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Searching for up to 100 curated homologs for WP_014147654.1 NCBI__GCF_000968535.2:WP_014147654.1 (397 a.a.)

Found high-coverage hits (≥70%) to 62 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ADH4 / P10127 alcohol dehydrogenase IV (EC 1.1.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 11 papers)
ADH4_YEAST / P10127 Alcohol dehydrogenase 4; Alcohol dehydrogenase IV; ADHIV; EC 1.1.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 11 papers)
    30% identity, 97% coverage of query (157 bits)

YiaY / b3589 L-threonine dehydrogenase (EC 1.1.1.103) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
yiaY / P37686 L-threonine dehydrogenase (EC 1.1.1.103) from Escherichia coli (strain K12) (see 5 papers)
    31% identity, 95% coverage of query (156 bits)

Build an alignment

Build an alignment for WP_014147654.1 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

hpfD / A0A374P995 3-hydroxypropane-1-sulfonate dehydrogenase from Hungatella hathewayi (see paper)
    29% identity, 91% coverage of query (149 bits)

adh1 / P13604 NADPH-dependent butanol dehydrogenase (EC 1.1.1.2) from Clostridium saccharobutylicum (see 3 papers)
adh1 / GB|AAA83520.1 NADPH-dependent butanol dehydrogenase; EC 1.1.1.1 from Clostridium saccharobutylicum (see paper)
    30% identity, 97% coverage of query (148 bits)

ADH4_SCHPO / Q09669 Alcohol dehydrogenase 4; Alcohol dehydrogenase IV; EC 1.1.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 4 papers)
Q09669 alcohol dehydrogenase (EC 1.1.1.1) from Schizosaccharomyces pombe (see paper)
adh4 / RF|NP_592819.1 alcohol dehydrogenase Adh4; EC 1.1.1.1 from Schizosaccharomyces pombe (see 3 papers)
    30% identity, 99% coverage of query (147 bits)

I3DVX6 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
    31% identity, 94% coverage of query (141 bits)

I3E949 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see 2 papers)
    31% identity, 93% coverage of query (140 bits)

A0A1D3TV27 alcohol dehydrogenase (EC 1.1.1.1) from Anaerobium acetethylicum (see paper)
    29% identity, 82% coverage of query (139 bits)

I3E2P9 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see 4 papers)
    31% identity, 93% coverage of query (139 bits)

I3DTP7 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
    29% identity, 97% coverage of query (135 bits)

I3DX19 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
    29% identity, 96% coverage of query (135 bits)

mdh / P31005 NAD-dependent methanol dehydrogenase monomer (EC 1.1.1.244) from Bacillus methanolicus (see paper)
MEDH_BACMT / P31005 NAD-dependent methanol dehydrogenase; MDH; MEDH; Type 3 alcohol dehydrogenase; EC 1.1.1.244 from Bacillus methanolicus (see 6 papers)
P31005 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
mdh methanol dehydrogenase; EC 1.1.1.244 from Bacillus methanolicus (see paper)
    29% identity, 97% coverage of query (130 bits)

B1HX72 methanol dehydrogenase (EC 1.1.1.244) from Lysinibacillus sphaericus (see paper)
    30% identity, 83% coverage of query (130 bits)

F8GNE5 methanol dehydrogenase (EC 1.1.1.244) from Cupriavidus necator (see paper)
    31% identity, 95% coverage of query (129 bits)

EUTG_SALTY / P41795 Probable alcohol dehydrogenase EutG; Ethanolamine utilization protein EutG; EC 1.1.1.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
    32% identity, 84% coverage of query (129 bits)

SQWF_CLOS9 / J1H1J3 Sulfoacetaldehyde reductase; EC 1.1.1.433 from Clostridium sp. (strain MSTE9)
    31% identity, 75% coverage of query (127 bits)

YffV / b2453 putative alcohol dehydrogenase EutG from Escherichia coli K-12 substr. MG1655 (see 2 papers)
EUTG_ECOLI / P76553 Probable alcohol dehydrogenase EutG; Ethanolamine utilization protein EutG; EC 1.1.1.1 from Escherichia coli (strain K12) (see paper)
eutG / GB|AAC75506.2 ethanolamine utilization protein eutG; EC 1.1.-.- from Escherichia coli K12 (see 3 papers)
    32% identity, 74% coverage of query (126 bits)

A0NIJ1 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Oenococcus oeni (see paper)
    30% identity, 86% coverage of query (125 bits)

A0A0C1Q6R1 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Levilactobacillus brevis (see paper)
    29% identity, 93% coverage of query (125 bits)

B0KBJ9 alcohol dehydrogenase (EC 1.1.1.1) from Thermoanaerobacter pseudethanolicus (see paper)
    29% identity, 90% coverage of query (124 bits)

B0K4A2 alcohol dehydrogenase (EC 1.1.1.1); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacter sp. X514 (see 2 papers)
    29% identity, 90% coverage of query (124 bits)

BT3767 L-lactaldehyde reductase FucO (EC 1.1.1.77) from Bacteroides thetaiotaomicron VPI-5482
    31% identity, 83% coverage of query (124 bits)

6jkoA / A0A0A7I0A5 Crystal structure of sulfoacetaldehyde reductase from bifidobacterium kashiwanohense (see paper)
    28% identity, 96% coverage of query (123 bits)

Q59477 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see 2 papers)
    32% identity, 82% coverage of query (123 bits)

6jkpA Crystal structure of sulfoacetaldehyde reductase from bifidobacterium kashiwanohense in complex with NAD+
    28% identity, 96% coverage of query (123 bits)

5br4A / P0A9S1 E. Coli lactaldehyde reductase (fuco) m185c mutant (see paper)
    28% identity, 88% coverage of query (122 bits)

3bfjA / Q7WRJ3 Crystal structure analysis of 1,3-propanediol oxidoreductase (see paper)
    31% identity, 92% coverage of query (121 bits)

Q7WRJ3 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see 3 papers)
    31% identity, 82% coverage of query (121 bits)

5yvmA / A0A133UP32 Crystal structure of the archaeal halo-thermophilic red sea brine pool alcohol dehydrogenase adh/d1 bound to nzq (see paper)
    27% identity, 100% coverage of query (121 bits)

5yvrA Crystal structure of the h277a mutant of adh/d1, an archaeal halo- thermophilic red sea brine pool alcohol dehydrogenase
    27% identity, 100% coverage of query (121 bits)

DHAT_CITFR / P45513 1,3-propanediol dehydrogenase; 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase; EC 1.1.1.202 from Citrobacter freundii (see paper)
P45513 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Citrobacter freundii (see paper)
dhaT / GB|AAB48848.1 1,3-propanediol dehydrogenase; EC 1.1.1.202 from Citrobacter freundii (see paper)
dhaT / AAB48848.1 1,3-propanediol dehydrogenase from Citrobacter freundii (see 4 papers)
    31% identity, 82% coverage of query (120 bits)

Q0PH30 alcohol dehydrogenase (EC 1.1.1.1) from Thermoanaerobacter ethanolicus (see paper)
    29% identity, 90% coverage of query (119 bits)

7qlgAAA Lactaldehyde reductase
    27% identity, 88% coverage of query (119 bits)

3zdrA Structure of the alcohol dehydrogenase (adh) domain of a bifunctional adhe dehydrogenase from geobacillus thermoglucosidasius ncimb 11955 (see paper)
    30% identity, 73% coverage of query (118 bits)

FucO / b2799 L-1,2-propanediol oxidoreductase (EC 1.1.1.77) from Escherichia coli K-12 substr. MG1655 (see 22 papers)
fucO / P0A9S1 L-1,2-propanediol oxidoreductase (EC 1.1.1.77) from Escherichia coli (strain K12) (see 23 papers)
FUCO_ECOLI / P0A9S1 Lactaldehyde reductase; Propanediol oxidoreductase; EC 1.1.1.77 from Escherichia coli (strain K12) (see paper)
    28% identity, 88% coverage of query (118 bits)

fucO / RF|NP_417279 propanediol oxidoreductase from Escherichia coli K12 (see 5 papers)
    28% identity, 88% coverage of query (118 bits)

pydE / A0A0A3J5T1 3-hydroxypropionate dehydrogenase (EC 1.1.1.59; EC 1.1.1.298) from Ureibacillus massiliensis 4400831 (see paper)
    26% identity, 96% coverage of query (118 bits)

A3RL85 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see paper)
    32% identity, 82% coverage of query (118 bits)

2bi4A Lactaldehyde:1,2-propanediol oxidoreductase of escherichia coli
    28% identity, 88% coverage of query (118 bits)

1rrmA Crystal structure of lactaldehyde reductase
    28% identity, 88% coverage of query (118 bits)

HP15_3135 ethanol oxidation regulatory protein ercA from Marinobacter adhaerens HP15
    27% identity, 94% coverage of query (117 bits)

1vhdA / Q9X022 Crystal structure of an iron containing alcohol dehydrogenase (see paper)
    31% identity, 76% coverage of query (117 bits)

Q9X022 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Thermotoga maritima (see paper)
    31% identity, 76% coverage of query (117 bits)

A0A0H3W5K4 acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacterium saccharolyticum (see paper)
I3VSF1 alcohol dehydrogenase (EC 1.1.1.1); L-lactate dehydrogenase (EC 1.1.1.27); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacterium saccharolyticum (see paper)
    30% identity, 77% coverage of query (117 bits)

1o2dA Crystal structure of alcohol dehydrogenase, iron-containing (tm0920) from thermotoga maritima at 1.30 a resolution
    31% identity, 76% coverage of query (117 bits)

ADH1 / A8JI07 alcohol dehydrogenase / acetaldehyde dehydrogenase (EC 1.2.1.10; EC 1.1.1.1) from Chlamydomonas reinhardtii (see 2 papers)
    28% identity, 87% coverage of query (116 bits)

Q1RS84 alcohol dehydrogenase (EC 1.1.1.1); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Chlamydomonas reinhardtii (see paper)
    28% identity, 87% coverage of query (116 bits)

7qlqAAA Lactaldehyde reductase
    28% identity, 88% coverage of query (114 bits)

ADH_THEBA / A0A0S1X9S7 Alcohol dehydrogenase; EC 1.1.1.1 from Thermococcus barophilus (see paper)
    25% identity, 99% coverage of query (108 bits)

4HBDH_CUPNE / Q59104 4-hydroxybutyrate dehydrogenase; 4HbD; Gamma-hydroxybutyrate dehydrogenase; GHBDH; EC 1.1.1.61 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see 2 papers)
Q59104 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) from Cupriavidus necator (see paper)
gbd / PRF|2104199G 4-hydroxybutyrate dehydrogenase; EC 1.1.1.61 from Cupriavidus necator (see paper)
    30% identity, 85% coverage of query (107 bits)

6c75B Structure of iron containing alcohol dehydrogenase from thermococcus thioreducens in a monoclinic crystal form
    27% identity, 75% coverage of query (86.3 bits)

A0A0Q2QQL1 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Thermococcus thioreducens (see paper)
6c75A / A0A0Q2QQL1 Structure of iron containing alcohol dehydrogenase from thermococcus thioreducens in a monoclinic crystal form (see paper)
    27% identity, 75% coverage of query (86.3 bits)

3rf7A / Q12MB1 Crystal structure of an iron-containing alcohol dehydrogenase (sden_2133) from shewanella denitrificans os-217 at 2.12 a resolution
    27% identity, 72% coverage of query (83.6 bits)

7w9yA Crystal structure of bacillus subtilis yugj in complex with NADP and nickel (see paper)
    24% identity, 99% coverage of query (79.7 bits)

7w9zA Crystal structure of bacillus subtilis yugj in complex with NADP and nitrate
    25% identity, 99% coverage of query (78.6 bits)

3jzdA / Q46TQ1 Crystal structure of putative alcohol dehedrogenase (yp_298327.1) from ralstonia eutropha jmp134 at 2.10 a resolution
    28% identity, 76% coverage of query (70.9 bits)

1vljB / Q9WZS7 Crystal structure of nadh-dependent butanol dehydrogenase a (tm0820) from thermotoga maritima at 1.78 a resolution
    24% identity, 93% coverage of query (66.2 bits)

YqhD / b3011 NADPH-dependent aldehyde reductase YqhD (EC 1.1.1.2) from Escherichia coli K-12 substr. MG1655 (see 35 papers)
yqhD / Q46856 NADPH-dependent aldehyde reductase YqhD (EC 1.1.1.21; EC 1.1.1.2) from Escherichia coli (strain K12) (see 38 papers)
YQHD_ECOLI / Q46856 Alcohol dehydrogenase YqhD; EC 1.1.1.2 from Escherichia coli (strain K12) (see paper)
Q46856 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Escherichia coli (see paper)
yqhD / RF|NP_417484 alcohol dehydrogenase yqhD; EC 1.1.1.- from Escherichia coli K12 (see 5 papers)
    26% identity, 89% coverage of query (64.7 bits)

1oj7B Structural genomics, unknown function crystal structure of e. Coli k- 12 yqhd
    26% identity, 89% coverage of query (64.3 bits)

1oj7A / Q46856 Structural genomics, unknown function crystal structure of e. Coli k- 12 yqhd (see paper)
    26% identity, 89% coverage of query (64.3 bits)

8i29A Crystal structure of butanol dehydrogenase a (yqdh) in complex with nadh from fusobacterium nucleatum
    25% identity, 74% coverage of query (62.0 bits)

7fjgA / Q8R612 Crystal structure of butanol dehydrogenase a (yqdh) in complex with partial nadh from fusobacterium nucleatum
    25% identity, 74% coverage of query (62.0 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory