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Searching for up to 100 curated homologs for WP_013518622.1 NCBI__GCF_000204645.1:WP_013518622.1 (222 a.a.)

Found high-coverage hits (≥70%) to 69 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Psest_3511 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas stutzeri RCH2
    62% identity, 97% coverage of query (258 bits)

SO1671 Maleylacetoacetate isomerase (EC 5.2.1.2) from Shewanella oneidensis MR-1
    57% identity, 96% coverage of query (241 bits)

Ac3H11_2306 Maleylacetoacetate isomerase (EC 5.2.1.2) from Acidovorax sp. GW101-3H11
    54% identity, 97% coverage of query (231 bits)

Q5K5T6 glutathione transferase subunit (EC 2.5.1.18) from Escherichia coli (see 8 papers)
    54% identity, 97% coverage of query (226 bits)

2v6kA / O86043 Structure of maleyl pyruvate isomerase, a bacterial glutathione-s- transferase in zeta class, in complex with substrate analogue dicarboxyethyl glutathione (see paper)
    50% identity, 97% coverage of query (203 bits)

nagL / O86043 glutathion-dependent maleylpyruvate isomerase (EC 5.2.1.4) from Ralstonia sp. (see paper)
NAGL_RALSP / O86043 Maleylpyruvate isomerase; MPI; Naphthalene degradation protein L; EC 5.2.1.4 from Ralstonia sp. (see 2 papers)
    50% identity, 97% coverage of query (203 bits)

2jl4A Holo structure of maleyl pyruvate isomerase, a bacterial glutathione- s-transferase in zeta class
    50% identity, 97% coverage of query (203 bits)

MAAI2_DROME / Q9VHD2 Probable maleylacetoacetate isomerase 2; MAAI 2; Glutathione S-transferase zeta 2; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    48% identity, 95% coverage of query (194 bits)

Pf6N2E2_5292 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E2
    50% identity, 97% coverage of query (192 bits)

AO356_16835 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2C3
    50% identity, 97% coverage of query (192 bits)

AO353_15560 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E3
    48% identity, 97% coverage of query (189 bits)

2cz2A / Q9WVL0 Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal)
    45% identity, 96% coverage of query (179 bits)

Q9WVL0 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Mus musculus (Mouse)
    45% identity, 96% coverage of query (179 bits)

MAAI_RAT / P57113 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Rattus norvegicus (Rat) (see paper)
    45% identity, 98% coverage of query (176 bits)

1fw1A / O43708 Glutathione transferase zeta/maleylacetoacetate isomerase (see paper)
    44% identity, 96% coverage of query (174 bits)

GSTZ1 / O43708 maleylacetoacetate isomerase/glutathione transferase ζ monomer (EC 2.5.1.18; EC 5.2.1.2) from Homo sapiens (see 11 papers)
MAAI_HUMAN / O43708 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Homo sapiens (Human) (see 3 papers)
O43708 glutathione transferase (EC 2.5.1.18); maleylacetoacetate isomerase (EC 5.2.1.2) from Homo sapiens (see 8 papers)
    43% identity, 98% coverage of query (171 bits)

4kdyA / B8J605 Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound gsh in the active site
    48% identity, 97% coverage of query (171 bits)

MAAI1_DROME / Q9VHD3 Probable maleylacetoacetate isomerase 1; MAAI 1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    40% identity, 99% coverage of query (171 bits)

4kaeA Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound dicarboxyethyl glutathione and citrate in the active site
    48% identity, 97% coverage of query (171 bits)

GSTZ1_ARATH / Q9ZVQ3 Glutathione S-transferase Z1; AtGSTZ1; GST class-zeta member 1; Glutathione S-transferase 18; Maleylacetone isomerase; MAI; EC 2.5.1.18; EC 5.2.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    43% identity, 97% coverage of query (153 bits)

MAIA_ASPFU / Q4WHT7 Maleylacetoacetate isomerase maiA; EC 5.2.1.2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    38% identity, 97% coverage of query (137 bits)

4pxoA / C5ATQ9 Crystal structure of maleylacetoacetate isomerase from methylobacteriu extorquens am1 with bound malonate and gsh (target efi-507068)
    40% identity, 97% coverage of query (136 bits)

maiA / O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (see paper)
MAAI_EMENI / O43123 Maleylacetoacetate isomerase; MAAI; EC 5.2.1.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Aspergillus nidulans (see paper)
GI|2832725 maleylacetoacetate isomerase; EC 5.2.1.2 from Emericella nidulans (see paper)
maiA / CAA05041.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
maiA / CAA05044.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
    37% identity, 97% coverage of query (135 bits)

3n5oA / D2YW48 Crystal structure of putative glutathione transferase from coccidioides immitis bound to glutathione (see paper)
    34% identity, 99% coverage of query (121 bits)

D2YW48 Probable glutathione S-transferase; EC 2.5.1.18 from Coccidioides immitis (strain RS) (Valley fever fungus)
    34% identity, 99% coverage of query (121 bits)

O04437 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    35% identity, 97% coverage of query (104 bits)

Build an alignment

Build an alignment for WP_013518622.1 and 26 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

A0A4Y5QZX0 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    26% identity, 95% coverage of query (58.5 bits)

se / Q9VSL3 pyrimidodiazepine synthase subunit (EC 1.5.4.1) from Drosophila melanogaster (see 2 papers)
SEPIA_DROME / Q9VSL3 Pyrimidodiazepine synthase; Protein sepia; EC 1.5.4.1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
    31% identity, 78% coverage of query (53.5 bits)

3vlnA Human glutathione transferase o1-1 c32s mutant in complex with ascorbic acid
    22% identity, 91% coverage of query (51.2 bits)

SSPA_COXBU / Q83AY0 Stringent starvation protein A homolog from Coxiella burnetii (strain RSA 493 / Nine Mile phase I) (see paper)
    28% identity, 78% coverage of query (50.1 bits)

4is0A Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of the non-catalytic ligandin site.
    22% identity, 91% coverage of query (49.7 bits)

GSTO1 / P78417 glutathione transferase, Ω class subunit (EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2) from Homo sapiens (see 2 papers)
GSTO1_HUMAN / P78417 Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Homo sapiens (Human) (see 5 papers)
P78417 methylarsonate reductase (EC 1.20.4.2); glutathione dehydrogenase (ascorbate) (EC 1.8.5.1); glutathione transferase (EC 2.5.1.18) from Homo sapiens (see 7 papers)
    22% identity, 91% coverage of query (49.3 bits)

A0A384E145 glutathione transferase (EC 2.5.1.18) from Trametes versicolor (see paper)
    28% identity, 82% coverage of query (49.3 bits)

6mhcA / P78417 Glutathione s-transferase omega 1 bound to covalent inhibitor 37 (see paper)
    22% identity, 91% coverage of query (49.3 bits)

6pnnA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n-(2- methoxyethyl)-n-methylsulfamoyl)phenyl)acetamide
    22% identity, 91% coverage of query (49.3 bits)

6pnoA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n- isopropylsulfamoyl)phenyl)acetamide
    22% identity, 91% coverage of query (49.3 bits)

6pnmA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3- (morpholinosulfonyl)phenyl)acetamide
    22% identity, 91% coverage of query (49.3 bits)

5v3qA Human gsto1-1 complexed with ml175
    22% identity, 91% coverage of query (49.3 bits)

5uehA Structure of gsto1 covalently conjugated to quinolinic acid fluorosulfate
    22% identity, 91% coverage of query (49.3 bits)

4yqvA Glutathione s-transferase omega 1 bound to covalent inhibitor c4-10
    22% identity, 91% coverage of query (49.3 bits)

4yqmA Glutathione s-transferase omega 1 bound to covalent inhibitor c1-27
    22% identity, 91% coverage of query (49.3 bits)

1eemA Glutathione transferase from homo sapiens
    22% identity, 91% coverage of query (49.3 bits)

6mhdA Glutathione s-transferase omega 1 bound to covalent inhibitor 44
    22% identity, 91% coverage of query (49.3 bits)

8awzA / A0A384E145 Crystal structure of trametes versicolor glutathione transferase omega 3s in complex with dinitrosyl glutathionyl iron complex (dngic) (see paper)
    28% identity, 82% coverage of query (48.9 bits)

A0A4Y5QZX9 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    29% identity, 78% coverage of query (48.9 bits)

8ax1A Crystal structure of trametes versicolor glutathione transferase omega 3s in complex with hydroxy-tetranitro-nitrosyl-ruthenate
    28% identity, 82% coverage of query (48.9 bits)

6f51A Crystal structure of glutathione transferase omega 3s from trametes versicolor in complex with glutathionyl-phenylacetophenone
    28% identity, 82% coverage of query (48.9 bits)

8ax0A Crystal structure of trametes versicolor glutathione transferase omega 3s in complex with sodium nitroprusside
    28% identity, 82% coverage of query (48.9 bits)

6hpeA Crystal structure of glutathione transferase omega 3s from trametes versicolor in complex with the glutathione adduct of phenethyl- isothiocyanate
    28% identity, 82% coverage of query (48.9 bits)

6f6aA Crystal structure of glutathione transferase omega 3s from trametes versicolor in complex with dihydrowogonin from wild-cherry extract
    28% identity, 82% coverage of query (48.9 bits)

6f69A Crystal structure of glutathione transferase omega 3s from trametes versicolor in complex with 2,3,4-trihydroxybenzophenone
    28% identity, 82% coverage of query (48.9 bits)

6f68A Crystal structure glutathione transferase omega 3s from trametes versicolor in complex with 2,4,4'-trihydroxybenzophenone
    28% identity, 82% coverage of query (48.9 bits)

6f67A Crystal structure of glutathione transferase omega 3s from trametes versicolor in complex with 3,4-dihydroxybenzophenone
    28% identity, 82% coverage of query (48.9 bits)

6f66A Crystal structure of glutathione transferase omega 3s from trametes versicolor in complex with 2,4-dihydroxybenzophenone
    28% identity, 82% coverage of query (48.9 bits)

6f4kA Crystal structure of glutathione transferase omega 3s from trametes versicolor in complex with hexyl-glutathione
    28% identity, 82% coverage of query (48.9 bits)

6f4fA Crystal structure of glutathione transferase omega 3s from trametes versicolor in complex with glutathionyl-s-dinitrobenzene
    28% identity, 82% coverage of query (48.9 bits)

3uarA / Q60CN1 Crystal structure of glutathione transferase (target efi-501774) from methylococcus capsulatus str. Bath with gsh bound
    26% identity, 94% coverage of query (48.5 bits)

gst7 / CAB38121.1 GST7 protein from Zea mays (see paper)
    27% identity, 79% coverage of query (48.5 bits)

3wd6A / A8R5V3 Crystal structure of bombyx mori omega-class glutathione transferase in complex with gsh (see paper)
    27% identity, 82% coverage of query (48.5 bits)

GSTO1_PIG / Q9N1F5 Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Sus scrofa (Pig) (see paper)
    23% identity, 92% coverage of query (47.8 bits)

GSTF9_ARATH / O80852 Glutathione S-transferase F9; AtGSTF9; AtGSTF7; GST class-phi member 9; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    29% identity, 78% coverage of query (47.4 bits)

3m3mA / Q4K8I0 Crystal structure of glutathione s-transferase from pseudomonas fluorescens [pf-5]
    24% identity, 91% coverage of query (47.4 bits)

6ezyB / O80852 Arabidopsis thaliana gstf9, gsh and gsoh bound (see paper)
    29% identity, 78% coverage of query (47.0 bits)

6f01B Arabidopsis thaliana gstf9, gso3 and gsoh bound
    29% identity, 78% coverage of query (47.0 bits)

GSTF3_MAIZE / P04907 Glutathione S-transferase 3; GST class-phi member 3; GST-III; EC 2.5.1.18 from Zea mays (Maize) (see 2 papers)
    30% identity, 93% coverage of query (46.6 bits)

7dw4A / A0A4Y5R032 Crystal structure of a glutathione s-transferase mutant sbgstu6(i55t) from salix babylonica in complex with glutathione
    27% identity, 77% coverage of query (46.2 bits)

4ielB / Q0B681 Crystal structure of a glutathione s-transferase family protein from burkholderia ambifaria, target efi-507141, with bound glutathione
    29% identity, 78% coverage of query (45.1 bits)

6f70A / A0A384E158 Crystal structure of glutathione transferase omega 6s from trametes versicolor (see paper)
    26% identity, 92% coverage of query (43.5 bits)

6f71A Crystal structure of glutathione transferase omega 6s from trametes versicolor in complex with naringenin
    27% identity, 92% coverage of query (43.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory