Searching for up to 100 curated homologs for WP_013258699.1 NCBI__GCF_000143965.1:WP_013258699.1 (343 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q9WYH8 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Thermotoga maritima (see paper)
3pg9A / Q9WYH8 Thermotoga maritima dah7p synthase in complex with inhibitor (see paper)
    45% identity, 89% coverage of query (246 bits)

1rzmA Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahps) from thermotoga maritima complexed with cd2+, pep and e4p
    45% identity, 89% coverage of query (246 bits)

4grsA / Q8U0A9,Q9WYH8 Crystal structure of a chimeric dah7ps (see paper)
    45% identity, 85% coverage of query (244 bits)

ccmA / BAA05463.1 32.4kD protein from Synechocystis sp. PCC 6803 (see paper)
    42% identity, 86% coverage of query (202 bits)

5j6fA / L8A208 Crystal structure of dah7ps-cm complex from geobacillus sp. With prephenate (see paper)
    43% identity, 75% coverage of query (194 bits)

P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis (see paper)
    43% identity, 75% coverage of query (182 bits)

P39912 Protein AroA(G); EC 2.5.1.54; EC 5.4.99.5 from Bacillus subtilis (strain 168)
    43% identity, 75% coverage of query (182 bits)

A0A482F152 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from uncultured bacterium (see paper)
    44% identity, 70% coverage of query (166 bits)

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Build an alignment for WP_013258699.1 and 8 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Q8GLK7 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Aquifex pyrophilus (see paper)
    28% identity, 71% coverage of query (79.0 bits)

1pcwA Aquifex aeolicus kdo8ps in complex with cadmium and app, a bisubstrate inhibitor
    29% identity, 70% coverage of query (77.4 bits)

1x6uA Kdo8p synthase in it's binary complex with the product kdo8p
    28% identity, 73% coverage of query (77.4 bits)

1phwA Crystal structure of kdo8p synthase in its binary complex with substrate analog 1-deoxy-a5p
    28% identity, 73% coverage of query (77.4 bits)

1phqA Crystal structure of kdo8p synthase in its binary complex with substrate analog e-fpep
    28% identity, 73% coverage of query (77.4 bits)

1gg0A Crystal structure analysis of kdop synthase at 3.0 a
    27% identity, 73% coverage of query (77.4 bits)

1pe1A Aquifex aeolicus kdo8ps in complex with cadmium and 2-pga
    29% identity, 70% coverage of query (77.4 bits)

1pckA Aquifex aeolicus kdo8ps in complex with z-methyl-pep
    28% identity, 70% coverage of query (77.0 bits)

3e12A Cu2+ substituted aquifex aeolicus kdo8ps in complex with kdo8p
    28% identity, 70% coverage of query (77.0 bits)

1jcxA Aquifex aeolicus kdo8p synthase in complex with api and cadmium
    28% identity, 70% coverage of query (76.6 bits)

KdsA / b1215 3-deoxy-D-manno-octulosonate 8-phosphate synthase (EC 2.5.1.55) from Escherichia coli K-12 substr. MG1655 (see 24 papers)
kdsA / P0A715 3-deoxy-D-manno-octulosonate 8-phosphate synthase (EC 2.5.1.55) from Escherichia coli (strain K12) (see 25 papers)
KDSA_ECOLI / P0A715 2-dehydro-3-deoxyphosphooctonate aldolase; 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase; EC 2.5.1.55 from Escherichia coli (strain K12) (see paper)
P0A715 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Escherichia coli (see 5 papers)
kdsA / PDB|1PHQ 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; EC 2.5.1.55 from Escherichia coli K12 (see 11 papers)
    27% identity, 73% coverage of query (75.5 bits)

1g7uA / P0A715 Crystal structures of kdo8p synthase in its binary complex with substrate phosphoenol pyruvate (see paper)
    27% identity, 73% coverage of query (75.5 bits)

1g7vA Crystal structures of kdo8p synthase in its binary complexes with the mechanism-based inhibitor
    27% identity, 73% coverage of query (75.5 bits)

O66496 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Aquifex aeolicus (see 5 papers)
    27% identity, 70% coverage of query (73.6 bits)

2a21A / O66496 Aquifex aeolicus kdo8ps in complex with pep, po4, and zn2+ (see paper)
    27% identity, 70% coverage of query (73.6 bits)

Q9ZFK4 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Pseudomonas aeruginosa (see paper)
    28% identity, 73% coverage of query (73.6 bits)

3e0iA Cu2+ substituted aquifex aeolicus kdo8ps in complex with pep
    27% identity, 70% coverage of query (73.6 bits)

1jcyA Aquifex aeolicus kdo8p synthase in complex with r5p, pep and cadmium
    27% identity, 70% coverage of query (73.6 bits)

1fwwA Aquifex aeolicus kdo8p synthase in complex with pep, a5p and cadmium
    27% identity, 70% coverage of query (73.6 bits)

1fwtA Aquifex aeolicus kdo8p synthase in complex with pep, e4p and cadmium
    27% identity, 70% coverage of query (73.6 bits)

Q9Z7I4 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) from Chlamydia pneumoniae (see paper)
    30% identity, 72% coverage of query (70.5 bits)

2nx1A Structural and mechanistic changes along an engineered path from metallo to non-metallo kdo8p synthase
    27% identity, 70% coverage of query (68.9 bits)

2nx3D Structural and mechanistic changes along an engineered path from metallo to non-metallo kdo8p synthase
    27% identity, 70% coverage of query (68.6 bits)

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