Searching for up to 100 curated homologs for WP_013403450.1 NCBI__GCF_000166355.1:WP_013403450.1 (343 a.a.)
Found high-coverage hits (≥70%) to 68 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
50% identity, 100% coverage of query (360 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
49% identity, 100% coverage of query (360 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
49% identity, 100% coverage of query (360 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
49% identity, 100% coverage of query (357 bits)
METN_BACSU / O32169 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.24.2 / O32169 MetN (C) (aka YusC), component of The L- and D-methionine porter (also transports methionine sulfoxide from Bacillus subtilis subsp. subtilis str. 168 (see 2 papers)
50% identity, 100% coverage of query (353 bits)
TC 3.A.1.24.5 / Q9HT70 Methionine import ATP-binding protein MetN 2, component of L-Histidine uptake porter, MetIQN from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
47% identity, 99% coverage of query (318 bits)
TC 3.A.1.24.3 / Q8K8K8 AtmD (MetN), component of The methionine porter, AtmBDE from Streptococcus pyogenes serotype M3 (see 2 papers)
48% identity, 94% coverage of query (310 bits)
TC 3.A.1.24.4 / Q8NSN2 Methionine import ATP-binding protein metN, component of L-Methionine uptake porter, MetQNI from Corynebacterium glutamicum (see paper)
46% identity, 93% coverage of query (298 bits)
ARTM_BACSU / P54537 Arginine transport ATP-binding protein ArtM from Bacillus subtilis (strain 168) (see paper)
44% identity, 71% coverage of query (213 bits)
GLNQ_BACSU / O34677 Glutamine transport ATP-binding protein GlnQ; EC 7.4.2.- from Bacillus subtilis (strain 168) (see paper)
43% identity, 70% coverage of query (201 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
42% identity, 71% coverage of query (199 bits)
YXEO_BACSU / P54954 Probable amino-acid import ATP-binding protein YxeO; EC 7.4.2.- from Bacillus subtilis (strain 168) (see paper)
41% identity, 71% coverage of query (197 bits)
GLUA_CORGL / P48243 Glutamate transport ATP-binding protein GluA; Glutamate uptake system protein GluA; EC 7.4.2.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
TC 3.A.1.3.9 / P48243 GluA aka CGL1950, component of Glutamate porter from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
44% identity, 70% coverage of query (195 bits)
TC 3.A.1.3.5 / P0A2V2 Octopine permease ATP-binding protein P aka occP, component of Octopine porter from Agrobacterium tumefaciens (see 2 papers)
40% identity, 70% coverage of query (194 bits)
PP_3597 L-lysine and D-lysine ABC transporter, ATPase component from Pseudomonas putida KT2440
41% identity, 70% coverage of query (194 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
41% identity, 70% coverage of query (192 bits)
TC 3.A.1.3.16 / A3ZI83 PEB1C, component of Uptake system for glutamate and aspartate from Campylobacter jejuni subsp. jejuni 84-25
42% identity, 70% coverage of query (192 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
41% identity, 70% coverage of query (192 bits)
2olkA Abc protein artp in complex with adp-beta-s
41% identity, 70% coverage of query (192 bits)
2oljA Abc protein artp in complex with adp/mg2+
41% identity, 70% coverage of query (192 bits)
SMc02121 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component from Sinorhizobium meliloti 1021
42% identity, 71% coverage of query (191 bits)
TC 3.A.1.3.14 / P39456 TcyC (YckI), component of Uptake system for L-cystine from Bacillus subtilis (see 7 papers)
42% identity, 70% coverage of query (190 bits)
GlnQ / b0809 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GlnQ / P10346 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli (strain K12) (see paper)
GLNQ_ECOLI / P10346 Glutamine transport ATP-binding protein GlnQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.2 / P10346 GlnQ aka B0809, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 5 papers)
glnQ / GB|ABB65374.1 glutamine ABC transporter, ATP-binding protein GlnQ from Escherichia coli K12 (see 5 papers)
41% identity, 71% coverage of query (190 bits)
GBUA_LISM4 / Q9RR46 Glycine betaine/carnitine transport ATP-binding protein GbuA; EC 7.6.2.9 from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
41% identity, 71% coverage of query (190 bits)
TCYN_BACSU / O34900 L-cystine import ATP-binding protein TcyN; EC 7.4.2.- from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.3.13 / O34900 TcyN (YtmN), component of Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine from Bacillus subtilis (see 4 papers)
45% identity, 71% coverage of query (190 bits)
TC 3.A.1.3.8 / Q52815 AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapP / CAA57936.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
41% identity, 71% coverage of query (188 bits)
8j5qD / P9WQJ5 Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- translocation state (see paper)
39% identity, 70% coverage of query (179 bits)
8j5tD Cryo-em structure of mycobacterium tuberculosis oppabcd in the catalytic intermediate state
38% identity, 70% coverage of query (178 bits)
8j5sD Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- catalytic intermediate state
38% identity, 70% coverage of query (178 bits)
8xfcD / I6Y482 Cryo-em structure of the atp-bound mtb dppabcd with the d445a mutation of dppa
34% identity, 70% coverage of query (152 bits)
8wdbD Cryo-em structure of the atp-bound dppabcd complex
34% identity, 70% coverage of query (152 bits)
1g291 / Q9YGA6 Malk (see paper)
32% identity, 71% coverage of query (147 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
32% identity, 84% coverage of query (145 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
31% identity, 73% coverage of query (143 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
32% identity, 73% coverage of query (141 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
32% identity, 73% coverage of query (140 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
32% identity, 73% coverage of query (140 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
32% identity, 73% coverage of query (140 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
32% identity, 73% coverage of query (140 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
32% identity, 73% coverage of query (140 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
32% identity, 73% coverage of query (140 bits)
Build an alignment for WP_013403450.1 and 41 homologs with ≥ 30% identity
Or download the sequences
8hprD Lpqy-sugabc in state 4
29% identity, 89% coverage of query (135 bits)
8hprC Lpqy-sugabc in state 4
29% identity, 89% coverage of query (135 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
29% identity, 84% coverage of query (134 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
29% identity, 72% coverage of query (126 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
29% identity, 71% coverage of query (126 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
29% identity, 71% coverage of query (125 bits)
8wooA Structure of the wild-type arabidopsis abcb19 in the brassinolide and amp-pnp bound state
31% identity, 77% coverage of query (117 bits)
8womA / Q9LJX0 Structure of the wild-type arabidopsis abcb19 in the brassinolide- bound state (see paper)
31% identity, 77% coverage of query (117 bits)
8wp0A Structure of the arabidopsis e529q/e1174q abcb19 in the atp bound state
31% identity, 77% coverage of query (115 bits)
SapD / b1291 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
SapD / P0AAH4 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli (strain K12) (see 5 papers)
SAPD_ECOLI / P0AAH4 Putrescine export system ATP-binding protein SapD from Escherichia coli (strain K12) (see 2 papers)
30% identity, 71% coverage of query (114 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
29% identity, 77% coverage of query (107 bits)
4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
33% identity, 71% coverage of query (106 bits)
DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
33% identity, 71% coverage of query (106 bits)
ABC1_MYCTU / O65934 ABC transporter ATP-binding/permease protein Rv1747; EC 7.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
27% identity, 80% coverage of query (104 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
27% identity, 78% coverage of query (102 bits)
ABCB7_HUMAN / O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.210.4 / O75027 ABC7 or ABCB7 iron transporter (X-linked sideroblastis anemia protein, XLSA/A (Fujiwara and Harigae 2013)) from Homo sapiens (Human) (see 9 papers)
29% identity, 70% coverage of query (99.4 bits)
ABCB7_MOUSE / Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Mus musculus (Mouse) (see 4 papers)
29% identity, 70% coverage of query (98.2 bits)
4myhB Structure of the glutathione bound mitochondrial abc transporter, atm1
30% identity, 74% coverage of query (98.2 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
25% identity, 71% coverage of query (93.6 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
26% identity, 73% coverage of query (93.6 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp (see paper)
25% identity, 71% coverage of query (93.2 bits)
7lkzA Structure of atp-bound human abca4
25% identity, 82% coverage of query (92.8 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
25% identity, 71% coverage of query (92.0 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
24% identity, 74% coverage of query (87.0 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
25% identity, 77% coverage of query (85.5 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
23% identity, 85% coverage of query (82.8 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
25% identity, 73% coverage of query (75.1 bits)
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Lawrence Berkeley National Laboratory