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Searching for up to 100 curated homologs for WP_013417865.1 NCBI__GCF_000166055.1:WP_013417865.1 (258 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q4FRT2 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Psychrobacter arcticus (see paper)
    64% identity, 100% coverage of query (333 bits)

6zzoC / Q4FRT2 Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and acetoacetate (see paper)
    64% identity, 100% coverage of query (333 bits)

6zzpA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and 3-oxovalerate
    64% identity, 100% coverage of query (333 bits)

Q5ZT49 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Legionella pneumophila subsp. pneumophila (see paper)
    63% identity, 100% coverage of query (329 bits)

8dt1C / A0A1V2Y0M0 Crystal structure of a putative d-beta-hydroxybutyrate dehydrogenase from burkholderia cenocepacia j2315 in complex with NAD
    63% identity, 99% coverage of query (318 bits)

Q2PEN3 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Ralstonia pickettii (see 2 papers)
    61% identity, 100% coverage of query (307 bits)

A0A1E3M3N6 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Acinetobacter baumannii (see paper)
6zzsD / A0A1E3M3N6 Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
    42% identity, 98% coverage of query (198 bits)

6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate
    42% identity, 98% coverage of query (198 bits)

5b4tA / D0VWQ0 Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
    39% identity, 98% coverage of query (169 bits)

Q5KST5 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Pseudomonas fragi (see 3 papers)
1wmbA / Q5KST5 Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
BAD86668.1 D(-)-3-hydroxybutyrate dehydrogenase from Pseudomonas fragi (see paper)
    39% identity, 98% coverage of query (169 bits)

3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
    39% identity, 98% coverage of query (169 bits)

3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+)
    39% identity, 98% coverage of query (169 bits)

3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate
    39% identity, 98% coverage of query (169 bits)

2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate
    39% identity, 98% coverage of query (169 bits)

A8R3J3 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Ralstonia pickettii (see paper)
    40% identity, 98% coverage of query (166 bits)

Q767A0 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Acidovorax sp. (see paper)
    41% identity, 98% coverage of query (165 bits)

Q9AE70 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Pseudomonas putida (see 2 papers)
    38% identity, 99% coverage of query (154 bits)

2q2qD / Q9AE70 Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
    38% identity, 98% coverage of query (152 bits)

5yssB / A0A0D7LY80 Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
    38% identity, 98% coverage of query (152 bits)

Q2PEN2 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Ralstonia pickettii (see 2 papers)
    37% identity, 98% coverage of query (150 bits)

1x1tA / Q5KST5 Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
    38% identity, 98% coverage of query (148 bits)

xecD / Q56840 2-(R)-hydroxypropyl-CoM dehydrogenase subunit (EC 1.1.1.268) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see 5 papers)
HCDR1_XANP2 / Q56840 2-(R)-hydroxypropyl-CoM dehydrogenase; R-HPCDH; 2-[(R)-2-hydroxypropylthio]ethanesulfonate dehydrogenase; Aliphatic epoxide carboxylation component III; Epoxide carboxylase component III; RHPCDH1; EC 1.1.1.268 from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see 7 papers)
Q56840 2-(R)-hydroxypropyl-CoM dehydrogenase (EC 1.1.1.268) from Xanthobacter autotrophicus (see 4 papers)
2cfcA / Q56840 Structural basis for stereo selectivity in the (r)- and (s)- hydroxypropylethane thiosulfonate dehydrogenases (see paper)
    35% identity, 97% coverage of query (147 bits)

6ixmC / X2D0L0 Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
    33% identity, 98% coverage of query (139 bits)

SDR / F1SWA0 zerumbone synthase (EC 1.1.1.326) from Zingiber zerumbet (see paper)
ZERSY_ZINZE / F1SWA0 Zerumbone synthase; EC 1.1.1.326 from Zingiber zerumbet (Shampoo ginger) (Amomum zerumbet) (see paper)
F1SWA0 zerumbone synthase (EC 1.1.1.326) from Zingiber zerumbet (see 2 papers)
    33% identity, 99% coverage of query (137 bits)

1zk1A Structure of r-specific alcohol dehydrogenase (mutant g37d) from lactobacillus brevis in complex with phenylethanol and NAD
    33% identity, 98% coverage of query (135 bits)

1zjzA Structure of r-specific alcohol dehydrogenase (mutant g37d) from lactobacillus brevis in complex with phenylethanol and NAD
    33% identity, 98% coverage of query (135 bits)

1zjyA Structure of r-specific alcohol dehydrogenase (mutant g37d) from lactobacillus brevis in complex with phenylethanol and nadh
    33% identity, 98% coverage of query (135 bits)

bacC / P39640 dihydroanticapsin dehydrogenase (EC 1.1.1.385) from Bacillus subtilis (strain 168) (see paper)
BACC_BACSU / P39640 Dihydroanticapsin 7-dehydrogenase; Bacilysin biosynthesis oxidoreductase BacC; EC 1.1.1.385 from Bacillus subtilis (strain 168) (see 3 papers)
P39640 dihydroanticapsin dehydrogenase (EC 1.1.1.385) from Bacillus subtilis (see paper)
    32% identity, 99% coverage of query (134 bits)

5itvA / P39640 Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
    32% identity, 99% coverage of query (134 bits)

ptmO8 / D8L2W5 ent-kauranol 7β-dehydrogenase from Streptomyces platensis (see paper)
    34% identity, 99% coverage of query (134 bits)

6y0sAAA / Q84EX5 6y0sAAA (see paper)
    33% identity, 98% coverage of query (132 bits)

1zk4A Structure of r-specific alcohol dehydrogenase (wildtype) from lactobacillus brevis in complex with acetophenone and NADP
    33% identity, 98% coverage of query (132 bits)

3ak4A / G1K3P5 Crystal structure of nadh-dependent quinuclidinone reductase from agrobacterium tumefaciens
    33% identity, 100% coverage of query (131 bits)

2ekpA / Q53W82 Structure of tt0495 protein from thermus thermophilus (see paper)
    36% identity, 97% coverage of query (130 bits)

HSERO_RS22235 rhamnulose-1-phosphate aldolase (EC 4.1.2.19) / lactaldehyde dehydrogenase (EC 1.2.1.22) from Herbaspirillum seropedicae SmR1
    37% identity, 98% coverage of query (130 bits)

A0JC04 octanol dehydrogenase (EC 1.1.1.73) from Ogataea wickerhamii (see paper)
    32% identity, 97% coverage of query (129 bits)

dhuD / Q8E370 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase monomer (EC 1.1.1.127) from Streptococcus agalactiae serotype III (strain NEM316) (see paper)
    33% identity, 98% coverage of query (128 bits)

W5VJM4 isopiperitenol dehydrogenase (EC 1.1.1.223) from Perilla frutescens var. hirtella (see paper)
    33% identity, 98% coverage of query (127 bits)

SQD_PSEPU / P0DOV5 Sulfoquinovose 1-dehydrogenase; SQ dehydrogenase; EC 1.1.1.390 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
P0DOV5 sulfoquinovose 1-dehydrogenase (EC 1.1.1.390) from Pseudomonas putida (see paper)
    32% identity, 98% coverage of query (126 bits)

G0HY85 acetoacetyl-CoA reductase (EC 1.1.1.36) from Haloarcula hispanica (see paper)
    33% identity, 96% coverage of query (125 bits)

YLX6_SCHPO / Q9URX0 Uncharacterized oxidoreductase C922.06; EC 1.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    31% identity, 98% coverage of query (125 bits)

8y83A / A0A562MSV3 Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
    34% identity, 97% coverage of query (125 bits)

RADH_LENKE / Q6WVP7 NADP-dependent (R)-specific alcohol dehydrogenase; (R)-specific ADH; Ketoreductase; KRED; EC 1.1.1.- from Lentilactobacillus kefiri (Lactobacillus kefiri)
    32% identity, 98% coverage of query (125 bits)

W5VJJ6 isopiperitenol dehydrogenase (EC 1.1.1.223) from Perilla frutescens (see paper)
    33% identity, 98% coverage of query (124 bits)

Q1J2J0 L-iditol 2-dehydrogenase (EC 1.1.1.14) from Deinococcus geothermalis (see paper)
    34% identity, 99% coverage of query (124 bits)

budC / H9XP47 meso-butanediol dehydrogenase [(R)-acetoin-forming] (EC 1.1.1.304; EC 1.1.1.76) from Serratia marcescens (see paper)
MBDH_SERMA / H9XP47 Meso-2,3-butanediol dehydrogenase; BDH; meso-2,3-BDH; (R,S)-butane-2,3-diol dehydrogenase; NAD(H)-dependent meso-2,3-BDH; SmBdh; EC 1.1.1.- from Serratia marcescens (see 3 papers)
    32% identity, 98% coverage of query (124 bits)

SMc02322 rhamnulose-1-phosphate aldolase (EC 4.1.2.19) / lactaldehyde dehydrogenase (EC 1.2.1.22) from Sinorhizobium meliloti 1021
    37% identity, 98% coverage of query (124 bits)

7ejhA / Q6WVP7 Crystal structure of kred mutant-f147l/l153q/y190p/l199a/m205f/m206f and 2-hydroxyisoindoline-1,3-dione complex
    32% identity, 98% coverage of query (123 bits)

uxaD / Q9WYS2 fructuronate reductase from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    30% identity, 100% coverage of query (123 bits)

LINX_SPHIU / D4Z260 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase LinX; 2,5-DDOL dehydrogenase; EC 1.1.1.- from Sphingobium indicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S) (Sphingobium japonicum) (see paper)
    32% identity, 98% coverage of query (123 bits)

7krmC / A0A077GFB1 Putative fabg bound to nadh from acinetobacter baumannii
    31% identity, 100% coverage of query (123 bits)

1vl8B / Q9WYS2 Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
    30% identity, 100% coverage of query (123 bits)

badH / O07457 BadH from Rhodopseudomonas palustris (see paper)
    35% identity, 100% coverage of query (123 bits)

4jroC / Q8Y690 Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
    34% identity, 100% coverage of query (123 bits)

7ejiB Crystal structure of kred f147l/l153q/y190p/l199a/m205f/m206f variant and methyl methacrylate complex
    32% identity, 98% coverage of query (123 bits)

AO356_20240 L-arabinose 1-dehydrogenase (EC 1.1.1.46) from Pseudomonas fluorescens FW300-N2C3
    39% identity, 73% coverage of query (122 bits)

GAME25 / Q9LEG3 3β-hydroxysteroid dehydrogenase/ Δ5,4 isomerase (EC 1.1.1.270) from Solanum lycopersicum (see 5 papers)
    36% identity, 99% coverage of query (122 bits)

6vspB / H9XP47 Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a (see paper)
    32% identity, 98% coverage of query (122 bits)

Pf6N2E2_5967 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) from Pseudomonas fluorescens FW300-N2E2
    38% identity, 73% coverage of query (121 bits)

4nbuB Crystal structure of fabg from bacillus sp (see paper)
    31% identity, 99% coverage of query (121 bits)

C5IFU0 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Lysinibacillus sphaericus (see 2 papers)
    31% identity, 98% coverage of query (121 bits)

A0A068FPP9 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Bacillus sp. (in: Bacteria) (see paper)
    30% identity, 98% coverage of query (121 bits)

2dteA / Q9HK51 Structure of thermoplasma acidophilum aldohexose dehydrogenase (aldt) in complex with nadh (see paper)
    31% identity, 98% coverage of query (121 bits)

Q9HK51 aldose 1-dehydrogenase (NAD+) (EC 1.1.1.121) from Thermoplasma acidophilum (see 2 papers)
    31% identity, 98% coverage of query (121 bits)

6xewA Structure of serratia marcescens 2,3-butanediol dehydrogenase
    32% identity, 98% coverage of query (121 bits)

6vspA Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a
    32% identity, 98% coverage of query (121 bits)

2dtxA Structure of thermoplasma acidophilum aldohexose dehydrogenase (aldt) in complex with d-mannose
    31% identity, 98% coverage of query (121 bits)

A6N8S2 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Bacillus subtilis (see paper)
    30% identity, 98% coverage of query (120 bits)

Q7XZH5 xanthoxin dehydrogenase (EC 1.1.1.288) from Oryza sativa (see paper)
    32% identity, 98% coverage of query (120 bits)

7x5jC / A0A520KTT2 Acp-dependent oxoacyl reductase
    34% identity, 98% coverage of query (120 bits)

5itvD / P39640 Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
    33% identity, 87% coverage of query (120 bits)

1zemA / Q8GR61 Crystal structure of NAD+-bound xylitol dehydrogenase (see paper)
    32% identity, 98% coverage of query (120 bits)

Q8GR61 D-xylulose reductase (EC 1.1.1.9) from Gluconobacter oxydans (see 2 papers)
    32% identity, 98% coverage of query (120 bits)

SILD_FORIN / Q94KL7 Secoisolariciresinol dehydrogenase; EC 1.1.1.331 from Forsythia intermedia (Border forsythia) (Forsythia suspensa x Forsythia viridissima) (see paper)
    32% identity, 98% coverage of query (119 bits)

BDH_LAVIN / K4N0V2 Borneol dehydrogenase, mitochondrial; LiBDH; EC 1.1.1.- from Lavandula x intermedia (Lavandin) (Lavandula angustifolia x Lavandula latifolia) (see paper)
K4N0V2 (+)-borneol dehydrogenase (EC 1.1.1.198) from Lavandula x intermedia (see paper)
    32% identity, 98% coverage of query (119 bits)

W5VJT8 isopiperitenol dehydrogenase (EC 1.1.1.223) from Perilla frutescens var. hirtella (see paper)
    30% identity, 98% coverage of query (119 bits)

PGDH_MOUSE / Q8VCC1 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-PGDH; Eicosanoid/docosanoid dehydrogenase [NAD(+)]; Prostaglandin dehydrogenase 1; EC 1.1.1.141; EC 1.1.1.-; EC 1.1.1.232 from Mus musculus (Mouse) (see 2 papers)
Q8VCC1 15-hydroxyprostaglandin dehydrogenase (NAD+) (EC 1.1.1.141) from Mus musculus (see paper)
    36% identity, 83% coverage of query (119 bits)

PfGW456L13_2119 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) from Pseudomonas fluorescens GW456-L13
    36% identity, 73% coverage of query (119 bits)

fabG / P51831 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Bacillus subtilis (strain 168) (see 3 papers)
    32% identity, 99% coverage of query (118 bits)

E2QX67 15-hydroxyprostaglandin dehydrogenase (NAD+) (EC 1.1.1.141) from Canis lupus familiaris (see paper)
    36% identity, 83% coverage of query (118 bits)

TPRL1_ERYCB / H9BFQ0 Tropinone reductase-like 1; EC 1.1.1.- from Erythroxylum coca (Coca plant) (see paper)
    33% identity, 98% coverage of query (118 bits)

Pf1N1B4_412 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) from Pseudomonas fluorescens FW300-N1B4
    36% identity, 73% coverage of query (118 bits)

gdh / P12310 glcDH (EC 1.1.1.47) from Bacillus subtilis (strain 168) (see 6 papers)
    31% identity, 98% coverage of query (118 bits)

BDH2_SALOF / A0A8F5XX49 (+)-borneol dehydrogenase 2; SoBDH2; EC 1.1.1.198 from Salvia officinalis (Sage) (see paper)
    33% identity, 99% coverage of query (118 bits)

E5DD06 (+)-borneol dehydrogenase (EC 1.1.1.198) from Artemisia annua (see paper)
    33% identity, 98% coverage of query (118 bits)

4cqlI / Q92506 Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD (see paper)
    32% identity, 99% coverage of query (118 bits)

3o03A Quaternary complex structure of gluconate 5-dehydrogenase from streptococcus suis type 2 (see paper)
    33% identity, 98% coverage of query (117 bits)

Q309F3 15-hydroxyprostaglandin dehydrogenase (NAD+) (EC 1.1.1.141) from Bos taurus (see paper)
    38% identity, 74% coverage of query (117 bits)

ADH1_EUPLT / A0A165U5V5 Short chain aldehyde dehydrogenase 1; ElADH1; Jolkinol C synthase; EC 1.1.1.1; EC 1.1.1.- from Euphorbia lathyris (Caper spurge) (see paper)
    31% identity, 98% coverage of query (117 bits)

6pejA / Q92N06 Structure of sorbitol dehydrogenase from sinorhizobium meliloti 1021 bound to sorbitol
    33% identity, 100% coverage of query (117 bits)

5h5xC / Q9KYM4 Crystal structure of nadh bound carbonyl reductase from streptomyces coelicolor
    40% identity, 77% coverage of query (117 bits)

TPRL2_ERYCB / H9BFQ1 Tropinone reductase-like 2; EC 1.1.1.- from Erythroxylum coca (Coca plant) (see paper)
    33% identity, 98% coverage of query (117 bits)

GOLD_LISIN / Q92EU6 NAD-dependent glycerol dehydrogenase; Dha-forming NAD-dependent glycerol dehydrogenase; EC 1.1.1.6 from Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) (see paper)
    30% identity, 97% coverage of query (116 bits)

6zyzA Structure of the borneol dehydrogenases of salvia rosmarinus with NAD+ (see paper)
    35% identity, 98% coverage of query (116 bits)

BPHYT_RS16120 sorbitol dehydrogenase, D-fructose forming (EC 1.1.1.14) from Burkholderia phytofirmans PsJN
    32% identity, 100% coverage of query (116 bits)

8cxaA / A0QVD5 Crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from mycobacterium smegmatis with bound NAD
    31% identity, 98% coverage of query (116 bits)

A0A545BBR2 (1R,2S)-ephedrine 1-dehydrogenase (EC 1.1.1.423) from Arthrobacter sp. TS-15 (see paper)
    33% identity, 99% coverage of query (116 bits)

P39482 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Priestia megaterium (see paper)
    30% identity, 98% coverage of query (116 bits)

HPGD / P15428 15-hydroxyprostaglandin dehydrogenase [NAD+] monomer (EC 1.1.1.141; EC 1.1.1.232) from Homo sapiens (see 6 papers)
PGDH_HUMAN / P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-PGDH; Eicosanoid/docosanoid dehydrogenase [NAD(+)]; Prostaglandin dehydrogenase 1; Short chain dehydrogenase/reductase family 36C member 1; EC 1.1.1.141; EC 1.1.1.-; EC 1.1.1.232 from Homo sapiens (Human) (see 13 papers)
P15428 15-hydroxyprostaglandin dehydrogenase (NAD+) (EC 1.1.1.141); 13,14-dehydro-15-oxoprostaglandin 13-reductase (EC 1.3.1.48) from Homo sapiens (see 11 papers)
    38% identity, 74% coverage of query (116 bits)

A0A0G2SJM3 17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) from Fimbriaphyllia ancora (see paper)
    30% identity, 98% coverage of query (115 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory