1 NCBI__GCF_000025605.1:WP_012991819.1 (508 a.a.)
Found high-coverage hits (≥70%) to 28 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
AZOBR_RS02940 large component of pyruvate transporter (actP-like) from Azospirillum brasilense Sp245
60% identity, 99% coverage of query (602 bits)
PS417_08865 large component of pyruvate transporter (actP-like) from Pseudomonas simiae WCS417
62% identity, 99% coverage of query (602 bits)
Pf1N1B4_3673 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N1B4
62% identity, 99% coverage of query (594 bits)
YjcG / b4067 acetate/glycolate:cation symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
actP / P32705 acetate/glycolate:cation symporter from Escherichia coli (strain K12) (see 5 papers)
ACTP_ECOLI / P32705 Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.21.7.2 / P32705 Acetate/glyoxylate permease, ActP from Escherichia coli (see 6 papers)
60% identity, 99% coverage of query (594 bits)
Pf6N2E2_5849 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N2E2
61% identity, 99% coverage of query (585 bits)
TC 2.A.21.7.1 / O50471 Phenylacetate permease, Ppa from Pseudomonas putida (see paper)
59% identity, 99% coverage of query (573 bits)
TC 2.A.21.7.4 / D5AU53 Acetate uptake permease, ActP1; also takes up tellurite from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
59% identity, 99% coverage of query (563 bits)
TC 2.A.21.7.5 / D5APM1 Acetate permease ActP-2/ActP2/ActP3 from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
56% identity, 99% coverage of query (537 bits)
MCTC_CORGL / Q8NS49 Monocarboxylic acid transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
TC 2.A.21.7.3 / Q8NS49 Pyruvate/acetate/propionate: H+ symporter, MctC (DhlC; cg0953) from Corynebacterium glutamicum (see paper)
48% identity, 98% coverage of query (409 bits)
Build an alignment for WP_012991819.1 and 9 homologs with ≥ 30% identity
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OPUE_BACSU / O06493 Osmoregulated proline transporter OpuE; Osmoprotectant uptake; Proline uptake system from Bacillus subtilis (strain 168) (see 2 papers)
TC 2.A.21.2.5 / M1TZ79 Proline uptake porter, OpuE (YerK) from Bacillus subtilis subsp. subtilis 6051-HGW
opuE / AAB72182.1 OpuE from Bacillus subtilis (see paper)
26% identity, 83% coverage of query (114 bits)
Psest_3078 L-proline:Na+ symporter from Pseudomonas stutzeri RCH2
27% identity, 86% coverage of query (111 bits)
TC 2.A.21.2.3 / Q9I5F5 L-proline uptake porter, PutP from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
26% identity, 85% coverage of query (99.0 bits)
PUTP_BACSU / P94392 High-affinity proline transporter PutP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.21.2.4 / J7JIE8 The high affinity nutritional proline uptake porter, PutP from Bacillus subtilis QB928
24% identity, 87% coverage of query (97.4 bits)
PUTP_STAA8 / Q2FWY7 Sodium/proline symporter; Proline permease from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
TC 2.A.21.2.2 / Q7A4Q7 Sodium/proline symporter (Proline permease) from Staphylococcus aureus (strain N315) (see paper)
25% identity, 96% coverage of query (90.5 bits)
putP / AAA79365.1 proline permease homolog from Staphylococcus aureus (see paper)
24% identity, 93% coverage of query (88.6 bits)
PUTP_SALTY / P10502 Sodium/proline symporter; Proline permease from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
25% identity, 89% coverage of query (88.2 bits)
PutC / b1015 proline:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 7 papers)
putP / P07117 proline:Na+ symporter from Escherichia coli (strain K12) (see 12 papers)
PUTP_ECOLI / P07117 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) (see 9 papers)
TC 2.A.21.2.1 / P07117 Proline:Na+ symporter, PutP from Escherichia coli (see 12 papers)
25% identity, 89% coverage of query (80.9 bits)
TC 2.A.21.2.6 / O24896 High affinity proline-specific Na+:proline symporter, PutP (Rivera-Ordaz et al. 2013). Proline is a preferred source of energy for this microaerophilic bacterium. PutP is efficiently inhibited by the proline analogs, 3,4-dehydro-D,L-proline and L-azetidine-2-carboxylic acid from Helicobacter pylori (strain ATCC 700392 / 26695)
24% identity, 85% coverage of query (77.8 bits)
PanF / b3258 pantothenate:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
panF / P16256 pantothenate:Na+ symporter from Escherichia coli (strain K12) (see 3 papers)
PANF_ECOLI / P16256 Sodium/pantothenate symporter; Pantothenate permease from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.21.1.1 / P16256 Pantothenate:Na+ symporter, PanF from Escherichia coli (see 5 papers)
panF / GB|AAC76290.2 sodium/pantothenate symporter from Escherichia coli K12 (see 5 papers)
24% identity, 84% coverage of query (70.5 bits)
SC5A4_RAT / D3ZIS0 Solute carrier family 5 member 4 from Rattus norvegicus (Rat) (see paper)
22% identity, 86% coverage of query (61.2 bits)
7slaA / P13866 Cryoem structure of sglt1 at 3.15 angstrom resolution (see paper)
24% identity, 76% coverage of query (53.5 bits)
7sl8A Cryoem structure of sglt1 at 3.4 a resolution
24% identity, 76% coverage of query (53.5 bits)
S5A4A_MOUSE / Q9ET37 Solute carrier family 5 member 4A; SGLT3-a from Mus musculus (Mouse) (see 2 papers)
22% identity, 86% coverage of query (50.1 bits)
7wmvA / P13866 Structure of human sglt1-map17 complex bound with lx2761 (see paper)
23% identity, 83% coverage of query (48.9 bits)
SC5A1_HUMAN / P13866 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Homo sapiens (Human) (see 13 papers)
TC 2.A.21.3.1 / P13866 Glucose or galactose:Na+ symporter, SGLT1 (galactose > glucose > fucose). Cotransports water against an osmotic gradient (Naftalin, 2008). TMS IV of the high-affinity sodium-glucose cotransporter participates in sugar binding from Homo sapiens (Human) (see 9 papers)
SLC5A1 / GI|56202462 sodium/glucose cotransporter 1 from Homo sapiens (see paper)
23% identity, 83% coverage of query (48.9 bits)
SC5A1_RABIT / P11170 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Oryctolagus cuniculus (Rabbit) (see paper)
23% identity, 86% coverage of query (47.4 bits)
SGLT_VIBPH / P96169 Sodium/glucose cotransporter; Na(+)/glucose symporter from Vibrio parahaemolyticus (see paper)
TC 2.A.21.3.2 / P96169 Glucose or galactose:Na+ symporter, SglS or SglT of 543 aas and 14 TMSs (Turk et al. 2006). The 3.0 Å structure is known (Faham et al., 2008). Sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required for substrate exit (Watanabe et al., 2010). The involvement of aromatic residue pi interactions, especially with Na+ binding, has been examined (see 3 papers)
AAF80602.1 Na+/galactose cotransporter SGLT from Vibrio parahaemolyticus (see paper)
20% identity, 87% coverage of query (47.4 bits)
SC5A3_MOUSE / Q9JKZ2 Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3 from Mus musculus (Mouse) (see 3 papers)
21% identity, 87% coverage of query (47.4 bits)
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Lawrence Berkeley National Laboratory