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Searching for up to 100 curated homologs for WP_013012191.1 NCBI__GCF_000025725.1:WP_013012191.1 (339 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q9WYH8 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Thermotoga maritima (see paper)
3pg9A / Q9WYH8 Thermotoga maritima dah7p synthase in complex with inhibitor (see paper)
    55% identity, 100% coverage of query (385 bits)

1rzmA Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahps) from thermotoga maritima complexed with cd2+, pep and e4p
    55% identity, 100% coverage of query (385 bits)

4grsA / Q8U0A9,Q9WYH8 Crystal structure of a chimeric dah7ps (see paper)
    54% identity, 96% coverage of query (382 bits)

4c1kA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
    54% identity, 76% coverage of query (313 bits)

1zcoB Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
    54% identity, 76% coverage of query (309 bits)

1zcoA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
    54% identity, 76% coverage of query (309 bits)

5j6fA / L8A208 Crystal structure of dah7ps-cm complex from geobacillus sp. With prephenate (see paper)
    52% identity, 76% coverage of query (285 bits)

3nvtA / Q8Y6T2 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e (see paper)
    53% identity, 76% coverage of query (283 bits)

P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis (see paper)
    54% identity, 76% coverage of query (283 bits)

3tfcA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e in complex with phosphoenolpyruvate
    53% identity, 76% coverage of query (283 bits)

P39912 Protein AroA(G); EC 2.5.1.54; EC 5.4.99.5 from Bacillus subtilis (strain 168)
    54% identity, 76% coverage of query (283 bits)

ccmA / BAA05463.1 32.4kD protein from Synechocystis sp. PCC 6803 (see paper)
    48% identity, 86% coverage of query (265 bits)

1vs1D / Q9YEJ7 Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep
    54% identity, 80% coverage of query (263 bits)

Q9YEJ7 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Aeropyrum pernix (see paper)
    56% identity, 76% coverage of query (262 bits)

A0A482F152 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from uncultured bacterium (see paper)
    50% identity, 75% coverage of query (236 bits)

Echvi_0120 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase / chorismate mutase (EC 2.5.1.54; EC 5.4.99.5) from Echinicola vietnamensis KMM 6221, DSM 17526
    31% identity, 71% coverage of query (125 bits)

Build an alignment

Build an alignment for WP_013012191.1 and 16 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q8GLK7 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Aquifex pyrophilus (see paper)
    28% identity, 72% coverage of query (93.2 bits)

Q9ZE84 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Rickettsia prowazekii (see paper)
    27% identity, 74% coverage of query (78.2 bits)

P45251 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Haemophilus influenzae (see paper)
    25% identity, 75% coverage of query (76.6 bits)

P95514 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Mannheimia haemolytica (see paper)
    26% identity, 73% coverage of query (72.4 bits)

1gg0A Crystal structure analysis of kdop synthase at 3.0 a
    26% identity, 72% coverage of query (72.4 bits)

O68662 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Actinobacillus pleuropneumoniae (see paper)
    27% identity, 72% coverage of query (71.6 bits)

Q9JZ55 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Neisseria meningitidis serogroup B (see paper)
    26% identity, 72% coverage of query (69.7 bits)

3fyoD / Q9JZ55 Crystal structure of the triple mutant (n23c/d247e/p249a) of 3-deoxy- d-manno-octulosonate 8-phosphate synthase (kdo8ps) from neisseria meningitidis (see paper)
    27% identity, 72% coverage of query (68.9 bits)

Q9ZFK4 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Pseudomonas aeruginosa (see paper)
    23% identity, 74% coverage of query (65.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory