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Searching for up to 100 curated homologs for WP_013420082.1 NCBI__GCF_000166055.1:WP_013420082.1 (463 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hpnO / B3QHB5 aminobacteriohopanetriol synthase from Rhodopseudomonas palustris (strain TIE-1) (see paper)
    65% identity, 99% coverage of query (640 bits)

4ppmA / A0A0J9X1Q5 Crystal structure of pige: a transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (map) from serratia sp. Fs14 (see paper)
    37% identity, 90% coverage of query (287 bits)

pigE / A0A0J9X1Q5 (S)-3-acetyloctanal aminotransferase monomer from Serratia sp. (strain FS14) (see 4 papers)
PIGE_SERSF / A0A0J9X1Q5 Aminotransferase PigE; EC 2.6.1.- from Serratia sp. (strain FS14) (see paper)
    35% identity, 90% coverage of query (282 bits)

PIGE_SERS3 / Q5W267 Aminotransferase PigE; EC 2.6.1.- from Serratia sp. (strain ATCC 39006) (Prodigiosinella confusarubida) (see paper)
    34% identity, 92% coverage of query (276 bits)

PatA / b3073 putrescine aminotransferase (EC 2.6.1.29) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
patA / P42588 putrescine aminotransferase (EC 2.6.1.82; EC 2.6.1.29) from Escherichia coli (strain K12) (see 15 papers)
PAT_ECOLI / P42588 Putrescine aminotransferase; PAT; PATase; Cadaverine transaminase; Diamine transaminase; Putrescine transaminase; Putrescine--2-oxoglutaric acid transaminase; Putrescine:2-OG aminotransferase; EC 2.6.1.82; EC 2.6.1.29 from Escherichia coli (strain K12) (see 8 papers)
P42588 putrescine-2-oxoglutarate transaminase (EC 2.6.1.82) from Escherichia coli (see 4 papers)
    35% identity, 90% coverage of query (227 bits)

8cplC / P38507,P42588 Yzw2 a scaffold for cryo-em of small proteins of interest
    36% identity, 90% coverage of query (227 bits)

4uoxA Crystal structure of ygjg in complex with pyridoxal-5'-phosphate and putrescine
    35% identity, 90% coverage of query (227 bits)

4uoyA Crystal structure of ygjg in complex with pyridoxal-5'-phosphate
    35% identity, 90% coverage of query (227 bits)

Q5SHH5 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
    34% identity, 86% coverage of query (213 bits)

1vefA / Q5SHH5 Acetylornithine aminotransferase from thermus thermophilus hb8
    34% identity, 86% coverage of query (211 bits)

lysJ / Q93R93 L-2-aminoadipate semialdehyde transaminase monomer (EC 2.6.1.118) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
LYSJ_THET2 / Q93R93 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
Q93R93 [amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase (EC 2.6.1.118) from Thermus thermophilus (see 2 papers)
    34% identity, 86% coverage of query (211 bits)

1wkhA Acetylornithine aminotransferase from thermus thermophilus hb8
    34% identity, 86% coverage of query (211 bits)

1wkgA Acetylornithine aminotransferase from thermus thermophilus hb8
    34% identity, 86% coverage of query (211 bits)

Echvi_0577 Ornithine aminotransferase (EC 2.6.1.13) from Echinicola vietnamensis KMM 6221, DSM 17526
    33% identity, 85% coverage of query (201 bits)

Q98TS5 ornithine aminotransferase (EC 2.6.1.13) from Xenopus laevis (see paper)
    34% identity, 86% coverage of query (201 bits)

δ-OAT / Q9FNK4 ornithine-δ-aminotransferase (EC 2.6.1.13) from Arabidopsis thaliana (see 2 papers)
OAT_ARATH / Q9FNK4 Ornithine aminotransferase, mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9FNK4 ornithine aminotransferase (EC 2.6.1.13) from Arabidopsis thaliana (see paper)
    34% identity, 84% coverage of query (198 bits)

OAT_RAT / P04182 Ornithine aminotransferase, mitochondrial; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Rattus norvegicus (Rat) (see paper)
    34% identity, 86% coverage of query (196 bits)

OAT_ORYSJ / Q10G56 Ornithine aminotransferase, mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Oryza sativa subsp. japonica (Rice) (see paper)
    33% identity, 89% coverage of query (194 bits)

OAT / P04181 Ornithine aminotransferase (EC 2.6.1.13) from Homo sapiens (see 3 papers)
OAT_HUMAN / P04181 Ornithine aminotransferase, mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Homo sapiens (Human) (see 8 papers)
    34% identity, 86% coverage of query (194 bits)

8v9mA Human ornithine aminotransferase cocrystallized with its inhibitor, (r)-3-amino-5,5-difluorocyclohex-1-ene-1-carboxylic acid.
    34% identity, 86% coverage of query (193 bits)

8ez1B Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid
    34% identity, 86% coverage of query (193 bits)

8ez1A Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid
    34% identity, 86% coverage of query (193 bits)

7tfpC Human ornithine aminotransferase cocrystallized with its inhibitor, (1s,3s)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid.
    34% identity, 86% coverage of query (193 bits)

7tedA Human ornithine aminotransferase cocrystallized with its inhibitor, (s,e)-3-amino-4-(fluoromethylene)cyclopent-1-ene-1-carboxylate
    34% identity, 86% coverage of query (193 bits)

7ta1A Human ornithine aminotransferase (hoat) soaked with gamma-aminobutyric acid
    34% identity, 86% coverage of query (193 bits)

7lnmB Ornithine aminotransferase (oat) cocrystallized with its inactivator - (1s,3s)-3-amino-4-(difluoromethylene)cyclopentene-1-carboxylic acid
    34% identity, 86% coverage of query (193 bits)

7lk1A Ornithine aminotransferase (oat) with its potent inhibitor - (s)-3- amino-4,4-difluorocyclopent-1-enecarboxylic acid (ss-1-148) - 1 hour soaking
    34% identity, 86% coverage of query (193 bits)

7lk0A Ornithine aminotransferase (oat) cocrystallized with its potent inhibitor - (s)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (ss-1-148)
    34% identity, 86% coverage of query (193 bits)

7jx9A The crystal structure of human ornithine aminotransferase with an intermediate bound during inactivation by (1s,3s)-3-amino-4- (hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic acid.
    34% identity, 86% coverage of query (193 bits)

6v8dA Design, synthesis, and mechanism of fluorine-substituted cyclohexene analogues of gama-aminobutyric acid (gaba) as selective ornithine aminotransferase inactivators
    34% identity, 86% coverage of query (193 bits)

6v8cA Design, synthesis, and mechanism of fluorine-substituted cyclohexene analogues of gama-aminobutyric acid (gaba) as selective ornithine aminotransferase inactivators
    34% identity, 86% coverage of query (193 bits)

6oiaA (1s,3s)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase
    34% identity, 86% coverage of query (193 bits)

5vwoA Ornithine aminotransferase inactivated by (1r,3s,4s)-3-amino-4- fluorocyclopentane-1-carboxylic acid (fcp)
    34% identity, 86% coverage of query (193 bits)

2oatA Ornithine aminotransferase complexed with 5-fluoromethylornithine
    34% identity, 86% coverage of query (193 bits)

2canA Human ornithine aminotransferase complexed with l-canaline
    34% identity, 86% coverage of query (193 bits)

1gbnB Human ornithine aminotransferase complexed with the neurotoxin gabaculine
    34% identity, 86% coverage of query (193 bits)

1gbnA Human ornithine aminotransferase complexed with the neurotoxin gabaculine
    34% identity, 86% coverage of query (193 bits)

7ta0A Human ornithine aminotransferase (hoat) soaked with 5-aminovaleric acid
    34% identity, 86% coverage of query (193 bits)

2byjA / P04181 Ornithine aminotransferase mutant y85i (see paper)
    34% identity, 86% coverage of query (191 bits)

A0A674DA32 ornithine aminotransferase (EC 2.6.1.13) from Salmo trutta (see paper)
    33% identity, 86% coverage of query (190 bits)

A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    39% identity, 72% coverage of query (190 bits)

A0A3B6KM96 ornithine aminotransferase (EC 2.6.1.13) from Triticum aestivum (see paper)
    32% identity, 89% coverage of query (189 bits)

B1XNF8 acetylornithine transaminase (EC 2.6.1.11); 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Synechococcus sp. PCC 7002 (see paper)
    34% identity, 72% coverage of query (189 bits)

8ht4B / Q59282 Crystal structure of acetylornithine aminotransferase complex with plp from corynebacterium glutamicum (see paper)
    35% identity, 86% coverage of query (188 bits)

7lomC Ornithine aminotransferase (oat) soaked with its inactivator - (1s, 3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    34% identity, 86% coverage of query (187 bits)

7lomA Ornithine aminotransferase (oat) soaked with its inactivator - (1s, 3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    34% identity, 86% coverage of query (187 bits)

7lonA Ornithine aminotransferase (oat) cocrystallized with its inactivator - (1s,3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    34% identity, 86% coverage of query (187 bits)

δOAT / Q1RPP3 ornithine δ-aminotransferase (EC 2.6.1.13) from Pinus sylvestris (see paper)
dOAT / CAJ76070.1 ornithine aminotransferase from Pinus sylvestris (see paper)
    33% identity, 87% coverage of query (186 bits)

A0A3B6MXE9 ornithine aminotransferase (EC 2.6.1.13) from Triticum aestivum (see paper)
    32% identity, 89% coverage of query (186 bits)

OAT_SCHPO / Q9P7L5 Ornithine aminotransferase car2; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
car2 / RF|NP_596588.1 ornithine transaminase Car2; EC 2.6.1.13 from Schizosaccharomyces pombe (see paper)
    32% identity, 83% coverage of query (185 bits)

2eh6A / O66442 Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
    36% identity, 72% coverage of query (185 bits)

O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
    36% identity, 72% coverage of query (185 bits)

2ordA / Q9X2A5 Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
    33% identity, 82% coverage of query (184 bits)

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
    33% identity, 82% coverage of query (184 bits)

slr1022 / P73133 bifunctional acetylornithine transaminase/4-aminobutyrate—2-oxoglutarate transaminase (EC 2.6.1.19; EC 2.6.1.11) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 4 papers)
ARGD_SYNY3 / P73133 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
P73133 acetylornithine transaminase (EC 2.6.1.11); 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Synechococcus sp. PCC 6803 (see paper)
    31% identity, 88% coverage of query (183 bits)

OAT_EMENI / Q92413 Ornithine aminotransferase; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
otaA ornithine aminotransferase; EC 2.6.1.13 from Emericella nidulans (see paper)
    32% identity, 87% coverage of query (181 bits)

Q3ZCF5 ornithine aminotransferase (EC 2.6.1.13) from Bos taurus (see paper)
    35% identity, 83% coverage of query (181 bits)

OAT_BACSU / P38021 Ornithine aminotransferase; OAT; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Bacillus subtilis (strain 168) (see 2 papers)
    31% identity, 82% coverage of query (180 bits)

ARGD_ARATH / Q9M8M7 Acetylornithine aminotransferase, chloroplastic/mitochondrial; ACOAT; Acetylornithine transaminase; AOTA; Protein HOPW1-1-INTERACTING 1; EC 2.6.1.11 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    32% identity, 85% coverage of query (180 bits)

dat / B0VCM6 diaminobutyrate—2-oxoglutarate transaminase monomer (EC 2.6.1.76) from Acinetobacter baumannii (strain AYE) (see 2 papers)
    30% identity, 93% coverage of query (179 bits)

Build an alignment

Build an alignment for WP_013420082.1 and 60 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

BARAC_PYRHO / O57878 Broad substrate specificity amino-acid racemase; BAR; EC 5.1.1.10 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 2 papers)
O57878 amino-acid racemase (EC 5.1.1.10) from Pyrococcus horikoshii (see 2 papers)
    29% identity, 88% coverage of query (179 bits)

A8J933 acetylornithine transaminase (EC 2.6.1.11) from Chlamydomonas reinhardtii (see paper)
    32% identity, 89% coverage of query (179 bits)

BT3758 N-succinylornithine aminotransferase (EC 2.6.1.81) from Bacteroides thetaiotaomicron VPI-5482
    32% identity, 84% coverage of query (179 bits)

pvdH / Q9I168 L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase monomer (EC 2.6.1.76) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
    32% identity, 84% coverage of query (179 bits)

gabT / Q0K2K2 4-aminobutyrate aminotransferase monomer (EC 2.6.1.19) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
Q0K2K2 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Cupriavidus necator (see paper)
    33% identity, 82% coverage of query (179 bits)

A0A5F9CII4 ornithine aminotransferase (EC 2.6.1.13) from Oryctolagus cuniculus (see paper)
    36% identity, 83% coverage of query (177 bits)

A0A5B8KQ12 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Agrobacterium tumefaciens (see paper)
    33% identity, 86% coverage of query (175 bits)

CH_124176 ornithine aminotransferase from Magnaporthe grisea 70-15 (see paper)
    31% identity, 90% coverage of query (174 bits)

rhbA / Q9Z3R2 diaminobutyrate--2-oxoglutarate transaminase (EC 2.6.1.76) from Rhizobium meliloti (strain 1021) (see paper)
    32% identity, 85% coverage of query (173 bits)

valM / Q1L2L3 validone 7-phosphate aminotransferase from Streptomyces hygroscopicus subsp. jinggangensis (see paper)
    32% identity, 86% coverage of query (172 bits)

A0A140N9B6 succinylornithine transaminase (EC 2.6.1.81) from Escherichia coli (see paper)
    31% identity, 84% coverage of query (171 bits)

AstC / b1748 succinylornithine transaminase (EC 2.6.1.81; EC 2.6.1.11) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
astC / P77581 succinylornithine transaminase (EC 2.6.1.81; EC 2.6.1.11) from Escherichia coli (strain K12) (see 6 papers)
ASTC_ECOLI / P77581 Succinylornithine transaminase; SOAT; Carbon starvation protein C; Succinylornithine aminotransferase; EC 2.6.1.81 from Escherichia coli (strain K12) (see paper)
astC / RF|NP_416262.1 succinylornithine transaminase; EC 2.6.1.81 from Escherichia coli K12 (see 5 papers)
    31% identity, 84% coverage of query (171 bits)

4adbB / P77581 Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
    31% identity, 84% coverage of query (171 bits)

Echvi_3848 N-succinylornithine aminotransferase (EC 2.6.1.81) from Echinicola vietnamensis KMM 6221, DSM 17526
    34% identity, 83% coverage of query (171 bits)

4addA Structural and functional study of succinyl-ornithine transaminase from e. Coli
    31% identity, 84% coverage of query (171 bits)

BWI76_RS11670 Succinylornithine transaminase (EC 2.6.1.81) from Klebsiella michiganensis M5al
    31% identity, 84% coverage of query (170 bits)

4jevB / P40732 N-acetylornithine aminotransferase from s. Typhimurium complexed with gabaculine
    34% identity, 70% coverage of query (170 bits)

A6UKD1 amino-acid racemase (EC 5.1.1.10); 2-aminohexano-6-lactam racemase (EC 5.1.1.15) from Sinorhizobium medicae (see paper)
    31% identity, 83% coverage of query (170 bits)

LMRAC_THEKO / Q5JGG6 Leucine/methionine racemase; Leu/Met racemase; EC 5.1.1.-; EC 5.1.1.2 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    32% identity, 85% coverage of query (169 bits)

dat / P56744 L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase monomer (EC 2.6.1.76) from Acinetobacter baumannii (see 2 papers)
P56744 diaminobutyrate decarboxylase (EC 4.1.1.86) from Acinetobacter baumannii (see paper)
dat / GB|BAA21844.1 diaminobutyrate--2-oxoglutarate transaminase; EC 2.6.1.76 from Acinetobacter baumannii (see paper)
    29% identity, 93% coverage of query (169 bits)

ARGD_SALTY / P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    34% identity, 70% coverage of query (168 bits)

4jewA N-acetylornithine aminotransferase from s. Typhimurium complexed with l-canaline
    34% identity, 70% coverage of query (168 bits)

7vo1A Structure of aminotransferase-substrate complex
    32% identity, 85% coverage of query (167 bits)

7vntA Structure of aminotransferase-substrate complex
    32% identity, 85% coverage of query (167 bits)

7vnoA / O50131 Structure of aminotransferase (see paper)
    32% identity, 85% coverage of query (167 bits)

ORNAT_PYRHO / O50131 Ornithine aminotransferase; Orn-AT; Ornithine delta-aminotransferase; EC 2.6.1.13 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
    32% identity, 85% coverage of query (167 bits)

2pb0A Structure of biosynthetic n-acetylornithine aminotransferase from salmonella typhimurium: studies on substrate specificity and inhibitor binding
    34% identity, 70% coverage of query (166 bits)

6zhkA / Q58696 Crystal structure of adenosylmethionine-8-amino-7-oxononanoate aminotransferase from methanocaldococcus jannaschii dsm 2661
    28% identity, 86% coverage of query (164 bits)

7nncC Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal-5'-phosphate and 6-methoxyquinoline-3-carboxylic acid
    38% identity, 71% coverage of query (164 bits)

7nn4A / P9WPZ7 Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal 5'-phosphate and 3-hydroxy-2-naphthoic acid.
    38% identity, 71% coverage of query (164 bits)

P9WPZ7 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    38% identity, 71% coverage of query (163 bits)

ASRAC_PYRHO / O58478 Alanine/serine racemase; ASR; Ala/Ser racemase; EC 5.1.1.-; EC 5.1.1.1 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
    30% identity, 85% coverage of query (161 bits)

4ysnC / M1GRN3 Structure of aminoacid racemase in complex with plp (see paper)
    32% identity, 74% coverage of query (158 bits)

5wyaA Structure of amino acid racemase, 2.65 a
    32% identity, 74% coverage of query (158 bits)

5wyfA Structure of amino acid racemase, 2.12 a
    32% identity, 74% coverage of query (157 bits)

2eo5A / F9VN77 Crystal structure of 4-aminobutyrate aminotransferase from sulfolobus tokodaii strain7
    30% identity, 85% coverage of query (152 bits)

2e7uA / Q5SJS4 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8
    34% identity, 73% coverage of query (152 bits)

6fyqA / A0A4P1LYG1 The crystal structure of a new transaminase from the marine bacterium virgibacillus (see paper)
    29% identity, 86% coverage of query (152 bits)

6g4dB Crystal structure of the omega transaminase from pseudomonas jessenii in complex with plp (see paper)
    29% identity, 84% coverage of query (149 bits)

6g4fA Crystal structure of the omega transaminase from pseudomonas jessenii in complex with pmp
    29% identity, 84% coverage of query (149 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory