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Searching for up to 100 curated homologs for WP_013553705.1 NCBI__GCF_000186245.1:WP_013553705.1 (430 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Gsa / b0154 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Escherichia coli K-12 substr. MG1655 (see 20 papers)
hemL / P23893 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Escherichia coli (strain K12) (see 19 papers)
GSA_ECOLI / P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see 3 papers)
    60% identity, 97% coverage of query (496 bits)

hemL / P0CL07 glutamate-1-semialdehyde 2,1-aminomutase subunit (EC 5.4.3.8) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    60% identity, 97% coverage of query (491 bits)

3bs8A / P30949 Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
    55% identity, 99% coverage of query (476 bits)

P30949 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Bacillus subtilis (see paper)
hemL / AAA22515.1 glutamate-1-semialdehyde 2,1-aminotransferase from Bacillus subtilis (see 2 papers)
    55% identity, 99% coverage of query (474 bits)

hemL / CAD48149.1 glutamate-1-semialdehyde 2,1-aminotransferase from Bacillus megaterium (see paper)
    55% identity, 100% coverage of query (473 bits)

3k28A / Q81LD0 Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
    57% identity, 95% coverage of query (466 bits)

5i92F / P48247 Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
    54% identity, 98% coverage of query (454 bits)

6w80A / B2FT35 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
    56% identity, 97% coverage of query (454 bits)

2e7uA / Q5SJS4 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8
    54% identity, 98% coverage of query (452 bits)

P24630 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Synechococcus sp. (see 2 papers)
    53% identity, 99% coverage of query (447 bits)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form)
    53% identity, 99% coverage of query (444 bits)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form)
    53% identity, 99% coverage of query (444 bits)

3fq7A / P24630 Gabaculine complex of gsam (see paper)
    53% identity, 99% coverage of query (443 bits)

3usfA Crystal structure of dava-4
    53% identity, 99% coverage of query (443 bits)

2hp2A Inter-subunit signaling in gsam
    53% identity, 99% coverage of query (443 bits)

2hp1A Inter-subunit signaling in gsam
    53% identity, 99% coverage of query (443 bits)

2hozA Inter-subunit signaling in gsam
    53% identity, 99% coverage of query (443 bits)

GSA1 / P42799 glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) from Arabidopsis thaliana (see paper)
GSA1_ARATH / P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
P42799 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Arabidopsis thaliana (see paper)
    52% identity, 99% coverage of query (442 bits)

GSA2_ARATH / Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    52% identity, 99% coverage of query (442 bits)

3fqaA Gabaculien complex of gabaculine resistant gsam version
    53% identity, 99% coverage of query (442 bits)

5hdmA / P42799 Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
    52% identity, 99% coverage of query (441 bits)

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase
    52% identity, 99% coverage of query (441 bits)

3usfB / Q31QJ2 Crystal structure of dava-4
    49% identity, 99% coverage of query (399 bits)

2hp1B Inter-subunit signaling in gsam
    48% identity, 99% coverage of query (393 bits)

Q8NT73 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Corynebacterium glutamicum (see paper)
    50% identity, 95% coverage of query (389 bits)

hemL / BAA21914.1 glutamate 1-semialdehyde 2,1-aminomutase from Propionibacterium freudenreichii (see 2 papers)
    48% identity, 97% coverage of query (372 bits)

GSA_SACS2 / Q980U5 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q980U5 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Saccharolobus solfataricus (see paper)
    45% identity, 96% coverage of query (361 bits)

2cfbA / Q8DLK8 Glutamate-1-semialdehyde 2,1-aminomutase from thermosynechococcus elongatus (see paper)
    48% identity, 92% coverage of query (347 bits)

2zsmA / Q9Y9I9 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from aeropyrum pernix, hexagonal form
    44% identity, 99% coverage of query (337 bits)

6k8hB / D1C218 Crystal structure of an omega-transaminase from sphaerobacter thermophilus (see paper)
    38% identity, 98% coverage of query (273 bits)

D1C218 beta-alanine-pyruvate transaminase (EC 2.6.1.18) from Sphaerobacter thermophilus (see paper)
    38% identity, 98% coverage of query (272 bits)

4ao9A / H8WR05 Biochemical properties and crystal structure of a novel beta- phenylalanine aminotransferase from variovorax paradoxus (see paper)
    38% identity, 96% coverage of query (229 bits)

4aoaA Biochemical properties and crystal structure of a novel beta- phenylalanine aminotransferase from variovorax paradoxus
    38% identity, 96% coverage of query (229 bits)

BFAT_VARPD / H8WR05 Beta-phenylalanine transaminase; Aromatic beta-amino acid aminotransferase; Beta-phenylalanine aminotransferase; VpAT; EC 2.6.1.- from Variovorax paradoxus (see paper)
H8WR05 tyrosine transaminase (EC 2.6.1.5) from Variovorax paradoxus (see paper)
    38% identity, 96% coverage of query (228 bits)

4zm4B / A8R0K5 Complex structure of pctv k276r mutant with pmp and 3-dehydroshkimate (see paper)
    35% identity, 93% coverage of query (216 bits)

4zm4D / A8R0K5 Complex structure of pctv k276r mutant with pmp and 3-dehydroshkimate (see paper)
    40% identity, 73% coverage of query (209 bits)

6ssdA Transaminase with plp bound (see paper)
    33% identity, 97% coverage of query (207 bits)

6ssgA Transaminase with dcs bound
    33% identity, 97% coverage of query (207 bits)

6ssfA Transaminase with lcs bound
    33% identity, 97% coverage of query (207 bits)

6sseA Transaminase with pmp bound
    33% identity, 97% coverage of query (207 bits)

2ykuA / A3EYF7 Structural determinants of the beta-selectivity of a bacterial aminotransferase (see paper)
    35% identity, 90% coverage of query (202 bits)

2ykvA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    35% identity, 90% coverage of query (202 bits)

2ykyA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    35% identity, 90% coverage of query (202 bits)

2ykxA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    35% identity, 90% coverage of query (202 bits)

4ao4A Structural determinants of the beta-selectivity of a bacterial aminotransferase
    35% identity, 90% coverage of query (202 bits)

KAT_CLOAI / B0VH76 3-aminobutyryl-CoA aminotransferase; HemL-like protein; EC 2.6.1.111 from Cloacimonas acidaminovorans (strain Evry) (see paper)
B0VH76 3-aminobutanoyl-CoA transaminase (EC 2.6.1.111) from Candidatus Cloacimonas acidaminovorans (see paper)
    31% identity, 99% coverage of query (189 bits)

6kfuA / Q9R9J1 A acp-amt fusion protein of hybrid polyketide/non-ribosomal peptide synthetase
    34% identity, 79% coverage of query (182 bits)

MYCA_BACIU / Q9R9J1 Mycosubtilin synthase subunit A; EC 2.3.1.- from Bacillus subtilis (see paper)
    34% identity, 79% coverage of query (182 bits)

6kfrA Amino-transferase (amt) domain - arg complex of hybrid polyketide/non- ribosomal peptide synthetase
    34% identity, 79% coverage of query (182 bits)

bmyA / CAE11250.1 BmyA protein from Bacillus amyloliquefaciens (see paper)
    33% identity, 79% coverage of query (175 bits)

gdnH / K4JEW9 guadinomine polyketide synthase module 4 from Streptomyces sp. K01-0509 (see paper)
    33% identity, 92% coverage of query (175 bits)

YC7B_SCHPO / O94492 Uncharacterized aminotransferase C417.11c; EC 2.6.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    31% identity, 92% coverage of query (169 bits)

mxcL / Q9F631 myxocheline aldehyde aminotransferase from Stigmatella aurantiaca (see 2 papers)
    30% identity, 100% coverage of query (165 bits)

Q5SHH5 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
    35% identity, 74% coverage of query (155 bits)

lysJ / Q93R93 L-2-aminoadipate semialdehyde transaminase monomer (EC 2.6.1.118) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
LYSJ_THET2 / Q93R93 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
Q93R93 [amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase (EC 2.6.1.118) from Thermus thermophilus (see 2 papers)
    35% identity, 74% coverage of query (154 bits)

1vefA / Q5SHH5 Acetylornithine aminotransferase from thermus thermophilus hb8
    35% identity, 74% coverage of query (154 bits)

1wkhA Acetylornithine aminotransferase from thermus thermophilus hb8
    35% identity, 74% coverage of query (154 bits)

1wkgA Acetylornithine aminotransferase from thermus thermophilus hb8
    35% identity, 74% coverage of query (154 bits)

Build an alignment

Build an alignment for WP_013553705.1 and 58 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

6hbvA / D2D3B2 Structure of plp internal aldimine form of sphingopyxis sp. Mta144 fumi protein
    29% identity, 97% coverage of query (153 bits)

fumI / D2D3B2 aminopentol aminotransferase from Sphingopyxis macrogoltabida (see paper)
FUMI_SPHMC / D2D3B2 Aminopentol aminotransferase; EC 2.6.1.- from Sphingopyxis macrogoltabida (Sphingomonas macrogoltabidus) (see 2 papers)
    29% identity, 97% coverage of query (152 bits)

A0A140N9B6 succinylornithine transaminase (EC 2.6.1.81) from Escherichia coli (see paper)
    36% identity, 74% coverage of query (147 bits)

davT / Q9I6M4 5-aminovalerate aminotransferase (EC 2.6.1.48) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
DAVT_PSEAE / Q9I6M4 5-aminovalerate aminotransferase DavT; 5-aminovalerate transaminase; Delta-aminovalerate aminotransferase; EC 2.6.1.48 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6M4 5-aminovalerate transaminase (EC 2.6.1.48) from Pseudomonas aeruginosa (see paper)
    32% identity, 86% coverage of query (147 bits)

4adbB / P77581 Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
    36% identity, 74% coverage of query (147 bits)

AstC / b1748 succinylornithine transaminase (EC 2.6.1.81; EC 2.6.1.11) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
astC / P77581 succinylornithine transaminase (EC 2.6.1.81; EC 2.6.1.11) from Escherichia coli (strain K12) (see 6 papers)
ASTC_ECOLI / P77581 Succinylornithine transaminase; SOAT; Carbon starvation protein C; Succinylornithine aminotransferase; EC 2.6.1.81 from Escherichia coli (strain K12) (see paper)
astC / RF|NP_416262.1 succinylornithine transaminase; EC 2.6.1.81 from Escherichia coli K12 (see 5 papers)
    36% identity, 74% coverage of query (147 bits)

lysJ / Q4JAP8 [amino group carrier protein]-C-terminal-L-glutamyl-γ-L-lysine aminotransferase (EC 2.6.1.118; EC 2.6.1.124) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see 2 papers)
    33% identity, 77% coverage of query (147 bits)

4addA Structural and functional study of succinyl-ornithine transaminase from e. Coli
    36% identity, 74% coverage of query (147 bits)

A8J933 acetylornithine transaminase (EC 2.6.1.11) from Chlamydomonas reinhardtii (see paper)
    32% identity, 75% coverage of query (144 bits)

Q9HWU0 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Pseudomonas aeruginosa (see paper)
    30% identity, 91% coverage of query (144 bits)

5yktA / Q9HWU0 Crystal structure of a glutamate-1-semialdehyde-aminomutase (k286a) from pseudomonas aeruginosa pao1 in complex with pmp (see paper)
    30% identity, 91% coverage of query (142 bits)

1sf2A / P22256 Structure of e. Coli gamma-aminobutyrate aminotransferase (see paper)
    30% identity, 90% coverage of query (142 bits)

GabT / b2662 4-aminobutyrate aminotransferase GabT (EC 2.6.1.19; EC 2.6.1.48; EC 2.6.1.11) from Escherichia coli K-12 substr. MG1655 (see 29 papers)
gabT / P22256 4-aminobutyrate aminotransferase GabT (EC 2.6.1.19; EC 2.6.1.48; EC 2.6.1.11) from Escherichia coli (strain K12) (see 28 papers)
GABT_ECOLI / P22256 4-aminobutyrate aminotransferase GabT; 5-aminovalerate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT; EC 2.6.1.19; EC 2.6.1.48 from Escherichia coli (strain K12) (see 6 papers)
    30% identity, 90% coverage of query (142 bits)

1szkA The structure of gamma-aminobutyrate aminotransferase mutant: e211s
    30% identity, 90% coverage of query (142 bits)

1sffA Structure of gamma-aminobutyrate aminotransferase complex with aminooxyacetate
    30% identity, 90% coverage of query (142 bits)

gabT / Q0K2K2 4-aminobutyrate aminotransferase monomer (EC 2.6.1.19) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
Q0K2K2 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Cupriavidus necator (see paper)
    31% identity, 85% coverage of query (140 bits)

5wyfA Structure of amino acid racemase, 2.12 a
    29% identity, 77% coverage of query (132 bits)

GoaG / b1302 4-aminobutyrate aminotransferase PuuE (EC 2.6.1.19; EC 2.6.1.48) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
puuE / P50457 4-aminobutyrate aminotransferase PuuE (EC 2.6.1.19; EC 2.6.1.48) from Escherichia coli (strain K12) (see 11 papers)
PUUE_ECOLI / P50457 4-aminobutyrate aminotransferase PuuE; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; EC 2.6.1.19 from Escherichia coli (strain K12) (see 2 papers)
puuE / BAD88710.1 gamma-aminobutyrate aminotransferase from Escherichia coli K-12 (see paper)
    29% identity, 90% coverage of query (130 bits)

4uoyA Crystal structure of ygjg in complex with pyridoxal-5'-phosphate
    32% identity, 82% coverage of query (126 bits)

4uoxA Crystal structure of ygjg in complex with pyridoxal-5'-phosphate and putrescine
    32% identity, 82% coverage of query (126 bits)

A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    32% identity, 80% coverage of query (126 bits)

8cplC / P38507,P42588 Yzw2 a scaffold for cryo-em of small proteins of interest
    31% identity, 92% coverage of query (126 bits)

PatA / b3073 putrescine aminotransferase (EC 2.6.1.29) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
patA / P42588 putrescine aminotransferase (EC 2.6.1.82; EC 2.6.1.29) from Escherichia coli (strain K12) (see 15 papers)
PAT_ECOLI / P42588 Putrescine aminotransferase; PAT; PATase; Cadaverine transaminase; Diamine transaminase; Putrescine transaminase; Putrescine--2-oxoglutaric acid transaminase; Putrescine:2-OG aminotransferase; EC 2.6.1.82; EC 2.6.1.29 from Escherichia coli (strain K12) (see 8 papers)
P42588 putrescine-2-oxoglutarate transaminase (EC 2.6.1.82) from Escherichia coli (see 4 papers)
    32% identity, 82% coverage of query (126 bits)

7lonA Ornithine aminotransferase (oat) cocrystallized with its inactivator - (1s,3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    32% identity, 75% coverage of query (126 bits)

7lomC Ornithine aminotransferase (oat) soaked with its inactivator - (1s, 3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    31% identity, 82% coverage of query (126 bits)

7lomA Ornithine aminotransferase (oat) soaked with its inactivator - (1s, 3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    31% identity, 82% coverage of query (126 bits)

8ez1B Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid
    32% identity, 75% coverage of query (125 bits)

8ez1A Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid
    32% identity, 75% coverage of query (125 bits)

7tfpC Human ornithine aminotransferase cocrystallized with its inhibitor, (1s,3s)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid.
    32% identity, 75% coverage of query (125 bits)

7lk0A Ornithine aminotransferase (oat) cocrystallized with its potent inhibitor - (s)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (ss-1-148)
    32% identity, 75% coverage of query (125 bits)

7jx9A The crystal structure of human ornithine aminotransferase with an intermediate bound during inactivation by (1s,3s)-3-amino-4- (hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic acid.
    32% identity, 75% coverage of query (125 bits)

6v8dA Design, synthesis, and mechanism of fluorine-substituted cyclohexene analogues of gama-aminobutyric acid (gaba) as selective ornithine aminotransferase inactivators
    32% identity, 75% coverage of query (125 bits)

2canA Human ornithine aminotransferase complexed with l-canaline
    32% identity, 75% coverage of query (125 bits)

1gbnB Human ornithine aminotransferase complexed with the neurotoxin gabaculine
    32% identity, 75% coverage of query (125 bits)

1gbnA Human ornithine aminotransferase complexed with the neurotoxin gabaculine
    32% identity, 75% coverage of query (125 bits)

OAT / P04181 Ornithine aminotransferase (EC 2.6.1.13) from Homo sapiens (see 3 papers)
OAT_HUMAN / P04181 Ornithine aminotransferase, mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Homo sapiens (Human) (see 8 papers)
    32% identity, 75% coverage of query (124 bits)

7ta0A Human ornithine aminotransferase (hoat) soaked with 5-aminovaleric acid
    31% identity, 82% coverage of query (124 bits)

8v9mA Human ornithine aminotransferase cocrystallized with its inhibitor, (r)-3-amino-5,5-difluorocyclohex-1-ene-1-carboxylic acid.
    32% identity, 75% coverage of query (124 bits)

7tedA Human ornithine aminotransferase cocrystallized with its inhibitor, (s,e)-3-amino-4-(fluoromethylene)cyclopent-1-ene-1-carboxylate
    32% identity, 75% coverage of query (124 bits)

7ta1A Human ornithine aminotransferase (hoat) soaked with gamma-aminobutyric acid
    32% identity, 75% coverage of query (124 bits)

7lnmB Ornithine aminotransferase (oat) cocrystallized with its inactivator - (1s,3s)-3-amino-4-(difluoromethylene)cyclopentene-1-carboxylic acid
    32% identity, 75% coverage of query (124 bits)

7lk1A Ornithine aminotransferase (oat) with its potent inhibitor - (s)-3- amino-4,4-difluorocyclopent-1-enecarboxylic acid (ss-1-148) - 1 hour soaking
    32% identity, 75% coverage of query (124 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory