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Searching for up to 100 curated homologs for WP_013259993.1 NCBI__GCF_000143965.1:WP_013259993.1 (182 a.a.)

Found high-coverage hits (≥70%) to 21 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q51799 pyruvate synthase (subunit 1/4) (EC 1.2.7.1) from Pyrococcus furiosus (see 2 papers)
    57% identity, 100% coverage of query (195 bits)

W8CQB1 pyruvate synthase (subunit 2/4) (EC 1.2.7.1); pyruvate decarboxylase (subunit 2/4) (EC 4.1.1.1) from Thermococcus guaymasensis (see paper)
    54% identity, 100% coverage of query (192 bits)

P80523 pyruvate synthase (subunit 2/4) (EC 1.2.7.1) from Methanosarcina barkeri (see paper)
    48% identity, 97% coverage of query (182 bits)

porC / O05650 pyruvate:ferredoxin oxidoreductase γ subunit (EC 1.2.7.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 7 papers)
O05650 pyruvate synthase (subunit 2/4) (EC 1.2.7.1) from Thermotoga maritima (see 2 papers)
    48% identity, 99% coverage of query (173 bits)

Q9P9E7 pyruvate synthase (subunit 2/5) (EC 1.2.7.1) from Methanococcus maripaludis (see paper)
    48% identity, 98% coverage of query (172 bits)

PORC_METTM / P80902 Pyruvate synthase subunit PorC; Pyruvate oxidoreductase gamma chain; POR; Pyruvic-ferredoxin oxidoreductase subunit gamma; EC 1.2.7.1 from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see paper)
    51% identity, 97% coverage of query (170 bits)

porC / O27772 pyruvate synthase subunit γ (EC 1.2.7.1) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see 7 papers)
    51% identity, 97% coverage of query (170 bits)

padE / Q8L3B3 phenylglyoxylate dehydrogenase (acylating) subunit PadE (EC 1.2.1.58) from Aromatoleum evansii (see 2 papers)
PADE_AROEV / Q8L3B3 NADH-dependent phenylglyoxylate dehydrogenase subunit gamma; Phenylglyoxylate:NAD oxidoreductase; Phenylglyoxylate:acceptor oxidoreductase; EC 1.2.1.58 from Aromatoleum evansii (Azoarcus evansii) (see paper)
    44% identity, 100% coverage of query (145 bits)

D3DIA3 2-oxoglutarate synthase (subunit 3/5) (EC 1.2.7.3) from Hydrogenobacter thermophilus (see 2 papers)
    33% identity, 86% coverage of query (92.8 bits)

porG / Q9LBF7 pyruvate:ferredoxin oxidoreductase γ subunit (EC 1.2.7.1) from Hydrogenobacter thermophilus (see 2 papers)
D3DJJ8 pyruvate synthase (subunit 1/2) (EC 1.2.7.1) from Hydrogenobacter thermophilus (see paper)
porG / BAA95607.1 pyruvate:ferredoxin oxidoreductase gamma subunit from Hydrogenobacter thermophilus (see paper)
    36% identity, 87% coverage of query (84.0 bits)

KORC_METTM / P80906 2-oxoglutarate synthase subunit KorC; 2-ketoglutarate oxidoreductase gamma chain; KOR; 2-oxoglutarate-ferredoxin oxidoreductase subunit gamma; EC 1.2.7.3 from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see paper)
    33% identity, 85% coverage of query (67.4 bits)

korG / Q6LXN4 2-oxoglutarate ferredoxin oxidoreductase γ subunit (EC 1.2.7.3) from Methanococcus maripaludis (strain S2 / LL) (see 2 papers)
    32% identity, 96% coverage of query (65.1 bits)

5c4iE / Q2RI40 Structure of an oxalate oxidoreductase (see paper)
    31% identity, 83% coverage of query (58.5 bits)

OORD_MOOTA / Q2RI40 Oxalate oxidoreductase subunit delta; OOR delta subunit; EC 1.2.7.10 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see paper)
Q2RI40 oxalate oxidoreductase (subunit 1/3) (EC 1.2.7.10) from Moorella thermoacetica (see paper)
    31% identity, 83% coverage of query (58.5 bits)

VORA_METTM / P80907 Ketoisovalerate oxidoreductase subunit VorA; VOR; 2-oxoisovalerate oxidoreductase alpha chain; 2-oxoisovalerate-ferredoxin oxidoreductase subunit alpha; EC 1.-.-.- from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see paper)
    32% identity, 77% coverage of query (58.2 bits)

5exdH / Q2RI40 Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-di-oxido-methyl-tpp (coom-tpp) intermediate (see paper)
    31% identity, 83% coverage of query (58.2 bits)

Build an alignment

Build an alignment for WP_013259993.1 and 16 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

6cinB / Q2RMD6 Crystal structure of pyruvate:ferredoxin oxidoreductase from moorella thermoacetica (see paper)
    25% identity, 95% coverage of query (48.5 bits)

6ciqA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with coenzyme a bound
    25% identity, 95% coverage of query (48.5 bits)

PFOR_MOOTA / Q2RMD6 Pyruvate:ferredoxin oxidoreductase; PFOR; Pyruvate synthase; EC 1.2.7.1 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see 3 papers)
Q2RMD6 pyruvate synthase (EC 1.2.7.1) from Moorella thermoacetica (see paper)
    25% identity, 95% coverage of query (48.1 bits)

6cioA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with lactyl-tpp bound
    25% identity, 95% coverage of query (48.1 bits)

6cipA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with acetyl-tpp bound
    25% identity, 95% coverage of query (48.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory