Searching for up to 100 curated homologs for WP_014026192.1 NCBI__GCF_000223395.1:WP_014026192.1 (476 a.a.)
Found high-coverage hits (≥70%) to 98 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
SYD_THEKO / Q52428 Aspartate--tRNA(Asp) ligase; Aspartyl-tRNA synthetase; AspRS; Discriminating aspartyl-tRNA synthetase; D-AspRS; EC 6.1.1.12 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see 4 papers)
Q52428 aspartate-tRNA ligase (EC 6.1.1.12) from Thermococcus kodakarensis (see 4 papers)
45% identity, 94% coverage of query (356 bits)
3nemB Aspartyl-tRNA synthetase complexed with aspartyl adenylate
45% identity, 94% coverage of query (356 bits)
3nemA Aspartyl-tRNA synthetase complexed with aspartyl adenylate
45% identity, 94% coverage of query (356 bits)
3nelA Aspartyl-tRNA synthetase complexed with aspartic acid
45% identity, 94% coverage of query (356 bits)
1b8aA / Q52428 Aspartyl-tRNA synthetase (see paper)
44% identity, 94% coverage of query (353 bits)
SYDND_METTH / O26328 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see paper)
O26328 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Methanothermobacter thermautotrophicus (see paper)
42% identity, 92% coverage of query (335 bits)
SYDND_HALSA / O07683 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) (see paper)
O07683 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Halobacterium salinarum (see paper)
40% identity, 94% coverage of query (313 bits)
SYDND_METMA / Q8Q0R2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) (see paper)
40% identity, 94% coverage of query (309 bits)
SYDND_THET8 / Q5SIC2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase 2; AspRS2; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 4 papers)
Q5SIC2 aspartate-tRNA ligase (EC 6.1.1.12) from Thermus thermophilus (see paper)
41% identity, 92% coverage of query (292 bits)
SYDC_MOUSE / Q922B2 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Mus musculus (Mouse) (see paper)
Q922B2 aspartate-tRNA ligase (EC 6.1.1.12) from Mus musculus (see paper)
36% identity, 90% coverage of query (277 bits)
SYDC_RAT / P15178 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Rattus norvegicus (Rat) (see paper)
36% identity, 90% coverage of query (276 bits)
SYDC_HUMAN / P14868 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; Cell proliferation-inducing gene 40 protein; EC 6.1.1.12 from Homo sapiens (Human) (see 4 papers)
P14868 aspartate-tRNA ligase (EC 6.1.1.12) from Homo sapiens (see 2 papers)
35% identity, 90% coverage of query (274 bits)
erdS / Q4WKG3 aspartate--tRNA ligase/ergosteryl-3β-O-L-aspartate synthase (EC 6.1.1.23; EC 2.3.2.37) from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (see paper)
37% identity, 92% coverage of query (261 bits)
SYDC_SCHPO / O74407 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
33% identity, 92% coverage of query (255 bits)
SYDC2_ARATH / Q9M084 Aspartate--tRNA ligase 2, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; Protein IMPAIRED IN BABA-INDUCED DISEASE IMMUNITY 1; EC 6.1.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
35% identity, 87% coverage of query (255 bits)
SYDC_YEAST / P04802 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
34% identity, 93% coverage of query (254 bits)
1asyA / P04802 Class ii aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA asp (see paper)
34% identity, 93% coverage of query (254 bits)
1aszA The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction
34% identity, 93% coverage of query (254 bits)
aspS2 / Q9RVH4 aspartyl-tRNA synthetase, non-discriminating (EC 6.1.1.23) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see 2 papers)
SYDND_DEIRA / Q9RVH4 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase 2; AspRS2; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see 2 papers)
36% identity, 92% coverage of query (246 bits)
C4LZN0 aspartate-tRNA ligase (EC 6.1.1.12); aspartate-tRNAAsn ligase (EC 6.1.1.23) from Entamoeba histolytica (see paper)
37% identity, 71% coverage of query (241 bits)
Q585M3 aspartate-tRNA ligase (EC 6.1.1.12) from Trypanosoma brucei (see paper)
33% identity, 93% coverage of query (241 bits)
1x54A / O57980 Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate (see paper)
34% identity, 92% coverage of query (241 bits)
1x55A Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate analogue
34% identity, 92% coverage of query (241 bits)
Build an alignment for WP_014026192.1 and 23 homologs with ≥ 30% identity
Or download the sequences
Q8I2B1 aspartate-tRNA ligase (EC 6.1.1.12) from Plasmodium falciparum (see paper)
29% identity, 92% coverage of query (231 bits)
Q38CB4 aspartate-tRNA ligase (EC 6.1.1.12) from Trypanosoma brucei (see paper)
33% identity, 91% coverage of query (227 bits)
3kfuC / Q5SIC2 Crystal structure of the transamidosome (see paper)
36% identity, 91% coverage of query (216 bits)
SYNC_YEAST / P38707 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
28% identity, 92% coverage of query (187 bits)
P54263 asparagine-tRNA ligase (EC 6.1.1.22) from Thermus thermophilus (see paper)
31% identity, 94% coverage of query (179 bits)
asnS / CAA62491.1 asparaginyl-tRNA synthetase from Thermus thermophilus (see paper)
31% identity, 94% coverage of query (179 bits)
SYNM_HUMAN / Q96I59 Asparaginyl-tRNA synthetase; AsnRS; NARS2; Asparagine--tRNA ligase, mitochondrial; EC 6.1.1.22 from Homo sapiens (Human) (see 4 papers)
Q96I59 asparagine-tRNA ligase (EC 6.1.1.22) from Homo sapiens (see 2 papers)
32% identity, 91% coverage of query (174 bits)
SYNC_SCHPO / O94567 Probable asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
28% identity, 93% coverage of query (174 bits)
SYNM_MOUSE / Q8BGV0 Asparaginyl-tRNA synthetase; AsnRS; NARS2; Asparagine--tRNA ligase, mitochondrial; EC 6.1.1.22 from Mus musculus (Mouse) (see paper)
31% identity, 93% coverage of query (173 bits)
8tc9A Human asparaginyl-tRNA synthetase bound to osm-s-106
28% identity, 92% coverage of query (165 bits)
8tc8A / O43776 Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate (see paper)
28% identity, 92% coverage of query (164 bits)
8h53A Human asparaginyl-tRNA synthetase in complex with asparagine-amp
28% identity, 92% coverage of query (164 bits)
SYNC_CAEEL / Q19722 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Caenorhabditis elegans (see paper)
29% identity, 90% coverage of query (163 bits)
SYNC_HUMAN / O43776 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; Asparaginyl-tRNA synthetase 1; EC 6.1.1.22 from Homo sapiens (Human) (see 6 papers)
O43776 asparagine-tRNA ligase (EC 6.1.1.22) from Homo sapiens (see 2 papers)
27% identity, 92% coverage of query (163 bits)
2xtiA Asparaginyl-tRNA synthetase from brugia malayi complexed with atp:mg and l-asp-beta-noh adenylate:ppi:mg
28% identity, 90% coverage of query (157 bits)
2xgtB Asparaginyl-tRNA synthetase from brugia malayi complexed with the sulphamoyl analogue of asparaginyl-adenylate (see paper)
28% identity, 90% coverage of query (156 bits)
SYNM_SCHPO / Q9P6I0 Asparagine--tRNA ligase, mitochondrial; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
29% identity, 90% coverage of query (147 bits)
3m4pA / C4LWW8 Entamoeba histolytica asparaginyl-tRNA synthetase (asnrs) in complex with asparaginyl-adenylate
29% identity, 92% coverage of query (147 bits)
4o2dB / A0QWN3 Crystal structure of aspartyl-tRNA synthetase from mycobacterium smegmatis with bound aspartic acid (see paper)
28% identity, 94% coverage of query (147 bits)
Tss / b0930 asparagine—tRNA ligase (EC 6.1.1.22) from Escherichia coli K-12 substr. MG1655 (see 13 papers)
asnS / P0A8M0 asparagine—tRNA ligase (EC 6.1.1.22) from Escherichia coli (strain K12) (see 14 papers)
SYN_ECOLI / P0A8M0 Asparagine--tRNA ligase; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Escherichia coli (strain K12) (see 2 papers)
30% identity, 93% coverage of query (145 bits)
2xtiB Asparaginyl-tRNA synthetase from brugia malayi complexed with atp:mg and l-asp-beta-noh adenylate:ppi:mg
28% identity, 90% coverage of query (145 bits)
SYNO_ARATH / O48593 Asparagine--tRNA ligase, chloroplastic/mitochondrial; Asparaginyl-tRNA synthetase; AsnRS; AtNS1; Protein OVULE ABORTION 8; EC 6.1.1.22 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
28% identity, 91% coverage of query (142 bits)
SYNC_BRUMA / P10723 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; Potentially protective 63 kDa antigen; EC 6.1.1.22 from Brugia malayi (Filarial nematode worm) (see paper)
P10723 asparagine-tRNA ligase (EC 6.1.1.22) from Brugia malayi (see paper)
27% identity, 90% coverage of query (138 bits)
Q1D380 lysine-tRNA ligase (EC 6.1.1.6) from Myxococcus xanthus (see 2 papers)
27% identity, 89% coverage of query (120 bits)
Q9RHV9 lysine-tRNA ligase (EC 6.1.1.6) from Geobacillus stearothermophilus (see 3 papers)
25% identity, 89% coverage of query (112 bits)
3a74A / Q9RHV9 Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with diadenosine tetraphosphate (ap4a)
25% identity, 89% coverage of query (111 bits)
3e9iA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysine hydroxamate-amp
25% identity, 89% coverage of query (111 bits)
3e9hA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysylsulfamoyl adenosine
25% identity, 89% coverage of query (111 bits)
6wbdB / B2FQ84 Crystal structure of lysyl-tRNA synthetase from stenotrophomonas maltophilia with bound l-lysine
27% identity, 93% coverage of query (107 bits)
5hgqB Loa loa lysyl-tRNA synthetase in complex with cladosporin. (see paper)
25% identity, 89% coverage of query (105 bits)
P0A8N5 Lysine--tRNA ligase, heat inducible; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Escherichia coli (strain K12)
25% identity, 89% coverage of query (105 bits)
5yzxA Crystal structure of e.Coli lysu t146d mutant
25% identity, 89% coverage of query (105 bits)
1bbuA / P0A8N3 Lysyl-tRNA synthetase (lyss) complexed with lysine (see paper)
26% identity, 89% coverage of query (105 bits)
4up9A Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with atp
24% identity, 91% coverage of query (104 bits)
1e24A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and atp and mn2+
25% identity, 89% coverage of query (104 bits)
1e22A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and the non-hydrolysable atp analogue amp-pcp
25% identity, 89% coverage of query (104 bits)
1e1tA / P0A8N5 Lysyl-tRNA synthetase (lysu) hexagonal form complexed with the lysyl_adenylate intermediate (see paper)
25% identity, 89% coverage of query (104 bits)
4upaA Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with amppnp
24% identity, 91% coverage of query (103 bits)
4dpgA Crystal structure of human lysrs: p38/aimp2 complex i
26% identity, 89% coverage of query (101 bits)
3bjuA Crystal structure of tetrameric form of human lysyl-tRNA synthetase
26% identity, 89% coverage of query (101 bits)
4up7A / C4M7X2 Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with lysyl-adenylate (see paper)
24% identity, 91% coverage of query (100 bits)
4ex5A / Q2SXD6 Crystal structure of lysyl-tRNA synthetase lysrs from burkholderia thailandensis bound to lysine (see paper)
28% identity, 89% coverage of query (99.8 bits)
1e1oA Lysyl-tRNA synthetase (lysu) hexagonal form, complexed with lysine
25% identity, 89% coverage of query (99.8 bits)
4ycuA Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase
26% identity, 89% coverage of query (99.8 bits)
6chdA / Q15046 Crystal structure of human lysyl-tRNA synthetase complexed with l- lysylsulfamoyl adenosine
26% identity, 89% coverage of query (99.8 bits)
SYK_HUMAN / Q15046 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Homo sapiens (Human) (see 25 papers)
Q15046 lysine-tRNA ligase (EC 6.1.1.6) from Homo sapiens (see 12 papers)
26% identity, 89% coverage of query (98.2 bits)
6o3fA Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis with complexed with l-lysine and a difluoro cyclohexyl chromone ligand
25% identity, 89% coverage of query (97.8 bits)
6ns0A Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and cladosporin
25% identity, 89% coverage of query (97.8 bits)
6ildB Crystal structure of human lysrs: p38/aimp2 complex ii
26% identity, 89% coverage of query (97.4 bits)
4ycwA Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant
26% identity, 89% coverage of query (95.5 bits)
6aqhB / G7CF12 Crystal structure of lysyl-tRNA synthetase from mycobacterium thermoresistibile complexed with l-lysine and cladosporin
26% identity, 93% coverage of query (90.9 bits)
6kctA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 5
24% identity, 81% coverage of query (85.9 bits)
6kabA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 2
24% identity, 81% coverage of query (85.9 bits)
6agtB / Q8IDJ8 Crystal structure of pfkrs complexed with chromone inhibitor (see paper)
24% identity, 81% coverage of query (85.9 bits)
6kbfA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3
24% identity, 81% coverage of query (85.5 bits)
6kcnA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4
24% identity, 81% coverage of query (84.7 bits)
6ka6A Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1
24% identity, 81% coverage of query (83.2 bits)
8k9vA Crystal structure of plasmodium lysrs complexing with asp3026 derived lysrs inhibitor 3 (adki3)
24% identity, 81% coverage of query (82.8 bits)
8k9sA Crystal structure of plasmodium lysrs complexing with asp3026 derived lysrs inhibitor 1 (adki1)
24% identity, 81% coverage of query (82.8 bits)
6m0tA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and cladosporin derivative (cl-2)
23% identity, 81% coverage of query (82.4 bits)
6l4qA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and clado-b
24% identity, 81% coverage of query (82.4 bits)
7qi8A Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and inhibitor
24% identity, 89% coverage of query (82.4 bits)
6bniA / Q5CR27 Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and adenosine
23% identity, 92% coverage of query (81.6 bits)
5eloA Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and cladosporin
23% identity, 92% coverage of query (81.6 bits)
6hcwA Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and a difluoro cyclohexyl chromone ligand
23% identity, 92% coverage of query (81.6 bits)
6c86A Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysylsulfamoyl adenosine
23% identity, 92% coverage of query (81.6 bits)
7bt5A Crystal structure of plasmodium lysrs complexing with an antitumor compound
23% identity, 81% coverage of query (79.3 bits)
6aqgC / A0PV47 Crystal structure of lysyl-tRNA synthetase from mycobacterium ulcerans complexed with l-lysine and cladosporin
24% identity, 93% coverage of query (79.3 bits)
8k9xA Crystal structure of plasmodium lysrs complexing with asp3026 derived lysrs inhibitor 5 (adki5)
23% identity, 81% coverage of query (79.0 bits)
7qh8A / P9WFU9 Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine (see paper)
25% identity, 89% coverage of query (78.6 bits)
7qhnA Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and an inhibitor
24% identity, 87% coverage of query (78.2 bits)
7zogA Crystal structure of cryptosporidium parvum -plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor
23% identity, 92% coverage of query (77.8 bits)
7f6wA / P15180 Crystal structure of saccharomyces cerevisiae lysyl-tRNA synthetase (see paper)
24% identity, 90% coverage of query (77.4 bits)
P15180 Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
24% identity, 90% coverage of query (76.6 bits)
6hcuA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand
23% identity, 81% coverage of query (75.5 bits)
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Lawrence Berkeley National Laboratory