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Searching for up to 100 curated homologs for WP_013536905.1 NCBI__GCF_000185805.1:WP_013536905.1 (459 a.a.)

Found high-coverage hits (≥70%) to 56 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

argH / BAC65282.1 argininosuccinate lyase from Burkholderia multivorans (see paper)
    57% identity, 96% coverage of query (527 bits)

Q8DVX5 argininosuccinate lyase (EC 4.3.2.1) from Streptococcus mutans (see paper)
    51% identity, 98% coverage of query (498 bits)

2e9fB / Q5SLL0 Crystal structure of t.Th.Hb8 argininosuccinate lyase complexed with l-arginine
    55% identity, 96% coverage of query (481 bits)

ARLY_NOSS1 / Q8YQE6 Argininosuccinate lyase; ASAL; Arginosuccinase; NoArgH; EC 4.3.2.1 from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see paper)
    51% identity, 99% coverage of query (480 bits)

ARLY_SYNY3 / P73257 Argininosuccinate lyase; ASAL; Arginosuccinase; SyArgH; EC 4.3.2.1 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    51% identity, 100% coverage of query (478 bits)

ARLY_NOSP7 / Q9LAE5 Argininosuccinate lyase; ASAL; ASL; Arginosuccinase; EC 4.3.2.1 from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see paper)
Q9LAE5 argininosuccinate lyase (EC 4.3.2.1) from Nostoc sp. (see paper)
    50% identity, 98% coverage of query (468 bits)

ARLY_ARTPN / P0DXD4 Argininosuccinate lyase; ASAL; ArArgH; Arginosuccinase; EC 4.3.2.1 from Arthrospira platensis (strain NIES-39 / UTEX 3086 / IAM M-135) (Spirulina platensis) (see paper)
    49% identity, 99% coverage of query (465 bits)

Q9P870 argininosuccinate lyase (EC 4.3.2.1) from Agaricus bisporus (see paper)
    48% identity, 98% coverage of query (449 bits)

ArgH / b3960 argininosuccinate lyase (EC 4.3.2.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
argH / P11447 argininosuccinate lyase (EC 4.3.2.1) from Escherichia coli (strain K12) (see 2 papers)
    49% identity, 97% coverage of query (444 bits)

ARG4 argininosuccinate lyase from Candida albicans (see paper)
    48% identity, 99% coverage of query (434 bits)

ARG7 / CAA09001.1 argininosuccinate lyase from Chlamydomonas reinhardtii (see paper)
    49% identity, 99% coverage of query (434 bits)

1tj7B / P11447 Structure determination and refinement at 2.44 a resolution of argininosuccinate lyase from e. Coli (see paper)
    49% identity, 96% coverage of query (432 bits)

ARLY2_ANAPL / P24058 Argininosuccinate lyase; ASAL; Arginosuccinase; Delta crystallin II; Delta-2 crystallin; EC 4.3.2.1 from Anas platyrhynchos (Mallard) (Anas boschas) (see 6 papers)
    47% identity, 98% coverage of query (428 bits)

arg7 / RF|NP_595129.1 argininosuccinate lyase; EC 4.3.2.1 from Schizosaccharomyces pombe (see paper)
    47% identity, 99% coverage of query (427 bits)

ASL / P04424 argininosuccinate lyase (EC 4.3.2.1) from Homo sapiens (see 5 papers)
ARLY_HUMAN / P04424 Argininosuccinate lyase; ASAL; Arginosuccinase; EC 4.3.2.1 from Homo sapiens (Human) (see 11 papers)
    48% identity, 98% coverage of query (425 bits)

ARLY_YEAST / P04076 Argininosuccinate lyase; ASAL; Arginosuccinase; EC 4.3.2.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    48% identity, 99% coverage of query (421 bits)

ARLY_COLLI / Q01592 Argininosuccinate lyase; ASAL; Arginosuccinase; Delta crystallin; EC 4.3.2.1 from Columba livia (Rock dove) (see 2 papers)
    46% identity, 98% coverage of query (419 bits)

argH / CAA88927.2 argininosuccinate lyase from Streptomyces clavuligerus (see 3 papers)
    49% identity, 99% coverage of query (418 bits)

ARLY_MOUSE / Q91YI0 Argininosuccinate lyase; ASAL; Arginosuccinase; EC 4.3.2.1 from Mus musculus (Mouse) (see paper)
    47% identity, 98% coverage of query (414 bits)

ARLY_ANSAN / P33110 Argininosuccinate lyase; ASAL; Arginosuccinase; Delta crystallin; EC 4.3.2.1 from Anser anser anser (Western greylag goose) (see 2 papers)
    46% identity, 98% coverage of query (413 bits)

argH(A) / CAB95024.1 argininosuccinase and n-acetylglutamate synthase from Moritella abyssi (see paper)
    49% identity, 96% coverage of query (413 bits)

ARLY1_ANAPL / P24057 Delta-1 crystallin; Delta crystallin I from Anas platyrhynchos (Mallard) (Anas boschas) (see 4 papers)
    46% identity, 98% coverage of query (413 bits)

1k7wD / P24058 Crystal structure of s283a duck delta 2 crystallin mutant (see paper)
    46% identity, 96% coverage of query (412 bits)

AN2914 arginosuccinate lyase (Eurofung) from Emericella nidulans (see paper)
    45% identity, 99% coverage of query (407 bits)

1hy0A Crystal structure of wild type duck delta 1 crystallin (eye lens protein)
    45% identity, 96% coverage of query (399 bits)

ARLY1_CHICK / P02521 Delta-1 crystallin; Delta crystallin I from Gallus gallus (Chicken) (see 2 papers)
    45% identity, 98% coverage of query (397 bits)

ARLY1_MELGA / Q7SIE0 Delta-1 crystallin; Delta crystallin I from Meleagris gallopavo (Wild turkey) (see paper)
    44% identity, 98% coverage of query (394 bits)

P9WPY7 argininosuccinate lyase (EC 4.3.2.1) from Mycobacterium tuberculosis (see 2 papers)
    44% identity, 98% coverage of query (352 bits)

6ienB / P9WPY7 Substrate/product bound argininosuccinate lyase from mycobacterium tuberculosis (see paper)
    44% identity, 94% coverage of query (336 bits)

6ienA Substrate/product bound argininosuccinate lyase from mycobacterium tuberculosis
    44% identity, 94% coverage of query (327 bits)

6ienC Substrate/product bound argininosuccinate lyase from mycobacterium tuberculosis
    43% identity, 94% coverage of query (321 bits)

Echvi_3852 arginosuccinate lyase (EC 4.3.2.1) from Echinicola vietnamensis KMM 6221, DSM 17526
    39% identity, 84% coverage of query (255 bits)

BT3733 arginosuccinate lyase (EC 4.3.2.1) from Bacteroides thetaiotaomicron VPI-5482
    38% identity, 85% coverage of query (249 bits)

CA265_RS18485 arginosuccinate lyase (EC 4.3.2.1) from Pedobacter sp. GW460-11-11-14-LB5
    36% identity, 85% coverage of query (247 bits)

6g3fA / Q11KV9 Crystal structure of edds lyase in complex with fumarate (see paper)
    35% identity, 87% coverage of query (241 bits)

6g3hA Crystal structure of edds lyase in complex with ss-edds
    35% identity, 87% coverage of query (241 bits)

6g3gA Crystal structure of edds lyase in complex with succinate
    35% identity, 87% coverage of query (241 bits)

6g3iA Crystal structure of edds lyase in complex with n-(2-aminoethyl) aspartic acid (aeaa)
    35% identity, 87% coverage of query (241 bits)

ABZR86_RS08695 arginosuccinate lyase (EC 4.3.2.1) from Dyella japonica UNC79MFTsu3.2
    34% identity, 78% coverage of query (182 bits)

Build an alignment

Build an alignment for WP_013536905.1 and 39 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

MJ0929 / Q58339 adenylosuccinate lyase (EC 4.3.2.2) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
    28% identity, 83% coverage of query (94.0 bits)

FUMC_SACS2 / P39461 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
P39461 fumarate hydratase (EC 4.2.1.2) from Saccharolobus solfataricus (see paper)
    28% identity, 75% coverage of query (90.1 bits)

ASPA_BACSP / Q9LCC6 Aspartate ammonia-lyase; Aspartase; EC 4.3.1.1 from Bacillus sp. (see 7 papers)
Q9LCC6 aspartate ammonia-lyase (EC 4.3.1.1) from Bacillus sp. (in: Bacteria) (see 4 papers)
    26% identity, 71% coverage of query (86.3 bits)

3r6vG / Q9LCC6 Crystal structure of aspartase from bacillus sp. Ym55-1 with bound l- aspartate (see paper)
    26% identity, 71% coverage of query (86.3 bits)

3r6qA A triclinic-lattice structure of aspartase from bacillus sp. Ym55-1
    26% identity, 71% coverage of query (86.3 bits)

4adlA Crystal structures of rv1098c in complex with malate
    25% identity, 73% coverage of query (64.3 bits)

FUMC_MYCTU / P9WN93 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WN93 fumarate hydratase (EC 4.2.1.2) from Mycobacterium tuberculosis (see paper)
    25% identity, 73% coverage of query (63.9 bits)

4apbD / P9WN93 Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate (see paper)
    25% identity, 73% coverage of query (62.4 bits)

FumC / b1611 fumarase C (EC 4.2.1.2) from Escherichia coli K-12 substr. MG1655 (see 28 papers)
fumC / P05042 fumarase C (EC 4.2.1.2) from Escherichia coli (strain K12) (see 26 papers)
FUMC_ECOLI / P05042 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Escherichia coli (strain K12) (see 8 papers)
    24% identity, 84% coverage of query (60.8 bits)

FUMC_RICPR / Q9ZCQ4 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Rickettsia prowazekii (strain Madrid E) (see paper)
Q9ZCQ4 fumarate hydratase (EC 4.2.1.2) from Rickettsia prowazekii (see paper)
    22% identity, 90% coverage of query (60.5 bits)

1fuqA Fumarase with bound 3-trimethylsilylsuccinic acid
    24% identity, 84% coverage of query (60.5 bits)

1fuoA / P05042 FumarasE C with bound citrate (see paper)
    24% identity, 84% coverage of query (60.5 bits)

1fupA Fumarase with bound pyromellitic acid
    24% identity, 84% coverage of query (60.5 bits)

6wngA / A0A077EBQ3 Crystal structure of an aspartate ammonia-lyase from elizabethkingia anophelis nuhp1
    23% identity, 76% coverage of query (57.0 bits)

7lubB / P07954 Crystal structure of recombinant human fumarase in complex with d-2- amino-3-phosphono-propionic acid (see paper)
    24% identity, 79% coverage of query (52.8 bits)

FH / P07954 fumarate hydratase monomer (EC 4.2.1.2) from Homo sapiens (see 7 papers)
FUMH_HUMAN / P07954 Fumarate hydratase, mitochondrial; Fumarase; HsFH; EC 4.2.1.2 from Homo sapiens (Human) (see 10 papers)
P07954 fumarate hydratase (EC 4.2.1.2) from Homo sapiens (see 3 papers)
    24% identity, 81% coverage of query (52.8 bits)

FUMH_YEAST / P08417 Fumarate hydratase, mitochondrial; Fumarase; EC 4.2.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
P08417 fumarate hydratase (EC 4.2.1.2) from Saccharomyces cerevisiae (see 2 papers)
    23% identity, 77% coverage of query (52.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory