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Searching for up to 100 curated homologs for WP_013537390.1 NCBI__GCF_000185805.1:WP_013537390.1 (287 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3gggD / O67636 The crystal structure of a. Aeolicus prephenate dehydrogenase in complex with tyrosine and NAD+ (see paper)
    47% identity, 97% coverage of query (256 bits)

3ggpA Crystal structure of prephenate dehydrogenase from a. Aeolicus in complex with hydroxyphenyl propionate and NAD+
    47% identity, 97% coverage of query (256 bits)

3ggoA Crystal structure of prephenate dehydrogenase from a. Aeolicus with hpp and nadh
    47% identity, 97% coverage of query (256 bits)

O67636 prephenate dehydrogenase (EC 1.3.1.12) from Aquifex aeolicus (see paper)
    48% identity, 97% coverage of query (255 bits)

4wjiA / Q92MG1 Crystal structure of cyclohexadienyl dehydrogenase from sinorhizobium meliloti in complex with NADP and tyrosine
    40% identity, 99% coverage of query (226 bits)

5uyyA / Q81P63 Crystal structure of prephenate dehydrogenase tyra from bacillus anthracis in complex with l-tyrosine (see paper)
    37% identity, 97% coverage of query (179 bits)

Q81P63 prephenate dehydrogenase (EC 1.3.1.12) from Bacillus anthracis (see paper)
    37% identity, 97% coverage of query (179 bits)

6u60B Crystal structure of prephenate dehydrogenase tyra from bacillus anthracis in complex with NAD and l-tyrosine
    37% identity, 97% coverage of query (179 bits)

J9XQS6 prephenate dehydrogenase (EC 1.3.1.12) from uncultured bacterium (see paper)
    40% identity, 77% coverage of query (169 bits)

Q8DUW0 prephenate dehydrogenase (EC 1.3.1.12) from Streptococcus mutans (see paper)
    35% identity, 98% coverage of query (159 bits)

TYRC_ZYMMO / Q04983 Cyclohexadienyl dehydrogenase; Arogenate dehydrogenase; ADH; Prephenate dehydrogenase; PDH; EC 1.3.1.43; EC 1.3.1.12 from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see paper)
    33% identity, 99% coverage of query (157 bits)

tyrAa / P73906 arogenate dehydrogenase monomer (EC 1.3.1.78) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
P73906 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Synechocystis sp. PCC 6803 (see paper)
2f1kA / P73906 Crystal structure of synechocystis arogenate dehydrogenase (see paper)
    30% identity, 97% coverage of query (149 bits)

3b1fA / Q8DUW0 Crystal structure of prephenate dehydrogenase from streptococcus mutans (see paper)
    34% identity, 98% coverage of query (149 bits)

Build an alignment

Build an alignment for WP_013537390.1 and 13 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

TYRA_MYCTU / O69721 Prephenate dehydrogenase; PDH; EC 1.3.1.12 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    29% identity, 96% coverage of query (95.9 bits)

2pv7B / P43902 Crystal structure of chorismate mutase / prephenate dehydrogenase (tyra) (1574749) from haemophilus influenzae rd at 2.00 a resolution (see paper)
    23% identity, 96% coverage of query (65.1 bits)

P43902 prephenate dehydrogenase (EC 1.3.1.12) from Haemophilus influenzae (see paper)
    23% identity, 96% coverage of query (64.7 bits)

novF / Q9L9G2 prephenate dehydrogenase (EC 1.3.1.12) from Streptomyces niveus (see paper)
    26% identity, 95% coverage of query (60.5 bits)

A0A101IGG2 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Methanothrix harundinacea (see paper)
    23% identity, 76% coverage of query (51.6 bits)

TyrA / b2600 fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
tyrA / P07023 fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12) from Escherichia coli (strain K12) (see 12 papers)
    23% identity, 75% coverage of query (50.8 bits)

E1R5M5 arogenate dehydrogenase [NAD(P)+] (EC 1.3.1.79) from Sediminispirochaeta smaragdinae (see paper)
    24% identity, 72% coverage of query (48.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory